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C14orf138, also named as VCPKMT or METTL21D, is 229 amino acid protein, which belongs to the methyltransferase superfamily. C14orf138 localizes in the cytoplasm and interacts with ALKBH6. C14orf138 as a Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity. C14orf138 exists as five isoforms. The calculated molecular weight of C14orf138 is 26 kDa, but we always detected a 46-50 kDa protein by western blot.
C14orf138; methyltransferase like 21D; methyltransferase-like protein 21D; METTL21D; Protein-lysine methyltransferase METTL21D; valosin containing protein lysine (K) methyltransferase; valosin containing protein lysine methyltransferase; valosin-containing protein lysine methyltransferase; VCP lysine methyltransferase; VCPKMT; VCP-KMT
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