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The protein encoded by this gene is a member of the protein tyrosine phosphatase family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
14 kDa phosphohistidine phosphatase; 14kDa phosphohistidine phosphatase; 1700008C22Rik; CGI-202; epididymis secretory sperm binding protein Li 132P; HEL-S-132P; HSPC141; hypothetical protein LOC445172; phosphohistidine phosphatase 1; PHP; PHP14; Phpt1; Protein histidine phosphatase; protein janus-A homolog; PTPH1; PTP-H1; sex-regulated protein janus-a; Unknown (protein for MGC:133682); wu:fb50e08; zgc:101086
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