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tRNA-guanine transglycosylase (TGT; EC 2.4.2.29) synthesizes queuosine (Q), which is found in tRNAs that recognize NAU and NAC codons, encoding tyr, asn, asp, and his. Prokaryotic TGT is a single protein of 43 kD. In contrast, mammalian TGT appears to be a heterodimer consisting of a 60-kD subunit (USP14; MIM 607274) and a 43-kD catalytic subunit (QTRT1) (Deshpande and Katze, 2001 [PubMed 11255023]).
2610028E17Rik; FP3235; Guanine insertion enzyme; QTRT1; queuine tRNA-ribosyltransferase; queuine tRNA-ribosyltransferase 1; queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase); queuine tRNA-ribosyltransferase catalytic subunit 1; queuine tRNA-ribosyltransferase; queuine tRNA-ribosyltransferase catalytic subunit 1; similar to queuine tRNA-ribosyltransferase 1; Tgt; TGT, 43-KD subunit; TGT, catalytic subunit; TGUT; tRNA-guanine transglycosylase; zgc:66378
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50 µg
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