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Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211).
IDAS; MCI; MCIDAS; McIdas protein; MCIN; multiciliate cell differentiation 1; multiciliate differentiation and DNA synthesis associated cell cycle protein; multiciliate differentiation and DNA synthesis-associated cell cycle protein; Multicilin; protein Idas
100 µL
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