Product References
Activating NO-sGC crosstalk in the mouse vascular niche promotes vascular integrity and mitigates acute lung injury.
The Journal of experimental medicine
He H,Yang W,Su N,Zhang C,Dai J,Han F,Singhal M,Bai W,Zhu X,Zhu J,Liu Z,Xia W,Liu X,Zhang C,Jiang K,Huang W,Chen D,Wang Z,He X,Kirchhoff F,Li Z,Liu C,Huan J,Wang X,Wei W,Wang J,Augustin HG,Hu J
12-5381-82 was used in Flow Cytometry to demonstrate that impaired NO-sGC crosstalk in the vascular niche results in elevated vascular permeability, and pharmacological activation of this crosstalk represents a promising translational therapy for ALI.
Mon Feb 06 00:00:00 EST 2023
Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress.
Research (Washington, D.C.)
Chang J,Guo B,Gao Y,Li W,Tong X,Feng Y,Abumaria N
12-5381-82 was used in Flow cytometry/Cell sorting to demonstrate the existence of lymphatic vessels deep in the brain parenchyma.
Thu May 25 00:00:00 EDT 2023
Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platform.
Genes & development
Naranjo S,Cabana CM,LaFave LM,Romero R,Shanahan SL,Bhutkar A,Westcott PMK,Schenkel JM,Ghosh A,Liao LZ,Del Priore I,Yang D,Jacks T
12-5381-82 was used in Flow cytometry/Cell sorting to show that this organoid platform is a powerful, versatile new model system to study LUAD.
Mon Aug 01 00:00:00 EDT 2022
A functional role of meningeal lymphatics in sex difference of stress susceptibility in mice.
Nature communications
Dai W,Yang M,Xia P,Xiao C,Huang S,Zhang Z,Cheng X,Li W,Jin J,Zhang J,Wu B,Zhang Y,Wu PH,Lin Y,Wu W,Zhao H,Zhang Y,Lin WJ,Ye X
12-5381-82 was used in Flow cytometry/Cell sorting to suggest meningeal lymphatic impairment contributes to susceptibility to stress in female mice, and that restoration of the meningeal lymphatics might have potential for modulation of depression-like behaviour.
Tue Aug 16 00:00:00 EDT 2022
Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity.
Nature immunology
Prados A,Onder L,Cheng HW,Mörbe U,Lütge M,Gil-Cruz C,Perez-Shibayama C,Koliaraki V,Ludewig B,Kollias G
Published figure using Podoplanin monoclonal antibody (Product # 12-5381-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses.
Cancer research
Cousin N,Cap S,Dihr M,Tacconi C,Detmar M,Dieterich LC
12-5381-82 was used in Flow Cytometry to present a new lymphatic-specific PD-L1 knockout mouse model reveals that lymphatic endothelial PD-L1 expression reduces tumor immunity, inducing apoptosis in tumor-specific CD8+ central memory cells in tumor-draining lymph nodes.
Sun Aug 01 00:00:00 EDT 2021
Lymph node formation and B cell homeostasis require IKK-α in distinct endothelial cell-derived compartments.
Proceedings of the National Academy of Sciences of the United States of America
McCorkell KA,Jayachandran N,Cully MD,Freund-Brown J,Weinkopff T,Monslow J,Hu Y,Puré E,Freedman BD,Alvarez JI,Cancro MP,May MJ
12-5381-82 was used in Flow cytometry/Cell sorting to reveal that IKK-α in distinct EC-derived compartments is uniquely required to promote B cell homeostasis and LN development, and establish that LEC-intrinsic IKK-α is absolutely essential for LN formation.
Tue Nov 30 00:00:00 EST 2021
Fibroblastic reticular cell response to dendritic cells requires coordinated activity of podoplanin, CD44 and CD9.
