Product References
The TIGIT+ T regulatory cells subset associates with nosocomial infection and fatal outcome in COVID-19 patients under mechanical ventilation.
Scientific reports
de Lima MHF,Machado CC,Nascimento DC,Silva CMS,Toller-Kawahisa JE,Rodrigues TS,Veras FP,Pontelli MC,Castro IA,Zamboni DS,Filho JA,Cunha TM,Arruda E,da Cunha LD,Oliveira RDR,Cunha FQ,Louzada-Junior P
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Mon Aug 21 00:00:00 EDT 2023
TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation.
Nature communications
Worboys JD,Vowell KN,Hare RK,Ambrose AR,Bertuzzi M,Conner MA,Patel FP,Zammit WH,Gali-Moya J,Hazime KS,Jones KL,Rey C,Jonjic S,Rovis TL,Tannahill GM,Cruz De Matos GDS,Waight JD,Davis DM
16-9500-82 was used in Flow cytometry/Cell sorting to provide evidence that TIGIT directly inhibits lymphocyte activation, acting independently of CD226, requiring intracellular signalling that is proximal to the TCR.
Fri Aug 18 00:00:00 EDT 2023
Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis.
The Journal of clinical investigation
Asashima H,Axisa PP,Pham THG,Longbrake EE,Ruff WE,Lele N,Cohen I,Raddassi K,Sumida TS,Hafler DA
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Mon Oct 17 00:00:00 EDT 2022
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Immunity
Schwabenland M,Salié H,Tanevski J,Killmer S,Lago MS,Schlaak AE,Mayer L,Matschke J,Püschel K,Fitzek A,Ondruschka B,Mei HE,Boettler T,Neumann-Haefelin C,Hofmann M,Breithaupt A,Genc N,Stadelmann C,Saez-Rodriguez J,Bronsert P,Knobeloch KP,Blank T,Thimme R,Glatzel M,Prinz M,Bengsch B
16-9500-82 was used in Mass cytometry to identify profound neuroinflammation with activation of innate and adaptive immune cells as correlates of COVID-19 neuropathology, with implications for potential therapeutic strategies.
Tue Jul 13 00:00:00 EDT 2021
Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis.
Oncogenesis
Xu K,Wang R,Xie H,Hu L,Wang C,Xu J,Zhu C,Liu Y,Gao F,Li X,Wang C,Huang J,Zhou W,Zhou G,Shu Y,Guan X
16-9500-82 was used in Immunohistochemistry-immunofluorescence to delineate the transcriptome profile of breast cancer lymph node metastasis using single-cell RNA sequencing.
Tue Oct 05 00:00:00 EDT 2021
Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis.
Oncogenesis
Xu K,Wang R,Xie H,Hu L,Wang C,Xu J,Zhu C,Liu Y,Gao F,Li X,Wang C,Huang J,Zhou W,Zhou G,Shu Y,Guan X
16-9500-82 was used in Immunohistochemistry-immunofluorescence to delineate the transcriptome profile of breast cancer lymph node metastasis using single-cell RNA sequencing.
Tue Oct 05 00:00:00 EDT 2021
Correlations of the expression of γδ T cells and their co-stimulatory molecules TIGIT, PD-1, ICOS and BTLA with PR and PIBF in the peripheral blood and decidual tissues of women with unexplained recurrent spontaneous abortion.
Clinical and experimental immunology
Liang Q,Tong L,Xiang L,Shen S,Pan C,Liu C,Zhang H
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Mycophenolate mofetil enhances the effects of tacrolimus on the inhibitory function of regulatory T cells in patients after liver transplantation via PD-1 and TIGIT receptors.
Immunopharmacology and immunotoxicology
Zeng Q,Yuan X,Cao J,Zhao X,Wang Y,Liu B,Liu W,Zhu Z,Dou J
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
TIGIT+ TIM-3+ NK cells are correlated with NK cell exhaustion and disease progression in patients with hepatitis B virus‑related hepatocellular carcinoma.
Oncoimmunology
Yu L,Liu X,Wang X,Yan F,Wang P,Jiang Y,Du J,Yang Z
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
DNAM1 and TIGIT balance the T cell response, with low T cell TIGIT expression corresponding to inflammation in psoriatic disease.
