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This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Five alternatively spliced transcripts encoding the same protein have been described.
9130022O19Rik; BC1 (ubiquinol-cytochrome c reductase) synthesis-like; BCS; BCS1; BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Bcs1l; BCS1-like (yeast); BCS1-like protein; BJS; FLNMS; GRACILE; h-BCS; h-BCS1; Hs.6719; MC3DN1; mitochondrial chaperone BCS1; mitochondrial complex III assembly; PTD
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