Invitrogen

CD127 Monoclonal Antibody (A7R34), PE-Cyanine5, eBioscience™

FIGURE: 1 / 19

CD127 Antibody (15-1271-82) in Flow

Staining of C57Bl/6 splenocytes with Anti-Mouse CD3e FITC (Product # 11-0031-82) and 0.25 µg of Rat IgG2a Isotype Control PE-Cyanine5 (Product # 15-4321-80) (left) or 0.25 µg of Anti-Mouse CD127 PE-Cyanine5 (right).Total viable cells were used for analysis.

Product Image Gallery

Product Details

15-1271-82

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.5 µg/test

View 41 publications 41 publications

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), PE-Cyanine5, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

A7R34

Conjugate

PE-Cyanine5 PE-Cyanine5 PE-Cyanine5

Excitation/Emission Max

568/666 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_468793

Product Specific Information

Description: The A7R34 monoclonal antibody reacts with mouse CD127, the high affinity alpha subunit of the mouse IL-7 receptor. IL-7 receptor alpha chain is expressed by immature B cells in the bone marrow, double-negative (CD4-CD8-), single-positive (CD4+ and CD8+), but not double-positive (CD4+CD8+) thymocytes. In the periphery, mature T cells express CD127 at low level. A7R34 inhibits binding of IL-7 to its receptor and has been used in in vivo and in vitro studies to elucidate the role of IL-7 in T and B cell development and activation. Binding of A7R34 blocks the binding of SB/199, another antibody which recognizes mouse CD127.

Applications Reported: The A7R34 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The A7R34 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-822-49) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 667 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Wed Mar 01 00:00:00 EST 2023

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Fri Jan 01 00:00:00 EST 2021

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Molecular medicine reports

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Fri Jan 01 00:00:00 EST 2021

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Tue Oct 12 00:00:00 EDT 2021

Hedgehog interacting protein-expressing lung fibroblasts suppress lymphocytic inflammation in mice.

JCI insight

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Resident memory T cells in tumor-distant tissues fortify against metastasis formation.

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15-1271-82 was used in Flow Cytometry to suggest a potential strategy to prevent metastasis in clinical oncology.

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RIPK3 and Caspase-1/11 Are Necessary for Optimal Antigen-Specific CD8 T Cell Response Elicited by Genetically Modified Listeria monocytogenes.

Frontiers in immunology

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An Id2^RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.

Immunity

Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP

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Activation of naïve CD4⁺ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4⁺ T cells.

Nature immunology

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Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase.

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Mon Jan 18 00:00:00 EST 2016

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15-1271 was used in Flow cytometry/Cell sorting to study the effect of MN1 overexpression in mice and human patients with acute myeloid leukemia and predict ATRA resistance.

Sat Sep 01 00:00:00 EDT 2007

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European journal of immunology

Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ

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Thu Nov 01 00:00:00 EDT 2007

Vaccines based on novel adeno-associated virus vectors elicit aberrant CD8+ T-cell responses in mice.

Journal of virology

Lin J,Zhi Y,Mays L,Wilson JM

15-1271 was used in Flow cytometry/Cell sorting to evaluate the potential of vectors based on several novel AAVs as vaccine carriers for HIV Gag.

Thu Nov 01 00:00:00 EDT 2007

Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.

Cell stem cell

Arinobu Y,Mizuno S,Chong Y,Shigematsu H,Iino T,Iwasaki H,Graf T,Mayfield R,Chan S,Kastner P,Akashi K

15-1271 was used in Flow cytometry/Cell sorting to investigate the mechanism and molecules involved in the initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages.

Thu Oct 11 00:00:00 EDT 2007

Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis.

The American journal of pathology

Leithäuser F,Meinhardt-Krajina T,Fink K,Wotschke B,Möller P,Reimann J

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Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation.

Blood

Iwasaki H,Somoza C,Shigematsu H,Duprez EA,Iwasaki-Arai J,Mizuno S,Arinobu Y,Geary K,Zhang P,Dayaram T,Fenyus ML,Elf S,Chan S,Kastner P,Huettner CS,Murray R,Tenen DG,Akashi K

15-1271 was used in Flow cytometry/Cell sorting to show that constitutive expression of PU.1 by HSCs is necessary for maintenance of the bone marrow HSC pool.

Thu Sep 01 00:00:00 EDT 2005

Beta-catenin is dispensable for hematopoiesis and lymphopoiesis.

The Journal of experimental medicine

Cobas M,Wilson A,Ernst B,Mancini SJ,MacDonald HR,Kemler R,Radtke F

15-1271 was used in Flow cytometry/Cell sorting to investigate an essential role for beta-catenin during hematopoiesis and lymphopoiesis.

Mon Jan 19 00:00:00 EST 2004

Bioinformatics

Protein Aliases: CD127; IL 7 receptor; IL 7R a; IL 7R subunit alpha; IL 7R α; IL 7Ra; IL 7Rα; IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; IL7 receptor; IL7 receptor subunit alpha; IL7R a; IL7R alpha; IL7R subunit alpha; IL7R α; IL7Rα; interleukin 7 receptor alpha chain; Interleukin-7 receptor subunit alpha; Interleukin7 receptor subunit alpha; MGC107557; sCD127; soluble IL 7 receptor; soluble IL 7R

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Gene Aliases: CD127; IL-7Ralpha; Il7r

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UniProt ID: (Mouse) P16872

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Entrez Gene ID: (Mouse) 16197

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Function(s)

cytokine receptor activity transmembrane signal receptor

Process(es)

cell morphogenesis negative regulation of T cell mediated cytotoxicity immunoglobulin production regulation of cell size positive regulation of gene expression cell growth T cell differentiation positive regulation of T cell differentiation in thymus B cell proliferation lymph node development homeostasis of number of cells

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD127 Monoclonal Antibody (A7R34), PE-Cyanine5, eBioscience™

CD127 Antibody (15-1271-82) in Flow

Product Details

15-1271-82

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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