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T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group(HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to beta-catenin in a cooperative manner. This TCF-4/ beta-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes.
5730422P05Rik; A130037E08Rik; Alf1; ASP-I2; bHLHb19; bHLHb20; Class A helix-loop-helix transcription factor ME1; class A helix-loop-helix transcription factor ME2; Class B basic helix-loop-helix protein 19; class B basic helix-loop-helix protein 20; CRS3; DNA-binding protein HTF4; E2.2; E2-2; E-box-binding protein; FECD3; HEB; HEBAlt; helix-loop-helix transcription factor 4; HsT17266; HTF4; HTF-4; Immunoglobulin transcription factor 2; immunoglobulin transcription factor-2; ITF2; ITF-2; ITF-2b; ME1; ME2; Meb; MITF-2; MITF-2A; MITF-2B; PTHS; R8f DNA-binding protein; REB; RITF-2; salivary-specific cAMP response element-binding protein alpha; SCBP alpha; SCBPA; SCBP-alpha; SEF2; SEF-2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; SL3-3 enhancer factor 2; TCF12; TCF-12; Tcf4; TCF-4; TFE; transcription factor 12; Transcription factor 4; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2); transcription factor 4, isoform C; transcription factor 4, isoform D; transcription factor 4, isoform E; transcription factor 4, isoform L; transcription factor 4, isoform M; transcription factor 4, isoform R; transcription factor HTF-4
100 µL
100 µL
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