Product References
Deletion Timing of Cic Alleles during Hematopoiesis Determines the Degree of Peripheral CD4+ T Cell Activation and Proliferation.
Immune network
Park GY,Lee GW,Kim S,Hong H,Park JS,Cho JH,Lee Y
14-7022-81 was used in ELISA to compare splenic CD4+ T cell activation and proliferation between whole immune cell-specific Cic-null (Cicf/f;Vav1-Cre) and T cell-specific Cic-null (Cicf/f;Cd4-Cre) mice.
Thu Oct 01 00:00:00 EDT 2020
Deletion Timing of Cic Alleles during Hematopoiesis Determines the Degree of Peripheral CD4+ T Cell Activation and Proliferation.
Immune network
Park GY,Lee GW,Kim S,Hong H,Park JS,Cho JH,Lee Y
14-7022-81 was used in ELISA to compare splenic CD4+ T cell activation and proliferation between whole immune cell-specific Cic-null (Cicf/f;Vav1-Cre) and T cell-specific Cic-null (Cicf/f;Cd4-Cre) mice.
Thu Oct 01 00:00:00 EDT 2020
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
The Journal of experimental medicine
Carpier JM,Zucchetti AE,Bataille L,Dogniaux S,Shafaq-Zadah M,Bardin S,Lucchino M,Maurin M,Joannas LD,Magalhaes JG,Johannes L,Galli T,Goud B,Hivroz C
14-7022 was used in ELISA to study the retrograde traffic of linker for activation of T cells from the plasma membrane to the Golgi-trans-Golgi network.
Mon Apr 02 00:00:00 EDT 2018
Opposing Roles of Dendritic Cell Subsets in Experimental GN.
Journal of the American Society of Nephrology : JASN
Brähler S,Zinselmeyer BH,Raju S,Nitschke M,Suleiman H,Saunders BT,Johnson MW,Böhner AMC,Viehmann SF,Theisen DJ,Kretzer NM,Briseño CG,Zaitsev K,Ornatsky O,Chang Q,Carrero JA,Kopp JB,Artyomov MN,Kurts C,Murphy KM,Miner JH,Shaw AS
14-7022 was used in an ELISA assay to study the function of dendritic cells in renal inflammation using DC specific reporters.
Mon Jan 01 00:00:00 EST 2018
Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis.
Nature communications
Mencarelli A,Khameneh HJ,Fric J,Vacca M,El Daker S,Janela B,Tang JP,Nabti S,Balachander A,Lim TS,Ginhoux F,Ricciardi-Castagnoli P,Mortellaro A
14-7022-81 was used in Flow Cytometry to show that mice lacking Calcineurin B in CD11chighMHCII+ cells spontaneously develop intestinal inflammation and are susceptible to induced colitis.
Fri Mar 16 00:00:00 EDT 2018
Toll like Receptor 2 engagement on CD4+ T cells promotes TH9 differentiation and function.
European journal of immunology
Karim AF,Reba SM,Li Q,Boom WH,Rojas RE
14-7022 was used in an ELISA assay to study the role of T-cell expressed TLR2 on CD4+ T-cell differentiation and function.
Fri Sep 01 00:00:00 EDT 2017
Potency-matched Dual Cytokine-Antibody Fusion Proteins for Cancer Therapy.
Molecular cancer therapeutics
De Luca R,Soltermann A,Pretto F,Pemberton-Ross C,Pellegrini G,Wulhfard S,Neri D
14-7022 was used in Immunofluorescence in immunohistochemistry on frozen tissues to develop a novel biopharmaceutical, consisting of the F8 mAb (specific to a splice isoform of fibronectin) simultaneously fused to both TNF and IL2, for cancer therapy.
Wed Nov 01 00:00:00 EDT 2017
Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5.
Nature communications
Park S,Lee S,Lee CG,Park GY,Hong H,Lee JS,Kim YM,Lee SB,Hwang D,Choi YS,Fryer JD,Im SH,Lee SW,Lee Y
14-7022 was used in an ELISA assay to investigate the role of Capicua in autoimmunity.
Wed Jul 12 00:00:00 EDT 2017
Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors.
