Product References
In Situ Vaccination Following Intratumoral Injection of IL2 and Poly-l-lysine/Iron Oxide/CpG Nanoparticles to a Radiated Tumor Site.
ACS nano
Zhang Y,Rahman MM,Clark PA,Sriramaneni RN,Havighurst T,Kerr CP,Zhu M,Jones J,Wang X,Kim K,Gong S,Morris ZS
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Tue Jun 13 00:00:00 EDT 2023
Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention.
NPJ precision oncology
Lee SB,Pan J,Xiong D,Palen K,Johnson B,Lubet RA,Shoemaker RH,Green JE,Fernando RI,Sei S,You M,Wang Y
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry (Paraffin)
Wed Oct 25 00:00:00 EDT 2023
Striking efficacy of a vaccine targeting TOP2A for triple-negative breast cancer immunoprevention.
NPJ precision oncology
Lee SB,Pan J,Xiong D,Palen K,Johnson B,Lubet RA,Shoemaker RH,Green JE,Fernando RI,Sei S,You M,Wang Y
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry (Paraffin)
Wed Oct 25 00:00:00 EDT 2023
Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma.
Frontiers in immunology
Digifico E,Erreni M,Mannarino L,Marchini S,Ummarino A,Anfray C,Bertola L,Recordati C,Pistillo D,Roncalli M,Bossi P,Zucali PA,D'Incalci M,Belgiovine C,Allavena P
14-9766-82 was used in Immunohistochemistry to demonstrate that OPN is an endogenous growth factor for mesothelial cells and inhibition of its signaling may be helpful to restrain tumor progression in vivo.
Mon Jul 10 00:00:00 EDT 2023
Important functional role of the protein osteopontin in the progression of malignant pleural mesothelioma.
Frontiers in immunology
Digifico E,Erreni M,Mannarino L,Marchini S,Ummarino A,Anfray C,Bertola L,Recordati C,Pistillo D,Roncalli M,Bossi P,Zucali PA,D'Incalci M,Belgiovine C,Allavena P
14-9766-82 was used in Immunohistochemistry to demonstrate that OPN is an endogenous growth factor for mesothelial cells and inhibition of its signaling may be helpful to restrain tumor progression in vivo.
Mon Jul 10 00:00:00 EDT 2023
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion.
Nature communications
Liu HJ,Du H,Khabibullin D,Zarei M,Wei K,Freeman GJ,Kwiatkowski DJ,Henske EP
14-9766-82 was used in Immunohistochemistry (Paraffin), Western Blot to show that mTORC1-hyperactivity, present in many human tumors including tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM), drives B7-H3 expression leading to suppression of cytotoxic CD4+ T cells.
Fri Mar 03 00:00:00 EST 2023
β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma.
Cancer gene therapy
Bruno G,Nastasi N,Subbiani A,Boaretto A,Ciullini Mannurita S,Mattei G,Nardini P,Della Bella C,Magi A,Pini A,De Marco E,Tondo A,Favre C,Calvani M
14-9766-82 was used in Immunohistochemistry to investigate whether the β3-adrenergic receptor modulation influenced the host immune system response against tumor.
Thu Jun 01 00:00:00 EDT 2023
Protocol for investigating tertiary lymphoid structures in human and murine fixed tissue sections using Opal™-TSA multiplex immunohistochemistry.
STAR protocols
Quigley LT,Pang L,Tavancheh E,Ernst M,Behren A,Huynh J,Da Gama Duarte J
14-9766-82 was used in Immunohistochemistry (Paraffin), Western Blot to identify immature and mature tertiary lymphoid structures (TLSs).
Fri Mar 17 00:00:00 EDT 2023
Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss.
Cell death & disease
Mejía-Hernández JO,Keam SP,Saleh R,Muntz F,Fox SB,Byrne D,Kogan A,Pang L,Huynh J,Litchfield C,Caramia F,Lozano G,He H,You JM,Sandhu S,Williams SG,Haupt Y,Haupt S
14-9766-82 was used in Immuno-assay to support the hypothesis that individual p53 mutations confer their own particular oncogenic gain of function in prostate cancer.
Thu Sep 08 00:00:00 EDT 2022
Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss.
Cell death & disease
Mejía-Hernández JO,Keam SP,Saleh R,Muntz F,Fox SB,Byrne D,Kogan A,Pang L,Huynh J,Litchfield C,Caramia F,Lozano G,He H,You JM,Sandhu S,Williams SG,Haupt Y,Haupt S
14-9766-82 was used in Immuno-assay to support the hypothesis that individual p53 mutations confer their own particular oncogenic gain of function in prostate cancer.
Thu Sep 08 00:00:00 EDT 2022
T cells specific for α-myosin drive immunotherapy-related myocarditis.
Nature
Axelrod ML,Meijers WC,Screever EM,Qin J,Carroll MG,Sun X,Tannous E,Zhang Y,Sugiura A,Taylor BC,Hanna A,Zhang S,Amancherla K,Tai W,Wright JJ,Wei SC,Opalenik SR,Toren AL,Rathmell JC,Ferrell PB,Phillips EJ,Mallal S,Johnson DB,Allison JP,Moslehi JJ,Balko JM
14-9766-82 was used in Immunohistochemistry to identify clonal effector CD8+ T cells as the dominant cell population.
Tue Nov 01 00:00:00 EDT 2022
Immunological conversion of solid tumours using a bispecific nanobioconjugate for cancer immunotherapy.
Nature nanotechnology
Lu Y,Huntoon K,Lee D,Wang Y,Ha J,Qie Y,Li X,Schrank BR,Dong S,Gallup TD,Kang M,Zhao H,An Y,Yang Z,Li J,Kim BYS,Jiang W
14-9766-82 was used in Immunohistochemistry-immunofluorescence to support an immunological conversion strategy that uses nano-adjuvants to improve the effectiveness of immunotherapies for solid tumours.
Thu Dec 01 00:00:00 EST 2022
Using CD69 PET Imaging to Monitor Immunotherapy-Induced Immune Activation.
Cancer immunology research
Edwards KJ,Chang B,Babazada H,Lohith K,Park DH,Farwell MD,Sellmyer MA
14-9766-82 was used in Immunohistochemistry to suggest that the CD69 PET imaging approach detects CD69 expression with sufficient sensitivity to quantify immune cell activation in a syngeneic mouse immunotherapy model and could allow for the prediction of therapeutic immune responses to novel immunotherapies.
Thu Sep 01 00:00:00 EDT 2022
ZEB1 transcription factor promotes immune escape in melanoma.
Journal for immunotherapy of cancer
Plaschka M,Benboubker V,Grimont M,Berthet J,Tonon L,Lopez J,Le-Bouar M,Balme B,Tondeur G,de la Fouchardière A,Larue L,Puisieux A,Grinberg-Bleyer Y,Bendriss-Vermare N,Dubois B,Caux C,Dalle S,Caramel J
14-9766-82 was used in Immunohistochemistry (Paraffin), Western Blot to identify the ZEB1 transcription factor as a key determinant of melanoma immune escape, highlighting a previously unknown therapeutic target to increase efficacy of immunotherapy in melanoma.
Tue Mar 01 00:00:00 EST 2022
Establishing a multiplex imaging panel to study T cell development in the thymus in mouse.
STAR protocols
Allam AH,Russell SM
14-9766-82 was used in Flow cytometry/Cell sorting to enable analysis of cellular and signaling events in the context of an intact mouse thymus.