Journal of cell science
de Winde CM,Makris S,Millward LJ,Cantoral-Rebordinos JA,Benjamin AC,Martínez VG,Acton SE
Published figure using Podoplanin monoclonal antibody (Product # 12-5381-82) in Flow Cytometry
Thu Jul 15 00:00:00 EDT 2021
CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice.
Theranostics
Tang C,Wang L,Sheng Y,Zheng Z,Xie Z,Wu F,You T,Ren L,Xia L,Ruan C,Zhu L
Published figure using Podoplanin monoclonal antibody (Product # 12-5381-82) in Flow Cytometry
Mon Feb 07 00:00:00 EST 2022
DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease.
The Journal of pathology
Choi C,Park J,Kim H,Chang KT,Park J,Min KT
12-5381-82 was used in Magnetic cell separation to show that Down syndrome critical region 1 (DSCR1) facilitates the growth of dorsal meningeal lymphatics to improve drainage efficiency and protect against Alzheimer's disease (AD).
Mon Nov 01 00:00:00 EDT 2021
STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury.
Nature cell biology
Paris AJ,Hayer KE,Oved JH,Avgousti DC,Toulmin SA,Zepp JA,Zacharias WJ,Katzen JB,Basil MC,Kremp MM,Slamowitz AR,Jayachandran S,Sivakumar A,Dai N,Wang P,Frank DB,Eisenlohr LC,Cantu E,Beers MF,Weitzman MD,Morrisey EE,Worthen GS
12-5381 was used in Flow cytometry/Cell sorting to elucidate repair mechanisms of proliferation and trandifferentiation of type II alveolar pneumocytes (AT2 cells) into type I alveolar pneumocytes (AT1 cells) after acute lung injury.
Thu Oct 01 00:00:00 EDT 2020
Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis.
Angiogenesis
Dieterich LC,Tacconi C,Menzi F,Proulx ST,Kapaklikaya K,Hamada M,Takahashi S,Detmar M
12-5381 was used in Flow cytometry/Cell sorting to investigate the mechanisms involve in in postnatal lymphangiogenesis.
Sat Aug 01 00:00:00 EDT 2020
Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes.
PLoS biology
Fujimoto N,He Y,D'Addio M,Tacconi C,Detmar M,Dieterich LC
Published figure using Podoplanin monoclonal antibody (Product # 12-5381-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes.
PLoS biology
Fujimoto N,He Y,D'Addio M,Tacconi C,Detmar M,Dieterich LC
Published figure using Podoplanin monoclonal antibody (Product # 12-5381-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
eLife
Frye M,Stritt S,Ortsäter H,Hernandez Vasquez M,Kaakinen M,Vicente A,Wiseman J,Eklund L,Martínez-Torrecuadrada JL,Vestweber D,Mäkinen T
12-5381 was used in Flow cytometry/Cell sorting to identify the transmembrane ligand EphrinB2 and its receptor EphB4 as critical homeostatic regulators of collecting lymphatic vessel integrity.
Tue Sep 08 00:00:00 EDT 2020
Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia.
Infection and immunity
Trevejo-Nunez G,Elsegeiny W,Aggor FEY,Tweedle JL,Kaplan Z,Gandhi P,Castillo P,Ferguson A,Alcorn JF,Chen K,Kolls JK,Gaffen SL
12-5381 was used in Flow cytometry/Cell sorting to demonstrate the role of IL-22BP as a natural inhibitor of IL-22 in the lung.
Fri Nov 01 00:00:00 EDT 2019
Transcriptional profiling of breast cancer-associated lymphatic vessels reveals VCAM-1 as regulator of lymphatic invasion and permeability.
International journal of cancer
Dieterich LC,Kapaklikaya K,Cetintas T,Proulx ST,Commerford CD,Ikenberg K,Bachmann SB,Scholl J,Detmar M
12-5381-82 was used in Flow cytometry/Cell sorting to suggest that disruption of lymphatic junctions and increased permeability via tumor-induced lymphatic VCAM-1 expression may represent a new target to block lymphatic invasion and metastasis.
