Product References
A Costimulatory CAR Improves TCR-based Cancer Immunotherapy.
Cancer immunology research
Omer B,Cardenas MG,Pfeiffer T,Daum R,Huynh M,Sharma S,Nouraee N,Xie C,Tat C,Perconti S,Van Pelt S,Scherer L,DeRenzo C,Shum T,Gottschalk S,Arber C,Rooney CM
14-5961-82 was used in Flow cytometry/Cell sorting to demonstrate that the CoCAR can increase the activity of T cells expressing both native and transgenic TCRs and enhance antitumor responses.
Fri Apr 01 00:00:00 EDT 2022
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Mon May 04 00:00:00 EDT 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2020
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Mon Jul 06 00:00:00 EDT 2020
TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.
Science immunology
Harbour SN,DiToro DF,Witte SJ,Zindl CL,Gao M,Schoeb TR,Jones GW,Jones SA,Hatton RD,Weaver CT
14-5961-82 was used in Flow Cytometry, Immunocytochemistry to find that IL-6 signaling is required for both induction and maintenance of mouse TH17 cells; IL-6Rα-deficient TH17 cells rapidly lost their TH17 phenotype and did not cause disease in two models of colitis.
Fri Jul 17 00:00:00 EDT 2020
TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.
Science immunology
Harbour SN,DiToro DF,Witte SJ,Zindl CL,Gao M,Schoeb TR,Jones GW,Jones SA,Hatton RD,Weaver CT
14-5961-82 was used in Flow Cytometry, Immunocytochemistry to find that IL-6 signaling is required for both induction and maintenance of mouse TH17 cells; IL-6Rα-deficient TH17 cells rapidly lost their TH17 phenotype and did not cause disease in two models of colitis.
Fri Jul 17 00:00:00 EDT 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
14-5961-82 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis.
Blood
Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE
14-5961-82 was used in Flow Cytometry to show that ruxolitinib operates through IFN-γ-dependent and -independent mechanisms to dampen HLH by targeting the deleterious effects of T cells and neutrophils, with the latter representing an unappreciated and understudied cell type that contributes to HLH pathogenesis.
Thu Jul 11 00:00:00 EDT 2019
Inhibition of T cell activation and function by the adaptor protein CIN85.
Science signaling
Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T
14-5961-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.
Tue Feb 05 00:00:00 EST 2019
CD24+ Cell Depletion Permits Effective Enrichment of Thymic iNKT Cells While Preserving Their Subset Composition.
Immune network
Park JY,Kwon J,Kim EY,Fink J,Kim HK,Park JH
14-5961 was used in Flow cytometry/Cell sorting to test magnetic-activated depletion of CD24+ immature thymocytes as an alternative method to enrich iNKT cells.
Mon Apr 01 00:00:00 EDT 2019
CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications
Kim TJ,Park G,Kim J,Lim SA,Kim J,Im K,Shin MH,Fu YX,Del Rio ML,Rodriguez-Barbosa JI,Yee C,Suh KS,Kim SJ,Ha SJ,Lee KM
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Mon Jul 22 00:00:00 EDT 2019
Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.
eLife
Carpentier KS,Davenport BJ,Haist KC,McCarthy MK,May NA,Robison A,Ruckert C,Ebel GD,Morrison TE
14-5961-82 was used in Flow Cytometry to reveal a previously unrecognized innate immune pathway that controls alphavirus viremia and dissemination in vertebrate hosts, ultimately influencing disease severity and likely transmission efficiency.
Wed Oct 09 00:00:00 EDT 2019
The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.
Science immunology
Neier SC,Ferrer A,Wilton KM,Smith SEP,Kelcher AMH,Pavelko KD,Canfield JM,Davis TR,Stiles RJ,Chen Z,McCluskey J,Burrows SR,Rossjohn J,Hebrink DM,Carmona EM,Limper AH,Kappes DJ,Wettstein PJ,Johnson AJ,Pease LR,Daniels MA,Neuhauser C,Gil D,Schrum AG
14-5961-82 was used in Flow Cytometry to investigate how signal specificity is communicated through a protein-protein interaction (PPI) network during αβ T cell development, instructing either positive selection to advance cell differentiation or death by negative selection.
Fri Feb 15 00:00:00 EST 2019
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis.