Fri Sep 16 00:00:00 EDT 2022
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
Nature materials
Maller O,Drain AP,Barrett AS,Borgquist S,Ruffell B,Zakharevich I,Pham TT,Gruosso T,Kuasne H,Lakins JN,Acerbi I,Barnes JM,Nemkov T,Chauhan A,Gruenberg J,Nasir A,Bjarnadottir O,Werb Z,Kabos P,Chen YY,Hwang ES,Park M,Coussens LM,Nelson AC,Hansen KC,Weaver VM
14-9766-82 was used in Immunohistochemistry (Paraffin) to link tissue inflammation, stromal cell-mediated collagen crosslinking and stiffening to tumour aggression and identify lysyl hydroxylase 2 as a stromal biomarker.
Thu Apr 01 00:00:00 EDT 2021
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
Nature materials
Maller O,Drain AP,Barrett AS,Borgquist S,Ruffell B,Zakharevich I,Pham TT,Gruosso T,Kuasne H,Lakins JN,Acerbi I,Barnes JM,Nemkov T,Chauhan A,Gruenberg J,Nasir A,Bjarnadottir O,Werb Z,Kabos P,Chen YY,Hwang ES,Park M,Coussens LM,Nelson AC,Hansen KC,Weaver VM
14-9766-82 was used in Immunohistochemistry (Paraffin) to link tissue inflammation, stromal cell-mediated collagen crosslinking and stiffening to tumour aggression and identify lysyl hydroxylase 2 as a stromal biomarker.
Thu Apr 01 00:00:00 EDT 2021
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
Nature materials
Maller O,Drain AP,Barrett AS,Borgquist S,Ruffell B,Zakharevich I,Pham TT,Gruosso T,Kuasne H,Lakins JN,Acerbi I,Barnes JM,Nemkov T,Chauhan A,Gruenberg J,Nasir A,Bjarnadottir O,Werb Z,Kabos P,Chen YY,Hwang ES,Park M,Coussens LM,Nelson AC,Hansen KC,Weaver VM
14-9766-82 was used in Immunohistochemistry (Paraffin) to link tissue inflammation, stromal cell-mediated collagen crosslinking and stiffening to tumour aggression and identify lysyl hydroxylase 2 as a stromal biomarker.
Thu Apr 01 00:00:00 EDT 2021
A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention.
Cancer discovery
Wei SC,Meijers WC,Axelrod ML,Anang NAS,Screever EM,Wescott EC,Johnson DB,Whitley E,Lehmann L,Courand PY,Mancuso JJ,Himmel LE,Lebrun-Vignes B,Wleklinski MJ,Knollmann BC,Srinivasan J,Li Y,Atolagbe OT,Rao X,Zhao Y,Wang J,Ehrlich LIR,Sharma P,Salem JE,Balko JM,Moslehi JJ,Allison JP
14-9766 was used in Immunohistochemistry to report a robust preclinical mouse model ofiImmune checkpoint inhibitors-associated myocarditis in which mono-allelic loss of Ctla4 in the context of complete genetic absence of Pdcd1 leads to premature death in approximately half of mice.
Mon Mar 01 00:00:00 EST 2021
Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells.
Cellular & molecular immunology
Yu M,Pan H,Che N,Li L,Wang C,Wang Y,Ma G,Qian M,Liu J,Zheng M,Xie H,Ling L,Zhao Y,Guan X,Ding Q,Zhou W,Wang S
14-9766-82 was used in Immunohistochemistry to demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis, and MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer.
Wed Sep 01 00:00:00 EDT 2021
The RAC1 Target NCKAP1 Plays a Crucial Role in the Progression of Braf;Pten-Driven Melanoma in Mice.
The Journal of investigative dermatology
Swaminathan K,Campbell A,Papalazarou V,Jaber-Hijazi F,Nixon C,McGhee E,Strathdee D,Sansom OJ,Machesky LM
14-9766 was used in Immunohistochemistry to examine the role of the NCKAP1 subunit of the pentameric cytoskeletal SCAR/WAVE complex in a mouse model of melanoma driven by BRAFV600E;PTEN loss.
Mon Mar 01 00:00:00 EST 2021
VX-765 reduces neuroinflammation after spinal cord injury in mice.
Neural regeneration research
Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ
14-9766-82 was used in Immunohistochemistry to suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18.
Wed Sep 01 00:00:00 EDT 2021
Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo.
The American journal of pathology
Li M,McGhee EM,Shinno L,Lee K,Lin YL
14-9766-82 was used in Immunohistochemistry to show that butyrate treatment changed the property of HPV16 E6/E7-immortalized keratinocytes.
Fri Oct 01 00:00:00 EDT 2021
Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo.
The American journal of pathology
Li M,McGhee EM,Shinno L,Lee K,Lin YL
14-9766-82 was used in Immunohistochemistry to show that butyrate treatment changed the property of HPV16 E6/E7-immortalized keratinocytes.
Fri Oct 01 00:00:00 EDT 2021
Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis.
Journal of immunology (Baltimore, Md. : 1950)
Bianchi A,Marchetti L,Hall Z,Lemos H,Vacca M,Paish H,Green K,Elliott B,Tiniakos D,Passos JF,Jurk D,Mann DA,Wilson CL
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Mon Feb 15 00:00:00 EST 2021
The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
Journal of immunology (Baltimore, Md. : 1950)
Jiang C,Zhao ML,Ramos L,Dobaczewska K,Herbert R,Hobbie K,Mikulski Z,Verkoczy L,Diaz M
14-9766-82 was used in Immunohistochemistry-immunofluorescence to implicate autoreactive IgM Abs in protection against T cell lymphoma.
Sat May 15 00:00:00 EDT 2021
Biology and Cellular Tropism of a Unique Astrovirus Strain: Murine Astrovirus 2.
Comparative medicine
Kelly SP,Ricart Arbona RJ,Michel AO,Wang C,Henderson KS,Lipman NS
14-9766-82 was used in Immunohistochemistry-immunofluorescence to characterize the viral shedding kinetics and tissue tropism of Murine astrovirus 2 MuAstV2 in immunocompetent C57BL/6NCrl mice and evaluated the apparent resistance of highly immunocompromised NOD- Prkdcem26Cd52Il2rgem26Cd22 /NjuCrl mice to MuAstV2 after oral inoculation.
Wed Dec 01 00:00:00 EST 2021
Multiparametric Analyses of Hepatocellular Carcinoma Somatic Mouse Models and Their Associated Tumor Microenvironment.
Current protocols
Taranto D,Ramirez CFA,Vegna S,de Groot MHP,de Wit N,Van Baalen M,Klarenbeek S,Akkari L
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Tue Jun 01 00:00:00 EDT 2021
STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis.
Biomedicines
Pang L,Huynh J,Alorro MG,Li X,Ernst M,Chand AL
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Fri Feb 12 00:00:00 EST 2021
STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis.
Biomedicines
Pang L,Huynh J,Alorro MG,Li X,Ernst M,Chand AL
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Fri Feb 12 00:00:00 EST 2021
Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells.
Communications biology
Vito A,Salem O,El-Sayes N,MacFawn IP,Portillo AL,Milne K,Harrington D,Ashkar AA,Wan Y,Workenhe ST,Nelson BH,Bruno TC,Mossman KL
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Mon Jul 12 00:00:00 EDT 2021
Role of CXCL5 in Regulating Chemotaxis of Innate and Adaptive Leukocytes in Infected Lungs Upon Pulmonary Influenza Infection.
