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WDYHV1 mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
2410187C16Rik; AU014961; AW550036; C8orf32; nt(Q)-amidase; Ntaq1; N-terminal Gln amidase; protein NH2-terminal glutamine deamidase; Protein N-terminal glutamine amidohydrolase; WDYHV motif containing 1; WDYHV motif-containing protein 1; WDYHV1
100 µL
100 µg
100 µL
100 µL
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