Immunotherapy advances
Jacobs ME,Pouw JN,Olde Nordkamp MA,Radstake TRDJ,Leijten EFA,Boes M
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Inhibition Assays
Fri Jan 01 00:00:00 EST 2021
SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells.
Nature communications
Jung JH,Rha MS,Sa M,Choi HK,Jeon JH,Seok H,Park DW,Park SH,Jeong HW,Choi WS,Shin EC
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Wed Jun 30 00:00:00 EDT 2021
TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells.
AIDS (London, England)
Vendrame E,Seiler C,Ranganath T,Zhao NQ,Vergara R,Alary M,Labbé AC,Guédou F,Poudrier J,Holmes S,Roger M,Blish CA
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Fri May 01 00:00:00 EDT 2020
TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells.
AIDS (London, England)
Vendrame E,Seiler C,Ranganath T,Zhao NQ,Vergara R,Alary M,Labbé AC,Guédou F,Poudrier J,Holmes S,Roger M,Blish CA
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Fri May 01 00:00:00 EDT 2020
Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL.
Genome medicine
Wierzbinska JA,Toth R,Ishaque N,Rippe K,Mallm JP,Klett LC,Mertens D,Zenz T,Hielscher T,Seifert M,Küppers R,Assenov Y,Lutsik P,Stilgenbauer S,Roessner PM,Seiffert M,Byrd J,Oakes CC,Plass C,Lipka DB
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Wed Mar 18 00:00:00 EDT 2020
Risk-associated alterations in marrow T cells in pediatric leukemia.
JCI insight
Bailur JK,McCachren SS,Pendleton K,Vasquez JC,Lim HS,Duffy A,Doxie DB,Kaushal A,Foster C,DeRyckere D,Castellino S,Kemp ML,Qiu P,Dhodapkar MV,Dhodapkar KM
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Thu Aug 20 00:00:00 EDT 2020
Exploration of T-Cell Diversity Using Mass Cytometry.
Methods in molecular biology (Clifton, N.J.)
O'Boyle KC,Ohtani T,Manne S,Bengsch B,Henrickson SE,Wherry EJ,Alanio C
16-9500-82 was used in Miscellaneous, Flow Cytometry, Functional Assay to provide R scripts that contain a detailed workflow for initial evaluation of high-dimensional data generated from cohorts of patients.
Tue Jan 26 00:00:00 EST 2021
Imbalance of the CD226/TIGIT Immune Checkpoint Is Involved in the Pathogenesis of Primary Biliary Cholangitis.
Frontiers in immunology
Deng C,Li W,Fei Y,Wang L,Chen Y,Zeng X,Zhang F,Li Y
16-9500 was used in Flow cytometry/Cell sorting to look at PBC patients (n = 42) showing significantly higher proportions of peripheral CD8+ T and CD4+ T cells expressing either CD226 or TIGIT than disease (n = 25) and healthy (n = 30) controls.
Mon Apr 19 00:00:00 EDT 2021
A Comprehensive Analysis of Key Immune Checkpoint Receptors on Tumor-Infiltrating T Cells From Multiple Types of Cancer.
Frontiers in oncology
Li X,Wang R,Fan P,Yao X,Qin L,Peng Y,Ma M,Asley N,Chang X,Feng Y,Hu Y,Zhang Y,Li C,Fanning G,Jones S,Verrill C,Maldonado-Perez D,Sopp P,Waugh C,Taylor S,Mcgowan S,Cerundolo V,Conlon C,McMichael A,Lu S,Wang X,Li N,Dong T
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Sun Jan 10 00:00:00 EST 2021
TIGIT signaling restores suppressor function of Th1 Tregs.
JCI insight
Lucca LE,Axisa PP,Singer ER,Nolan NM,Dominguez-Villar M,Hafler DA
16-9500 was used in Flow cytometry/Cell sorting to demonstrate an important role for TIGIT in controlling the functional stability of Tregs through repression of Akt, suggesting that the TIGIT pathway could be targeted for immunomodulatory therapies in human autoimmune disorders.
