Product References
TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages.
Frontiers in immunology
Mahish C,De S,Chatterjee S,Ghosh S,Keshry SS,Mukherjee T,Khamaru S,Tung KS,Subudhi BB,Chattopadhyay S,Chattopadhyay S
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu May 18 00:00:00 EDT 2023
Carvacrol protects mice against LPS-induced sepsis and attenuates inflammatory response in macrophages by modulating the ERK1/2 pathway.
Scientific reports
Yan C,Kuang W,Jin L,Wang R,Niu L,Xie C,Ding J,Liao Y,Wang L,Wan H,Ma G
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Aug 07 00:00:00 EDT 2023
TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum.
Journal of cellular and molecular medicine
Zhu D,Huang M,Shen P,Zhang B,Chen G,Chen J,Duan L,Duan Y
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2023
A platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance.
Bioactive materials
Li W,Yan J,Tian H,Li B,Wang G,Sang W,Zhang Z,Zhang X,Dai Y
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
BushenHuoxue decoction suppresses M1 macrophage polarization and prevents LPS induced inflammatory bone loss by activating AMPK pathway.
Heliyon
Chen S,Tao L,Zhu F,Wang Z,Zhuang Q,Li Y,Yang Y,Feng C,Shi H,Shi J,Zhu L,Xiao L,Geng D,Wang Z
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon May 01 00:00:00 EDT 2023
CD8α+ dendritic cells potentiate antitumor and immune activities against murine ovarian cancers.
Scientific reports
Lee SW,Lee H,Lee KW,Kim MJ,Kang SW,Lee YJ,Kim H,Kim YM
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Jan 03 00:00:00 EST 2023
Acinetobacter baumannii outer membrane protein A induces autophagy in bone marrow-derived dendritic cells involving the PI3K/mTOR pathway.
Immunity, inflammation and disease
Tan H,Cao L
12-0862-82 was used in Flow cytometry/Cell sorting to study the role and molecular mechanisms of OmpA-induced mouse bone marrow-derived dendritic cells (BMDCs) autophagy in the immune response of A. baumannii.
Sat Apr 01 00:00:00 EDT 2023
Acinetobacter baumannii outer membrane protein A induces autophagy in bone marrow-derived dendritic cells involving the PI3K/mTOR pathway.
Immunity, inflammation and disease
Tan H,Cao L
12-0862-82 was used in Flow cytometry/Cell sorting to study the role and molecular mechanisms of OmpA-induced mouse bone marrow-derived dendritic cells (BMDCs) autophagy in the immune response of A. baumannii.
Sat Apr 01 00:00:00 EDT 2023
Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X/NLRP3 axis.
Journal of nanobiotechnology
Chen Y,Wu Y,Guo L,Yuan S,Sun J,Zhao K,Wang J,An R
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Mar 20 00:00:00 EDT 2023
Macrophage Reprogramming via the Modulation of Unfolded Protein Response with siRNA-Loaded Magnetic Nanoparticles in a TAM-like Experimental Model.
Pharmaceutics
D'Urso A,Oltolina F,Borsotti C,Prat M,Colangelo D,Follenzi A
12-0862-82 was used in Immunocytochemistry to provide a novel strategy for the development of new tumor immunotherapies in vivo.
Mon Jun 12 00:00:00 EDT 2023
Role of low-intensity pulsed ultrasound in regulating macrophage polarization to accelerate tendon-bone interface repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Xu Z,Li S,Wan L,Hu J,Lu H,Zhang T
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon May 01 00:00:00 EDT 2023
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization.
NPJ Regenerative medicine
Wang J,Xue Y,Wang Y,Liu C,Hu S,Zhao H,Gu Q,Yang H,Huang L,Zhou X,Shi Q
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Feb 09 00:00:00 EST 2023
BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization.
NPJ Regenerative medicine
Wang J,Xue Y,Wang Y,Liu C,Hu S,Zhao H,Gu Q,Yang H,Huang L,Zhou X,Shi Q
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Feb 09 00:00:00 EST 2023
Isolated Peptide from Spider Venom Modulates Dendritic Cells In Vitro: A Possible Application in Oncoimmunotherapy for Glioblastoma.
Cells
de Mato FC,Barreto N,Cordeiro G,Munhoz J,Bonfanti AP,da Rocha-E-Silva TAA,Sutti R,Cruz PBM,Sanches LR,Bombeiro AL,Chalbatani GM,Verinaud L,Rapôso C
12-0862-82 was used in Flow cytometry/Cell sorting to test Phoneutria nigriventer spider venom (PnV) and its purified fractions in dendritic cells in vitro.
Mon Mar 27 00:00:00 EDT 2023
Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.
Materials today. Bio
Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.
Materials today. Bio
Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Gallium-modified gelatin nanoparticles loaded with quercetin promote skin wound healing via the regulation of bacterial proliferation and macrophage polarization.
Frontiers in bioengineering and biotechnology
Yang N,Shi N,Yao Z,Liu H,Guo W
12-0862-82 was used in Flow cytometry/Cell sorting to develop gallium-modified gelatin nanoparticles loaded with quercetin, which demonstrated biocompatibility, enhanced fibroblast function, anti-bacterial capacity, inflammation suppression, and scar inhibition during wound healing.
Tue Feb 14 00:00:00 EST 2023
Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model.
Acta pharmaceutica Sinica. B
Zhang L,Zhu Y,Wei X,Chen X,Li Y,Zhu Y,Xia J,Huang Y,Huang Y,Wang J,Pang Z
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment.
Acta pharmaceutica Sinica. B
Xi L,Lin Z,Qiu F,Chen S,Li P,Chen X,Wang Z,Zheng Y
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat Jan 01 00:00:00 EST 2022
Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment.
Acta pharmaceutica Sinica. B
Xi L,Lin Z,Qiu F,Chen S,Li P,Chen X,Wang Z,Zheng Y
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat Jan 01 00:00:00 EST 2022
Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype.
Molecular therapy. Nucleic acids
De Santi C,Nally FK,Afzal R,Duffy CP,Fitzsimons S,Annett SL,Robson T,Dowling JK,Cryan SA,McCoy CE
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Sep 13 00:00:00 EDT 2022
Oncolytic Zika virus promotes intratumoral T cell infiltration and improves immunotherapy efficacy in glioblastoma.
Molecular therapy oncolytics
Chen L,Zhou C,Chen Q,Shang J,Liu Z,Guo Y,Li C,Wang H,Ye Q,Li X,Zu S,Li F,Xia Q,Zhou T,Li A,Wang C,Chen Y,Wu A,Qin C,Man J
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Mar 17 00:00:00 EDT 2022
G9a promotes inflammation in Streptococcus pneumoniae induced pneumonia mice by stimulating M1 macrophage polarization and H3K9me2 methylation in FOXP1 promoter region.
Annals of translational medicine
Li Y,Li G,Zhang L,Li Y,Zhao Z
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2022
Intranasal Immunization With a c-di-GMP-Adjuvanted Acellular Pertussis Vaccine Provides Superior Immunity Against Bordetella pertussis in a Mouse Model.
Frontiers in immunology
Jiang W,Wang X,Su Y,Cai L,Li J,Liang J,Gu Q,Sun M,Shi L
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue May 03 00:00:00 EDT 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Wed Dec 21 00:00:00 EST 2022
MicroRNA-382 Promotes M2-Like Macrophage via the SIRP-α/STAT3 Signaling Pathway in Aristolochic Acid-Induced Renal Fibrosis.
Frontiers in immunology
Wang X,Jia P,Ren T,Zou Z,Xu S,Zhang Y,Shi Y,Bao S,Li Y,Fang Y,Ding X
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri May 20 00:00:00 EDT 2022
CD4+ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.
Aging and disease
Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Chromomycin A5 induces bona fide immunogenic cell death in melanoma.
Frontiers in immunology
Florêncio KGD,Edson EA,Fernandes KSDS,Luiz JPM,Pinto FDCL,Pessoa ODL,Cunha FQ,Machado-Neto JA,Wilke DV
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Nov 29 00:00:00 EST 2022
In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses.
