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Bioss
14-3-3 Alpha/Beta/Gamma/Delta/Epsilon Polyclonal Antibody
FIGURE: 1 / 2
14-3-3 Alpha/Beta/Gamma/Delta/Epsilon Antibody (BS-0237R) in IHC (P)
Formalin-fixed and paraffin embedded: human rectal carcinoma labeled with Anti-14-3-3 Polyclonal Antibody (bs-0237R, Unconjugated) at 1:200,, followed by conjugation to the secondary antibody was Goat Anti-Rabbit IgG, PE conjugated(bs-0295G-PE) at 1:200 for 40 minutes at 37°C.
Product Details
BS-0237R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Yeast
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human 14-3-3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14-3-3 alpha; 14-3-3 delta; 14-3-3 epsilon; 14-3-3 gamma; 14-3-3 protein beta; 14-3-3 protein beta-subtype; 14-3-3 protein beta/alpha; 14-3-3 protein epsilon; 14-3-3 protein gamma; 14-3-3 protein gamma subtype; 14-3-3 protein gamma-subtype; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3 protein zeta/delta; 14-3-3 protein/cytosolic phospholipase A2; 14-3-3 tau; 14-3-3 theta; 14-3-3 zeta; 14-3-3E; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; brain protein 14-3-3, beta isoform; epididymis luminal protein 2; epididymis luminal protein 4; epididymis secretory protein Li 1; epididymis secretory protein Li 3; epididymis secretory protein Li 93; KCIP-1; mitochondrial import stimulation factor (MSF) L subunit; Mitochondrial import stimulation factor L subunit; Mitochondrial import stimulation factor S1 subunit; MSF L; phospholipase A2; Prepronerve growth factor RNH-1; Protein 1054; Protein HS1; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; protein phosphatase 1, regulatory subunit 170; protein, theta; SEZ-2; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide; tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein epsilon polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide
Gene Aliases: 1110013I11Rik; 1300003C17Rik; 14-3-3; 14-3-3-zeta; 14-3-3E; 14-3-3G; 14-3-3GAMMA; 14-3-3t; 14-3-3z; 14-3-3zeta; 1C5; 2700028P07Rik; AA409740; AI596267; AL022924; AU019196; AU020854; AU021156; D7Bwg1348e; GW128; HEL-S-1; HEL-S-3; HEL-S-93; HEL2; HEL4; HS1; KCIP-1; MDCR; MDS; Msfs1; PPP1R170; R74690; YWHAA; YWHAB; YWHAD; YWHAE; YWHAG; YWHAQ; YWHAZ
transcription corepressor activity
protein binding
protein C-terminus binding
enzyme binding
protein domain specific binding
protein complex binding
histone deacetylase binding
phosphoserine binding
phosphoprotein binding
cadherin binding involved in cell-cell adhesion
potassium channel regulator activity
MHC class II protein complex binding
ubiquitin protein ligase binding
ion channel binding
poly(A) RNA binding
protein heterodimerization activity
protein kinase C binding
insulin-like growth factor receptor binding
protein kinase C inhibitor activity
receptor tyrosine kinase binding
protein N-terminus binding
14-3-3 protein binding
transcription factor binding
protein kinase binding
identical protein binding
actin binding
enzyme regulator activity
scaffold/adaptor protein
transporter
MAPK cascade
protein targeting
viral process
negative regulation of protein dephosphorylation
hippo signaling
positive regulation of catalytic activity
regulation of mRNA stability
negative regulation of G-protein coupled receptor protein signaling pathway
negative regulation of transcription, DNA-templated
cytoplasmic sequestering of protein
protein heterooligomerization
membrane organization
cell-cell adhesion
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
G2/M transition of mitotic cell cycle
neuron migration
regulation of heart rate by hormone
substantia nigra development
hippocampus development
cerebral cortex development
intracellular signal transduction
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of membrane repolarization
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
regulation of cellular response to heat
regulation of potassium ion transmembrane transporter activity
negative regulation of peptidyl-serine dephosphorylation
negative regulation of protein kinase activity
regulation of signal transduction
cellular response to insulin stimulus
regulation of neuron differentiation
regulation of synaptic plasticity
negative regulation of protein serine/threonine kinase activity
small GTPase mediated signal transduction
negative regulation of ion transmembrane transport
signal transduction
platelet activation
negative regulation of apoptotic process
establishment of Golgi localization
Golgi reassembly
regulation of catalytic activity
histamine secretion by mast cell
protein targeting to mitochondrion
regulation of cell death
response to drug
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