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Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor. [UniProt]
9130404H11Rik; AL024349; D130004H04Rik; dep; DHHC21; DHHC-21; DNZ1; GABA-A receptor-associated membrane protein 3; Gramp3; HSPC097; palmitoyltransferase ZDHHC21; palmitoyltransferase ZDHHC21-like protein; probable palmitoyltransferase ZDHHC21; Zdhhc21; Zinc finger DHHC domain-containing protein 21; zinc finger DHHC-type containing 21; zinc finger DHHC-type palmitoyltransferase 21; zinc finger, DHHC domain containing 21; zinc finger, DHHC-type containing 21
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