Nature communications
Guo Y,Wang SZ,Zhang X,Jia HR,Zhu YX,Zhang X,Gao G,Jiang YW,Li C,Chen X,Wu SY,Liu Y,Wu FG
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2022
Targeting dendritic cells with TLR-2 ligand-coated nanoparticles loaded with Mycobacterium tuberculosis epitope induce antituberculosis immunity.
The Journal of biological chemistry
Kumar Das D,Zafar MA,Nanda S,Singh S,Lamba T,Bashir H,Singh P,Maurya SK,Nadeem S,Sehrawat S,Bhalla V,Agrewala JN
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling.
Molecular cancer
Rizzello C,Cancila V,Sangaletti S,Botti L,Ratti C,Milani M,Dugo M,Bertoni F,Tripodo C,Chiodoni C,Colombo MP
12-0862-82 was used in Flow cytometry/Cell sorting to indicate that, in the setting of SLE-like syndrome in which double strand-DNA chronically circulates and activates TLRs, B cell intracellular OPN exerts a protective role in autoimmunity-driven DLBCL development, mainly acting as a brake in the TLR9-MYD88-STAT3 signaling pathway.
Mon Dec 12 00:00:00 EST 2022
Intracellular osteopontin protects from autoimmunity-driven lymphoma development inhibiting TLR9-MYD88-STAT3 signaling.
Molecular cancer
Rizzello C,Cancila V,Sangaletti S,Botti L,Ratti C,Milani M,Dugo M,Bertoni F,Tripodo C,Chiodoni C,Colombo MP
12-0862-82 was used in Flow cytometry/Cell sorting to indicate that, in the setting of SLE-like syndrome in which double strand-DNA chronically circulates and activates TLRs, B cell intracellular OPN exerts a protective role in autoimmunity-driven DLBCL development, mainly acting as a brake in the TLR9-MYD88-STAT3 signaling pathway.
Mon Dec 12 00:00:00 EST 2022
Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury.
Journal of nanobiotechnology
Liu C,Hu F,Jiao G,Guo Y,Zhou P,Zhang Y,Zhang Z,Yi J,You Y,Li Z,Wang H,Zhang X
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Wed Feb 02 00:00:00 EST 2022
Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury.
Journal of nanobiotechnology
Liu C,Hu F,Jiao G,Guo Y,Zhou P,Zhang Y,Zhang Z,Yi J,You Y,Li Z,Wang H,Zhang X
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Wed Feb 02 00:00:00 EST 2022
Self-assembled traditional Chinese nanomedicine modulating tumor immunosuppressive microenvironment for colorectal cancer immunotherapy.
Theranostics
Mao Q,Min J,Zeng R,Liu H,Li H,Zhang C,Zheng A,Lin J,Liu X,Wu M
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Sep 29 00:00:00 EDT 2022
Role of circular RNA cdr1as in modulation of macrophage phenotype.
Life sciences
Gonzalez C,Cimini M,Cheng Z,Benedict C,Wang C,Trungcao M,Mallaredy V,Rajan S,Garikipati VNS,Kishore R
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2022
A bilirubin-derived nanomedicine attenuates the pathological cascade of pulmonary fibrosis.
Biomaterials
Keum H,Kim D,Kim J,Kim TW,Whang CH,Jung W,Jon S
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sun Aug 01 00:00:00 EDT 2021
Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses.
Cancer research
Cousin N,Cap S,Dihr M,Tacconi C,Detmar M,Dieterich LC
12-0862-82 was used in Flow Cytometry to present a new lymphatic-specific PD-L1 knockout mouse model reveals that lymphatic endothelial PD-L1 expression reduces tumor immunity, inducing apoptosis in tumor-specific CD8+ central memory cells in tumor-draining lymph nodes.
Sun Aug 01 00:00:00 EDT 2021
Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.
Cell death and differentiation
Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.
Cell death and differentiation
Velletri T,Huang Y,Wang Y,Li Q,Hu M,Xie N,Yang Q,Chen X,Chen Q,Shou P,Gan Y,Candi E,Annicchiarico-Petruzzelli M,Agostini M,Yang H,Melino G,Shi Y,Wang Y
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages.
Immune network
Sim H,Jeong D,Kim HI,Pak S,Thapa B,Kwon HJ,Lee K
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Pseudomonas aeruginosa PcrV Enhances the Nitric Oxide-Mediated Tumoricidal Activity of Tumor-Associated Macrophages via a TLR4/PI3K/AKT/mTOR-Glycolysis-Nitric Oxide Circuit.
Frontiers in oncology
Yu H,Bai Y,Qiu J,He X,Xiong J,Dai Q,Wang X,Li Y,Sheng H,Xin R,Jiang L,Li Q,Li D,Zhang H,Zhang L,Chen Q,Peng J,Hu X,Zhang K
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Wed Dec 15 00:00:00 EST 2021
Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells.
International journal of molecular medicine
Diao G,Huang J,Zheng X,Sun X,Tian M,Han J,Guo J
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells.
International journal of molecular medicine
Diao G,Huang J,Zheng X,Sun X,Tian M,Han J,Guo J
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Exosomes derived from inflammatory myoblasts promote M1 polarization and break the balance of myoblast proliferation/differentiation.
World journal of stem cells
Luo ZW,Sun YY,Lin JR,Qi BJ,Chen JW
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Nov 26 00:00:00 EST 2021
Myeloid and plasmacytoid dendritic cell combined vaccines loaded with heat-treated tumor cell lysates enhance antitumor activity in murine lung cancer.
Oncology letters
Chen H,Tan J,Li X,Li H,Wu W,Wu Y,Zhang J,Gu L
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.
Cells
Jhan MK,Chen CL,Shen TJ,Tseng PC,Wang YT,Satria RD,Yu CY,Lin CF
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Nov 15 00:00:00 EST 2021
Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.
Journal for immunotherapy of cancer
Wang Z,Xu F,Hu J,Zhang H,Cui L,Lu W,He W,Wang X,Li M,Zhang H,Xiong W,Xie C,Liu Y,Zhou P,Liu J,Huang P,Qin XF,Xia X
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.
Journal for immunotherapy of cancer
Wang Z,Xu F,Hu J,Zhang H,Cui L,Lu W,He W,Wang X,Li M,Zhang H,Xiong W,Xie C,Liu Y,Zhou P,Liu J,Huang P,Qin XF,Xia X
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
A two-adjuvant multiantigen candidate vaccine induces superior protective immune responses against SARS-CoV-2 challenge.
Cell reports
Jiang W,Shi L,Cai L,Wang X,Li J,Li H,Liang J,Gu Q,Ji G,Li J,Liu L,Sun M
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Dec 14 00:00:00 EST 2021
Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.
Nature communications
Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Dec 09 00:00:00 EST 2021
Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics.
iScience
Nascimento Da Conceicao V,Sun Y,Ramachandran K,Chauhan A,Raveendran A,Venkatesan M,DeKumar B,Maity S,Vishnu N,Kotsakis GA,Worley PF,Gill DL,Mishra BB,Madesh M,Singh BB
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Nov 19 00:00:00 EST 2021
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.
Journal of neuroinflammation
Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J
12-0862 was used in Flow cytometry/Cell sorting to identify the critical contribution of TLR4-mediated macrophage activation in disease course and provided strong evidence to support TLR4 as a useful drug target for treating inflammatory autoimmune neuropathy.
Mon Mar 22 00:00:00 EDT 2021
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.
Journal of neuroinflammation
Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J
12-0862 was used in Flow cytometry/Cell sorting to identify the critical contribution of TLR4-mediated macrophage activation in disease course and provided strong evidence to support TLR4 as a useful drug target for treating inflammatory autoimmune neuropathy.
Mon Mar 22 00:00:00 EDT 2021
Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis.
Stem cell research & therapy
Wang F,Kong L,Wang W,Shi L,Wang M,Chai Y,Xu J,Kang Q
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu May 13 00:00:00 EDT 2021
Adrenomedullin 2 improves bone regeneration in type 1 diabetic rats by restoring imbalanced macrophage polarization and impaired osteogenesis.
Stem cell research & therapy
Wang F,Kong L,Wang W,Shi L,Wang M,Chai Y,Xu J,Kang Q
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu May 13 00:00:00 EDT 2021
Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis.