Fri Nov 15 00:00:00 EST 2019
Transcriptional profiling of breast cancer-associated lymphatic vessels reveals VCAM-1 as regulator of lymphatic invasion and permeability.
International journal of cancer
Dieterich LC,Kapaklikaya K,Cetintas T,Proulx ST,Commerford CD,Ikenberg K,Bachmann SB,Scholl J,Detmar M
12-5381-82 was used in Flow cytometry/Cell sorting to suggest that disruption of lymphatic junctions and increased permeability via tumor-induced lymphatic VCAM-1 expression may represent a new target to block lymphatic invasion and metastasis.
Fri Nov 15 00:00:00 EST 2019
Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation.
Cell reports
Helbling PM,Piñeiro-Yáñez E,Gerosa R,Boettcher S,Al-Shahrour F,Manz MG,Nombela-Arrieta C
12-5381 was used in Flow cytometry/Cell sorting to reveal (1) molecular fingerprints defining cell-specific anatomical and functional features, (2) a radical reprogramming of pro-hematopoietic, immune, and matrisomic transcriptional programs during the transition from juvenile stages to adulthood, and (3) the aging-driven progressive upregulation of pro-inflammatory gene expression in stroma.
Tue Dec 03 00:00:00 EST 2019
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Nature neuroscience
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J
12-5381 was used in Immunohistochemistry-immunofluorescence to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.
Mon Oct 01 00:00:00 EDT 2018
Podoplanin is an important stromal prognostic marker in perihilar cholangiocarcinoma.
Oncology letters
Obulkasim H,Shi X,Wang J,Li J,Dai B,Wu P,Wang S,Wang X,Ding Y
Published figure using Podoplanin monoclonal antibody (Product # 12-5381-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation.
Frontiers in immunology
Dieterich LC,Ikenberg K,Cetintas T,Kapaklikaya K,Hutmacher C,Detmar M
12-5381 was used in Flow cytometry/Cell sorting to study the mechanism by which tumour associated lymphatic vesicles regulate T cell-activation.
Wed Nov 20 00:00:00 EST 2019
Cornea lymphatics drive the CD8+ T-cell response to herpes simplex virus-1.
Immunology and cell biology
Gurung HR,Carr MM,Carr DJ
12-5381 was used in Flow cytometry/Cell sorting to suggest that newly created lymphatic vessels in the cornea driven by HSV-1 infection are critical in the delivery of soluble viral antigen to the draining lymph node.
Sun Jan 01 00:00:00 EST 2017
Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.
Cell reports
Eddens T,Elsegeiny W,Garcia-Hernadez ML,Castillo P,Trevejo-Nunez G,Serody K,Campfield BT,Khader SA,Chen K,Rangel-Moreno J,Kolls JK
12-5381 was used in Flow cytometry/Cell sorting to develop a model for fungal-mediated inducible bronchus-associated lymphoid tissue.
Tue Mar 28 00:00:00 EDT 2017
Lymphatic Contribution to the Cellular Niche in Heterotopic Ossification.
Annals of surgery
Loder S,Agarwal S,Sorkin M,Breuler C,Li J,Peterson J,Gardenier J,Hsieh HH,Wang SC,Mehrara BJ,Levi B
Published figure using Podoplanin monoclonal antibody (Product # 12-5381-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2016
DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C.
Journal of cell science
Klein S,Dieterich LC,Mathelier A,Chong C,Sliwa-Primorac A,Hong YK,Shin JW,Lizio M,Itoh M,Kawaji H,Lassmann T,Daub CO,Arner E,Carninci P,Hayashizaki Y,Forrest AR,Wasserman WW,Detmar M
12-5381 was used in Flow cytometry/Cell sorting to identify HOXD10 to be specifically activated at early time points following VEGFR-3 stimulation, and to regulate the expression of early transcription factors, including NR4A1.