Frontiers in immunology
Guo L,Li N,Yang Z,Li H,Zheng H,Yang J,Chen Y,Zhao X,Mei J,Shi H,Worthen GS,Liu L
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunocytochemistry
Tue Feb 08 00:00:00 EST 2022
A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing.
Nature communications
Zhang J,Zheng Y,Lee J,Hua J,Li S,Panchamukhi A,Yue J,Gou X,Xia Z,Zhu L,Wu X
14-9766 was used in Immunohistochemistry-immunofluorescence to present a strategy for scarless wound repair.
Mon Mar 15 00:00:00 EDT 2021
A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing.
Nature communications
Zhang J,Zheng Y,Lee J,Hua J,Li S,Panchamukhi A,Yue J,Gou X,Xia Z,Zhu L,Wu X
14-9766 was used in Immunohistochemistry-immunofluorescence to present a strategy for scarless wound repair.
Mon Mar 15 00:00:00 EDT 2021
A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing.
Nature communications
Zhang J,Zheng Y,Lee J,Hua J,Li S,Panchamukhi A,Yue J,Gou X,Xia Z,Zhu L,Wu X
14-9766 was used in Immunohistochemistry-immunofluorescence to present a strategy for scarless wound repair.
Mon Mar 15 00:00:00 EDT 2021
Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer.
International journal of molecular sciences
Vito A,Rathmann S,Mercanti N,El-Sayes N,Mossman K,Valliant J
14-9766-82 was used in Immunohistochemistry to develop a combined therapy for triple negative breast cancer utilising radionuclide therapy and immune checkpoint blockade which improves overall survival.
Mon May 03 00:00:00 EDT 2021
Combined Radionuclide Therapy and Immunotherapy for Treatment of Triple Negative Breast Cancer.
International journal of molecular sciences
Vito A,Rathmann S,Mercanti N,El-Sayes N,Mossman K,Valliant J
14-9766-82 was used in Immunohistochemistry to develop a combined therapy for triple negative breast cancer utilising radionuclide therapy and immune checkpoint blockade which improves overall survival.
Mon May 03 00:00:00 EDT 2021
Development of a Multiplex Immunohistochemistry Workflow to Investigate the Immune Microenvironment in Mouse Models of Inflammatory Bowel Disease and Colon Cancer.
International journal of molecular sciences
Pang L,Ernst M,Huynh J
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Tue Oct 12 00:00:00 EDT 2021
Development of a Multiplex Immunohistochemistry Workflow to Investigate the Immune Microenvironment in Mouse Models of Inflammatory Bowel Disease and Colon Cancer.
International journal of molecular sciences
Pang L,Ernst M,Huynh J
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Tue Oct 12 00:00:00 EDT 2021
CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells.
iScience
Qadir AS,Guégan JP,Ginestier C,Chaibi A,Bessede A,Charafe-Jauffret E,Macario M,Lavoué V,Rouge TM,Law C,Vilker J,Wang H,Stroup E,Schipma MJ,Bridgeman B,Murmann AE,Ji Z,Legembre P,Peter ME
14-9766-82 was used in Immunohistochemistry to demonstrate that in addition to its tumor and metastasis promoting activities, CD95 expression by tumor cells can exert immune suppressive activities on NK cells, providing a new target for immune therapy.
Fri Nov 19 00:00:00 EST 2021
Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model.
Gastroenterology
Gebert J,Gelincik O,Oezcan-Wahlbrink M,Marshall JD,Hernandez-Sanchez A,Urban K,Long M,Cortes E,Tosti E,Katzenmaier EM,Song Y,Elsaadi A,Deng N,Vilar E,Fuchs V,Nelius N,Yuan YP,Ahadova A,Sei S,Shoemaker RH,Umar A,Wei L,Liu S,Bork P,Edelmann W,von Knebel Doeberitz M,Lipkin SM,Kloor M
14-9766-82 was used in Immunohistochemistry (Paraffin), Western Blot to test the hypothesis that recurrent FSP vaccination alone or in combination with NSAID treatment can promote anti-FSP adaptive immunity sufficiently to reduce intestinal tumor burden and prolong overall survival.
Fri Oct 01 00:00:00 EDT 2021
Role of epidermal growth factor receptor inhibitor-induced interferon pathway signaling in the head and neck squamous cell carcinoma therapeutic response.
Journal of translational medicine
Korpela SP,Hinz TK,Oweida A,Kim J,Calhoun J,Ferris R,Nemenoff RA,Karam SD,Clambey ET,Heasley LE
14-9766-82 was used in Immunohistochemistry (Paraffin) to reveal heterogeneous, tumor cell-intrinsic, EGFR/ERBB inhibitor-induced IFN pathway activation in HNSCC and suggest that individual tumor responses to oncogene-targeted agents are a sum of direct growth inhibitory effects and variably-induced participation of host immune cells.
Sat Jan 23 00:00:00 EST 2021
Deficiency in CD4 T Cells Leads to Enhanced Postpartum Internal Carotid Artery Vasoconstriction in Mice: The Role of Nitric Oxide.
Frontiers in physiology
Gokina NI,Fairchild RI,Prakash K,DeLance NM,Bonney EA
14-9766-82 was used in Immunohistochemistry-immunofluorescence to show that dDysregulation of the CD4 T cell population in pregnancy may make ICA vulnerable to vasospasm due to decreased NO-dependent control of ICA constriction.
Tue Aug 01 00:00:00 EDT 2023
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells.
Cell reports
Matas-Rico E,Frijlink E,van der Haar Àvila I,Menegakis A,van Zon M,Morris AJ,Koster J,Salgado-Polo F,de Kivit S,Lança T,Mazzocca A,Johnson Z,Haanen J,Schumacher TN,Perrakis A,Verbrugge I,van den Berg JH,Borst J,Moolenaar WH
14-9766-82 was used in Flow cytometry/Cell sorting to highlight an unexpected role for the pro-metastatic ATX-LPAR axis in suppressing CD8+ T cell infiltration to impede anti-tumor immunity, suggesting new therapeutic opportunities.
Tue Nov 16 00:00:00 EST 2021
Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Nature
Conlon TM,John-Schuster G,Heide D,Pfister D,Lehmann M,Hu Y,Ertüz Z,Lopez MA,Ansari M,Strunz M,Mayr C,Angelidis I,Ciminieri C,Costa R,Kohlhepp MS,Guillot A,Günes G,Jeridi A,Funk MC,Beroshvili G,Prokosch S,Hetzer J,Verleden SE,Alsafadi H,Lindner M,Burgstaller G,Becker L,Irmler M,Dudek M,Janzen J,Goffin E,Gosens R,Knolle P,Pirotte B,Stoeger T,Beckers J,Wagner D,Singh I,Theis FJ,de Angelis MH,O'Connor T,Tacke F,Boutros M,Dejardin E,Eickelberg O,Schiller HB,Königshoff M,Heikenwalder M,Yildirim AÖ
14-9766-82 was used in Immunohistochemistry (Paraffin) to demonstrate differential expression, signalling, and target gene expression of the lymphotoxin β-receptor in response to cigarette smoke in humans and mice.
Tue Dec 01 00:00:00 EST 2020
Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma.
