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Cryptic is a 224 amino acid member of the epidermal growth factor-Cripto-1/ FRL1/cryptic family that consists of extracellular and cell-associated proteins which function as co-receptors for the transforming growth factor b subfamily of proteins. Cryptic is involved in the appropriate establishment of the left-right axis of the organism, and it may play a role in the development of mesoderm and/or neural patterning during gastrulation. Loss-of-function mutations in CFC1, the gene encoding for Cryptic, are associated with human left-right laterality defects. Defects in CFC1 also cause visceral heterotaxy (HTX2), an autosomal disease characterized by a variable group of congenital anomalies that include complex cardiac malformations such as conotruncal heart malformations that may lead to cardiac outflow tract defects, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis and aortic arch anomalies.
AV265756; b2b970Clo; CFC1; CFC1B; cripto, FRL-1, cryptic family 1; cripto, FRL-1, cryptic family 1B; cryptic; Cryptic family protein 1; cryptic family protein 1B; Cryptic protein; DTGA2; heterotaxy 2 (autosomal dominant); HTX2; RGD1562188
100 µL
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