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Polyadenylation of the 3-prime ends of eukaryotic mRNAs is a key event that takes place in the nucleus during maturation of mRNA. The reaction includes endoribonucleolytic cleavage of the pre-RNA at the poly(A) site that leads to synthesis of the poly(A) tail at the 3-prime end of the upstream cleavage product. The poly(A) polymerase (PAP) is required The adenosine addition reaction depends on poly(A) polymerase (PAP) activity. The testis express PAP-beta (TPAP) in the cytoplasm of spermatogenic cells. The adenosine addition function of PAP-beta plays a critical role in male germ cell production. PAP-beta-deficient transgenic mice display impaired expression of haploid-specific genes that are necessary for spermatogenesis. The intronless gene encoding human PAP-beta maps to chromosome 7p22.3.
9630006B20Rik; Neo-PAP; neo-poly(A) polymerase; nuclear poly(A) polymerase gamma; PAP; PAP2; PAP-alpha; PAP-beta; PAPG; PAP-gamma; PapIII; Paplob; PAPOLA; Papola-ps; PAPOLB; Papolg; PAPT; Plap; Plap-ps; poly (A) polymerase alpha; poly (A) polymerase beta (testis specific); poly(A) polymerase alpha; Poly(A) polymerase beta; poly(A) polymerase beta (testis specific); poly(A) polymerase gamma; Polynucleotide adenylyltransferase; polynucleotide adenylyltransferase alpha; Polynucleotide adenylyltransferase beta; polynucleotide adenylyltransferase gamma; Signal recognition particle RNA-adenylating enzyme; SRP 3'-adenylating protein; SRP RNA 3' adenylating enzyme/pap2; SRP RNA 3'-adenylating enzyme; SRP RNA-adenylating enzyme; testis-specific poly(A) polymerase; Tpap
100 µL
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