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Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death.
D13Ucla1; DAP kinase 1; DAP kinase 2; DAPK; DAPK1; Dapk2; DAP-Kinase; DAP-kinase-related protein 1; DAP-kinase-related protein 1 beta isoform; death associated protein kinase 1; death associated protein kinase 2; death-associated kinase 2; death-associated protein kinase 1; Death-associated protein kinase 2; DRP1; DRP-1
100 µL
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