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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
frizzled 7, seven transmembrane spanning receptor; frizzled class receptor 7; frizzled family receptor 7; frizzled homolog 7; frizzled homolog 7 (Drosophila); Frizzled, drosophila, homolog of, 7; frizzled-7; Fz7; Fz-7; FZD7; FzE3; hFz7; LOC100360552; mFz7; rCG22430-like; rizzled 7
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