Bioactive materials
Huang J,Jiang Y,Liu Y,Ren Y,Xu Z,Li Z,Zhao Y,Wu X,Ren J
12-0862 was used in Flow cytometry/Cell sorting to demonstrates a strategy for generating an adhesive by synergistic mimicry inspired by two marine animals.
Mon Mar 01 00:00:00 EST 2021
Marine-inspired molecular mimicry generates a drug-free, but immunogenic hydrogel adhesive protecting surgical anastomosis.
Bioactive materials
Huang J,Jiang Y,Liu Y,Ren Y,Xu Z,Li Z,Zhao Y,Wu X,Ren J
12-0862 was used in Flow cytometry/Cell sorting to demonstrates a strategy for generating an adhesive by synergistic mimicry inspired by two marine animals.
Mon Mar 01 00:00:00 EST 2021
Cytochrome P450 26A1 Modulates the Polarization of Uterine Macrophages During the Peri-Implantation Period.
Frontiers in immunology
Ji WH,Li DD,Wei DP,Gu AQ,Yang Y,Peng JP
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Feb 10 00:00:00 EST 2022
C-Reactive Protein Suppresses the Th17 Response Indirectly by Attenuating the Antigen Presentation Ability of Monocyte Derived Dendritic Cells in Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology
Shen ZY,Zheng Y,Pecsok MK,Wang K,Li W,Gong MJ,Wu F,Zhang L
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Jul 01 00:00:00 EDT 2021
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Journal of hematology & oncology
Kim HR,Park JS,Park JH,Yasmin F,Kim CH,Oh SK,Chung IJ,Jun CD
12-0862 was used in Flow cytometry/Cell sorting to indicate that cell-permeable transgelin-2 have a potential clinical value as a cancer immunotherapy based on DCs.
Wed Mar 17 00:00:00 EDT 2021
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Frontiers in immunology
Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L
12-0862-82 was used in Flow Cytometry to show that the phosphatase PP2Cδ played a pivotal role in regulating dendritic cells (DC) activation and function, as PP2Cδ ablation caused aberrant maturation, activation, and Th1/Th17-priming of DCs, and hence induced onset of exacerbated experimental autoimmune encephalomyelitis.
Mon Feb 28 00:00:00 EST 2022
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Frontiers in immunology
Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L
12-0862-82 was used in Flow Cytometry to show that the phosphatase PP2Cδ played a pivotal role in regulating dendritic cells (DC) activation and function, as PP2Cδ ablation caused aberrant maturation, activation, and Th1/Th17-priming of DCs, and hence induced onset of exacerbated experimental autoimmune encephalomyelitis.
Mon Feb 28 00:00:00 EST 2022
Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y
12-0862 was used in Flow cytometry/Cell sorting to presents a multifunctional metal-phenolic nanoplatform for efficient X-ray mediated RT-RDT in combination with immunotherapy and may provide a new therapeutic option for cancer treatment.
Mon Feb 01 00:00:00 EST 2021
A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.
Immunity
Yewdell WT,Kim Y,Chowdhury P,Lau CM,Smolkin RM,Belcheva KT,Fernandez KC,Cols M,Yen WF,Vaidyanathan B,Angeletti D,McDermott AB,Yewdell JW,Sun JC,Chaudhuri J
12-0862-82 was used in Flow cytometry/Cell sorting to indicate a crucial role for G4 binding in AID targeting and suggest that AID activity may extend beyond Ig loci to regulate the expression of genes relevant to the physiology and pathology of activated B cells.
Tue Nov 17 00:00:00 EST 2020
A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy.
Nature nanotechnology
Xu J,Lv J,Zhuang Q,Yang Z,Cao Z,Xu L,Pei P,Wang C,Wu H,Dong Z,Chao Y,Wang C,Yang K,Peng R,Cheng Y,Liu Z
12-0862-82 was used in Flow Cytometry to offer a simple and general strategy for the preparation of personalized cancer vaccines to prevent post-operative cancer recurrence and metastasis.
Tue Dec 01 00:00:00 EST 2020
Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of Mycobacterium tuberculosis.
Autophagy
Pahari S,Negi S,Aqdas M,Arnett E,Schlesinger LS,Agrewala JN
12-0862-82 was used in Flow Cytometry to invesigate if a unique immunotherapeutic approach involving CLEC4E in conjunction with TLR4 to restrict the survival of mycobacterium tuberculosis through autophagy exists.
Mon Jun 01 00:00:00 EDT 2020
Podocytes present antigen to activate specific T cell immune responses in inflammatory renal disease.
The Journal of pathology
Li S,Liu Y,He Y,Rong W,Zhang M,Li L,Liu Z,Zen K
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions.
International journal of oncology
Huang J,Diao G,Zhang Q,Chen Y,Han J,Guo J
12-0862 was used in Flow cytometry/Cell sorting to study whether E6 increases the expression levels of PGE2 in cervical lesions, which could eventually induce inhibition of the migration of DCs.
Wed Apr 01 00:00:00 EDT 2020
E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions.
International journal of oncology
Huang J,Diao G,Zhang Q,Chen Y,Han J,Guo J
12-0862 was used in Flow cytometry/Cell sorting to study whether E6 increases the expression levels of PGE2 in cervical lesions, which could eventually induce inhibition of the migration of DCs.
Wed Apr 01 00:00:00 EDT 2020
Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME
12-0862-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.
Sat Feb 01 00:00:00 EST 2020
Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME
12-0862-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.
Sat Feb 01 00:00:00 EST 2020
Mesenchymal stem cell-secreted extracellular vesicles carrying TGF-β1 up-regulate miR-132 and promote mouse M2 macrophage polarization.
Journal of cellular and molecular medicine
Wang Y,Han B,Wang Y,Wang C,Zhang H,Xue J,Wang X,Niu T,Niu Z,Chen Y
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages.
Molecules and cells
Park SM,Do-Thi VA,Lee JO,Lee H,Kim YS
12-0862 was used in Flow cytometry/Cell sorting to demonstrate that IL-9 can induce an anti-metastasis effect by enhancing the polarization and proliferation of M1 macrophages.
Sun May 31 00:00:00 EDT 2020
Interleukin-9 Inhibits Lung Metastasis of Melanoma through Stimulating Anti-Tumor M1 Macrophages.
Molecules and cells
Park SM,Do-Thi VA,Lee JO,Lee H,Kim YS
12-0862 was used in Flow cytometry/Cell sorting to demonstrate that IL-9 can induce an anti-metastasis effect by enhancing the polarization and proliferation of M1 macrophages.
Sun May 31 00:00:00 EDT 2020
Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model.
Molecular medicine reports
Li G,Yang L,Li D,Zhang J,Du L,Xia L,Liu Y,Hu W
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Angiotensin II induces RAW264.7 macrophage polarization to the M1‑type through the connexin 43/NF‑κB pathway.
Molecular medicine reports
Wu L,Chen K,Xiao J,Xin J,Zhang L,Li X,Li L,Si J,Wang L,Ma K
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri May 01 00:00:00 EDT 2020
Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity.
Journal for immunotherapy of cancer
Efimova I,Catanzaro E,Van der Meeren L,Turubanova VD,Hammad H,Mishchenko TA,Vedunova MV,Fimognari C,Bachert C,Coppieters F,Lefever S,Skirtach AG,Krysko O,Krysko DV
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Intravenous injection of the oncolytic virus M1 awakens antitumor T cells and overcomes resistance to checkpoint blockade.
Cell death & disease
Liu Y,Cai J,Liu W,Lin Y,Guo L,Liu X,Qin Z,Xu C,Zhang Y,Su X,Deng K,Yan G,Liang J
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat Dec 12 00:00:00 EST 2020
MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.
International journal of biological sciences
Zhu X,Liu H,Zhang Z,Wei R,Zhou X,Wang Z,Zhao L,Guo Q,Zhang Y,Chu C,Wang L,Li X
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Nov 12 00:00:00 EST 2021
Photodynamic Therapy-Based Dendritic Cell Vaccination Suited to Treat Peritoneal Mesothelioma.
