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TAL-1 is a basic helix-loop-helix transcription. It regulates differentiation and survival during hemopoiesis. TAL-1 is also implicated in the genesis of hemopoietic malignancies and it may play an important role in hemopoietic differentiation. It serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. TAL-1 is know to bind to the LIM domain containing protein Rhombotin-2.
basic helix-loop-helix transcription factor; bHLHa17; Class A basic helix-loop-helix protein 17; HGNC:11556; LOW QUALITY PROTEIN: T-cell acute lymphocytic leukemia protein 1; Scl; scl/tal1; SCL/tal-1; SCL-alpha; SCL-beta; si:ch211-135j1.3; stem cell leukemia protein; stem cell leukemia protein SCL; stem cell protein; stem-cell leukemia hematopoietic transcription factor; T cell acute lymphocytic leukemia 1; TAL bHLH transcription factor 1, erythroid differentiation factor; TAL1; Tal-1; tal-1 product; T-cell acute lymphocytic leukemia 1; T-cell acute lymphocytic leukemia protein 1; T-cell acute lymphocytic leukemia protein 1 homolog; T-cell leukemia/lymphoma protein 5; TCL5; transcription factor; zgc:85605; zSCL
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