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L1RE1 encodes a nucleic acid-binding protein, which is essential for retrotransposition of LINE-1 elements in the genome. The proteins act as nucleic acid chaperones binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. Long interspersed element-1/LINE-1/L1 retrotransposons are present in more than 500'000 full (6 kb) or truncated copies in the human genome. Most of them are inactive but one estimate is that 80 to 100 of those elements could be transcribed, translated and active in any individual. An active LINE-1 encodes for 2 proteins translated from a single RNA containing two non-overlapping ORFs, ORF1 and ORF2.
100 µg
100 µL
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