Nature communications
Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM
14-5961 was used in Flow cytometry/Cell sorting to reveal the innate-like pathogenic function of antigen non-related memory CD4+ T cells, which contribute to the development of autoimmune diseases.
Tue Feb 12 00:00:00 EST 2019
Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.
Nature
Que X,Hung MY,Yeang C,Gonen A,Prohaska TA,Sun X,Diehl C,Määttä A,Gaddis DE,Bowden K,Pattison J,MacDonald JG,Ylä-Herttuala S,Mellon PL,Hedrick CC,Ley K,Miller YI,Glass CK,Peterson KL,Binder CJ,Tsimikas S,Witztum JL
14-5961 was used in Flow cytometry/Cell sorting to determine the role of oxidised phospholipids in atherogenesis within transgenic mice.
Fri Jun 01 00:00:00 EDT 2018
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
The Journal of experimental medicine
Yang J,Cornelissen F,Papazian N,Reijmers RM,Llorian M,Cupedo T,Coles M,Seddon B
14-5961 was used in Flow cytometry/Cell sorting to investigate whether continued IL-7 expression was required for the maintenance of fully developed, adult lymph nodes.
Mon Apr 02 00:00:00 EDT 2018
Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection.
PLoS pathogens
Sparber F,Dolowschiak T,Mertens S,Lauener L,Clausen BE,Joller N,Stoitzner P,Tussiwand R,LeibundGut-Landmann S
14-5961 was used in Flow cytometry/Cell sorting to study innate IL-17 dependent antifungal immunity in the oral mucosa.
Tue May 01 00:00:00 EDT 2018
The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection.
PLoS pathogens
Raju S,Kometani K,Kurosaki T,Shaw AS,Egawa T
14-5961 was used in Flow cytometry/Cell sorting to demonstrate that inactivation of the signaling adaptor CD2-associated protein (CD2AP) promotes CD4 T cell differentiation towards the follicular helper lineage.
Tue May 01 00:00:00 EDT 2018
STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer.
Molecular oncology
Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Nature communications
Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC
14-5961 was used in Flow cytometry/Cell sorting to study the mechanism of IL-15 function in autophagy and natural killer cell survival.
Wed Jul 18 00:00:00 EDT 2018
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Cancer cell
Robles-Valero J,Lorenzo-Martín LF,Menacho-Márquez M,Fernández-Pisonero I,Abad A,Camós M,Toribio ML,Espinosa L,Bigas A,Bustelo XR
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Mon Nov 13 00:00:00 EST 2017
Identification of lineage-specifying cytokines that signal all CD8+-cytotoxic-lineage-fate 'decisions' in the thymus.
Nature immunology
Etzensperger R,Kadakia T,Tai X,Alag A,Guinter TI,Egawa T,Erman B,Singer A
14-5961 was used in Flow cytometry/Cell sorting to prove that signaling during positive selection by lineage-specifying cytokines is responsible for all CD8+-lineage-fate 'decisions' in the thymus.
Wed Nov 01 00:00:00 EDT 2017
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-5961 was used in Flow cytometry/Cell sorting to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 EDT 2017
NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine.
Cancer immunology research
Alkayyal AA,Tai LH,Kennedy MA,de Souza CT,Zhang J,Lefebvre C,Sahi S,Ananth AA,Mahmoud AB,Makrigiannis AP,Cron GO,Macdonald B,Marginean EC,Stojdl DF,Bell JC,Auer RC
14-5961 was used in Flow cytometry/Cell sorting to suggest that an MG1-IL12-ICV is a promising therapy that could provide benefit to the thousands of patients diagnosed with PC each year.
Wed Mar 01 00:00:00 EST 2017
A non-canonical function of Ezh2 preserves immune homeostasis.
EMBO reports
Vasanthakumar A,Xu D,Lun AT,Kueh AJ,van Gisbergen KP,Iannarella N,Li X,Yu L,Wang D,Williams BR,Lee SC,Majewski IJ,Godfrey DI,Smyth GK,Alexander WS,Herold MJ,Kallies A,Nutt SL,Allan RS
14-5961 was used in Flow cytometry/Cell sorting to identify a chromatin-independent function of enhancer of zeste 2 that impacts on the development of the immune system.
Sat Apr 01 00:00:00 EDT 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes.