Cancers
Trempolec N,Doix B,Degavre C,Brusa D,Bouzin C,Riant O,Feron O
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Feb 27 00:00:00 EST 2020
Photodynamic Therapy-Based Dendritic Cell Vaccination Suited to Treat Peritoneal Mesothelioma.
Cancers
Trempolec N,Doix B,Degavre C,Brusa D,Bouzin C,Riant O,Feron O
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Feb 27 00:00:00 EST 2020
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Nature communications
Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Aug 27 00:00:00 EDT 2020
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.
Biomedicines
Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Wed Dec 16 00:00:00 EST 2020
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
12-0862 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.
Tue Apr 14 00:00:00 EDT 2020
Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response.
Cancers
Trempolec N,Degavre C,Doix B,Brusa D,Corbet C,Feron O
12-0862-82 was used in Flow cytometry/Cell sorting to identify that acidic mesothelioma milieu drives dendritic cell (DC) dysfunction and altered T cell response through pharmacologically reversible TGF-β2-dependent mechanisms.
Tue May 19 00:00:00 EDT 2020
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.
Scientific reports
Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Mar 24 00:00:00 EDT 2020
Immunoadjuvant Activity of Fucoidans from the Brown Alga Fucus evanescens.
Marine drugs
Kuznetsova TA,Smolina TP,Makarenkova ID,Ivanushko LA,Persiyanova EV,Ermakova SP,Silchenko AS,Zaporozhets TS,Besednova NN,Fedyanina LN,Kryzhanovsky SP
12-0862 was used in Flow cytometry/Cell sorting to comparatively evaluate the effect of fucoidans from the brown alga Fucus evanescens on effector functions of innate and adaptive immunity cells in vitro and in vivo.
Wed Mar 11 00:00:00 EDT 2020
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Jun 29 00:00:00 EDT 2020
Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression.
International journal of nanomedicine
Darling R,Senapati S,Christiansen J,Liu L,Ramer-Tait AE,Narasimhan B,Wannemuehler M
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Dec 07 00:00:00 EST 2020
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
12-0862 was used in Flow cytometry/Cell sorting to show that teniposide could trigger tumor immunogenicity and enable a potential chemoimmunotherapeutic approach to potentiating the therapeutic efficacy of anti-PD1 immunotherapy.
Tue Aug 13 00:00:00 EDT 2019
Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.
Molecular oncology
Zhou Z,Chen H,Xie R,Wang H,Li S,Xu Q,Xu N,Cheng Q,Qian Y,Huang R,Shao Z,Xiang M
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Apr 01 00:00:00 EDT 2019
Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.
Journal of cellular and molecular medicine
Gu AQ,Li DD,Wei DP,Liu YQ,Ji WH,Yang Y,Lin HY,Peng JP
12-0862 was used in Flow cytometry/Cell sorting to study the relationship between cytochrome P450 26A1 and immune cells during the peri-implantation period in mice.
Thu Aug 01 00:00:00 EDT 2019
Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells.
Stem cells and development
Fujii S,Yoshida S,Inagaki E,Hatou S,Tsubota K,Takahashi M,Shimmura S,Sugita S
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection.
International journal of molecular sciences
Li Q,Liu C,Yue R,El-Ashram S,Wang J,He X,Zhao D,Zhou X,Xu L
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Feb 19 00:00:00 EST 2019
Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation.
eLife
Bolger-Munro M,Choi K,Scurll JM,Abraham L,Chappell RS,Sheen D,Dang-Lawson M,Wu X,Priatel JJ,Coombs D,Hammer JA,Gold MR
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Jun 03 00:00:00 EDT 2019
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.
Frontiers in immunology
Fenninger F,Han J,Stanwood SR,Nohara LL,Arora H,Choi KB,Munro L,Pfeifer CG,Shanina I,Horwitz MS,Jefferies WA
12-0862 was used in Flow cytometry/Cell sorting to investigate how a mutation in an L-Type calcium channel gene influences T lymphocyte dysfunction.
Thu Oct 29 00:00:00 EDT 2020
Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins.
Nature communications
Serradell MC,Rupil LL,Martino RA,Prucca CG,Carranza PG,Saura A,Fernández EA,Gargantini PR,Tenaglia AH,Petiti JP,Tonelli RR,Reinoso-Vizcaino N,Echenique J,Berod L,Piaggio E,Bellier B,Sparwasser T,Klatzmann D,Luján HD
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Jan 21 00:00:00 EST 2019
Doxorubicin-polyglycerol-nanodiamond conjugate is a cytostatic agent that evades chemoresistance and reverses cancer-induced immunosuppression in triple-negative breast cancer.
Journal of nanobiotechnology
Yuan SJ,Xu YH,Wang C,An HC,Xu HZ,Li K,Komatsu N,Zhao L,Chen X
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Oct 17 00:00:00 EDT 2019
TGFβ depletion does neither modulate acute E. coli-induced inflammatory immune responses nor impair the protective effect by chronic filarial infection.
GMS infectious diseases
Buerfent BC,Ajendra J,Stamminger W,Gondorf F,Hoerauf A,Hübner MP
12-0862-82 was used in Flow Cytometry to investigate whether this protective effect is dependent on TGFβ signaling and whether depletion of TGFβ before E. coli challenge alters the early course of sepsis per se.
Thu Oct 01 00:00:00 EDT 2020
B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen.
Immunity
Hong S,Zhang Z,Liu H,Tian M,Zhu X,Zhang Z,Wang W,Zhou X,Zhang F,Ge Q,Zhu B,Tang H,Hua Z,Hou B
12-0862-82 was used in Flow Cytometry to demonstrate that antigen-specific B cells were the dominant antigen-presenting cells that initiated naive CD4+ T cell activation. Using RNA phage Qβ-derived VLP (Qβ-VLP) as a model antigen.
Tue Oct 16 00:00:00 EDT 2018
Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-/- Mice by Skewing Macrophages to the M2 Phenotype.
Frontiers in pharmacology
Guo M,Xiao J,Sheng X,Zhang X,Tie Y,Wang L,Zhao L,Ji X
12-0862 was used in Flow cytometry/Cell sorting to demonstrate an immunomodulatory role of ginsenoside 20(S)-Rg3 in promoting macrophages to a profile of the M2 type through PPARγ-dependent mechanisms.
Thu Oct 01 00:00:00 EDT 2020
Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain.
Molecular pain
Lee S,Shi XQ,Fan A,West B,Zhang J
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Oct 22 00:00:00 EDT 2018
T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells.
Nature communications
Kim HR,Mun Y,Lee KS,Park YJ,Park JS,Park JH,Jeon BN,Kim CH,Jun Y,Hyun YM,Kim M,Lee SM,Park CS,Im SH,Jun CD
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Sep 07 00:00:00 EDT 2018
Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation.
JCI insight
Matsumoto R,Dainichi T,Tsuchiya S,Nomura T,Kitoh A,Hayden MS,Ishii KJ,Tanaka M,Honda T,Egawa G,Otsuka A,Nakajima S,Sakurai K,Nakano Y,Kobayashi T,Sugimoto Y,Kabashima K
12-0862 was used in Flow cytometry/Cell sorting to examine whether specific epithelial signalling pathways are essential for the development of robust IL-17-mediated immune responses.
Thu Aug 09 00:00:00 EDT 2018
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Cancer cell
Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH
12-0862 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.
Mon Dec 11 00:00:00 EST 2017
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
12-0862 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 EDT 2017
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.
Nature immunology
Minguet S,Kläsener K,Schaffer AM,Fiala GJ,Osteso-Ibánez T,Raute K,Navarro-Lérida I,Hartl FA,Seidl M,Reth M,Del Pozo MA
12-0862 was used in Flow cytometry/Cell sorting to study the role of Caveolin-1 in controlling the distribution of nanoclusters of isotype-specific B cell antigen receptors on the surface of B cells.
Sun Oct 01 00:00:00 EDT 2017
FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells.
Frontiers in immunology
Pan YG,Yu YL,Lin CC,Lanier LL,Chu CL
Wed Nov 20 00:00:00 EST 2019
Role of Protein Kinase C and Nox2-Derived Reactive Oxygen Species Formation in the Activation and Maturation of Dendritic Cells by Phorbol Ester and Lipopolysaccharide.
