Product References
Macrophages and neutrophils are necessary for ER stress-induced β cell loss.
Cell reports
Yang B,Yang L,Wang Y,Maddison LA,Tang Z,Haigh S,Gong Y,Zhang Y,Covington BA,Bosma KJ,Tong X,Page-McCaw P,Gannon M,Deng Q,Chen W
14-7423-81 was used in Immunohistochemistry (Frozen) and Neutralization to reveal an important role of neutrophils in persistent ER stress-induced β cell loss.
Tue Aug 23 00:00:00 EDT 2022
Macrophages and neutrophils are necessary for ER stress-induced β cell loss.
Cell reports
Yang B,Yang L,Wang Y,Maddison LA,Tang Z,Haigh S,Gong Y,Zhang Y,Covington BA,Bosma KJ,Tong X,Page-McCaw P,Gannon M,Deng Q,Chen W
14-7423-81 was used in Immunohistochemistry (Frozen) and Neutralization to reveal an important role of neutrophils in persistent ER stress-induced β cell loss.
Tue Aug 23 00:00:00 EDT 2022
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis.
Journal for immunotherapy of cancer
Tang T,Huang X,Zhang G,Lu M,Hong Z,Wang M,Huang J,Zhi X,Liang T
Published figure using TNF alpha monoclonal antibody (Product # 14-7423-81) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
Tenascin-C fibronectin D domain is involved in the fine-tuning of glial response to CNS injury in vitro.
Frontiers in cell and developmental biology
Bijelić D,Adžić M,Perić M,Reiss G,Milošević M,Andjus PR,Jakovčevski I
14-7423-81 was used in Enzyme-linked immunosorbent assay to show versatile functions of TnC and in particular FnD after injury, mostly contributing to ongoing inflammation in the injury region.
Tue Sep 13 00:00:00 EDT 2022
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Immunity
Xian H,Liu Y,Rundberg Nilsson A,Gatchalian R,Crother TR,Tourtellotte WG,Zhang Y,Aleman-Muench GR,Lewis G,Chen W,Kang S,Luevanos M,Trudler D,Lipton SA,Soroosh P,Teijaro J,de la Torre JC,Arditi M,Karin M,Sanchez-Lopez E
14-7423-81 was used in ELISA to conclude that inhibition of ATP and mtDNA synthesis is sufficient for ARDS amelioration.
Tue Jul 13 00:00:00 EDT 2021
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.
Immunity
Xian H,Liu Y,Rundberg Nilsson A,Gatchalian R,Crother TR,Tourtellotte WG,Zhang Y,Aleman-Muench GR,Lewis G,Chen W,Kang S,Luevanos M,Trudler D,Lipton SA,Soroosh P,Teijaro J,de la Torre JC,Arditi M,Karin M,Sanchez-Lopez E
14-7423-81 was used in ELISA to conclude that inhibition of ATP and mtDNA synthesis is sufficient for ARDS amelioration.
Tue Jul 13 00:00:00 EDT 2021
Origin and Function of Stress-Induced IL-6 in Murine Models.
Cell
Qing H,Desrouleaux R,Israni-Winger K,Mineur YS,Fogelman N,Zhang C,Rashed S,Palm NW,Sinha R,Picciotto MR,Perry RJ,Wang A
14-7423-81 was used in ELISA to study the cytokine interleukin-6 (IL-6) and its induction following acute stress in mouse models.
Thu Jul 23 00:00:00 EDT 2020
Successful activation of rat T lymphocytes by sperm specific antigens in vitro.
The Journal of reproduction and development
Noguchi J,Ikeda M,Kikuchi K,Dang-Nguyen TQ,Kasashima M,Tatematsu KI,Sezutsu H,Furusawa T
Published figure using TNF alpha monoclonal antibody (Product # 14-7423-81) in Flow Cytometry
Tue Dec 22 00:00:00 EST 2020
GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance.