Frontiers in immunology
Serrano D,Ghobadi F,Boulay G,Ilangumaran S,Lavoie C,Ramanathan S
14596182 was used in blocking or activating experiment to investigate the role of GIMAP5 in regulating calcium flux in T cells
Wed Nov 20 00:00:00 EST 2019
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Fri Sep 29 00:00:00 EDT 2017
Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice.
International journal of chronic obstructive pulmonary disease
Lee B,Ko E,Lee J,Jo Y,Hwang H,Goh TS,Joo M,Hong C
14-5961 was used in Flow cytometry/Cell sorting to suggest that sγc may be one of the target molecules for the control of immunopathogenic progresses in COPD.
Wed Oct 11 00:00:00 EDT 2017
ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content.
Scientific reports
Nowyhed HN,Chandra S,Kiosses W,Marcovecchio P,Andary F,Zhao M,Fitzgerald ML,Kronenberg M,Hedrick CC
14596182 was used in flow cytometry to show that ABCA7 regulates natural killer T cell development in a cell-extrinsic manner
Mon Jan 16 00:00:00 EST 2017
Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients.
Gastroenterology
Klemann C,Schröder A,Dreier A,Möhn N,Dippel S,Winterberg T,Wilde A,Yu Y,Thorenz A,Gueler F,Jörns A,Tolosa E,Leonhardt J,Haas JD,Prinz I,Vieten G,Petersen C,Kuebler JF
14-5961 was used in Flow cytometry/Cell sorting to study the role of IL17A, and cells that produce this cytokine, in a mouse model of biliary atresia.
Fri Jan 01 00:00:00 EST 2016
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
Nature immunology
Xing S,Li F,Zeng Z,Zhao Y,Yu S,Shan Q,Li Y,Phillips FC,Maina PK,Qi HH,Liu C,Zhu J,Pope RM,Musselman CA,Zeng C,Peng W,Xue HH
14-5961 was used in Flow cytometry/Cell sorting to reveal that sequence-specific transcription factors can utilise intrinsic HDAC activity to guard cell identity by repressing lineage-inappropriate genes.
Wed Jun 01 00:00:00 EDT 2016
LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity.
The Journal of clinical investigation
Proekt I,Miller CN,Jeanne M,Fasano KJ,Moon JJ,Lowell CA,Gould DB,Anderson MS,DeFranco AL
14-5961 was used in Flow cytometry/Cell sorting to demonstrate how two distinct tolerance pathways can synergize to unleash organ-specific autoimmunity.
Mon Oct 03 00:00:00 EDT 2016
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Zhang J,Han C,Dai H,Hou J,Dong Y,Cui X,Xu L,Zhang M,Xia Q
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Environmental and Genetic Activation of Hypothalamic BDNF Modulates T-cell Immunity to Exert an Anticancer Phenotype.
Cancer immunology research
Xiao R,Bergin SM,Huang W,Slater AM,Liu X,Judd RT,Lin ED,Widstrom KJ,Scoville SD,Yu J,Caligiuri MA,Cao L
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Wed Jun 01 00:00:00 EDT 2016
Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.
Mucosal immunology
Borthwick LA,Barron L,Hart KM,Vannella KM,Thompson RW,Oland S,Cheever A,Sciurba J,Ramalingam TR,Fisher AJ,Wynn TA
14-5961 was used in Flow cytometry/Cell sorting to show that macrophages are required for the maintenance of type 2 immunity within affected tissues but not within secondary lymphoid organs.
Fri Jan 01 00:00:00 EST 2016
CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.
Mucosal immunology
Arnold IC,Mathisen S,Schulthess J,Danne C,Hegazy AN,Powrie F
14-5961 was used in Flow cytometry/Cell sorting to investigate the mechanism by which IL-23 produced by CD11c+ monocytes/macrophages promotes chronic Helicobacter hepaticus-induced intestinal inflammation.
Tue Mar 01 00:00:00 EST 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-5961 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.
Nature communications
Ishikawa E,Kosako H,Yasuda T,Ohmuraya M,Araki K,Kurosaki T,Saito T,Yamasaki S
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Tue Sep 27 00:00:00 EDT 2016
CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.
PloS one
Huang B,Gomez-Rodriguez J,Preite S,Garrett LJ,Harper UL,Schwartzberg PL
14-5961 was used in Flow cytometry/Cell sorting to elucidate the contribution of the SLAM receptors in immunodysregulation observed in X-linked lymphoproliferative syndrome Type 1.
