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Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
4931417M11Rik; AI326872; Cell cycle regulatory protein; chc1; chc1-a; chromosome condensation 1; chromosome condensation protein 1; fj77f08; guanine nucleotide-releasing protein; RanGEF; RCC1; rcc1.L; rcc1-a; rcc1-b; RCC1-I; Regulator of chromosome condensation; regulator of chromosome condensation 1; regulator of chromosome condensation 1 L homeolog; SNHG3-RCC1; SNHG3-RCC1 readthrough; wu:fj77f08; XELAEV_18012073mg; xrcc1; zgc:65796; zgc:77114
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