Proceedings of the National Academy of Sciences of the United States of America
Silberman D,Krovi SH,Tuttle KD,Crooks J,Reisdorph R,White J,Gross J,Matsuda JL,Gapin L,Marrack P,Kappler JW
14-7022 was used in an ELISA assay to determine whether T-cell antigen receptors have evolved to react with MHC or processes in the thymus involving coreceptors which select MHC-specific TCRs de novo from a random repertoire.
Tue Sep 20 00:00:00 EDT 2016
Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes.
The Journal of cell biology
Hecht VC,Sullivan LB,Kimmerling RJ,Kim DH,Hosios AM,Stockslager MA,Stevens MM,Kang JH,Wirtz D,Vander Heiden MG,Manalis SR
14-7022 was used in Flow cytometry/Cell sorting to examine how cellular biophysical changes that occur immediately after growth factor depletion promote adaptation to reduced nutrient uptake.
Mon Feb 15 00:00:00 EST 2016
Strategies to target long-lived plasma cells for treating hemophilia A inhibitors.
Cellular immunology
Liu CL,Lyle MJ,Shin SC,Miao CH
14-7022 was used in Functional assays to investigate strategies to target long-lived plasma cells for treating haemophilia A inhibitors.
Tue Mar 01 00:00:00 EST 2016
Loss of immune tolerance to IL-2 in type 1 diabetes.
Nature communications
Pérol L,Lindner JM,Caudana P,Nunez NG,Baeyens A,Valle A,Sedlik C,Loirat D,Boyer O,Créange A,Cohen JL,Rogner UC,Yamanouchi J,Marchant M,Leber XC,Scharenberg M,Gagnerault MC,Mallone R,Battaglia M,Santamaria P,Hartemann A,Traggiai E,Piaggio E
14-7022 was used in an ELISA assay to study the role of the loss of immune tolerance to IL-2 in type 1 diabetes.
Thu Oct 06 00:00:00 EDT 2016
A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice.
Nature communications
Tripathi D,Venkatasubramanian S,Cheekatla SS,Paidipally P,Welch E,Tvinnereim AR,Vankayalapati R
14-7022 was used in Functional assays to investigate the role of NK1.1(+) cells in islet allograft tolerance in a model of type 1 diabetes, showing that a TLR9 agonist promotes IL-22-dependent allograft survival.
Fri Dec 16 00:00:00 EST 2016
Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.
Cell research
Hannani D,Vétizou M,Enot D,Rusakiewicz S,Chaput N,Klatzmann D,Desbois M,Jacquelot N,Vimond N,Chouaib S,Mateus C,Allison JP,Ribas A,Wolchok JD,Yuan J,Wong P,Postow M,Mackiewicz A,Mackiewicz J,Schadendorff D,Jaeger D,Zörnig I,Hassel J,Korman AJ,Bahjat K,Maio M,Calabro L,Teng MW,Smyth MJ,Eggermont A,Robert C,Kroemer G,Zitvogel L
14-7022 was used in in vivo experiments to provide the first immunologically relevant biomarker, namely elevated serum sCD25, that predicts resistance to CTLA-4 blockade in patients with melanoma.
Sun Feb 01 00:00:00 EST 2015
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Nature immunology
Basu R,Whitley SK,Bhaumik S,Zindl CL,Schoeb TR,Benveniste EN,Pear WS,Hatton RD,Weaver CT
14-7022 was used in Functional assays to assess the ability of IL-1 to override retinoic acid-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses.
Sun Mar 01 00:00:00 EST 2015
Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice.
Hypertension (Dallas, Tex. : 1979)
Yodoi K,Yamashita T,Sasaki N,Kasahara K,Emoto T,Matsumoto T,Kita T,Sasaki Y,Mizoguchi T,Sparwasser T,Hirata K
14-7022 was used in in vivo experiments to suggest that Foxp3(+) Tregs may play a protective role in abdominal aortic aneurysm formation.
Wed Apr 01 00:00:00 EDT 2015
Hair follicle dermal sheath derived cells improve islet allograft survival without systemic immunosuppression.
Journal of immunology research
Wang X,Hao J,Leung G,Breitkopf T,Wang E,Kwong N,Akhoundsadegh N,Warnock GL,Shapiro J,McElwee KJ
14-7022 was used in an ELISA assay to investigate a new treatment for autoimmune diabetes using naturally immune privileged, hair follicle derived, autologous cells.