Mon Jul 24 00:00:00 EDT 2017
The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine.
Scientific reports
Lebrero-Fernández C,Bas-Forsberg A
14-5961 was used in Flow cytometry/Cell sorting to show that the expression of Btnl1 and Btnl6 is delayed in the murine neonatal gut.
Tue Aug 16 00:00:00 EDT 2016
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.
Nature communications
Cruz AC,Ramaswamy M,Ouyang C,Klebanoff CA,Sengupta P,Yamamoto TN,Meylan F,Thomas SK,Richoz N,Eil R,Price S,Casellas R,Rao VK,Lippincott-Schwartz J,Restifo NP,Siegel RM
14-5961 was used in Flow cytometry/Cell sorting to elucidate how palmitoylation defects in the Fas/CD95 receptor impact primary immune cells.
Fri Dec 23 00:00:00 EST 2016
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
The Journal of biological chemistry
Li X,Acuff NV,Peeks AR,Kirkland R,Wyatt KD,Nagy T,Watford WT
14-5961-82 was used in Flow Cytometry to demonstrate that the serine/threonine kinase tumour progression locus 2 constrains the development of inducible regulatory T cells.
Fri Aug 05 00:00:00 EDT 2016
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Nature medicine
Alam MS,Gaida MM,Bergmann F,Lasitschka F,Giese T,Giese NA,Hackert T,Hinz U,Hussain SP,Kozlov SV,Ashwell JD
14-5961 was used in Flow cytometry/Cell sorting to demonstrate that TCR-mediated activation of CD4+ TIL results in alternative p38 activation and production of pro-tumorigenic factors.
Sun Nov 01 00:00:00 EDT 2015
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
14-5961-82 was used in Flow Cytometry to show that receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) on T cells regulates C-C type chemokine ligand 20 (CCL20) production by astrocytes and T cell localization in the CNS.
Tue Dec 15 00:00:00 EST 2015
Renal F4/80+ CD11c+ mononuclear phagocytes display phenotypic and functional characteristics of macrophages in health and in adriamycin nephropathy.
Journal of the American Society of Nephrology : JASN
Cao Q,Wang Y,Wang XM,Lu J,Lee VW,Ye Q,Nguyen H,Zheng G,Zhao Y,Alexander SI,Harris DC
14-5961 was used in Flow cytometry/Cell sorting to identify the phenotype and function of renal mononuclear phagocytes expressing key markers of both macrophages and dendritic cells.
Sun Feb 01 00:00:00 EST 2015
Commensal microbiota influence systemic autoimmune responses.
The EMBO journal
Van Praet JT,Donovan E,Vanassche I,Drennan MB,Windels F,Dendooven A,Allais L,Cuvelier CA,van de Loo F,Norris PS,Kruglov AA,Nedospasov SA,Rabot S,Tito R,Raes J,Gaboriau-Routhiau V,Cerf-Bensussan N,Van de Wiele T,Eberl G,Ware CF,Elewaut D
14-5961 was used in Flow cytometry/Cell sorting to indicate that neonatal colonization of gut microbiota influences generalized autoimmunity in adult life.
Thu Feb 12 00:00:00 EST 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
Intestinal microbiota modulates gluten-induced immunopathology in humanized mice.
The American journal of pathology
Galipeau HJ,McCarville JL,Huebener S,Litwin O,Meisel M,Jabri B,Sanz Y,Murray JA,Jordana M,Alaedini A,Chirdo FG,Verdu EF
14-5961 was used in Flow cytometry/Cell sorting to assess whether specific microbiota compositions influence immune responses to gluten in mice expressing the human DQ8 gene, which confers moderate CD genetic susceptibility.
Sun Nov 01 00:00:00 EDT 2015
Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin.
Journal of immunology (Baltimore, Md. : 1950)
Grinberg-Bleyer Y,Dainichi T,Oh H,Heise N,Klein U,Schmid RM,Hayden MS,Ghosh S
14-5961-82 was used in Flow Cytometry to analyse the function of canonical NF-κB in the epidermis using CRE-mediated deletion of p65 and c-Rel in keratinocytes.
Sun Mar 15 00:00:00 EDT 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Tue Sep 29 00:00:00 EDT 2015
DNAM-1 expression marks an alternative program of NK cell maturation.