Oxidative medicine and cellular longevity
Stein J,Steven S,Bros M,Sudowe S,Hausding M,Oelze M,Münzel T,Grabbe S,Reske-Kunz A,Daiber A
12-0862 was used in Flow cytometry/Cell sorting to investigate the pathway of reactive oxygen species in antigen processing and (cross-) activation of T cells.
Tue Feb 20 00:00:00 EST 2018
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Journal of immunology (Baltimore, Md. : 1950)
Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH
12-0862 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.
Wed Mar 15 00:00:00 EDT 2017
IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages.
Endocrinology
Li C,Ying W,Huang Z,Brehm T,Morin A,Vella AT,Zhou B
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Sep 01 00:00:00 EDT 2017
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Wed Nov 01 00:00:00 EDT 2017
Calreticulin is an effective immunologic adjuvant to tumor-associated antigens.
Experimental and therapeutic medicine
Wang J,Gao ZP,Qin S,Liu CB,Zou LL
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sun Oct 01 00:00:00 EDT 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Feb 06 00:00:00 EST 2017
Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.
Oncoimmunology
Shen Y,Guo D,Weng L,Wang S,Ma Z,Yang Y,Wang P,Wang J,Cai Z
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
MyD88-dependent pro-interleukin-1β induction in dendritic cells exposed to food-grade synthetic amorphous silica.
Particle and fibre toxicology
Winkler HC,Kornprobst J,Wick P,von Moos LM,Trantakis I,Schraner EM,Bathke B,Hochrein H,Suter M,Naegeli H
12-0862 was used in Flow cytometry/Cell sorting to unexpectedly show that food-grade SAS particles are able to directly initiate the endosomal MyD88-dependent pathogen pattern recognition and signaling pathway in steady-state DCs.
Fri Jun 23 00:00:00 EDT 2017
Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.
Immunology
Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H
12-0862 was used in In vitro assays to identify a novel pathway of cross-talk between macrophages and dendritic cells.
Sat Oct 01 00:00:00 EDT 2016
Pioglitazone alleviates inflammation in diabetic mice fed a high-fat diet via inhibiting advanced glycation end-product-induced classical macrophage activation.
The FEBS journal
Jin X,Liu L,Zhou Z,Ge J,Yao T,Shen C
12-0862 was used in Flow cytometry/Cell sorting to demonstrate that pioglitazone blocks classical activation of macrophages and attenuates inflammation in mouse models of diabetes.
Wed Jun 01 00:00:00 EDT 2016
Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.
Journal of immunology (Baltimore, Md. : 1950)
Levit-Zerdoun E,Becker M,Pohlmeyer R,Wilhelm I,Maity PC,Rajewsky K,Reth M,Hobeika E
12-0862 was used in Flow cytometry/Cell sorting to assess the importance of the expression of a functional B-cell receptor for B cell maintenance.
Tue Mar 01 00:00:00 EST 2016
Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS.
Human vaccines & immunotherapeutics
Xu X,Gao Y,Zhai Z,Zhang S,Shan F,Feng J
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Aug 02 00:00:00 EDT 2016
Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression.
Journal of diabetes research
Zhou Z,Tang Y,Jin X,Chen C,Lu Y,Liu L,Shen C
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Jun 06 00:00:00 EDT 2017
CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice.
Experimental and therapeutic medicine
Li JG,DU YM,Yan ZD,Yan J,Zhuansun YX,Chen R,Zhang W,Feng SL,Ran PX
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury.
Frontiers in cellular neuroscience
Hellström Erkenstam N,Smith PL,Fleiss B,Nair S,Svedin P,Wang W,Boström M,Gressens P,Hagberg H,Brown KL,Sävman K,Mallard C
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat Jan 29 00:00:00 EST 2022
Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.
Oncoimmunology
Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW
12-0862 was used in Flow cytometry/Cell sorting to advocate the use of protein oxidation-inducing modalities like irradiation for increasing the immunogenicity of tumour lysate/cells used for pulsing DC vaccines.
Mon Feb 01 00:00:00 EST 2016
Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions.
PLoS neglected tropical diseases
Vendelova E,Camargo de Lima J,Lorenzatto KR,Monteiro KM,Mueller T,Veepaschit J,Grimm C,Brehm K,Hrčková G,Lutz MB,Ferreira HB,Nono JK
12-0862 was used in Flow cytometry/Cell sorting to study the immunomodulatory effects of excretory-secretory products derived from M. corti tetrathyridia.
Sat Oct 01 00:00:00 EDT 2016
Evaluation of Cross-presentation in Bone Marrow-derived Dendritic Cells in vitro and Splenic Dendritic Cells ex vivo Using Antigen-coated Beads.
Bio-protocol
Alloatti A,Kotsias F,Hoffmann E,Amigorena S
12-0862 was used in Flow cytometry/Cell sorting to develop a protocol for evaluating antigen cross-presentation by dendritic cells, both in vivo and ex vivo.
Sun Nov 20 00:00:00 EST 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
12-0862 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.
Wed Jun 01 00:00:00 EDT 2016
Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer.
Nature communications
Dubeykovskaya Z,Si Y,Chen X,Worthley DL,Renz BW,Urbanska AM,Hayakawa Y,Xu T,Westphalen CB,Dubeykovskiy A,Chen D,Friedman RA,Asfaha S,Nagar K,Tailor Y,Muthupalani S,Fox JG,Kitajewski J,Wang TC
12-0862 was used in Flow cytometry/Cell sorting to show that TFF2 is released by vagally modulated memory T cells to suppress the expansion of myeloid-derived suppressor cells through CXCR4.
Thu Feb 04 00:00:00 EST 2016
Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant.
Journal for immunotherapy of cancer
Andersen BM,Xia J,Epstein AL,Ohlfest JR,Chen W,Blazar BR,Pennell CA,Olin MR
12-0862 was used in Flow cytometry/Cell sorting to study the effect of ANXA2m on CD80 and CD86 expression, antigen cross-presentation, and the secretion of various cytokines.
Wed Feb 17 00:00:00 EST 2016
D-Alanylation of Teichoic Acids and Loss of Poly-N-Acetyl Glucosamine in Staphylococcus aureus during Exponential Growth Phase Enhance IL-12 Production in Murine Dendritic Cells.
PloS one
Lund LD,Ingmer H,Frøkiær H
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Jul 14 00:00:00 EDT 2016
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Nature biotechnology
Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Thu Jan 01 00:00:00 EST 2015
Towards programming immune tolerance through geometric manipulation of phosphatidylserine.
Biomaterials
Roberts RA,Eitas TK,Byrne JD,Johnson BM,Short PJ,McKinnon KP,Reisdorf S,Luft JC,DeSimone JM,Ting JP
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2015
Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.
Journal of immunology (Baltimore, Md. : 1950)
Yang L,Lewkowich I,Apsley K,Fritz JM,Wills-Karp M,Weaver TE
12-0862 was used in Flow cytometry/Cell sorting to determine whether loss of Stard7 expression promotes allergic responses, showing that haploinsufficiency for Stard7 is associated with enhanced allergic responses.
Mon Jun 15 00:00:00 EDT 2015
The Cnes2 locus on mouse chromosome 17 regulates host defense against cryptococcal infection through pleiotropic effects on host immunity.
Infection and immunity
Shourian M,Flaczyk A,Angers I,Mindt BC,Fritz JH,Qureshi ST
12-0862 was used in Flow cytometry/Cell sorting to show that Cryptococcus neoformans infected lungs showed a significantly higher number of neutrophils, exudate macrophages, CD11b(+) dendritic cells, and CD4(+) cells in B6.CBA-Cnes2 than in C57BL/6 mice.
Tue Dec 01 00:00:00 EST 2015
Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.
Molecular medicine reports
Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.
BioMed research international
Jin X,Yao T,Zhou Z,Zhu J,Zhang S,Hu W,Shen C
12-0862 was used in Flow cytometry/Cell sorting to assess the effects of AGEs on macrophage polarization.
Fri Mar 18 00:00:00 EDT 2016
Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.
BioMed research international
Jin X,Yao T,Zhou Z,Zhu J,Zhang S,Hu W,Shen C
12-0862 was used in Flow cytometry/Cell sorting to assess the effects of AGEs on macrophage polarization.