Cancer cell
Dheilly E,Battistello E,Katanayeva N,Sungalee S,Michaux J,Duns G,Wehrle S,Sordet-Dessimoz J,Mina M,Racle J,Farinha P,Coukos G,Gfeller D,Mottok A,Kridel R,Correia BE,Steidl C,Bassani-Sternberg M,Ciriello G,Zoete V,Oricchio E
14-9766-82 was used in Immunohistochemistry (Paraffin) to find that follicular lymphoma patients harbor a recurrent hotspot mutation targeting tyrosine 132 (Y132D) in cathepsin S (CTSS) that enhances protein activity.
Mon May 11 00:00:00 EDT 2020
Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice.
Gastroenterology
Michler T,Kosinska AD,Festag J,Bunse T,Su J,Ringelhan M,Imhof H,Grimm D,Steiger K,Mogler C,Heikenwalder M,Michel ML,Guzman CA,Milstein S,Sepp-Lorenzino L,Knolle P,Protzer U
14-9766 was used in Immunohistochemistry to investigate whether knocking down expression levels of HBV antigens in liver might increase the efficacy of HBV vaccines in mice.
Fri May 01 00:00:00 EDT 2020
CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients.
Gastroenterology
Hirth M,Gandla J,Höper C,Gaida MM,Agarwal N,Simonetti M,Demir A,Xie Y,Weiss C,Michalski CW,Hackert T,Ebert MP,Kuner R
14-9766 was used in Immunohistochemistry to determine that CCL21 and CXCL10 proteins promote the migration of pancreatic cancer cells toward sensory neurons in mice and are associated with increased frequency of cancer-associated pain in pancreatic ductal adenocarcinoma patients.
Sat Aug 01 00:00:00 EDT 2020
Aggressive Mammary Cancers Lacking Lymphocytic Infiltration Arise in Irradiated Mice and Can Be Prevented by Dietary Intervention.
Cancer immunology research
Omene C,Ma L,Moore J,Ouyang H,Illa-Bochaca I,Chou W,Patel MS,Sebastiano C,Demaria S,Mao JH,Karagoz K,Gatza ML,Barcellos-Hoff MH
14-9766 was used in Immunohistochemistry to show that aged mice exposed to ionizing radiation drives mammary cancers that are more aggressive by repressing aspects of antitumor immunity resulting in an immunosuppressive TME.
Sat Feb 01 00:00:00 EST 2020
Generation of protective pneumococcal-specific nasal resident memory CD4+ T cells via parenteral immunization.
Mucosal immunology
O'Hara JM,Redhu NS,Cheung E,Robertson NG,Patik I,Sayed SE,Thompson CM,Herd M,Lucas KB,Conaway E,Morton CC,Farber DL,Malley R,Horwitz BH
14-9766-82 was used in Immunohistochemistry to show that intranasal administration of live or killed pneumococci to mice generates pneumococcus-responsive IL-17A-producing CD4+ mucosal tissue-resident memory T cells.
Wed Jan 01 00:00:00 EST 2020
Therapeutic cooperation between auranofin, a thioredoxin reductase inhibitor and anti-PD-L1 antibody for treatment of triple-negative breast cancer.
International journal of cancer
Raninga PV,Lee AC,Sinha D,Shih YY,Mittal D,Makhale A,Bain AL,Nanayakarra D,Tonissen KF,Kalimutho M,Khanna KK
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Wed Jan 01 00:00:00 EST 2020
NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy.
Journal of immunology (Baltimore, Md. : 1950)
Ogawa T,Ishitsuka Y,Nakamura Y,Kubota N,Saito A,Fujisawa Y,Watanabe R,Okiyama N,Suga Y,Roop DR,Fujimoto M
14-9766-82 was used immunohistochemistry (paraffin) show that the immunogenicity of a given hapten depends directly on the extent to which it induces antioxidant host defenses within the epidermal tissue.
Sat Aug 15 00:00:00 EDT 2020
Cancer Cell-Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma.
Journal of immunology (Baltimore, Md. : 1950)
Johnson AM,Bullock BL,Neuwelt AJ,Poczobutt JM,Kaspar RE,Li HY,Kwak JW,Hopp K,Weiser-Evans MCM,Heasley LE,Schenk EL,Clambey ET,Nemenoff RA
14-9766 was used in Immunohistochemistry-immunofluorescence to examine the effect of cancer cell-specific MHC class II (csMHCII) expression in lung adenocarcinoma on T cell recruitment to tumors and response to anti-PD-1 therapy using two orthotopic immunocompetent murine models of non-small cell lung cancer: CMT167 (CMT) and Lewis lung carcinoma (LLC).
Wed Apr 15 00:00:00 EDT 2020
Morphologic and Immunohistochemical Characterization of Spontaneous Lymphoma/Leukemia in NSG Mice.
Veterinary pathology
Tillman H,Janke LJ,Funk A,Vogel P,Rehg JE
14-9766-82 was used in Immunohistochemistry (Paraffin) to highlight that NSG mice may develop T-cell lymphoma at low frequency, necessitating the recognition of this spontaneously arising disease when interpreting studies.
Wed Jan 01 00:00:00 EST 2020
Dual Role of Hepatic Macrophages in the Establishment of the Echinococcus multilocularis Metacestode in Mice.
Frontiers in immunology
Wang H,Zhang CS,Fang BB,Hou J,Li WD,Li ZD,Li L,Bi XJ,Li L,Abulizi A,Shao YM,Lin RY,Wen H
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Wed Jun 16 00:00:00 EDT 2021
Dual Role of Hepatic Macrophages in the Establishment of the Echinococcus multilocularis Metacestode in Mice.
Frontiers in immunology
Wang H,Zhang CS,Fang BB,Hou J,Li WD,Li ZD,Li L,Bi XJ,Li L,Abulizi A,Shao YM,Lin RY,Wen H
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Wed Jun 16 00:00:00 EDT 2021
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.
Nature communications
Hoefflin R,Harlander S,Schäfer S,Metzger P,Kuo F,Schönenberger D,Adlesic M,Peighambari A,Seidel P,Chen CY,Consenza-Contreras M,Jud A,Lahrmann B,Grabe N,Heide D,Uhl FM,Chan TA,Duyster J,Zeiser R,Schell C,Heikenwalder M,Schilling O,Hakimi AA,Boerries M,Frew IJ
14-9766 was used in Immunohistochemistry to show using an autochthonous ccRCC model that Hif1a is essential for tumour formation whereas Hif2a deletion has only minor effects on tumour initiation and growth.
Mon Aug 17 00:00:00 EDT 2020
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.
Nature communications
Hoefflin R,Harlander S,Schäfer S,Metzger P,Kuo F,Schönenberger D,Adlesic M,Peighambari A,Seidel P,Chen CY,Consenza-Contreras M,Jud A,Lahrmann B,Grabe N,Heide D,Uhl FM,Chan TA,Duyster J,Zeiser R,Schell C,Heikenwalder M,Schilling O,Hakimi AA,Boerries M,Frew IJ
14-9766 was used in Immunohistochemistry to show using an autochthonous ccRCC model that Hif1a is essential for tumour formation whereas Hif2a deletion has only minor effects on tumour initiation and growth.
Mon Aug 17 00:00:00 EDT 2020
Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma.
Journal for immunotherapy of cancer
Saha D,Rabkin SD,Martuza RL
14-9766 was used in Immunohistochemistry to examine the combination of temozolomide and an oncolytic herpes simplex virus encoding murine interleukin 12, G47Δ-mIL12, in a mouse immunocompetent glioblastoma model generated from non-immunogenic 005 glioblastoma stem-like cells.
