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Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity. [UniProt]
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; glucosaminyl N-deacetylase/N-sulfotransferase 4; Heparan sulfate N-deacetylase 4; Heparan sulfate N-sulfotransferase 4; HSST4; N-deacetylase and N-sulfotransferase 4; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; N-deacetylase/N-sulfotransferase 4; NDST4; NDST-4; N-heparan sulfate sulfotransferase 4; N-HSST; N-HSST 4; NHSST4
100 µL
50 µg
100 µg
100 µL
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