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Product Details
PA5-29689
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 34 and 246 of Human 14-3-3 beta
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2547163
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, mouse brain, YWHAB shRNA-transfected 293T.
Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (89%), Chicken (97%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
14-3-3, a family of acidic and soluble proteins, highly conserved in amino acid sequences from yeast to mammals, is expressed in all eukaryotic cells. Seven isoforms(beta, gamma, epsilon, eta, zeta, sigma and tau/theta) encoded by seven distinct genes are identified in mammals and forms homo- and hetero- dimeric cup-shaped structures. As 14-3-3 is interacted with more than 100 binding partners, it regulates key proteins involved in various biological processes such as signal trans-duction, cell cycle, transcriptional control, cell proliferation, apoptosis, and ion channel physiology. Most 14-3-3 requires phosphorylation of serine or threonine residues in the target sequence. This protein is abundantly expressed in the brain and has been detected in the cerebrospinal fluid of patients with different neurological disorders.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14-3-3 alpha; 14-3-3 protein beta; 14-3-3 protein beta/alpha; brain protein 14-3-3, beta isoform; epididymis secretory protein Li 1; KCIP 1; KCIP-1; KCIP1; Protein 1054; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; RP1-148E22.1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
Gene Aliases: 1300003C17Rik; GW128; HEL-S-1; HS1; KCIP-1; YWHAA; YWHAB
UniProt ID: (Human) P31946, (Mouse) Q9CQV8
Entrez Gene ID: (Human) 7529, (Mouse) 54401
MAPK cascade
protein targeting
viral process
negative regulation of protein dephosphorylation
hippo signaling
positive regulation of catalytic activity
regulation of mRNA stability
negative regulation of G-protein coupled receptor protein signaling pathway
negative regulation of transcription, DNA-templated
cytoplasmic sequestering of protein
protein heterooligomerization
membrane organization
cell-cell adhesion
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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