Fri May 01 00:00:00 EDT 2020
Temozolomide antagonizes oncolytic immunovirotherapy in glioblastoma.
Journal for immunotherapy of cancer
Saha D,Rabkin SD,Martuza RL
14-9766 was used in Immunohistochemistry to examine the combination of temozolomide and an oncolytic herpes simplex virus encoding murine interleukin 12, G47Δ-mIL12, in a mouse immunocompetent glioblastoma model generated from non-immunogenic 005 glioblastoma stem-like cells.
Fri May 01 00:00:00 EDT 2020
Shift work influences the outcomes of Chlamydia infection and pathogenesis.
Scientific reports
Lundy SR,Richardson S,Ramsey A,Ellerson D,Fengxia Y,Onyeabor S,Kirlin W,Thompson W,Black CM,DeBruyne JP,Davidson AJ,Immergluck LC,Blas-Machado U,Eko FO,Igietseme JU,He Q,Omosun YO
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Mon Sep 21 00:00:00 EDT 2020
Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer.
Oncoimmunology
Alvero AB,Hanlon D,Pitruzzello M,Filler R,Robinson E,Sobolev O,Tedja R,Ventura A,Bosenberg M,Han P,Edelson RL,Mor G
14-9766 was used in Immunohistochemistry to study the results of transimmunization in high-grade serous ovarian cancer (HGSOC) mouse models.
Wed May 13 00:00:00 EDT 2020
Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer.
Oncoimmunology
Alvero AB,Hanlon D,Pitruzzello M,Filler R,Robinson E,Sobolev O,Tedja R,Ventura A,Bosenberg M,Han P,Edelson RL,Mor G
14-9766 was used in Immunohistochemistry to study the results of transimmunization in high-grade serous ovarian cancer (HGSOC) mouse models.
Wed May 13 00:00:00 EDT 2020
IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice.
Oncoimmunology
Richardson LG,Nieman LT,Stemmer-Rachamimov AO,Zheng XS,Stafford K,Nagashima H,Miller JJ,Kiyokawa J,Ting DT,Wakimoto H,Cahill DP,Choi BD,Curry WT
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunocytochemistry
Thu Aug 20 00:00:00 EDT 2020
IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice.
Oncoimmunology
Richardson LG,Nieman LT,Stemmer-Rachamimov AO,Zheng XS,Stafford K,Nagashima H,Miller JJ,Kiyokawa J,Ting DT,Wakimoto H,Cahill DP,Choi BD,Curry WT
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunocytochemistry
Thu Aug 20 00:00:00 EDT 2020
IDH-mutant gliomas harbor fewer regulatory T cells in humans and mice.
Oncoimmunology
Richardson LG,Nieman LT,Stemmer-Rachamimov AO,Zheng XS,Stafford K,Nagashima H,Miller JJ,Kiyokawa J,Ting DT,Wakimoto H,Cahill DP,Choi BD,Curry WT
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunocytochemistry
Thu Aug 20 00:00:00 EDT 2020
Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.
Journal for immunotherapy of cancer
Bergamaschi C,Pandit H,Nagy BA,Stellas D,Jensen SM,Bear J,Cam M,Valentin A,Fox BA,Felber BK,Pavlakis GN
14-9766 was used in Immunohistochemistry to show that hetIL-15 administration enhances T cell entry into tumors, increasing the success rate of immunotherapy interventions.
Fri May 01 00:00:00 EDT 2020
Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.
Journal for immunotherapy of cancer
Bergamaschi C,Pandit H,Nagy BA,Stellas D,Jensen SM,Bear J,Cam M,Valentin A,Fox BA,Felber BK,Pavlakis GN
14-9766 was used in Immunohistochemistry to show that hetIL-15 administration enhances T cell entry into tumors, increasing the success rate of immunotherapy interventions.
Fri May 01 00:00:00 EDT 2020
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.
Nature communications
von Roemeling CA,Wang Y,Qie Y,Yuan H,Zhao H,Liu X,Yang Z,Yang M,Deng W,Bruno KA,Chan CK,Lee AS,Rosenfeld SS,Yun K,Johnson AJ,Mitchell DA,Jiang W,Kim BYS
14-9766 was used in Immunohistochemistry to show stimulation of glioma cell phagocytosis by blockage of anti-phagocytosis molecule CD47 is an ineffective process.
Fri Mar 20 00:00:00 EDT 2020
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.
Nature communications
von Roemeling CA,Wang Y,Qie Y,Yuan H,Zhao H,Liu X,Yang Z,Yang M,Deng W,Bruno KA,Chan CK,Lee AS,Rosenfeld SS,Yun K,Johnson AJ,Mitchell DA,Jiang W,Kim BYS
14-9766 was used in Immunohistochemistry to show stimulation of glioma cell phagocytosis by blockage of anti-phagocytosis molecule CD47 is an ineffective process.
Fri Mar 20 00:00:00 EDT 2020
CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.
Journal of neuroinflammation
Chen YQ,Wang SN,Shi YJ,Chen J,Ding SQ,Tang J,Shen L,Wang R,Ding H,Hu JG,Lü HZ
14-9766-82 was used in Immunohistochemistry (Frozen) to study the effect of CRID3 on the local microenvironment and the possible role in neuroprotection following spinal cord injury.
Sat Aug 29 00:00:00 EDT 2020
Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system.
Oncoimmunology
Klarenbeek S,Doornebal CW,Kas SM,Bonzanni N,Bhin J,Braumuller TM,van der Heijden I,Opdam M,Schouten PC,Kersten K,de Bruijn R,Zingg D,Yemelyanenko J,Wessels LFA,de Visser KE,Jonkers J
14-9766-82 was used in Immunohistochemistry to investigate treatment response and resistance to AZD8055, an inhibitor of mammalian target of rapamycin (mTOR), in the K14-cre;Cdh1Flox/Flox;Trp53Flox/Flox (KEP) mouse model of metastatic ILC.
Wed Jul 28 00:00:00 EDT 2021
In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases.
Journal for immunotherapy of cancer
Clark PA,Sriramaneni RN,Jin WJ,Jagodinsky JC,Bates AM,Jaquish AA,Anderson BR,Le T,Lubin JA,Chakravarty I,Arthur IS,Heinze CM,Guy EI,Kler J,Klar KA,Carlson PM,Kim KM,Kuo JS,Morris ZS
14-9766 was used in Immunohistochemistry to test whether in situ vaccination inhibits the development of brain metastases in a murine melanoma model.
Wed Jul 01 00:00:00 EDT 2020
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.
Cancer cell
Jackstadt R,van Hooff SR,Leach JD,Cortes-Lavaud X,Lohuis JO,Ridgway RA,Wouters VM,Roper J,Kendall TJ,Roxburgh CS,Horgan PG,Nixon C,Nourse C,Gunzer M,Clark W,Hedley A,Yilmaz OH,Rashid M,Bailey P,Biankin AV,Campbell AD,Adams DJ,Barry ST,Steele CW,Medema JP,Sansom OJ
14-9766-82 was used in Immunohistochemistry to propose that NOTCH1 signaling is key to CRC progression and should be exploited clinically.
Mon Sep 16 00:00:00 EDT 2019
Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice.
