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GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides. GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism.
CBG; CBGL1; Cytosolic beta-glucosidase; cytosolic beta-glucosidase-like protein 1; Cytosolic GCase; Cytosolic glycosylceramidase; Gba3; GLUC; Glucosidase beta acid 3; glucosidase, beta, acid 3; glucosidase, beta, acid 3 (cytosolic); Glucosylceramidase beta 3; glucosylceramidase beta 3 (gene/pseudogene); klotho-related protein; KLRP
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