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ATP-dependent DNA helicase involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Necessary for excision of pyrimidine dimers. Also unwinds DNA/RNA duplexes. Plays an essential role in the cell viability. Involved in the maintenance of the fidelity of DNA replication. Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.
DNA repair helicase RAD3; General transcription and DNA repair factor IIH helicase subunit XPD; RAD3; REM1; RNA polymerase II transcription factor B subunit RAD3; TFB subunit RAD3; TFIIH subunit XPD; TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3; YER171W
100 µL
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