Tue Jan 26 00:00:00 EST 2016
T Cells Integrate Local and Global Cues to Discriminate between Structurally Similar Antigens.
Cell reports
Voisinne G,Nixon BG,Melbinger A,Gasteiger G,Vergassola M,Altan-Bonnet G
14-7022 was used in Neutralization experiments to identify the PI3K pathway as being critical for integrating the antigen and cytokine responses necessary for controlling cell-cycle entry.
Tue May 26 00:00:00 EDT 2015
Glucosamine Modulates T Cell Differentiation through Down-regulating N-Linked Glycosylation of CD25.
The Journal of biological chemistry
Chien MW,Lin MH,Huang SH,Fu SH,Hsu CY,Yen BL,Chen JT,Chang DM,Sytwu HK
14-7022 was used in Functional assays to suggest that glucosamine may be an important modulator of T cell differentiation and immune homeostasis.
Fri Dec 04 00:00:00 EST 2015
MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.
Immunity
Oliphant CJ,Hwang YY,Walker JA,Salimi M,Wong SH,Brewer JM,Englezakis A,Barlow JL,Hams E,Scanlon ST,Ogg GS,Fallon PG,McKenzie AN
14-7022 was used in Flow cytometry/Cell sorting to demonstrate that ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production.
Thu Aug 21 00:00:00 EDT 2014
Long-term tolerance to factor VIII is achieved by administration of interleukin-2/interleukin-2 monoclonal antibody complexes and low dosages of factor VIII.
Journal of thrombosis and haemostasis : JTH
Liu CL,Ye P,Lin J,Djukovic D,Miao CH
14-7022 was used in Functional assays to investigate the use of interleukin (IL)-2 mixed with IL-2 monoclonal antibody (mAb) to induce and maintain factor VIII (FVIII)-specific tolerance after FVIII protein replacement therapy.
Sun Jun 01 00:00:00 EDT 2014
mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.
Proceedings of the National Academy of Sciences of the United States of America
Limon JJ,So L,Jellbauer S,Chiu H,Corado J,Sykes SM,Raffatellu M,Fruman DA
14-7022 was used in Functional assays to further elucidate the complexity of mTOR signalling in B cells.
Tue Nov 25 00:00:00 EST 2014
IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival.
Mucosal immunology
Webster KE,Kim HO,Kyparissoudis K,Corpuz TM,Pinget GV,Uldrich AP,Brink R,Belz GT,Cho JH,Godfrey DI,Sprent J
14702281 was used in blocking or activating experiment to report the survival requirement of IL-17-producing natural killer T cells
Mon Sep 01 00:00:00 EDT 2014
Natural killer T cells are essential for the development of contact hypersensitivity in BALB/c mice.
The Journal of investigative dermatology
Shimizuhira C,Otsuka A,Honda T,Kitoh A,Egawa G,Nakajima S,Nakashima C,Watarai H,Miyachi Y,Kabashima K
14-7022 was used in Flow cytometry/Cell sorting to report the pivotal contribution of dendritic and natural killer T cell interactions to hypersensitivity.
Sat Nov 01 00:00:00 EDT 2014
IL-2-inducible T cell kinase tunes T regulatory cell development and is required for suppressive function.
Journal of immunology (Baltimore, Md. : 1950)
Huang W,Jeong AR,Kannan AK,Huang L,August A
14-7022 was used in Functional assays to identify that IL-2-inducible T cell kinase regulates the development and function of Tregs.
Mon Sep 01 00:00:00 EDT 2014
Analysis of the vaccine potential of plasmid DNA encoding nine mycolactone polyketide synthase domains in Mycobacterium ulcerans infected mice.
PLoS neglected tropical diseases
Roupie V,Pidot SJ,Einarsdottir T,Van Den Poel C,Jurion F,Stinear TP,Huygen K
14-7022 was used in an ELISA assay to analyse the vaccine potential of nine polyketide synthase domains using a DNA prime/protein boost strategy.
Mon Sep 08 00:00:00 EDT 2014
T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks.
eLife
Tkach KE,Barik D,Voisinne G,Malandro N,Hathorn MM,Cotari JW,Vogel R,Merghoub T,Wolchok J,Krichevsky O,Altan-Bonnet G
14-7022 was used in an ELISA assay to investigate how T cells produce cytokines as a function of antigen input.
