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This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
A530043O15Rik; CAAX prenyl protease 1 homolog; D030046F19; Face1; Face-1; Farnesylated proteins-converting enzyme 1; farnesylated-proteins converting enzyme 1; fi45a02; FLJ14968; HGPS; MADB; Prenyl protein-specific endoprotease 1; PRO1; STE24; Ste24p; wu:fi45a02; zgc:55655; zinc metallopeptidase STE24; zinc metallopeptidase STE24 homolog; zinc metallopeptidase, STE24; zinc metallopeptidase, STE24 homolog; zinc metalloproteinase (STE24 homolog, yeast); zinc metalloproteinase Ste24 homolog; zinc metalloproteinase, STE24 homolog; Zmpste24
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