Cell reports
Martinet L,Ferrari De Andrade L,Guillerey C,Lee JS,Liu J,Souza-Fonseca-Guimaraes F,Hutchinson DS,Kolesnik TB,Nicholson SE,Huntington ND,Smyth MJ
14-5961 was used in Flow cytometry/Cell sorting to reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
Tue Apr 07 00:00:00 EDT 2015
Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
PloS one
Tamehiro N,Oda H,Shirai M,Suzuki H
14-5961 was used in Flow cytometry/Cell sorting to indicate that an excess amount of RhoH is able to initiate pre-TCR signalling in the absence of pre-TCR complexes.
Mon Apr 25 00:00:00 EDT 2016
DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation.
PLoS genetics
Prochazkova J,Sakaguchi S,Owusu M,Mazouzi A,Wiedner M,Velimezi G,Moder M,Turchinovich G,Hladik A,Gurnhofer E,Hayday A,Behrens A,Knapp S,Kenner L,Ellmeier W,Loizou JI
14-5961 was used in Flow cytometry/Cell sorting to investigate the roles of ATMIN and NBS1, either alone or in combination, in T cells.
Sun Nov 01 00:00:00 EDT 2015
Macrophages and β-cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes.
EMBO molecular medicine
Diana J,Lehuen A
14-5961 was used in Flow cytometry/Cell sorting to determine the cellular and molecular mechanisms leading to the recruitment of neutrophils in the pancreatic islets of non-obese diabetic mice.
Fri Aug 01 00:00:00 EDT 2014
The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions.
Frontiers in immunology
Nandagopal N,Ali AK,Komal AK,Lee SH
14-5961 was used in Flow cytometry/Cell sorting to investigate whether the effect of IL-15 priming of NK cells can be extended to other cytokines, showing a critical role of the IL-15-PI3K-mTOR in NK effector functions.
Mon May 05 00:00:00 EDT 2014
In vivo functional mapping of the conserved protein domains within murine Themis1.
Immunology and cell biology
Zvezdova E,Lee J,El-Khoury D,Barr V,Akpan I,Samelson L,Love PE
14-5961 was used in Flow cytometry/Cell sorting to investigate the functional importance of different Themis1 domains.
Mon Sep 01 00:00:00 EDT 2014
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G
14-5961 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.
Sat Mar 15 00:00:00 EDT 2014
Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Saunders AE,Shim YA,Johnson P
14-5961 was used in Flow cytometry/Cell sorting to demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation.
Mon Sep 15 00:00:00 EDT 2014
B cell-specific loss of Lyn kinase leads to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Lamagna C,Hu Y,DeFranco AL,Lowell CA
14-5961-82 was used in Flow Cytometry to demonstrate that B cell-intrinsic Lyn-dependent signalling pathways regulate B cell homeostasis and activation.
Sat Feb 01 00:00:00 EST 2014
Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time.
PloS one
Kaczmarek J,Homsi Y,van Üüm J,Metzger C,Knolle PA,Kolanus W,Lang T,Diehl L
14-5961 was used in Immunofluorescence to show that during LSEC-mediated T-cell priming, integration of co-inhibitory PD-1 signaling turns on a program for CD8 T-cell development.
Thu Jan 29 00:00:00 EST 2015
T cell factor 1 is required for group 2 innate lymphoid cell generation.
Immunity
Yang Q,Monticelli LA,Saenz SA,Chi AW,Sonnenberg GF,Tang J,De Obaldia ME,Bailis W,Bryson JL,Toscano K,Huang J,Haczku A,Pear WS,Artis D,Bhandoola A
14-5961 was used in Flow cytometry/Cell sorting to study group 2 innate lymphoid cell development.
Thu Apr 18 00:00:00 EDT 2013
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using TCR beta monoclonal antibody (Product # 14-5961-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.
The Journal of clinical investigation
Kansara M,Leong HS,Lin DM,Popkiss S,Pang P,Garsed DW,Walkley CR,Cullinane C,Ellul J,Haynes NM,Hicks R,Kuijjer ML,Cleton-Jansen AM,Hinds PW,Smyth MJ,Thomas DM
14-5961 was used in Flow cytometry/Cell sorting to indicate that overcoming the immune response to senescence is a rate-limiting step in the formation of IR-induced osteosarcoma.
