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Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
DKFZp586J0119; EIF2B; EIF-2B; eIF-2B GDP-GTP exchange factor subunit delta; EIF2B4; Eif2bd; EIF2Bdelta; eukaryotic translation initiation factor 2B subunit 4 delta; eukaryotic translation initiation factor 2B subunit delta; eukaryotic translation initiation factor 2B, subunit 4 delta; eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa; Jgr1a; translation initiation factor eIF-2b delta subunit; translation initiation factor eIF-2B subunit delta
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