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MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).
9530046H09Rik; E3 ubiquitin-protein ligase MARCH2; HSPC240; MARCH2; MARCHF2; MARCH-II; membrane associated ring finger 2; membrane associated RING-CH finger protein II; membrane associated ring-CH-type finger 2; membrane-associated ring finger (C3HC4) 2; membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RGD1306395; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2; RNF172; syntaxin-6-binding protein
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