Sun Dec 01 00:00:00 EST 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
The Journal of experimental medicine
Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L
14-5961 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.
Mon Feb 11 00:00:00 EST 2013
TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Wu X,Zhou Q,Howard OM,Netea MG,Oppenheim JJ
14-5961 was used in Flow cytometry/Cell sorting to investigate means of promoting stability of Tregs, showing that TNFR2 is critical for stabilisation in the inflammatory environment.
Fri Feb 01 00:00:00 EST 2013
Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Saligrama N,Case LK,del Rio R,Noubade R,Teuscher C
14-5961 was used in Flow cytometry/Cell sorting to explore the contributions of different histamine receptors to the pathogenesis of experimental allergic encephalomyelitis.
Mon Jul 15 00:00:00 EDT 2013
Interleukin-6 expands homeostatic space for peripheral T cells.
Cytokine
Hong C,Nam AS,Keller HR,Ligons DL,Park JY,Yoon HW,Park JJ,Luckey MA,Park JH
14-5961 was used in Flow cytometry/Cell sorting to investigate whether IL-6 promotes T cell survival and homeostasis in vivo, showing that it expands homeostatic space for peripheral T cells.
Fri Nov 01 00:00:00 EDT 2013
Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection.
PloS one
Stoppelenburg AJ,Salimi V,Hennus M,Plantinga M,Huis in 't Veld R,Walk J,Meerding J,Coenjaerts F,Bont L,Boes M
14-5961 was used in Flow cytometry/Cell sorting to elucidate whether local IL-17A facilitates the innate neutrophil infiltration into RSV infected lungs prior to adaptive immunity.
Tue Feb 24 00:00:00 EST 2015
Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.
PloS one
Duarte JH,Di Meglio P,Hirota K,Ahlfors H,Stockinger B
14-5961 was used in Flow cytometry/Cell sorting to study how the immuno-modulatory effect of TCDD administration for EAE is not the consequence of de novo Treg generation, but the inhibition of Th17 cell differentiation.
Tue Aug 12 00:00:00 EDT 2014
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
14-5961 was used in Flow cytometry/Cell sorting to propose that TGF-β signaling controls the self-reactivity of peripheral T cells but that in the absence of TGF-β signals, an added trigger such as lymphopenia is needed to drive overt autoimmune disease.
Sun May 27 00:00:00 EDT 2012
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Blood
Berent-Maoz B,Montecino-Rodriguez E,Signer RA,Dorshkind K
14-5961 was used in Flow cytometry/Cell sorting to define a genetic basis for thymocyte progenitor aging.
Thu Jun 14 00:00:00 EDT 2012
PIDDosome-independent tumor suppression by Caspase-2.
Cell death and differentiation
Manzl C,Peintner L,Krumschnabel G,Bock F,Labi V,Drach M,Newbold A,Johnstone R,Villunger A
14-5961 was used in Flow cytometry/Cell sorting to investigate the role of PIDD, RIP-1 kinase and Nemo/IKKγ in oncogenesis induced by DNA damage or oncogenic stress in gene-ablated mice.
Mon Oct 01 00:00:00 EDT 2012
Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system.
European journal of immunology
Saligrama N,Noubade R,Case LK,del Rio R,Teuscher C
14-5961 was used in Flow cytometry/Cell sorting to generate histamine H1-H2 and H3-H4 receptor knockout mice and study them for susceptibility to experimental allergic encephalomyelitis.
Fri Jun 01 00:00:00 EDT 2012
CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice.
PloS one
van Helden MJ,Zaiss DM,Sijts AJ
14-5961 was used in Flow cytometry/Cell sorting to determine the role of CCR2 in NK cell migration during intranasal influenza virus infection, showing that it defines a distinct population of NK cells and mediates their migration.
Mon Jun 10 00:00:00 EDT 2013
Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.
Immunity
Hall JA,Cannons JL,Grainger JR,Dos Santos LM,Hand TW,Naik S,Wohlfert EA,Chou DB,Oldenhove G,Robinson M,Grigg ME,Kastenmayer R,Schwartzberg PL,Belkaid Y
14-5961 was used in Flow cytometry/Cell sorting to investigate the role of retinoic acid in responses to infection, showing that it is essential in the promotion of CD4(+) T cell effector responses.
Fri Mar 25 00:00:00 EDT 2011
NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism.