Cell
Luan HH,Wang A,Hilliard BK,Carvalho F,Rosen CE,Ahasic AM,Herzog EL,Kang I,Pisani MA,Yu S,Zhang C,Ring AM,Young LH,Medzhitov R
14-7423 was used in an ELISA assay to show that GDF15 coordinates tolerance to inflammatory damage through regulation of triglyceride metabolism.
Thu Aug 22 00:00:00 EDT 2019
Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production.
Cell metabolism
Sanchez-Lopez E,Zhong Z,Stubelius A,Sweeney SR,Booshehri LM,Antonucci L,Liu-Bryan R,Lodi A,Terkeltaub R,Lacal JC,Murphy AN,Hoffman HM,Tiziani S,Guma M,Karin M
14-7423 was used in Western Blotting to conclude that choline kinase inhibitors ameliorated acute and chronic models of IL-1β-dependent inflammation.
Tue Jun 04 00:00:00 EDT 2019
Four spices prevent mice from contracting Salmonella enterica serovar Typhimurium.
Experimental and therapeutic medicine
Chang CH,Fu JH,Su CH,Yin MC,Hsu YM
14-7423-81 was used in Functional assay to investigate the anti-Salmonella effects of the four spices using aqueous extracts.
Tue Oct 01 00:00:00 EDT 2019
Serum developmental endothelial locus-1 is associated with severity of sepsis in animals and humans.
Scientific reports
Kim WY,Lee SH,Kim DY,Ryu HJ,Chon GR,Park YY,Fu Y,Huh JW,Lim CM,Koh Y,Choi EY,Hong SB
14-7423-81 was used in ELISA to hypothesize that degradation of the endothelial glycocalyx during sepsis may increase serum Del-1.
Tue Sep 10 00:00:00 EDT 2019
Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress.
Oxidative medicine and cellular longevity
Bai YD,Yang YR,Mu XP,Lin G,Wang YP,Jin S,Chen Y,Wang MJ,Zhu YC
14-7423 was used in an ELISA assay to investigate the influence of excessive oxidative stress on cardiac injury during acute myocardial ischemia.
Wed Dec 19 00:00:00 EST 2018
Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress.
Oxidative medicine and cellular longevity
Bai YD,Yang YR,Mu XP,Lin G,Wang YP,Jin S,Chen Y,Wang MJ,Zhu YC
14-7423 was used in an ELISA assay to investigate the influence of excessive oxidative stress on cardiac injury during acute myocardial ischemia.
Wed Dec 19 00:00:00 EST 2018
Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.
JCI insight
Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S
Published figure using TNF alpha monoclonal antibody (Product # 14-7423-81) in ELISA
Thu Mar 22 00:00:00 EDT 2018
Anti-TNF-alpha antibody attenuates subarachnoid hemorrhage-induced apoptosis in the hypothalamus by inhibiting the activation of Erk.
Neuropsychiatric disease and treatment
Ma L,Jiang Y,Dong Y,Gao J,Du B,Liu D
Wed Mar 16 00:00:00 EDT 2022
Anti-TNF-alpha antibody attenuates subarachnoid hemorrhage-induced apoptosis in the hypothalamus by inhibiting the activation of Erk.
Neuropsychiatric disease and treatment
Ma L,Jiang Y,Dong Y,Gao J,Du B,Liu D
Wed Mar 16 00:00:00 EDT 2022
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using TNF alpha monoclonal antibody (Product # 14-7423-81) in Neutralization
Wed Oct 11 00:00:00 EDT 2017
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.
Cell
Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R
14-7423 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.
Thu Sep 08 00:00:00 EDT 2016
Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12.
The Journal of experimental medicine
Everts B,Tussiwand R,Dreesen L,Fairfax KC,Huang SC,Smith AM,O'Neill CM,Lam WY,Edelson BT,Urban JF,Murphy KM,Pearce EJ
14-7423 was used in Flow cytometry/Cell sorting to investigate the role of CD8α+ and CD103+ dendritic cells in suppressing helminth-driven type 2 immune responses.
