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LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
cysteine-rich protein TTG-2; LIM domain only 2; LIM domain only 2 (rhombotin-like 1); LIM domain only protein 2; LIM domain only-2; LIM only 2; LMO2; LMO-2; LMO2 protein; Rbtn2; Rbtn-2; RBTNL1; RHOM2; Rhom-2; rhombotin 2; rhombotin-2; rhombotin-like 1; si:dkey-10o6.5; T-cell translocation gene 2; T-cell translocation protein 2; TTG2; wu:fc83a08; zgc:111930; zlmo2
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