Journal of hepatology
Cheng CW,Duwaerts CC,Rooijen Nv,Wintermeyer P,Mott S,Gregory SH
14-5961 was used in Flow cytometry/Cell sorting to investigate the response of NK cells to liver injury that occurs in a mouse model of biliary obstruction.
Fri Apr 01 00:00:00 EDT 2011
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
14-5961 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 EDT 2011
High prevalence of low affinity peptide-MHC II tetramer-negative effectors during polyclonal CD4+ T cell responses.
The Journal of experimental medicine
Sabatino JJ,Huang J,Zhu C,Evavold BD
14-5961 was used in Flow cytometry/Cell sorting to demonstrate that low as well as high affinity CD4(+) T cells are critical effectors in autoimmune and pathogen-specific responses.
Mon Jan 17 00:00:00 EST 2011
Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis.
Annals of neurology
Blankenhorn EP,Butterfield R,Case LK,Wall EH,del Rio R,Diehl SA,Krementsov DN,Saligrama N,Teuscher C
14-5961 was used in Flow cytometry/Cell sorting to support the polygenic model of MS/EAE, requiring MHC susceptibility, confirming dependence on CD4 T(H)-cell differentiation and function.
Thu Dec 01 00:00:00 EST 2011
Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection.
Journal of immunology (Baltimore, Md. : 1950)
Busche A,Schmitz S,Fleige H,Robbins SH,Walzer T,Stewart CA,Förster R,Messerle M,Prinz I
14-5961 was used in Flow cytometry/Cell sorting to determine that antiviral immune responses may induce sustained alterations in natural killer cell populations.
Tue Mar 01 00:00:00 EST 2011
NKT cells are required for complete Freund's adjuvant-mediated protection from autoimmune diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Lee IF,van den Elzen P,Tan R,Priatel JJ
14-5961 was used in Flow cytometry/Cell sorting to elucidate roles for NKT cells in the adjuvant-promoting effects of CFA on innate and adaptive immunity.
Thu Sep 15 00:00:00 EDT 2011
β-Actin specifically controls cell growth, migration, and the G-actin pool.
Molecular biology of the cell
Bunnell TM,Burbach BJ,Shimizu Y,Ervasti JM
14-5961 was used in Flow cytometry/Cell sorting to study the role of beta-actin in cell migration and gene expression.
Tue Nov 01 00:00:00 EDT 2011
Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.
PloS one
Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I
14-5961 was used in Flow cytometry/Cell sorting to investigate epigenetic modifications of the Il17a/f locus, showing that expression of miRNAs miR-133b and miR-206 is co-regulated with IL-17 production in αβ and γδ T cells.
Thu Sep 29 00:00:00 EDT 2011
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
Blood
Frenzel A,Labi V,Chmelewskij W,Ploner C,Geley S,Fiegl H,Tzankov A,Villunger A
14-5961 was used in Flow cytometry/Cell sorting to demonstrate the potential of BH3-only proapoptotic Bcl-2 family members to regulate excessive lymphocyte proliferation.
Thu Feb 04 00:00:00 EST 2010
Notch dimerization is required for leukemogenesis and T-cell development.
Genes & development
Liu H,Chi AW,Arnett KL,Chiang MY,Xu L,Shestova O,Wang H,Li YM,Bhandoola A,Aster JC,Blacklow SC,Pear WS
14-5961 was used in Flow cytometry/Cell sorting to show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor.
Mon Nov 01 00:00:00 EDT 2010
Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.
Proceedings of the National Academy of Sciences of the United States of America
Ishikawa E,Miyake Y,Hara H,Saito T,Yamasaki S
14-5961 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying this ligand-independent pre-T-cell receptor (TCR) signalling in vivo, showing that germ-line elimination of electric charge on pre-T-cell receptor impairs autonomous signaling for beta-selection and TCR repertoire formation.
Tue Nov 16 00:00:00 EST 2010
A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models.
British journal of pharmacology
Chen Q,Muramoto K,Masaaki N,Ding Y,Yang H,Mackey M,Li W,Inoue Y,Ackermann K,Shirota H,Matsumoto I,Spyvee M,Schiller S,Sumida T,Gusovsky F,Lamphier M
14-5961 was used in Functional assays to show that prostaglandin E(2) stimulates EP(4) receptors, promoting T helper (Th) 1 differentiation, Th17 expansion and development of arthritis in two animal models.