Brain, behavior, and immunity
Xiao R,Bergin SM,Huang W,Mansour AG,Liu X,Judd RT,Widstrom KJ,Queen NJ,Wilkins RK,Siu JJ,Ali S,Caligiuri MA,Cao L
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Tue Jan 01 00:00:00 EST 2019
Enriched environment regulates thymocyte development and alleviates experimental autoimmune encephalomyelitis in mice.
Brain, behavior, and immunity
Xiao R,Bergin SM,Huang W,Mansour AG,Liu X,Judd RT,Widstrom KJ,Queen NJ,Wilkins RK,Siu JJ,Ali S,Caligiuri MA,Cao L
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Tue Jan 01 00:00:00 EST 2019
The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer.
British journal of cancer
Schreiber LM,Urbiola C,Das K,Spiesschaert B,Kimpel J,Heinemann F,Stierstorfer B,Müller P,Petersson M,Erlmann P,von Laer D,Wollmann G
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Tue Oct 01 00:00:00 EDT 2019
The lytic activity of VSV-GP treatment dominates the therapeutic effects in a syngeneic model of lung cancer.
British journal of cancer
Schreiber LM,Urbiola C,Das K,Spiesschaert B,Kimpel J,Heinemann F,Stierstorfer B,Müller P,Petersson M,Erlmann P,von Laer D,Wollmann G
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Tue Oct 01 00:00:00 EDT 2019
Allium hookeri root extract regulates asthmatic changes through immunological modulation of Th1/Th2‑related factors in an ovalbumin‑induced asthma mouse model.
Molecular medicine reports
Bok SH,Seo JH,Bae CS,Kang B,Cho SS,Park DH
14-9766-82 was used in Immunohistochemistry to lucidate the anti‚asthmatic effects and mechanism of action of A.hookeri root extracts in an ovalbumin‚induced asthma mouse model.
Tue Oct 01 00:00:00 EDT 2019
A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.
Journal of mammary gland biology and neoplasia
Pénzváltó Z,Chen JQ,Tepper CG,Davis RR,Silvestrini MT,Umeh-Garcia M,Sweeney C,Borowsky AD
14-9766-82 was used in Immunohistochemistry to show that the NDLUCD cells have, so far, remained genetically and phenotypically stable over many generations, with consistent and reproducible results in immune intact preclinical cohorts.
Sat Jun 01 00:00:00 EDT 2019
Development of a new fusion-enhanced oncolytic immunotherapy platform based on herpes simplex virus type 1.
Journal for immunotherapy of cancer
Thomas S,Kuncheria L,Roulstone V,Kyula JN,Mansfield D,Bommareddy PK,Smith H,Kaufman HL,Harrington KJ,Coffin RS
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunocytochemistry
Sat Aug 10 00:00:00 EDT 2019
Development of a new fusion-enhanced oncolytic immunotherapy platform based on herpes simplex virus type 1.
Journal for immunotherapy of cancer
Thomas S,Kuncheria L,Roulstone V,Kyula JN,Mansfield D,Bommareddy PK,Smith H,Kaufman HL,Harrington KJ,Coffin RS
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunocytochemistry
Sat Aug 10 00:00:00 EDT 2019
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
14-9766-82 was used in Immunohistochemistry to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 EDT 2019
Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells.
Science advances
Feng M,Jin JQ,Xia L,Xiao T,Mei S,Wang X,Huang X,Chen J,Liu M,Chen C,Rafi S,Zhu AX,Feng YX,Zhu D
14-9766 was used in Immunohistochemistry to develop potent, selective inhibitors targeting the Wnt/B catenin pathway.
Wed May 01 00:00:00 EDT 2019
Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy.
Journal for immunotherapy of cancer
Hanoteau A,Newton JM,Krupar R,Huang C,Liu HC,Gaspero A,Gartrell RD,Saenger YM,Hart TD,Santegoets SJ,Laoui D,Spanos C,Parikh F,Jayaraman P,Zhang B,Van der Burg SH,Van Ginderachter JA,Melief CJM,Sikora AG
14-9766 was used in Immunohistochemistry to identify that modulation of he tumor immune microenvironment with immunomodulatory drugs enhances susceptibility of treatment refractory tumors to chemradiotherapy.
Tue Jan 15 00:00:00 EST 2019
A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy.
Advanced materials (Deerfield Beach, Fla.)
Mi Y,Smith CC,Yang F,Qi Y,Roche KC,Serody JS,Vincent BG,Wang AZ
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2018
A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy.
Advanced materials (Deerfield Beach, Fla.)
Mi Y,Smith CC,Yang F,Qi Y,Roche KC,Serody JS,Vincent BG,Wang AZ
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2018
Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response.
The Journal of clinical investigation
Ubil E,Caskey L,Holtzhausen A,Hunter D,Story C,Earp HS
14-9766 was used in Immunohistochemistry to demonstrate that tumour-secreted protein S, a Mer/Tyro3 ligand, decreases macrophage M1 cytokine expression in vitro and in vivo.
Fri Jun 01 00:00:00 EDT 2018
GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever.
The Journal of experimental medicine
Kanneganti A,Malireddi RKS,Saavedra PHV,Vande Walle L,Van Gorp H,Kambara H,Tillman H,Vogel P,Luo HR,Xavier RJ,Chi H,Lamkanfi M
14-9766 was used in Immunohistochemistry to study the role of gasdermin D in autoinflammatory pathology in a mouse model of Familial Mediterranean Fever.
Mon Jun 04 00:00:00 EDT 2018
Combinatorial Effects of VEGFR Kinase Inhibitor Axitinib and Oncolytic Virotherapy in Mouse and Human Glioblastoma Stem-Like Cell Models.
Clinical cancer research : an official journal of the American Association for Cancer Research
Saha D,Wakimoto H,Peters CW,Antoszczyk SJ,Rabkin SD,Martuza RL
14-9766-82 was used in Immunohistochemistry to evaluate the cytotoxic effects of VEFGR tyrosine kinase inhibitor (TKI) axitinib in vitro and then tested antitumor efficacy of axitinib in combination with oncolytic herpes simplex virus (oHSV) expressing antiangiogenic cytokine murine IL12 (G47Δ-mIL12) in two orthotopic GSC-derived GBM models: patient-derived recurrent MGG123 GSCs, forming vascular xenografts in immunodeficient mice; and mouse 005 GSCs, forming syngeneic tumors in immunocomp
Sun Jul 15 00:00:00 EDT 2018
MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB
14-9766 was used in Immunohistochemistry to show that p38/MAPKAP Kinase 2 activity in the myeloid compartment promotes tumour progression by supporting tumour neoangiogenesis in vivo.
Tue May 01 00:00:00 EDT 2018
Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol.
International journal of cancer
Unver N,Delgado O,Zeleke K,Cumpian A,Tang X,Caetano MS,Wang H,Katayama H,Yu H,Szabo E,Wistuba II,Moghaddam SJ,Hanash SM,Ostrin EJ
14-9766 was used in Immunohistochemistry to study the role of alterations in macrophage recruitment and phenotype switching in the anti-cancer response produced in a mouse model of lung cancer chemoprevention with myo-inositol.
Sun Apr 01 00:00:00 EDT 2018
Mycoleptodonoides aitchisonii suppresses asthma via Th2 and Th1 cell regulation in an ovalbumin‑induced asthma mouse model.