Fri Mar 18 00:00:00 EDT 2016
Injectable cryogel-based whole-cell cancer vaccines.
Nature communications
Bencherif SA,Warren Sands R,Ali OA,Li WA,Lewin SA,Braschler TM,Shih TY,Verbeke CS,Bhatta D,Dranoff G,Mooney DJ
12-0862 was used in Flow cytometry/Cell sorting to investigate cancer vaccines based on injectable whole-cell cryogels.
Wed Aug 12 00:00:00 EDT 2015
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
12-0862 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
An autologous leukemia cell vaccine prevents murine acute leukemia relapse after cytarabine treatment.
Blood
Gibbins JD,Ancelet LR,Weinkove R,Compton BJ,Painter GF,Petersen TR,Hermans IF
12-0862 was used in Flow cytometry/Cell sorting to investigate the efficacy of an intravenously administered vaccine consisting of irradiated leukemia cells loaded with α-GalCer.
Thu Nov 06 00:00:00 EST 2014
Paclitaxel-exposed ovarian cancer cells induce cancer‑specific CD4+ T cells after doxorubicin exposure through regulation of MyD88 expression.
International journal of oncology
Kim JE,Jang MJ,Jin DH,Chung YH,Choi BS,Park GB,Kim YS,Kim S,Hur DY,Hung CF,Kim D
12-0862 was used in Flow cytometry/Cell sorting to study induction of cancer-specific CD4+ T cells by paclitaxel-exposed ovarian cancer cells after doxorubicin exposure through regulation of MyD88 expression.
Thu May 01 00:00:00 EDT 2014
Oxidized lipids block antigen cross-presentation by dendritic cells in cancer.
Journal of immunology (Baltimore, Md. : 1950)
Ramakrishnan R,Tyurin VA,Veglia F,Condamine T,Amoscato A,Mohammadyani D,Johnson JJ,Zhang LM,Klein-Seetharaman J,Celis E,Kagan VE,Gabrilovich DI
12-0862 was used in Flow cytometry/Cell sorting to show that oxidised lipids block antigen cross-presentation by dendritic cells in cancer.
Sat Mar 15 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Virology
Wolf AI,Strauman MC,Mozdzanowska K,Williams KL,Osborne LC,Shen H,Liu Q,Garlick D,Artis D,Hensley SE,Caton AJ,Weiser JN,Erikson J
12-0862-82 was used in Flow Cytometry to investigate severity of influenza virus response with respiratory microbe presence.
Fri Aug 01 00:00:00 EDT 2014
Lung dendritic cells undergo maturation and polarization towards a T helper type 2-stimulating phenotype in a mouse model of asthma: Role of nerve growth factor.
Experimental and therapeutic medicine
Qin Q,Wang Z,Pan P,Cao Z,Xia Q,Tan H,Hu C
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sat Nov 01 00:00:00 EDT 2014
Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes.
PloS one
Qian L,Zhang M,Wu S,Zhong Y,Van Tol E,Cai W
12-0862 was used in Flow cytometry/Cell sorting to demonstrate that AKGs can modulate immune responses by boosting the proliferation and maturation of murine lymphocytes in vitro.
Fri Jul 31 00:00:00 EDT 2015
A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome.
Acta neuropathologica communications
Yang M,Rainone A,Shi XQ,Fournier S,Zhang J
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Wed Jan 08 00:00:00 EST 2014
Self DNA from lymphocytes that have undergone activation-induced cell death enhances murine B cell proliferation and antibody production.
PloS one
Lu Q,Wang JY,Wang L,Jiang X,Chu Y
12-0862 was used in Flow cytometry/Cell sorting to study how self DNA can act as a damage-associated molecular pattern which promotes B cell activation and differentiation in autoimmune disease.
Wed Jun 24 00:00:00 EDT 2015
Calcitonin gene-related peptide regulates type IV hypersensitivity through dendritic cell functions.
PloS one
Mikami N,Sueda K,Ogitani Y,Otani I,Takatsuji M,Wada Y,Watanabe K,Yoshikawa R,Nishioka S,Hashimoto N,Miyagi Y,Fukada S,Yamamoto H,Tsujikawa K
12-0862 was used in Flow cytometry/Cell sorting to study how calcionin gene-related peptide (CGRP) affects dendritic cells in adaptive immunity, showing that CGRP suppresses Th1 cell differentiation via inhibition of IL-12 and down regulates the expression of chemokine receptor and its ligand.
Mon Sep 15 00:00:00 EDT 2014
Adrenergic β2 receptor activation stimulates anti-inflammatory properties of dendritic cells in vitro.
PloS one
Nijhuis LE,Olivier BJ,Dhawan S,Hilbers FW,Boon L,Wolkers MC,Samsom JN,de Jonge WJ
12-0862 was used in Flow cytometry/Cell sorting to provide evidence that the adrenergic, rather than cholinergic, receptor activation on bone marrow derived DCs results in enhanced endocytosis uptake, enhanced IL-10 production but a decreased IL-6, IL-12p70 and IL-23 production.
Wed Dec 03 00:00:00 EST 2014
Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.
Molecular therapy : the journal of the American Society of Gene Therapy
Gujar S,Dielschneider R,Clements D,Helson E,Shmulevitz M,Marcato P,Pan D,Pan LZ,Ahn DG,Alawadhi A,Lee PW
12-0862 was used in Flow cytometry/Cell sorting to develop a virus-based therapy that suppresses immunomodulation and targets ovarian peritoneal carcinomatosis.
Fri Feb 01 00:00:00 EST 2013
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
McKee AS,Burchill MA,Munks MW,Jin L,Kappler JW,Friedman RS,Jacobelli J,Marrack P
12-0862 was used in Flow cytometry/Cell sorting to study how aluminium acts as an adjuvant by introducing host DNA into the cytoplasm of dendritic cells, where it engages receptors promoting MHC II presentation.
Tue Mar 19 00:00:00 EDT 2013
Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells.
Experimental & molecular medicine
Park SN,Noh KT,Jeong YI,Jung ID,Kang HK,Cha GS,Lee SJ,Seo JK,Kang DH,Hwang TH,Lee EK,Kwon B,Park YM
12-0862 was used in Flow cytometry/Cell sorting to evaluate the effectiveness of RG-II-stimulated BMDC vaccination on the induction of antitumor immunity, showing that it inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells.
Fri Feb 08 00:00:00 EST 2013
Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.
Diabetes
Thomas DC,Wong FS,Zaccone P,Green EA,Wållberg M
12-0862 was used in Flow cytometry/Cell sorting to investigate methods to achieve long-term β-islet graft tolerance for diabetes type 1, showing that islets can be protected through expression of TGF-β.
Sun Sep 01 00:00:00 EDT 2013
Novel immunomodulators from hard ticks selectively reprogramme human dendritic cell responses.
PLoS pathogens
Preston SG,Majtán J,Kouremenou C,Rysnik O,Burger LF,Cabezas Cruz A,Chiong Guzman M,Nunn MA,Paesen GC,Nuttall PA,Austyn JM
12-0862 was used in Flow cytometry/Cell sorting to provide a previously unknown mechanism for parasite-induced subversion of adaptive immunity.
Fri Jan 17 00:00:00 EST 2014
Traumatic brain injury induces macrophage subsets in the brain.
European journal of immunology
Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE
12-0862 was used in Flow cytometry/Cell sorting to better understand the mechanisms involved in the innate inflammatory responses to brain injury.
Thu Aug 01 00:00:00 EDT 2013
Inactivation of tumor-specific CD8⁺ CTLs by tumor-infiltrating tolerogenic dendritic cells.
Immunology and cell biology
Harimoto H,Shimizu M,Nakagawa Y,Nakatsuka K,Wakabayashi A,Sakamoto C,Takahashi H
12-0862 was used in Flow cytometry/Cell sorting to investigate cancer immunosurveillance failure caused by the inactivation of CD8+ cytotoxic T lymphocytes by tolerogenic dendritic cells.
Tue Oct 01 00:00:00 EDT 2013
Histone deacetylase inhibitors suppress immune activation in primary mouse microglia.