Wed Apr 09 00:00:00 EDT 2014
Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response.
Immunity
Bailey-Bucktrout SL,Martinez-Llordella M,Zhou X,Anthony B,Rosenthal W,Luche H,Fehling HJ,Bluestone JA
14-7022 was used in Functional assays to investigate the effect of self-antigen-driven activation on Tregs.
Thu Nov 14 00:00:00 EST 2013
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.
Nature immunology
Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A
14-7022 was used in in vivo experiments to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.
Sun Sep 01 00:00:00 EDT 2013
CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response.
The Journal of experimental medicine
Martínez-Llordella M,Esensten JH,Bailey-Bucktrout SL,Lipsky RH,Marini A,Chen J,Mughal M,Mattson MP,Taub DD,Bluestone JA
14-7022 was used in an ELISA assay to identify DEC1 as a critical transcriptional mediator in the activation of naive CD4(+) T cells that is required for the development of a T cell-mediated autoimmune disease.
Mon Jul 29 00:00:00 EDT 2013
CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response.
The Journal of experimental medicine
Martínez-Llordella M,Esensten JH,Bailey-Bucktrout SL,Lipsky RH,Marini A,Chen J,Mughal M,Mattson MP,Taub DD,Bluestone JA
14-7022 was used in an ELISA assay to identify DEC1 as a critical transcriptional mediator in the activation of naive CD4(+) T cells that is required for the development of a T cell-mediated autoimmune disease.
Mon Jul 29 00:00:00 EDT 2013
The systemic immune state of super-shedder mice is characterized by a unique neutrophil-dependent blunting of TH1 responses.
PLoS pathogens
Gopinath S,Hotson A,Johns J,Nolan G,Monack D
Published figure using IL-2 monoclonal antibody (Product # 14-7022-81) in Immunofluorescence
Fri Jan 17 00:00:00 EST 2014
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens
Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M
14-7022 was used in Functional assays to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
Mon Dec 09 00:00:00 EST 2013
STAT6 controls the number of regulatory T cells in vivo, thereby regulating allergic lung inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Dorsey NJ,Chapoval SP,Smith EP,Skupsky J,Scott DW,Keegan AD
14-7022 was used in Functional assays to study the interactions between STAT6 and Tregs during in vivo allergic airway inflammation.
Thu Aug 15 00:00:00 EDT 2013
Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Baine I,Basu S,Ames R,Sellers RS,Macian F
14-7022 was used in Neutralization experiments to identify that the transcription factor, Helios, maintains the anergic phenotype of Tregs by suppressing transcription of interleukin 2.
Fri Feb 01 00:00:00 EST 2013
Shaping T cell - B cell collaboration in the response to human immunodeficiency virus type 1 envelope glycoprotein gp120 by peptide priming.
PloS one
Steede NK,Rust BJ,Hossain MM,Freytag LC,Robinson JE,Landry SJ
14-7022 was used in an ELISpot assay to investigate how dominant B-cell subsets recruit the dominant T-cell subsets and that T-B collaborations can be shaped by epitope-specific priming.
Thu Jan 16 00:00:00 EST 2014
Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Nature communications
Yao C,Hirata T,Soontrapa K,Ma X,Takemori H,Narumiya S
14-7022 was used in Functional assays to investigate the role of cAMP in Th1 differentiation, showing that prostaglandin E2 promotes differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Tue Oct 22 00:00:00 EDT 2013
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Castillo EF,Dekonenko A,Arko-Mensah J,Mandell MA,Dupont N,Jiang S,Delgado-Vargas M,Timmins GS,Bhattacharya D,Yang H,Hutt J,Lyons CR,Dobos KM,Deretic V
14-7022 was used in Flow cytometry/Cell sorting to study the role of autophagy during immune responses to tuberculosis.
Tue Nov 13 00:00:00 EST 2012
Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis.
Clinical immunology (Orlando, Fla.)
Lin JT,Stein EA,Wong MT,Kalpathy KJ,Su LL,Utz PJ,Robinson WH,Fathman CG
14-7022 was used in Neutralization experiments to evaluate the signalling pathways utilised by naïve and experienced effector CD4 T cells during activation and proliferation.
