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This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene.
bHLHb11; Class B basic helix-loop-helix protein 11; FCHL; FCHL1; HYPLIP1; Major late transcription factor 1; MLTF; MLTFI; UEF; Upstream stimulatory factor 1; upstream transcription factor 1; USF; USF1; usf1-bd
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