Journal of neuroscience research
Kannan V,Brouwer N,Hanisch UK,Regen T,Eggen BJ,Boddeke HW
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Sun Sep 01 00:00:00 EDT 2013
Properties of immature myeloid progenitors with nitric-oxide-dependent immunosuppressive activity isolated from bone marrow of tumor-free mice.
PloS one
Forghani P,Harris W,Giver CR,Mirshafiey A,Galipeau J,Waller EK
12-0862 was used in Flow cytometry/Cell sorting to determine the role of immature myeloid cells in regulating T-cell activation and proliferation in bone marrow.
Thu Jan 23 00:00:00 EST 2014
Exercise reduces activation of microglia isolated from hippocampus and brain of aged mice.
Journal of neuroinflammation
Kohman RA,Bhattacharya TK,Wojcik E,Rhodes JS
12-0862-82 was used in Flow cytometry/Cell sorting to indicate that running-wheel access modulates microglia activation, but these effects vary by age, sex, and brain region.
Wed Sep 18 00:00:00 EDT 2013
Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite.
PloS one
Chen ZG,Zhang TT,Li HT,Chen FH,Zou XL,Ji JZ,Chen H
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Tue Aug 20 00:00:00 EDT 2013
Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity.
Molecular therapy : the journal of the American Society of Gene Therapy
Reyes-Sandoval A,Rollier CS,Milicic A,Bauza K,Cottingham MG,Tang CK,Dicks MD,Wang D,Longley RJ,Wyllie DH,Hill AV
12-0862 was used in Flow cytometry/Cell sorting to investigate whether the two vaccine components adenovirus and modified vaccinia virus Ankara can be co-injected to enhance protection against malaria.
Wed Aug 01 00:00:00 EDT 2012
ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.
Molecular therapy : the journal of the American Society of Gene Therapy
Rintoul JL,Lemay CG,Tai LH,Stanford MM,Falls TJ,de Souza CT,Bridle BW,Daneshmand M,Ohashi PS,Wan Y,Lichty BD,Mercer AA,Auer RC,Atkins HL,Bell JC
12-0862 was used in Flow cytometry/Cell sorting to investigate the use of Parapoxvirus ovis for the treatment of cancer.
Fri Jun 01 00:00:00 EDT 2012
Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice.
Journal of immunology (Baltimore, Md. : 1950)
Iwata Y,Boström EA,Menke J,Rabacal WA,Morel L,Wada T,Kelley VR
12-0862 was used in Flow cytometry/Cell sorting to elucidate the macrophage-associated effects of CSF-1 expression by tubular epithelial cells during kidney inflammation.
Tue May 01 00:00:00 EDT 2012
Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice.
PloS one
Kamphuis T,Meijerhof T,Stegmann T,Lederhofer J,Wilschut J,de Haan A
12-0862 was used in Flow cytometry/Cell sorting to assess the efficacy of a novel respiratory syncytial virus vaccine in mice.
Wed Sep 19 00:00:00 EDT 2012
A critical role for SOCS3 in innate resistance to Toxoplasma gondii.
Cell host & microbe
Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA
12-0862 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.
Thu Sep 15 00:00:00 EDT 2011
Langerhans cells regulate cutaneous injury by licensing CD8 effector cells recruited to the skin.
Blood
Bennett CL,Fallah-Arani F,Conlan T,Trouillet C,Goold H,Chorro L,Flutter B,Means TK,Geissmann F,Chakraverty R
12-0862 was used in Flow cytometry/Cell sorting to explore the role of Langerhans cells in the development of tissue injury using a tractable model of cutaneous graft-versus-host disease.
Thu Jun 30 00:00:00 EDT 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
12-0862 was used in Flow cytometry/Cell sorting to study how PGE2 stimulates the expression of the inducible cyclic AMP early repressor, which appears to directly inhibit RALDH expression in DCs.
Mon Apr 11 00:00:00 EDT 2011
Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages.
Immunology
Buhtoiarov IN,Sondel PM,Wigginton JM,Buhtoiarova TN,Yanke EM,Mahvi DA,Rakhmilevich AL
12-0862 was used in Flow cytometry/Cell sorting to show that chemotherapy and anti-CD40 + CpG-ODN IT synergise in the induction of anti-tumour effects which are associated with the phenotypic repolarisation of tumour-associated Mφ.
Tue Feb 01 00:00:00 EST 2011
Early acceptance of renal allografts in mice is dependent on foxp3(+) cells.
The American journal of pathology
Miyajima M,Chase CM,Alessandrini A,Farkash EA,Della Pelle P,Benichou G,Graham JA,Madsen JC,Russell PS,Colvin RB
12-0862 was used in Flow cytometry/Cell sorting to investigate how Foxp3(+) cells are needed to maintain acceptance of major histocompatibility complex-incompatible renal allografts in the first 3 months after transplantation and may act by inhibiting DC maturation.
Fri Apr 01 00:00:00 EDT 2011
Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Lochner M,Bérard M,Sawa S,Hauer S,Gaboriau-Routhiau V,Fernandez TD,Snel J,Bousso P,Cerf-Bensussan N,Eberl G
12-0862 was used in Flow cytometry/Cell sorting to demonstrate that a complex microbiota and cognate antigen are required to generate a properly regulated set of Foxp3+RORγt+ T cells and Th17 cells.
Tue Feb 01 00:00:00 EST 2011
Calcitonin gene-related peptide is an important regulator of cutaneous immunity: effect on dendritic cell and T cell functions.
Journal of immunology (Baltimore, Md. : 1950)
Mikami N,Matsushita H,Kato T,Kawasaki R,Sawazaki T,Kishimoto T,Ogitani Y,Watanabe K,Miyagi Y,Sueda K,Fukada S,Yamamoto H,Tsujikawa K
12-0862 was used in Flow cytometry/Cell sorting to study how calcitonin gene-related peptide effects dendritic and T cells, and regulation of inflammation.
Wed Jun 15 00:00:00 EDT 2011
The actin-bundling protein L-plastin is essential for marginal zone B cell development.
Journal of immunology (Baltimore, Md. : 1950)
Todd EM,Deady LE,Morley SC
12-0862 was used in Flow cytometry/Cell sorting to study the role of the actin-bundling protein L-plastin in B cell chemotaxis.
Thu Sep 15 00:00:00 EDT 2011
Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages.
Journal of medical microbiology
Daim S,Kawamura I,Tsuchiya K,Hara H,Kurenuma T,Shen Y,Dewamitta SR,Sakai S,Nomura T,Qu H,Mitsuyama M
12-0862 was used in Flow cytometry/Cell sorting to suggest a potential role of PPE37 in interfering with the pro-inflammatory cytokine response of infected macrophages.
Sun May 01 00:00:00 EDT 2011
Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout.
Arthritis and rheumatism
Martin WJ,Shaw O,Liu X,Steiger S,Harper JL
12-0862 was used in an ELISA assay to study how MSU crystal-recruited monocytes differentiate into proinflammatory M1-like macrophages in vivo.
Sun May 01 00:00:00 EDT 2011
T cell immunoglobulin- and mucin-domain-containing molecule-4 attenuates concanavalin A-induced hepatitis by regulating macrophage.
Journal of leukocyte biology
Xu L,Qi J,Zhao P,Liang X,Ju Y,Liu P,Liu B,Guo C,Zhang L,Ma C,Gao L
12-0862 was used in Flow cytometry/Cell sorting to study how Tim-4 plays an important role in alleviating liver damage through inhibition of macrophage activity.
Sun Aug 01 00:00:00 EDT 2010
Dendritic cells continue to capture and present antigens after maturation in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Drutman SB,Trombetta ES
12-0862 was used in Flow cytometry/Cell sorting to study the dynamics of Ag capture and presentation in situ, showing that dendritic cells continue to capture and present antigens after maturation.
Sun Aug 15 00:00:00 EDT 2010
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
Journal of immunology (Baltimore, Md. : 1950)
Ishiwata K,Watanabe N,Guo M,Tomihara K,Brumlik MJ,Yagita H,Pardoll D,Chen L,Shin T
12-0862 was used in Flow cytometry/Cell sorting to demonstrate that the inhibition of Th2 responses by B7-DC occurs independently of programmed death 1 but conceivably acts through an as yet unknown alternative receptor that enhances Th1 responses.
