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This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway.
BC027084; C130052H20Rik; EH domain containing 2; EH domain-containing protein 2; Ehd2; EH-domain containing 2; FLJ96617; MGEPS; PAST homolog 2; PAST2; putative eps protein
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