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The L1 (LINE-1), or Long INterspersed Element, retrotransposon ORF2 is the most common open reading frame in the human genome, present in various forms in many thousands of copies. This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signaling. Both intact ORF1 and ORF2 are absolutely required for autonomous retro-transposition. ORF2 encodes an endonuclease, reverse transcriptase, and zinc knuckle domains. The expression of ORF2 appears to be tightly regulated except in germ line tissues, embryonic tissues, and certain cancers including teratomas, testicular cancers, and leukemias. This antibody is intended for use in studying control of L1 retrotransposons.
cancer/testis antigen 134; Cenexin; cenexin 1; CT134; ODF2; ODF2/1; ODF2/2; ODF84; outer dense fiber of sperm tails 2; Outer dense fiber of sperm tails protein 2; outer dense fiber of sperm tails, 84-kD; outer dense fiber protein 2; sperm tail structural protein; testis tissue sperm-binding protein Li 51e
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