Mon Feb 15 00:00:00 EST 2010
Foxa2 programs Th2 cell-mediated innate immunity in the developing lung.
Journal of immunology (Baltimore, Md. : 1950)
Chen G,Wan H,Luo F,Zhang L,Xu Y,Lewkowich I,Wills-Karp M,Whitsett JA
12-0862 was used in Flow cytometry/Cell sorting to demonstrate that selective expression of Foxa2 plays a key role in regulating Th2 cell-mediated pulmonary inflammation.
Tue Jun 01 00:00:00 EDT 2010
Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950)
Giannattasio G,Fujioka D,Xing W,Katz HR,Boyce JA,Balestrieri B
12-0862 was used in Flow cytometry/Cell sorting to demonstrate the role of group V secretory phospholipase A(2) in antigen presenting cells following infection with the house dust mite, Dermatophagoides farinae.
Fri Oct 01 00:00:00 EDT 2010
Inhibition of B-cell activation by retinal pigment epithelium.
Investigative ophthalmology & visual science
Sugita S,Horie S,Yamada Y,Mochizuki M
12-0862 was used in Flow cytometry/Cell sorting to determine whether retinal pigment epithelial (RPE) cells can inhibit B-cell activation in vitro, showing that B-cell proliferation was suppressed.
Mon Nov 01 00:00:00 EDT 2010
FLT-3 expression and function on microglia in multiple sclerosis.
Experimental and molecular pathology
DeBoy CA,Rus H,Tegla C,Cudrici C,Jones MV,Pardo CA,Small D,Whartenby KA,Calabresi PA
12-0862 was used in Flow cytometry/Cell sorting to study the expression and function of FLT-3 in microglia in multiple sclerosis, suggesting that FLT-3 could be a therapeutic target to mitigate CNS inflammation.
Fri Oct 01 00:00:00 EDT 2010
Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
Journal of immunological methods
Holl TM,Haynes BF,Kelsoe G
12-0862 was used in Flow cytometry/Cell sorting to describe a stromal cell independent culture system that efficiently supports pro-B cell to IgM+ B cell development with near normal levels of IgH and Igkappa diversity.
Wed Mar 31 00:00:00 EDT 2010
Chemoimmunotherapy reduces the progression of multiple myeloma in a mouse model.
Cancer prevention research (Philadelphia, Pa.)
Sharabi A,Laronne-Bar-On A,Meshorer A,Haran-Ghera N
12-0862 was used in Flow cytometry/Cell sorting to determine the effects, and their modes of action, of CYC treatment on MM progression.
Fri Oct 01 00:00:00 EDT 2010
Cell-cell cooperation at the T helper cell/mast cell immunological synapse.
Blood
Gaudenzio N,Espagnolle N,Mars LT,Liblau R,Valitutti S,Espinosa E
12-0862 was used in Flow cytometry/Cell sorting to investigate whether cognate interactions between mast cells and class II-restricted CD4(+) T cells occur.
Thu Dec 03 00:00:00 EST 2009
A role for cFLIP in B cell proliferation and stress MAPK regulation.
Journal of immunology (Baltimore, Md. : 1950)
Zhang H,Rosenberg S,Coffey FJ,He YW,Manser T,Hardy RR,Zhang J
12-0862 was used in Flow cytometry/Cell sorting to reveal the novel functions of cFLIP in B cells.
Thu Jan 01 00:00:00 EST 2009
Transcriptional IL-15-directed in vivo DC targeting DNA vaccine.
Gene therapy
Tian S,Liu Z,Donahue C,Noh HS,Falo LD,You Z
12-0862 was used in Flow cytometry/Cell sorting to investigate next generation DNA vaccines against cancers and infectious diseases in both healthy and CD4 deficient individuals.
Thu Oct 01 00:00:00 EDT 2009
Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis.
The Journal of biological chemistry
Turner JD,Langley RS,Johnston KL,Gentil K,Ford L,Wu B,Graham M,Sharpley F,Slatko B,Pearlman E,Taylor MJ
12-0862 was used in Flow cytometry/Cell sorting to investigate the role of Wolbachia lipoprotein in pathogenesis of filariasis, showing that it stimulates innate and adaptive immunity through Toll-like receptors 2 and 6.
Fri Aug 14 00:00:00 EDT 2009
MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo.
PloS one
Kumamoto Y,Denda-Nagai K,Aida S,Higashi N,Irimura T
12-0862 was used in Flow cytometry/Cell sorting to investigate the functional and phenotypic differences between Langerhans and dermal dendritic cells, showing that macrophage galactose-type C-type lectin (MGL) 2 is only expression in dermal dendritic cells, which are sufficient to initiate contact hypersensitivity in vivo.
Thu Aug 06 00:00:00 EDT 2009
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.
Nature immunology
Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M
Published figure using CD86 (B7-2) monoclonal antibody (Product # 12-0862-82) in Flow Cytometry
Fri Aug 01 00:00:00 EDT 2008
CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.
Journal of the American Society of Nephrology : JASN
Menke J,Zeller GC,Kikawada E,Means TK,Huang XR,Lan HY,Lu B,Farber J,Luster AD,Kelley VR
12-0862 was used in Flow cytometry/Cell sorting to identify additional therapeutic chemokine targets for immune-mediated nephritis.
Sun Jun 01 00:00:00 EDT 2008
Nitric oxide is a key component in inflammation-accelerated tumorigenesis.
Cancer research
Hussain SP,He P,Subleski J,Hofseth LJ,Trivers GE,Mechanic L,Hofseth AB,Bernard M,Schwank J,Nguyen G,Mathe E,Djurickovic D,Haines D,Weiss J,Back T,Gruys E,Laubach VE,Wiltrout RH,Harris CC
12-0862 was used in Flow cytometry/Cell sorting to test the hypothesis that an inflammatory microenvironment with an enhanced level of nitric oxide accelerates spontaneous tumour development (tumorigenesis).
Mon Sep 01 00:00:00 EDT 2008
IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Journal of immunology (Baltimore, Md. : 1950)
Kikuchi K,Kasai H,Watanabe A,Lai AY,Kondo M
12-0862 was used in Flow cytometry/Cell sorting to investigate when IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice, showing that IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
Tue Jul 01 00:00:00 EDT 2008
Role of CD80 and CD86 in host immune responses to the recombinant hemagglutinin domain of Porphyromonas gingivalis gingipain and in the adjuvanticity of cholera toxin B and monophosphoryl lipid A.
Vaccine
Zhang P,Lewis JP,Michalek SM,Katz J
12-0862 was used in Flow cytometry/Cell sorting to demonstrate CD80 and CD86 play a role in mediating a systemic immune response towards P. gingivalis proteases.
Tue Aug 14 00:00:00 EDT 2007
Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy.
Infection and immunity
Schierloh P,Yokobori N,Alemán M,Landoni V,Geffner L,Musella RM,Castagnino J,Baldini M,Abbate E,de la Barrera SS,Sasiain MC
12-0862 was used in Flow cytometry/Cell sorting to study how the interplay between M. tuberculosis and NK cells/APC triggering IFN-gamma may play a beneficial role in tuberculous pleurisy by helping to maintain a type 1 profile.
Thu Nov 01 00:00:00 EDT 2007
The Fas-associated death domain protein is required in apoptosis and TLR-induced proliferative responses in B cells.
Journal of immunology (Baltimore, Md. : 1950)
Imtiyaz HZ,Rosenberg S,Zhang Y,Rahman ZS,Hou YJ,Manser T,Zhang J
12-0862 was used in Flow cytometry/Cell sorting to show that the deletion of the Fas-associated death domain protein at the pro-B cell stage has effects on B cell apoptosis and development.
Thu Jun 01 00:00:00 EDT 2006
-Flow-20170216130641.jpg?time=20240507 "CD86 (B7-2) Antibody in Flow Cytometry (Flow)")
-Flow-20170216130641.jpg?time=20240507)
-Flow-20170216130641.jpg?time=20240507?time=20240507 "CD86 (B7-2) Antibody (12-0862-82) in Flow")
