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Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Historically, CD183 was the third CXC chemokine receptor discovered and therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. The CXC chemokine receptor (CXCR) 3, a G-protein-coupled 7-transmembrane receptor, is expressed at high levels on activated and memory T cells, B cells, natural killer cells, and plasmacytoid monocytes.
CD182; CD183; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; CKR-L2; CMKAR3; C-X-C chemokine receptor type 3; C-X-C motif chemokine receptor 3; CXCR3; CXC-R3; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP-10 receptor; IP10-R; Mig receptor; MigR; Mig-R
150 µL
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