Mon Jan 11 00:00:00 EST 2016
Cutting Edge: Resident Memory CD8 T Cells Express High-Affinity TCRs.
Journal of immunology (Baltimore, Md. : 1950)
Frost EL,Kersh AE,Evavold BD,Lukacher AE
14-7423 was used in Flow cytometry/Cell sorting to demonstrate that tissue-resident memory T cells retain high TCR affinity, facillitating their ability to sense viral antigen during low level persistent infections.
Thu Oct 15 00:00:00 EDT 2015
JUNB is a key transcriptional modulator of macrophage activation.
Journal of immunology (Baltimore, Md. : 1950)
Fontana MF,Baccarella A,Pancholi N,Pufall MA,Herbert DR,Kim CC
14-7423 was used in Flow cytometry/Cell sorting to validate putative key transcription factors that control macrophage activation, showing that JUNB is a key transcriptional modulator of activation.
Thu Jan 01 00:00:00 EST 2015
Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals.
mBio
Daniels BP,Holman DW,Cruz-Orengo L,Jujjavarapu H,Durrant DM,Klein RS
14-7423 was used in Neutralization experiments to demonstrate that West Nile virus (WNV) PAMPs orchestrate endothelial responses to WNV via competing innate immune cytokine signals at the blood-brain barrier.
Tue Aug 26 00:00:00 EDT 2014
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.
PLoS pathogens
Maelfait J,Roose K,Bogaert P,Sze M,Saelens X,Pasparakis M,Carpentier I,van Loo G,Beyaert R
14-7423 was used in an ELISA assay to examine the role of the ubiquitin-editing protein A20 in the innate immune responses to IAV and other viruses.
Mon Jul 09 00:00:00 EDT 2012
Autoreactive preplasma cells break tolerance in the absence of regulation by dendritic cells and macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gilbert MR,Wagner NJ,Jones SZ,Wisz AB,Roques JR,Krum KN,Lee SR,Nickeleit V,Hulbert C,Thomas JW,Gauld SB,Vilen BJ
14-7423 was used in Immunohistochemistry to investigate the effects of toll-like receptor 4 stimulation in the absence of the repressive factors IL-6, CD40L, and TNF-α.
Sun Jul 15 00:00:00 EDT 2012
T cells localized to the androgen-deprived prostate are TH1 and TH17 biased.
The Prostate
Morse MD,McNeel DG
14-7423 was used in Flow cytometry/Cell sorting to investigate the nature and timing of the T cell response in the prostate following castration.
Wed Aug 01 00:00:00 EDT 2012
Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection.
Transplantation
Braun RK,Molitor-Dart M,Wigfield C,Xiang Z,Fain SB,Jankowska-Gan E,Seroogy CM,Burlingham WJ,Wilkes DS,Brand DD,Torrealba J,Love RB
14-7423 was used in Neutralization experiments to test whether Tregs from tolerant rats could suppress Th17-mediated rejection in the syngeneic model of lung transplantation.
Sun Dec 27 00:00:00 EST 2009
Mucosal immunotherapy for protection from pneumonic infection with Francisella tularensis.
Vaccine
Troyer RM,Propst KL,Fairman J,Bosio CM,Dow SW
14-7423 was used in Neutralization experiments to conclude that activation of local pulmonary innate immune responses is capable of eliciting significant protection from inhalational exposure to a virulent bacterial pathogen.
Thu Jul 16 00:00:00 EDT 2009
Protection from pneumonic infection with burkholderia species by inhalational immunotherapy.
Infection and immunity
Goodyear A,Kellihan L,Bielefeldt-Ohmann H,Troyer R,Propst K,Dow S
14-7423 was used in an ELISA assay to study how the burkholderia species protects from pneumonic infection by inhalational immunotherapy.
Wed Apr 01 00:00:00 EDT 2009