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This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
AW556229; hypothetical protein LOC553597; lamtor3; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; Map2k1ip1; MAPBP; MAPK scaffold protein 1; MAPKSP1; MEK binding partner 1; MEK partner 1; MEK-binding partner 1; mitogen activated protein, binding protein; mitogen-activated protein kinase kinase 1 interacting protein 1; mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1; mitogen-activated protein kinase scaffold protein 1; ragulator complex protein LAMTOR3; Mp1; PRO0633; PRO2783; Ragulator complex protein LAMTOR3; Ragulator3; zgc:110207
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