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WDR39 is a member of the WD40 family of proteins. WDR39 specifically interacts with WT1 both in vitro and in vivo. This interaction results in a decrease in transcriptional activation mediated by WT1. WDR39 does not inhibit binding of WT1 to its consensus nucleotide sequence and does not affect the repression activity of WT1. Thus, WDR39 appears to specifically modulate the transactivation activity of WT1 and may function to regulate the physiological functions of WT1 in cell growth and differentiation.
AW210570; CIA1; ciao1; ciao1 {ECO:0000255; cytosolic iron-sulfur assembly component 1; cytosolic iron-sulfur protein assembly 1; cytosolic iron-sulfur protein assembly 1 homolog; HAMAP-Rule:MF_03037}; probable cytosolic iron-sulfur protein assembly protein CIAO1; probable cytosolic iron-sulfur protein assembly protein CIAO1 {ECO:0000255; WD repeat domain 39; WD repeat-containing protein 39; WD repeat-containing protein 39 {ECO:0000255; WD40 protein Ciao1; Wdr39
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