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DNA fragmentation is one of the critical steps in apoptosis, which is induced by DNA fragmentation factor (DFF). DFF is composed of two subunits, a 40 kDa caspase-activated nuclease (DFF40) and a 45 kDa inhibitor (DFF45). Recently a novel family of cell-death-inducing DFF45-like effectors (CIDEs) has been identified. Human CIDE-3 is a novel member of CIDEs. There are 2 transcripts, CIDE-3 and CIDE-3alpha, were present in HepG2 and A375 cells. Consistent with its chromosome localization at 3p25, a region associated with high frequency loss of heterozygosity in many tumours, CIDE-3 may play an important role in prevention of tumorigenesis.
cell death activator CIDE-3; cell death inducing DFFA like effector c; cell death-inducing DFFA-like effector c; cell death-inducing DFFA-like effector protein C; CID; cide 3; CIDE3; CIDE-3; CIDE-3alpha; Cidec; fat specific gene 27; fat specific protein 27; fat-specific protein FSP27; Fat-specific protein FSP27 homolog; FPLD5; FSP27
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