Wed Feb 01 00:00:00 EST 2012
CD70-driven costimulation induces survival or Fas-mediated apoptosis of T cells depending on antigenic load.
Journal of immunology (Baltimore, Md. : 1950)
Wensveen FM,Unger PP,Kragten NA,Derks IA,ten Brinke A,Arens R,van Lier RA,Eldering E,van Gisbergen KP
14-7022 was used in an ELISA assay to investigate how BIm-dependent apoptosis is initiated in CD8 T cells.
Tue May 01 00:00:00 EDT 2012
B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.
Journal of immunology (Baltimore, Md. : 1950)
Ribot JC,Debarros A,Mancio-Silva L,Pamplona A,Silva-Santos B
14-7022 was used in Blocking experiments to show that CD28 signals are required for IL-2-mediated survival and proliferation of both CD27(+) and CD27(-) γδ T cell subsets.
Wed Aug 01 00:00:00 EDT 2012
Abrogation of CD40-CD154 signaling impedes the homeostasis of thymic resident regulatory T cells by altering the levels of IL-2, but does not affect regulatory T cell development.
Journal of immunology (Baltimore, Md. : 1950)
Cuss SM,Green EA
14-7022 was used in Functional assays to show that CD40-CD154 blockade specifically targeted thymic resident Treg cells, but not newly developed Treg cells.
Wed Aug 15 00:00:00 EDT 2012
Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Benson A,Murray S,Divakar P,Burnaevskiy N,Pifer R,Forman J,Yarovinsky F
14-7022 was used in an ELISA assay to identify a cell-intrinsic mechanism by which effector CD4 T cells overcome the suppressive effects of regulatory T cells in the context of Toxoplasma gondii, Listeria monocytogenes, and vaccinia virus infections.
Sun Jan 15 00:00:00 EST 2012
Dendritic cells control CD4+CD25+ Treg cell suppressor function in vitro through juxtacrine delivery of IL-2.
PloS one
Kulhankova K,Rouse T,Nasr ME,Field EH
14-7022 was used in an ELISpot assay to establish the exogenous source of IL-2 that is required by Tregs for their expansion and suppressive function.
Tue Mar 12 00:00:00 EDT 2013
Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function.
Scientific reports
Chang RA,Miller SD,Longnecker R
14-7022 was used in an ELISpot assay to investigate the Epstein-Barr virus as a possible etiological agent involved in multiple sclerosis.
Mon Feb 25 00:00:00 EST 2013
TSLP enhances the function of helper type 2 cells.
European journal of immunology
Kitajima M,Lee HC,Nakayama T,Ziegler SF
14-7022 was used in Functional assays to investigate the direct effect of TSLP on effector T cells.
Fri Jul 01 00:00:00 EDT 2011
Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway.
The Journal of biological chemistry
Wakabayashi Y,Tamiya T,Takada I,Fukaya T,Sugiyama Y,Inoue N,Kimura A,Morita R,Kashiwagi I,Takimoto T,Nomura M,Yoshimura A
14-7022 was used in Flow cytometry/Cell sorting to investigate the roles of Smad2 and Smad3 in TGF-β-mediated suppression of IL-2 production in CD4(+) T cells.
Fri Oct 14 00:00:00 EDT 2011
Regulation of T cell priming by lymphoid stroma.
PloS one
Khan O,Headley M,Gerard A,Wei W,Liu L,Krummel MF
14-7022 was used in Blocking experiments to show that murine fibroblastic reticular cells (FRCs) play a more direct role in the immune response by sensing and modulating T cell activation.
Mon Mar 26 00:00:00 EDT 2012
Hematopoietic progenitor cell regulation by CD4+CD25+ T cells.
Blood
Urbieta M,Barao I,Jones M,Jurecic R,Panoskaltsis-Mortari A,Blazar BR,Murphy WJ,Levy RB
14-7022-81 was used in Flow cytometry/Cell sorting to investigate whether T regulatory cells regulate haematopoiesis via the production of cytokine effector molecules.
Thu Jun 10 00:00:00 EDT 2010
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation.
The Journal of clinical investigation
Schreiber TH,Wolf D,Tsai MS,Chirinos J,Deyev VV,Gonzalez L,Malek TR,Levy RB,Podack ER
14-7022 was used in Flow cytometry/Cell sorting to study the effects of TNF receptor superfamily member 25 signalling on Tregs in vivo in mice.