Fri Jul 01 00:00:00 EDT 2016
Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease.
Nature medicine
Chimen M,McGettrick HM,Apta B,Kuravi SJ,Yates CM,Kennedy A,Odedra A,Alassiri M,Harrison M,Martin A,Barone F,Nayar S,Hitchcock JR,Cunningham AF,Raza K,Filer A,Copland DA,Dick AD,Robinson J,Kalia N,Walker LSK,Buckley CD,Nash GB,Narendran P,Rainger GE
12-5381 was used in Flow cytometry/Cell sorting to demonstrate that exogenous PEPITEM reduces T cell recruitment into inflamed tissues in multiple animal models of autoimmune, inflammatory diseases.
Fri May 01 00:00:00 EDT 2015
Alveolar progenitor and stem cells in lung development, renewal and cancer.
Nature
Desai TJ,Brownfield DG,Krasnow MA
12-5381 was used in Flow cytometry/Cell sorting to identify alveolar progenitor and stem cells in mice in vivo, and map their locations and activity throughout the lifespan.
Thu Mar 13 00:00:00 EDT 2014
Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing.
Nature immunology
Lee M,Kiefel H,LaJevic MD,Macauley MS,Kawashima H,O'Hara E,Pan J,Paulson JC,Butcher EC
12-5381 was used in Flow cytometry/Cell sorting to investigate the molecular signatures that distinguish HEVs from capillary endothelium, revealing control mechanisms for lymphocyte homing.
Wed Oct 01 00:00:00 EDT 2014
CLEC-2 is required for development and maintenance of lymph nodes.
Blood
Bénézech C,Nayar S,Finney BA,Withers DR,Lowe K,Desanti GE,Marriott CL,Watson SP,Caamaño JH,Buckley CD,Barone F
12-5381 was used in Flow cytometry/Cell sorting to investigate the role that CLEC-2 plays in the development and maintenance of lymph nodes.
Thu May 15 00:00:00 EDT 2014
Alveolar epithelial dynamics in postpneumonectomy lung growth.
Anatomical record (Hoboken, N.J. : 2007)
Chamoto K,Gibney BC,Ackermann M,Lee GS,Konerding MA,Tsuda A,Mentzer SJ
12-5381 was used in Flow cytometry/Cell sorting to investigate the relationship between epithelial and endothelial cells within the alveolus in post-pneumonectomy lung growth.
Fri Mar 01 00:00:00 EST 2013
Migration of CD11b+ accessory cells during murine lung regeneration.
Stem cell research
Chamoto K,Gibney BC,Lee GS,Ackermann M,Konerding MA,Tsuda A,Mentzer SJ
12-5381 was used in Flow cytometry/Cell sorting to characterise the factors contributing to neoalveolarization within 21 days of pneumonectomy.
Wed May 01 00:00:00 EDT 2013
Differential host response, rather than early viral replication efficiency, correlates with pathogenicity caused by influenza viruses.
PloS one
Askovich PS,Sanders CJ,Rosenberger CM,Diercks AH,Dash P,Navarro G,Vogel P,Doherty PC,Thomas PG,Aderem A
12-5381 was used in Flow cytometry/Cell sorting to identify separate gene networks in lung and tracheal tissues and their responses correlate with influenza pathogenicity.
Tue May 27 00:00:00 EDT 2014
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
Blood
Finney BA,Schweighoffer E,Navarro-Núñez L,Bénézech C,Barone F,Hughes CE,Langan SA,Lowe KL,Pollitt AY,Mourao-Sa D,Sheardown S,Nash GB,Smithers N,Reis e Sousa C,Tybulewicz VL,Watson SP
12-5381 was used in Flow cytometry/Cell sorting to study the relationship between the C-type lectin receptor, CLEC-2, and the tyrosine kinase Syk on multiple developmental processes in mice.
Thu Feb 16 00:00:00 EST 2012