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LIN-28 is a highly conserved, RNA-binding, cytoplasmic protein. It consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs that were first identified in Caenorhabditis elegans. LIN-28 controls the timing of events during embryonic development and is readily expressed in embryos, embryonic stem cells and embryonal carcinoma cells. The presence of LIN-28 persists in some adult tissues including cardiac and skeletal muscle. In differentiating myoblasts, LIN-28 increases protein synthesis efficiency and binds to the growth and differentiation factor IGF-II.
2810403D23Rik; AL024421; CSDD1; CSDD2; D030047M17Rik; ENSMUSG00000070700; Gm10299; Lin28; Lin-28; lin-28 homolog A; lin-28 homolog A (C. elegans); lin-28 homolog B; lin-28 homolog B (C. elegans); Lin-28.2; LIN28A; lin-28A; Lin28b; Lin-28B; Protein lin-28 homolog A; protein lin-28 homolog B; RGD1566408; RNA-binding protein LIN-28; testis expressed gene 17; testis-expressed protein 17; Tex17; ZCCHC1; Zinc finger CCHC domain-containing protein 1; zinc finger, CCHC domain containing 1
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