Fri Oct 01 00:00:00 EDT 2010
Immune responses to coiled coil supramolecular biomaterials.
Biomaterials
Rudra JS,Tripathi PK,Hildeman DA,Jung JP,Collier JH
14-7022 was used in an ELISA assay to investigate murine immune responses to a set of self-oligomerization assembled biomaterials.
Mon Nov 01 00:00:00 EDT 2010
IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25.
Proceedings of the National Academy of Sciences of the United States of America
Létourneau S,van Leeuwen EM,Krieg C,Martin C,Pantaleo G,Sprent J,Surh CD,Boyman O
14-7022 was used in in vivo experiments to show that IL-2 receptor alpha subunit CD25 plays a crucial role in IL-2 homeostasis.
Tue Feb 02 00:00:00 EST 2010
CD30 ligand/CD30 plays a critical role in Th17 differentiation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Sun X,Yamada H,Shibata K,Muta H,Tani K,Podack ER,Yoshikai Y
14-7022 was used in Flow cytometry/Cell sorting to elucidate a role for CD30 in T cell differentiation.
Sun Aug 15 00:00:00 EDT 2010
Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Barron L,Dooms H,Hoyer KK,Kuswanto W,Hofmann J,O'Gorman WE,Abbas AK
14-7022 was used in Functional assays to show that the suppressive capacity of Tregs critically depends on IL-2 even when Treg survival is independent of this cytokine.
Wed Dec 01 00:00:00 EST 2010
Cellular requirements for diabetes induction in DO11.10xRIPmOVA mice.
Journal of immunology (Baltimore, Md. : 1950)
Wesley JD,Sather BD,Perdue NR,Ziegler SF,Campbell DJ
14-7022 was used in Functional assays to explore the cellular requirements for type 1 diabetes disease development in DO11.10xRIP-OVA (DORmO) mice.
Fri Oct 15 00:00:00 EDT 2010
"Default" generation of neonatal regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang G,Miyahara Y,Guo Z,Khattar M,Stepkowski SM,Chen W
14-7022 was used in Neutralization experiments to demonstrate that neonatal CD4(+) T cells have an intrinsic mechanism to become Treg cells upon TCR stimulation.
Thu Jul 01 00:00:00 EDT 2010
Manipulating IL-2 availability amid presentation of donor MHC antigens suppresses murine alloimmune responses by inducing regulatory T cells.
PloS one
Zhang S,Dai H,Wan N,Moore Y,Dai Z
14-7022 was used in in vivo experiments to investigate whether MHC class-II and/or class-I donor antigen presentation by DNA vaccination suppresses alloimmune responses and promotes long-term allograft acceptance.
Mon Jan 18 00:00:00 EST 2010
Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response.
Molecular systems biology
Feinerman O,Jentsch G,Tkach KE,Coward JW,Hathorn MM,Sneddon MW,Emonet T,Smith KA,Altan-Bonnet G
14-7022 was used in an ELISA assay to demonstrate quantitative, experimentally validated predictions for the manipulation of T(reg) suppression.
Tue Nov 30 00:00:00 EST 2010
Role of plasmacytoid dendritic cells for aberrant class II expression in exocrine glands from estrogen-deficient mice of healthy background.
The American journal of pathology
Arakaki R,Nagaoka A,Ishimaru N,Yamada A,Yoshida S,Hayashi Y
14-7022 was used in an ELISA assay to indicate that estrogen deficiency initiates class II transactivator type IV mRNA expression in exocrine glands via epithelial and plasmacytoid DC interactions.
Fri May 01 00:00:00 EDT 2009
Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.
Journal of immunology (Baltimore, Md. : 1950)
Lin JT,Lineberry NB,Kattah MG,Su LL,Utz PJ,Fathman CG,Wu L
14-7022 was used in an ELISA assay to investigate the role of GRAIL in CD4 T cells, showing that proliferation is controlled by mTOR regulation of GRAIL expression.
Fri May 15 00:00:00 EDT 2009
Tissue-specific abundance of regulatory T cells correlates with CD8+ T cell dysfunction and chronic retrovirus loads.