Molecular medicine reports
Lee SY,Bae CS,Seo JH,Cho SS,Bae MS,Oh DS,Park DH
14-9766 was used in Immunohistochemistry-immunofluorescence to evaluate the anti-asthmatic effects of M. atichisonii using an ovalbumin-induced asthma mouse model.
Mon Jan 01 00:00:00 EST 2018
Immunohistochemistry in Investigative and Toxicologic Pathology.
Toxicologic pathology
Janardhan KS,Jensen H,Clayton NP,Herbert RA
14-9766 was used in Immunohistochemistry to review the technical aspects of immunohistochemistry, the variables that affect the results, interpretation, and reproducibility of IHC results.
Sun Jul 01 00:00:00 EDT 2018
Au-CGKRK Nanoconjugates for Combating Cancer through T-Cell-Driven Therapeutic RNA Interference.
ACS omega
Gulla SK,Kotcherlakota R,Nimushakavi S,Nimmu NV,Khalid S,Patra CR,Chaudhuri A
14-9766-82 was used in Western Blot to report on the design, synthesis, physicochemical characterizations, and bioactivity evaluation of novel tumor- and tumor-vasculature-targeting noncytotoxic Au-CGKRK nanoconjugates (17-80 nm) for combating tumor.
Fri Aug 31 00:00:00 EDT 2018
Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II.
Oncoimmunology
Li HY,McSharry M,Walker D,Johnson A,Kwak J,Bullock B,Neuwelt A,Poczobutt JM,Sippel TR,Keith RL,Weiser-Evans MCM,Clambey E,Nemenoff RA
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunocytochemistry
Tue Jan 12 00:00:00 EST 2021
Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II.
Oncoimmunology
Li HY,McSharry M,Walker D,Johnson A,Kwak J,Bullock B,Neuwelt A,Poczobutt JM,Sippel TR,Keith RL,Weiser-Evans MCM,Clambey E,Nemenoff RA
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunocytochemistry
Tue Jan 12 00:00:00 EST 2021
Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II.
Oncoimmunology
Li HY,McSharry M,Walker D,Johnson A,Kwak J,Bullock B,Neuwelt A,Poczobutt JM,Sippel TR,Keith RL,Weiser-Evans MCM,Clambey E,Nemenoff RA
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunocytochemistry
Tue Jan 12 00:00:00 EST 2021
C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event.
Cell death & disease
Messenger ZJ,Hall JR,Jima DD,House JS,Tam HW,Tokarz DA,Smart RC
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry (Paraffin)
Mon Oct 15 00:00:00 EDT 2018
C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event.
Cell death & disease
Messenger ZJ,Hall JR,Jima DD,House JS,Tam HW,Tokarz DA,Smart RC
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry (Paraffin)
Mon Oct 15 00:00:00 EDT 2018
Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Cell reports
Simula L,Pacella I,Colamatteo A,Procaccini C,Cancila V,Bordi M,Tregnago C,Corrado M,Pigazzi M,Barnaba V,Tripodo C,Matarese G,Piconese S,Campello S
14-9766 was used in Immunohistochemistry to describe the crucial role of the mitochondrial protein Drp1 in T cell development and regulation of lymphocyte immune-surveillance.
Tue Dec 11 00:00:00 EST 2018
Deciphering the immune microenvironment of a tissue by digital imaging and cognition network.
Scientific reports
Lopès A,Cassé AH,Billard E,Boulcourt-Sambou E,Roche G,Larois C,Barnich N,Naimi S,Bonnet M,Dumas B
14-9766 was used in Immunohistochemistry-immunofluorescence to show this algorithm is a new and robust preclinical research tool, for investigating immune contexture exemplified by T cells but it is also applicable to other immune cells such as other myeloid and lymphoid populations or other cellular phenomenon along mouse gut.
Mon Nov 12 00:00:00 EST 2018
DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.
Nature communications
Luo N,Nixon MJ,Gonzalez-Ericsson PI,Sanchez V,Opalenik SR,Li H,Zahnow CA,Nickels ML,Liu F,Tantawy MN,Sanders ME,Manning HC,Balko JM
14-9766 was used in Immunohistochemistry-immunofluorescence to demonstrate up regulation of MHC-1 expression in human breast cancer in response to hypomethylating agent guadecitabine to aid anti-tumour immunity.
Tue Jan 16 00:00:00 EST 2018
DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.
Nature communications
Luo N,Nixon MJ,Gonzalez-Ericsson PI,Sanchez V,Opalenik SR,Li H,Zahnow CA,Nickels ML,Liu F,Tantawy MN,Sanders ME,Manning HC,Balko JM
14-9766 was used in Immunohistochemistry-immunofluorescence to demonstrate up regulation of MHC-1 expression in human breast cancer in response to hypomethylating agent guadecitabine to aid anti-tumour immunity.
Tue Jan 16 00:00:00 EST 2018
Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr-/-.Leiden Mice.
Hepatology communications
Morrison MC,Verschuren L,Salic K,Verheij J,Menke A,Wielinga PY,Iruarrizaga-Lejarreta M,Gole L,Yu WM,Turner S,Caspers MPM,Martínez-Arranz I,Pieterman E,Stoop R,van Koppen A,van den Hoek AM,Mato JM,Hanemaaijer R,Alonso C,Kleemann R
14-9766 was used in Immunohistochemistry to show that human molecular signatures can be used to evaluate the translational character of preclinical models for nonalcoholic steatohepatitis.
Sat Dec 01 00:00:00 EST 2018
Flightless I Alters the Inflammatory Response and Autoantibody Profile in an OVA-Induced Atopic Dermatitis Skin-Like Disease.
Frontiers in immunology
Kopecki Z,Stevens NE,Chong HT,Yang GN,Cowin AJ
14-9766-82 was used in Immunohistochemistry to study the effect of Fiji expression on the development of atopic dermatitis and its contribution to autoimmune aspects of inflammatory skin conditions.
Mon Sep 30 00:00:00 EDT 2019
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
The Journal of clinical investigation
Horng S,Therattil A,Moyon S,Gordon A,Kim K,Argaw AT,Hara Y,Mariani JN,Sawai S,Flodby P,Crandall ED,Borok Z,Sofroniew MV,Chapouly C,John GR
14-9766 was used in Flow cytometry/Cell sorting to identify a inducible barrier to CNS entry at the glia limitans, which may be therapeutically targetable in inflammatory CNS disease.
Tue Aug 01 00:00:00 EDT 2017
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL
14976682 was used in immunohistochemistry to investigate the use of red blood cells expressing disease-associated autoantigenas a means of inducing antigen-specific tolerance
Tue Mar 21 00:00:00 EDT 2017
Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis.
The Journal of investigative dermatology
Liu Y,Wang Z,De La Torre R,Barling A,Tsujikawa T,Hornick N,Hanifin J,Simpson E,Wang Y,Swanzey E,Wortham A,Ding H,Coussens LM,Kulesz-Martin M
14-9766 was used in Immunohistochemistry to show depletion of Trim32, a protein with innate antiviral activity, can cause a biased T helper type 2 response and induce atopic dermatitis-like phenotypes in mice.
Wed Feb 01 00:00:00 EST 2017
Mycobacterium tuberculosis infection modulates adipose tissue biology.
PLoS pathogens
Beigier-Bompadre M,Montagna GN,Kühl AA,Lozza L,Weiner J,Kupz A,Vogelzang A,Mollenkopf HJ,Löwe D,Bandermann S,Dorhoi A,Brinkmann V,Matuschewski K,Kaufmann SHE
14-9766 was used in Immunohistochemistry to conclude that adipose tissue is a potential niche for Mtb and that due to infection CD8+ T cells and NK cells are attracted to this tissue.
