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Proteintech
14-3-3 sigma Monoclonal Antibody (3F10D9)
Product Details
66251-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3F10D9
Immunogen
14-3-3 sigma Fusion Protein Ag12644 (1-248 aa encoded by BC002995)
Conjugate
Form
Liquid
Concentration
1.37 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERASLIQK AKLAEQAERY EDMAAFMKGA VEKGEELSCE ERNLLSVAYK NVVGGQRAAW RVLSSIEQKS NEEGSEEKGP EVREYREKVE TELQGVCDTV LGLLDSHLIK EAGDAESRVF YLKMKGDYYR YLAEVATGDD KKRIIDSARS AYQEAMDISK KEMPPTNPIR LGLALNFSVF HYEIANSPEE AISLAKTTFD EAMADLHTLS EDSYKDSTLI MQLLRDNLTL WTADNAGEEG GEAPQEPQS (1-248 aa encoded by BC002995 )
Target Information
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 14-3-3 protein sigma; 14-3-3 sigma; 14-3-3sigma; Epithelial cell marker protein 1; HGNC:10773; Stratifin
Gene Aliases: HME1; SFN; YWHAS
UniProt ID: (Human) P31947
Entrez Gene ID: (Human) 2810
regulation of cyclin-dependent protein serine/threonine kinase activity
release of cytochrome c from mitochondria
keratinocyte development
negative regulation of protein kinase activity
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
signal transduction
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of epidermal cell division
negative regulation of keratinocyte proliferation
positive regulation of cell growth
keratinization
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of epidermal cell differentiation
positive regulation of protein export from nucleus
membrane organization
establishment of skin barrier
negative regulation of protein serine/threonine kinase activity
cell-cell adhesion
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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