NOTCH1 Monoclonal Antibody (22E5), APC, eBioscience™

core promoter binding transcriptional activator activity, RNA polymerase II transcription factor binding chromatin binding transcription factor activity, sequence-specific DNA binding enzyme inhibitor activity receptor activity Notch binding calcium ion binding protein binding enzyme binding chromatin DNA binding sequence-specific DNA binding metal ion binding protein heterodimerization activity

negative regulation of transcription from RNA polymerase II promoter angiogenesis in utero embryonic development cell fate specification epithelial to mesenchymal transition liver development heart looping sprouting angiogenesis osteoblast fate commitment positive regulation of neuroblast proliferation inflammatory response to antigenic stimulus endocardium development endocardium morphogenesis atrioventricular node development coronary vein morphogenesis aortic valve morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis mitral valve formation epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis cardiac chamber formation cardiac ventricle morphogenesis cardiac atrium morphogenesis cardiac right atrium morphogenesis cardiac left ventricle morphogenesis cardiac right ventricle formation ventricular trabecula myocardium morphogenesis growth involved in heart morphogenesis regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation regulation of cardioblast proliferation Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation cell migration involved in endocardial cushion formation pericardium morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter humoral immune response Notch signaling pathway positive regulation of transcription of Notch receptor target multicellular organism development spermatogenesis determination of left/right symmetry compartment pattern specification axonogenesis foregut morphogenesis endoderm development heart development positive regulation of cell proliferation negative regulation of cell proliferation epidermis development regulation of Notch signaling pathway auditory receptor cell fate commitment glial cell differentiation regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of cell-substrate adhesion negative regulation of myotube differentiation mesenchymal cell development regulation of somitogenesis neural tube development cell differentiation neuron differentiation keratinocyte differentiation negative regulation of ossification lung development embryonic limb morphogenesis regulation of cell migration positive regulation of cell migration positive regulation of BMP signaling pathway negative regulation of BMP signaling pathway forebrain development hair follicle morphogenesis response to muramyl dipeptide embryonic hindlimb morphogenesis tube formation skeletal muscle cell differentiation cellular response to vascular endothelial growth factor stimulus regulation of cell proliferation anagen positive regulation of apoptotic process negative regulation of catalytic activity cell fate commitment negative regulation of cell differentiation positive regulation of endothelial cell differentiation regulation of auditory receptor cell differentiation negative regulation of auditory receptor cell differentiation positive regulation of keratinocyte differentiation negative regulation of myoblast differentiation negative regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of glial cell differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of calcium ion-dependent exocytosis positive regulation of JAK-STAT cascade negative regulation of photoreceptor cell differentiation somatic stem cell division neuron fate commitment astrocyte differentiation positive regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation branching morphogenesis of an epithelial tube regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation regulation of neurogenesis negative regulation of neurogenesis regulation of developmental process cardiac muscle tissue morphogenesis cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation negative regulation of glial cell proliferation cardiac epithelial to mesenchymal transition cardiac septum morphogenesis ventricular septum morphogenesis secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development negative regulation of cell death prostate gland epithelium morphogenesis regulation of epithelial cell proliferation involved in prostate gland development arterial endothelial cell differentiation venous endothelial cell differentiation cardiac vascular smooth muscle cell development endocardial cell differentiation vasculogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis Notch signaling involved in heart development regulation of cell adhesion involved in heart morphogenesis heart trabecula morphogenesis positive regulation of transcription from RNA polymerase II promoter in response to hypoxia left/right axis specification cellular response to follicle-stimulating hormone stimulus interleukin-4 secretion negative regulation of cell migration involved in sprouting angiogenesis negative regulation of canonical Wnt signaling pathway positive regulation of ephrin receptor signaling pathway regulation of extracellular matrix assembly apoptotic process involved in embryonic digit morphogenesis negative regulation of stem cell differentiation negative regulation of anoikis negative regulation of pro-B cell differentiation negative regulation of endothelial cell chemotaxis