Sun Oct 01 00:00:00 EDT 2017
Acute Renal Graft-Versus-Host Disease in a Murine Model of Allogeneic Bone Marrow Transplantation.
Cell transplantation
Schmid PM,Bouazzaoui A,Schmid K,Birner C,Schach C,Maier LS,Holler E,Endemann DH
14-9766 was used in Immunohistochemistry-immunofluorescence to support the entity of renal graft-versus-host disease with histological features suggestive of cell-mediated renal injury.
Tue Aug 01 00:00:00 EDT 2017
Treatment with Allogenic Mesenchymal Stromal Cells in a Murine Model of Systemic Lupus Erythematosus.
International journal of stem cells
Tani C,Vagnani S,Carli L,Querci F,Kühl AA,Spieckermann S,Cieluch CP,Pacini S,Fazzi R,Mosca M
14-9766 was used in Immunohistochemistry on paraffin embedded tissues to study whether repeated administrations of 1x106/kg body weight of allogenic mesenchymal stromal cells can be effective in improving the clinical course of a murine systemic lupus erythematosus model.
Thu Nov 30 00:00:00 EST 2017
hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer.
PLoS genetics
Jin Z,Liang F,Yang J,Mei W
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunofluorescence
Wed Mar 01 00:00:00 EST 2017
Overcoming resistance to anti-PD immunotherapy in a syngeneic mouse lung cancer model using locoregional virotherapy.
Oncoimmunology
Yan X,Wang L,Zhang R,Pu X,Wu S,Yu L,Meraz IM,Zhang X,Wang JF,Gibbons DL,Mehran RJ,Swisher SG,Roth JA,Fang B
14-9766 was used in Immunohistochemistry to demonstrate that resistance to anti-PD-1 immunotherapy in syngeneic mouse lung cancer can be overcome by locoregional virotherapy.
Thu Feb 02 00:00:00 EST 2023
Immunotherapeutic target expression on breast tumors can be amplified by hormone receptor antagonism: a novel strategy for enhancing efficacy of targeted immunotherapy.
Oncotarget
Jaini R,Loya MG,Eng C
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Tue May 16 00:00:00 EDT 2017
Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer.
Journal of translational medicine
Li L,Wang W,Pan H,Ma G,Shi X,Xie H,Liu X,Ding Q,Zhou W,Wang S
14-9766 was used in Immunohistochemistry on paraffin embedded tissues to show T-cell responses were induced by microwave ablation in a murine breast cancer model, and by combining microwave ablation with OK-432 treatment, the Th1-type response was induced.
Tue Jan 31 00:00:00 EST 2017
The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model.
Oncotarget
Melis MHM,Nevedomskaya E,van Burgsteden J,Cioni B,van Zeeburg HJT,Song JY,Zevenhoven J,Hawinkels LJAC,de Visser KE,Bergman AM
14-9766-82 was used in Immunohistochemistry to provide new insights into the promoting role of the adaptive immune system in prostate cancer development.
Tue Nov 07 00:00:00 EST 2017
MAVS-dependent host species range and pathogenicity of human hepatitis A virus.
Science (New York, N.Y.)
Hirai-Yuki A,Hensley L,McGivern DR,González-López O,Das A,Feng H,Sun L,Wilson JE,Hu F,Feng Z,Lovell W,Misumi I,Ting JP,Montgomery S,Cullen J,Whitmire JK,Lemon SM
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Fri Sep 30 00:00:00 EDT 2016
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.
Cancer immunology, immunotherapy : CII
Kroon P,Gadiot J,Peeters M,Gasparini A,Deken MA,Yagita H,Verheij M,Borst J,Blank CU,Verbrugge I
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Flow Cytometry
Wed Jun 01 00:00:00 EDT 2016
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.
Cancer immunology, immunotherapy : CII
Kroon P,Gadiot J,Peeters M,Gasparini A,Deken MA,Yagita H,Verheij M,Borst J,Blank CU,Verbrugge I
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Flow Cytometry
Wed Jun 01 00:00:00 EDT 2016
Erythronium japonicum attenuates histopathological lung abnormalities in a mouse model of ovalbumin-induced asthma.
International journal of molecular medicine
Seo JH,Bang MA,Kim G,Cho SS,Park DH
Sun May 01 00:00:00 EDT 2016
5-fluorouracil attenuates dextran sodium sulfate-induced acute colitis in mice.
Molecular medicine reports
Xiao J,Lu Z,Sheng J,Song Y,Jiang W,Liu F,Zheng P
14-9766 was used in Immunohistochemistry on paraffin embedded tissues to investigate the potential therapeutic role of 5-Fluorouracil in dextran sodium sulphate-induced acute mouse colitis.
Tue Mar 01 00:00:00 EST 2016
Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover.
PloS one
Marek I,Lichtneger T,Cordasic N,Hilgers KF,Volkert G,Fahlbusch F,Rascher W,Hartner A,Menendez-Castro C
14-9766 was used in Immunohistochemistry on paraffin embedded tissues to investigate whether increased tubulointerstitial damage after unilateral ureteral obstruction in Itga8-/- mice is associated with altered cell turnover and apoptotic mechanisms.
Thu Jul 28 00:00:00 EDT 2016
Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover.
PloS one
Marek I,Lichtneger T,Cordasic N,Hilgers KF,Volkert G,Fahlbusch F,Rascher W,Hartner A,Menendez-Castro C
14-9766 was used in Immunohistochemistry on paraffin embedded tissues to investigate whether increased tubulointerstitial damage after unilateral ureteral obstruction in Itga8-/- mice is associated with altered cell turnover and apoptotic mechanisms.
Thu Jul 28 00:00:00 EDT 2016
Characterization of Proliferating Lesion-Resident Cells During All Stages of Atherosclerotic Growth.
Journal of the American Heart Association
Lhoták Š,Gyulay G,Cutz JC,Al-Hashimi A,Trigatti BL,Richards CD,Igdoura SA,Steinberg GR,Bramson J,Ask K,Austin RC
14-9766 was used in Immunohistochemistry to characterise the populations of proliferating cells during atherosclerotic lesion growth.
Mon Aug 15 00:00:00 EDT 2016
Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.
Human gene therapy
Wang D,Mou H,Li S,Li Y,Hough S,Tran K,Li J,Yin H,Anderson DG,Sontheimer EJ,Weng Z,Gao G,Xue W
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Wed Jul 01 00:00:00 EDT 2015
Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.
Human gene therapy
Wang D,Mou H,Li S,Li Y,Hough S,Tran K,Li J,Yin H,Anderson DG,Sontheimer EJ,Weng Z,Gao G,Xue W
Published figure using CD4 monoclonal antibody (Product # 14-9766-82) in Immunohistochemistry
Wed Jul 01 00:00:00 EDT 2015
Bacillus subtilis KCTC 11782BP-produced alginate oligosaccharide effectively suppresses asthma via T-helper cell type 2-related cytokines.
PloS one
Bang MA,Seo JH,Seo JW,Jo GH,Jung SK,Yu R,Park DH,Park SJ
14-9766 was used in Immunohistochemistry to evaluate the anti-asthmatic effect of alginate oligosaccharide.
Tue Feb 02 00:00:00 EST 2016