Journal of immunology (Baltimore, Md. : 1950)
Myers L,Messer RJ,Carmody AB,Hasenkrug KJ
14-7022 was used in Flow cytometry/Cell sorting to reveal Treg-mediated suppression of CD8(+) T cells in specific tissues which correlates with profound effects on localised levels of chronic infection.
Sat Aug 01 00:00:00 EDT 2009
In vivo expansion of activated naive CD8+ T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Tomala J,Chmelova H,Mrkvan T,Rihova B,Kovar M
14-7022 was used in Flow cytometry/Cell sorting to investigate the potential for replacement of IL-2 by IL-2 immunocomplexes for cancer therapy.
Thu Oct 15 00:00:00 EDT 2009
Estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming in response to intravaginal immunization.
Vaccine
Seavey MM,Mosmann TR
14-7022 was used in an ELISpot assay to investigate the effect of estradiol during intravaginal immunisation, showing that estradiol-induced vaginal mucus inhibits antigen penetration and CD8(+) T cell priming.
Tue Apr 14 00:00:00 EDT 2009
Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion.
Computer methods and programs in biomedicine
Rebhahn JA,Bishop C,Divekar AA,Jiminez-Garcia K,Kobie JJ,Lee FE,Maupin GM,Snyder-Cappione JE,Zaiss DM,Mosmann TR
14-7022 was used in Functional assays to develop an automated counting program to detect and quantify Fluorospots in automated fluorescence microscope images.
Wed Oct 01 00:00:00 EDT 2008
Enhanced T cell apoptosis within Drak2-deficient mice promotes resistance to autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Ramos SJ,Hernandez JB,Gatzka M,Walsh CM
14-7022 was used in an ELISA assay to investigate the basis of autoimmune resistance in Drak2(-/-) mice.
Mon Dec 01 00:00:00 EST 2008
Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wilson MS,Pesce JT,Ramalingam TR,Thompson RW,Cheever A,Wynn TA
14-7022 was used in a Functional assay to demonstrate that cytokine:antibody complexes of IL-2 and anti-IL-2 mAb reduce the severity of allergen-induced inflammation in the lung by expanding regulatory T cells in vivo.
Sat Nov 15 00:00:00 EST 2008
Modulation of pulmonary dendritic cell function during mycobacterial infection.
Infection and immunity
Anis MM,Fulton SA,Reba SM,Liu Y,Harding CV,Boom WH
14-7022 was used in an ELISA assay to investigate the role of chemokine receptor CCR7 and its ligands to activate naïve T cells during pulmonary infection.
Fri Feb 01 00:00:00 EST 2008
Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation.
Cellular immunology
Denkinger CM,Denkinger MD,Forsthuber TG
14-7022 was used in an ELISpot assay to discern that costimulation is the predominant mediator between pertussis toxin-induced cytokine differentiation and clonal expansion of T cells.
Thu Mar 01 00:00:00 EST 2007
Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.
Infection and immunity
Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH
14-7022 was used in an ELISA assay to demonstrate that infection alters lung DCs for activation of antigen-specific lung T cells in response to airway antigen challenge.
Tue May 01 00:00:00 EDT 2007
Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.
The Journal of experimental medicine
Gadola SD,Silk JD,Jeans A,Illarionov PA,Salio M,Besra GS,Dwek R,Butters TD,Platt FM,Cerundolo V
14-7022 was used in an ELISA assay to investigate whether accumulation of glycosphingolipids in lysosomal storage diseases affects iNKT cell secretion or function.
Mon Oct 02 00:00:00 EDT 2006
Direct stimulation of T cells by membrane vesicles from antigen-presenting cells.
Proceedings of the National Academy of Sciences of the United States of America
Kovar M,Boyman O,Shen X,Hwang I,Kohler R,Sprent J
14-7022 was used in Flow cytometry/Cell sorting to study how dissociated cell membrane fragments from a DC line can be used as an effective substitute for viable DC.
Tue Aug 01 00:00:00 EDT 2006
BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Manders PM,Hunter PJ,Telaranta AI,Carr JM,Marshall JL,Carrasco M,Murakami Y,Palmowski MJ,Cerundolo V,Kaech SM,Ahmed R,Fearon DT
14-7022 was used in Flow cytometry/Cell sorting to examine the role of the transcriptional repressor BCL6b in the secondary immune response.
Tue May 24 00:00:00 EDT 2005