Thu Feb 07 00:00:00 EST 2019
Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells.
The Journal of experimental medicine
Seki A,Rutz S
16-9500 was used in Flow cytometry/Cell sorting to develop an optimised approach for Cas9/RNP transfection of primary mouse and human T cells without TCR stimulation, that results in near complete loss of target gene expression at the population level.
Mon Mar 05 00:00:00 EST 2018
PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells.
Frontiers in immunology
Stecher C,Battin C,Leitner J,Zettl M,Grabmeier-Pfistershammer K,Höller C,Zlabinger GJ,Steinberger P
16-9500 was used in Flow cytometry/Cell sorting to use human T cells stimulated with allogeneic dendritic cells were used to compare immune checkpoint inhibitors targeting TIM-3, BTLA, LAG-3, CTLA-4 and TIGIT alone or in combination with a PD-1 antibody.
Wed Mar 30 00:00:00 EDT 2022
HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors.
PLoS pathogens
Kinosada H,Yasunaga JI,Shimura K,Miyazato P,Onishi C,Iyoda T,Inaba K,Matsuoka M
16-9500 was used in Flow cytometry/Cell sorting to study how HTLV-1 bZIP factor influences the expression and function of multiple co-inhibitory receptors to induce proliferation of infected T-cells.
Sun Jan 01 00:00:00 EST 2017
OMIP-037: 16-color panel to measure inhibitory receptor signatures from multiple human immune cell subsets.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Belkina AC,Snyder-Cappione JE
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia.
Oncoimmunology
Catakovic K,Gassner FJ,Ratswohl C,Zaborsky N,Rebhandl S,Schubert M,Steiner M,Gutjahr JC,Pleyer L,Egle A,Hartmann TN,Greil R,Geisberger R
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Sat Jan 29 00:00:00 EST 2022
Atorvastatin downregulates co-inhibitory receptor expression by targeting Ras-activated mTOR signalling.
Oncotarget
Okoye I,Namdar A,Xu L,Crux N,Elahi S
16-9500 was used in Flow cytometry/Cell sorting to suggest that statins may hold particular promise in reinvigorating T cell function in chronic conditions.
Fri Nov 17 00:00:00 EST 2017
TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.
PLoS pathogens
Chew GM,Fujita T,Webb GM,Burwitz BJ,Wu HL,Reed JS,Hammond KB,Clayton KL,Ishii N,Abdel-Mohsen M,Liegler T,Mitchell BI,Hecht FM,Ostrowski M,Shikuma CM,Hansen SG,Maurer M,Korman AJ,Deeks SG,Sacha JB,Ndhlovu LC
Published figure using TIGIT monoclonal antibody (Product # 16-9500-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Effect of chorioamnionitis on regulatory T cells in moderate/late preterm neonates.
Human immunology
Rueda CM,Wells CB,Gisslen T,Jobe AH,Kallapur SG,Chougnet CA
Thu Jan 01 00:00:00 EST 2015
Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation.
BMC cancer
Fionda C,Abruzzese MP,Zingoni A,Soriani A,Ricci B,Molfetta R,Paolini R,Santoni A,Cippitelli M
16-9500 was used in Immunofluorescence to explore the anti-myeloma activity of nitric oxide donors.
Thu Jan 22 00:00:00 EST 2015
Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation.
BMC cancer
Fionda C,Abruzzese MP,Zingoni A,Soriani A,Ricci B,Molfetta R,Paolini R,Santoni A,Cippitelli M
16-9500 was used in Immunofluorescence to explore the anti-myeloma activity of nitric oxide donors.
Thu Jan 22 00:00:00 EST 2015
The TIGIT/CD226 axis regulates human T cell function.
Journal of immunology (Baltimore, Md. : 1950)
Lozano E,Dominguez-Villar M,Kuchroo V,Hafler DA
16-9500 was used in Flow cytometry/Cell sorting to demonstrate that TIGIT can inhibit T cell functions by competing with CD226 and can also directly inhibit T cells in a T cell-intrinsic manner.
Sun Apr 15 00:00:00 EDT 2012