Sat May 01 00:00:00 EDT 2010
Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.
PLoS pathogens
Wilson DC,Grotenbreg GM,Liu K,Zhao Y,Frickel EM,Gubbels MJ,Ploegh HL,Yap GS
14-5961 was used in Flow cytometry/Cell sorting to identify a novel H-2K(b)-restricted CTL population specific for the Toxoplasma antigen tgd057.
Fri Mar 19 00:00:00 EDT 2010
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
14-5961 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 EST 2010
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B
14-5961 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.
Wed Sep 15 00:00:00 EDT 2010
ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Armstrong AJ,Gebre AK,Parks JS,Hedrick CC
14-5961 was used in Flow cytometry/Cell sorting to demonstrate that ATP-binding cassette transporter G1 regulates cholesterol homeostasis in thymocytes and peripheral CD4 T cells.
Fri Jan 01 00:00:00 EST 2010
Pharmacologic inhibition of MEK-ERK signaling enhances Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Tan AH,Lam KP
14-5961 was used in Flow cytometry/Cell sorting to suggest that MEK-ERK signalling negatively regulates Th17 differentiation in a T helper cell-intrinsic way.
Mon Feb 15 00:00:00 EST 2010
Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling.
Blood
Banh C,Fugère C,Brossay L
14-5961 was used in Flow cytometry/Cell sorting to provide novel insight into KLRG1 and E-cadherin interaction are in differential regulation of KLRG1(+) cells and E-cadherin-expressing cells.
Thu Dec 17 00:00:00 EST 2009
Caspase-2 activation in the absence of PIDDosome formation.
The Journal of cell biology
Manzl C,Krumschnabel G,Bock F,Sohm B,Labi V,Baumgartner F,Logette E,Tschopp J,Villunger A
14-5961 was used in Flow cytometry/Cell sorting to suggest at least one alternative PIDDosome-independent mechanism of caspase-2 activation exists in mammals in response to DNA damage.
Mon Apr 20 00:00:00 EDT 2009
Critical roles of lysosomal acid lipase in T cell development and function.
The American journal of pathology
Qu P,Du H,Wilkes DS,Yan C
14-5961-82 was used in Flow Cytometry to conclude that the altered development and function of lal(-/-) T cells contributes to disease formation in various organs during LAL deficiency.
Sun Mar 01 00:00:00 EST 2009
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.
Journal of immunology (Baltimore, Md. : 1950)
Kohu K,Ohmori H,Wong WF,Onda D,Wakoh T,Kon S,Yamashita M,Nakayama T,Kubo M,Satake M
14-5961 was used in Functional assays to investigate the role of Runx3 in Th1 and Th2 cells.
Tue Dec 15 00:00:00 EST 2009
Identification of CD4 T-cell epitopes in soluble liver antigen/liver pancreas autoantigen in autoimmune hepatitis.
Gastroenterology
Mix H,Weiler-Normann C,Thimme R,Ahlenstiel G,Shin EC,Herkel J,David CS,Lohse AW,Rehermann B
14-5961 was used in Flow cytometry/Cell sorting to describe two autoantigenic peptides within human autoimmune hepatitis-specific soluble liver antigen/liver pancreas antigen that are targeted by CD4(+) T cells.
Mon Dec 01 00:00:00 EST 2008
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
The Journal of experimental medicine
Lahl K,Loddenkemper C,Drouin C,Freyer J,Arnason J,Eberl G,Hamann A,Wagner H,Huehn J,Sparwasser T
14-5961 was used in Flow cytometry/Cell sorting to investigate whether dysfunction or a lack of T reg cells is etiologically involved in scurfy pathogenesis, showing that selective depletion of Foxp3+ Tregs leads to scurfy.
Mon Jan 22 00:00:00 EST 2007
Role of T and NK cells and IL7/IL7r interactions during neonatal maturation of lymph nodes.
Proceedings of the National Academy of Sciences of the United States of America
Coles MC,Veiga-Fernandes H,Foster KE,Norton T,Pagakis SN,Seddon B,Kioussis D
14-5961 was used in Flow cytometry/Cell sorting to reveal a potential role for mature lymphocytes and IL7/IL7r interactions in postnatal lymph node development.
Tue Sep 05 00:00:00 EDT 2006
