Product References
Invasive margin tissue-resident macrophages of high CD163 expression impede responses to T cell-based immunotherapy.
Journal for immunotherapy of cancer
van Elsas MJ,Labrie C,Etzerodt A,Charoentong P,van Stigt Thans JJC,Van Hall T,van der Burg SH
17-6691-82 was used in Flow Cytometry to identify a small but discernible CD163hi macrophage population, with high expression of several tumor-promoting macrophage markers and a functional anti-inflammatory transcriptome profile, but not other macrophages, to be responsible.
Wed Mar 01 00:00:00 EST 2023
NF-κB subunits direct kinetically distinct transcriptional cascades in antigen receptor-activated B cells.
Nature immunology
Zhao M,Chauhan P,Sherman CA,Singh A,Kaileh M,Mazan-Mamczarz K,Ji H,Joy J,Nandi S,De S,Zhang Y,Fan J,Becker KG,Loke P,Zhou W,Sen R
17-6691-82 was used in Flow cytometry/Cell sorting to provide insights into exclusive functions of Rel and RelA in immunity and cancer.
Fri Sep 01 00:00:00 EDT 2023
Guadecitabine increases response to combined anti-CTLA-4 and anti-PD-1 treatment in mouse melanoma in vivo by controlling T-cells, myeloid derived suppressor and NK cells.
Journal of experimental & clinical cancer research : CR
Amaro A,Reggiani F,Fenoglio D,Gangemi R,Tosi A,Parodi A,Banelli B,Rigo V,Mastracci L,Grillo F,Cereghetti A,Tastanova A,Ghosh A,Sallustio F,Emionite L,Daga A,Altosole T,Filaci G,Rosato A,Levesque M,Maio M,Pfeffer U,Croce M
17-6691-82 was used in Immunohistochemistry to indicate Guadecitabine as a promising epigenetic drug to be added to ICBs therapy.
Sat Mar 18 00:00:00 EDT 2023
CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis.
JCI insight
Bauer KM,Nelson MC,Tang WW,Chiaro TR,Brown DG,Ghazaryan A,Lee SH,Weis AM,Hill JH,Klag KA,Tran VB,Thompson JW,Ramstead AG,Monts JK,Marvin JE,Alexander M,Voth WP,Stephens WZ,Ward DM,Petrey AC,Round JL,O'Connell RM
Published figure using EGR2 monoclonal antibody (Product # 17-6691-82) in Flow Cytometry
Mon Oct 10 00:00:00 EDT 2022
Pro-inflammatory immunity supports fibrosis advancement in epidermolysis bullosa: intervention with Ang-(1-7).
EMBO molecular medicine
Bernasconi R,Thriene K,Romero-Fernández E,Gretzmeier C,Kühl T,Maler M,Nauroy P,Kleiser S,Rühl-Muth AC,Stumpe M,Kiritsi D,Martin SF,Hinz B,Bruckner-Tuderman L,Dengjel J,Nyström A
Published figure using EGR2 monoclonal antibody (Product # 17-6691-82) in Flow Cytometry
Thu Oct 07 00:00:00 EDT 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
Published figure using EGR2 monoclonal antibody (Product # 17-6691-82) in Flow Cytometry
Thu Dec 02 00:00:00 EST 2021
CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy.
Nature communications
Rodriguez-Garcia A,Lynn RC,Poussin M,Eiva MA,Shaw LC,O'Connor RS,Minutolo NG,Casado-Medrano V,Lopez G,Matsuyama T,Powell DJ
Published figure using EGR2 monoclonal antibody (Product # 17-6691-82) in Flow Cytometry
Tue Feb 09 00:00:00 EST 2021
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
Published figure using EGR2 monoclonal antibody (Product # 17-6691-82) in Flow Cytometry
Tue Sep 21 00:00:00 EDT 2021
Mycobacterial Trehalose 6,6'-Dimycolate-Induced M1-Type Inflammation.
The American journal of pathology
Nguyen TKT,d'Aigle J,Chinea L,Niaz Z,Hunter RL,Hwang SA,Actor JK
17-6691 was used in Flow cytometry/Cell sorting to investigate the role of trehalose 6,6'-dimycolate (TDM) in the early macrophages response during initiation of granulomas of primary pathology.
Sat Feb 01 00:00:00 EST 2020
Mycobacterial Trehalose 6,6'-Dimycolate-Induced M1-Type Inflammation.
The American journal of pathology
Nguyen TKT,d'Aigle J,Chinea L,Niaz Z,Hunter RL,Hwang SA,Actor JK
17-6691 was used in Flow cytometry/Cell sorting to investigate the role of trehalose 6,6'-dimycolate (TDM) in the early macrophages response during initiation of granulomas of primary pathology.
Sat Feb 01 00:00:00 EST 2020
Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells.
Nature communications
Harsha Krovi S,Zhang J,Michaels-Foster MJ,Brunetti T,Loh L,Scott-Browne J,Gapin L
17-6691 was used in Flow cytometry/Cell sorting to highlight the common requirements for the development of innate-like T cells with a focus on how Hivep3 impacts the maturation of these lymphocytes.
Mon Dec 07 00:00:00 EST 2020
CCR7 defines a precursor for murine iNKT cells in thymus and periphery.
eLife
Wang H,Hogquist KA
17-6691 was used in Flow cytometry/Cell sorting to demonstrate that the thymus is both a source of iNKT progenitors and a site of tissue dependent effector cell differentiation.
Mon Aug 13 00:00:00 EDT 2018
Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.
Immunity, inflammation and disease
Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P
17-6691 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.
Fri Jun 01 00:00:00 EDT 2018
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Mon Jun 05 00:00:00 EDT 2017
A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development.
Nature communications
Mao AP,Ishizuka IE,Kasal DN,Mandal M,Bendelac A
Published figure using EGR2 monoclonal antibody (Product # 17-6691-82) in Flow Cytometry
Mon Oct 16 00:00:00 EDT 2017
Robust growth of avirulent phase II Coxiella burnetii in bone marrow-derived murine macrophages.
PloS one
Cockrell DC,Long CM,Robertson SJ,Shannon JG,Miller HE,Myers L,Larson CL,Starr T,Beare PA,Heinzen RA
17669182 was used in flow cytometry to develop and describe reagents to study Coxiella-macrophage interactions
Wed Sep 06 00:00:00 EDT 2017
Novel Markers to Delineate Murine M1 and M2 Macrophages.
PloS one
Jablonski KA,Amici SA,Webb LM,Ruiz-Rosado Jde D,Popovich PG,Partida-Sanchez S,Guerau-de-Arellano M
17-6691 was used in Flow cytometry/Cell sorting to perform a transcriptome analysis of M1 and M2 macrophages and validate candidate phenotype-specific markers.
Tue Jul 19 00:00:00 EDT 2016
NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology.
PLoS biology
Vahl JC,Heger K,Knies N,Hein MY,Boon L,Yagita H,Polic B,Schmidt-Supprian M
Mon Jan 06 00:00:00 EST 2014
Egr-2 transcription factor is required for Blimp-1-mediated IL-10 production in IL-27-stimulated CD4+ T cells.
European journal of immunology
Iwasaki Y,Fujio K,Okamura T,Yanai A,Sumitomo S,Shoda H,Tamura T,Yoshida H,Charnay P,Yamamoto K
Mon Apr 01 00:00:00 EDT 2013
Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling.
Nature immunology
Seiler MP,Mathew R,Liszewski MK,Spooner CJ,Barr K,Meng F,Singh H,Bendelac A
Sun Feb 05 00:00:00 EST 2012