Product References
Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment.
Cellular & molecular biology letters
Meng Y,Pospiech M,Ali A,Chandwani R,Vergel M,Onyemaechi S,Yaghmour G,Lu R,Alachkar H
25-5981-82 was used in Flow cytometry/Cell sorting to investigate whether targeting CD36 has any detrimental impact on normal hematopoietic cells.
Wed May 24 00:00:00 EDT 2023
MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape.
Molecular cell
Olsen SN,Godfrey L,Healy JP,Choi YA,Kai Y,Hatton C,Perner F,Haarer EL,Nabet B,Yuan GC,Armstrong SA
25-5981-82 was used in Flow cytometry/Cell sorting to show that MLL::AF9 degradation leads to decreases in transcriptional elongation prior to changes in chromatin landscape at select loci and that combined inhibition of chromatin complexes releases the MLL::AF9 oncoprotein from chromatin globally.
Thu Mar 17 00:00:00 EDT 2022
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.
Cell stem cell
Zhang D,Gao X,Li H,Borger DK,Wei Q,Yang E,Xu C,Pinho S,Frenette PS
25-5981-82 was used in Flow cytometry/Cell sorting to reveal an intricate interplay between the microbiota, macrophages, and iron, and their essential roles in regulating critical HSC fate decisions under stress.
Thu Feb 03 00:00:00 EST 2022
A comparative study of mouse bone marrow mesenchymal stem cells isolated using three easy-to-perform approaches.
FEBS open bio
Lu Y,Han Y,Zhou L,Shi G,Bai L,Wang K,Qin C
25-5981-82 was used in Flow Cytometry to provide a fundamental reference for development of MSC isolation methods.
Thu Dec 01 00:00:00 EST 2022
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
Cell metabolism
Wang L,Wang B,Gasek NS,Zhou Y,Cohn RL,Martin DE,Zuo W,Flynn WF,Guo C,Jellison ER,Kim T,Prata LGPL,Palmer AK,Li M,Inman CL,Barber LS,Al-Naggar IMA,Zhou Y,Du W,Kuchel GA,Meves A,Tchkonia T,Kirkland JL,Robson P,Xu M
25-5981-82 was used in Flow cytometry/Cell sorting to establish that p21high cells within fat are sufficient to cause insulin resistance in vivo.
Tue Jan 04 00:00:00 EST 2022
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.
Cell stem cell
Muto T,Guillamot M,Yeung J,Fang J,Bennett J,Nadorp B,Lasry A,Redondo LZ,Choi K,Gong Y,Walker CS,Hueneman K,Bolanos LC,Barreyro L,Lee LH,Greis KD,Vasyliev N,Khodadadi-Jamayran A,Nudler E,Lujambio A,Lowe SW,Aifantis I,Starczynowski DT
25-5981-82 was used in Flow cytometry/Cell sorting to identify signaling states that cooperate with pre-leukemic cells and, notably, the study aimed to uncover the role of the ubiquitin ligase TRAF6 in preventing the transition from a pre-leukemic stage to overt myeloid leukemia by regulating MYC through ubiquitination and acetylation mechanisms.
Thu Feb 03 00:00:00 EST 2022
Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.
Molecular cell
Riedel SS,Lu C,Xie HM,Nestler K,Vermunt MW,Lenard A,Bennett L,Speck NA,Hanamura I,Lessard JA,Blobel GA,Garcia BA,Bernt KM
25-5981-82 was used in Flow cytometry/Cell sorting to detail how the overexpression of a polyQ protein, in the absence of any coding sequence mutation, can be sufficient to cause malignant transformation.
Thu Jun 03 00:00:00 EDT 2021
In Vivo HSC Gene Therapy Using a Bi-modular HDAd5/35++ Vector Cures Sickle Cell Disease in a Mouse Model.
Molecular therapy : the journal of the American Society of Gene Therapy
Li C,Wang H,Georgakopoulou A,Gil S,Yannaki E,Lieber A
25-5981-82 was used in Flow Cytometry to report that, after in vivo hematopoietic stem cell/progenitor (HSPC) transduction with HDAd5/35++ vectors, SB100x transposase-mediated γ-globin gene addition achieved 10%-15% γ-globin of adult mouse globin, resulting in significant but incomplete phenotypic correction in a thalassemia intermedia mouse model.
Wed Feb 03 00:00:00 EST 2021
Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.
Nature communications
Lei H,Xu HZ,Shan HZ,Liu M,Lu Y,Fang ZX,Jin J,Jing B,Xiao XH,Gao SM,Gao FH,Xia L,Yang L,Liu LG,Wang WW,Liu CX,Tong Y,Wu YZ,Zheng JK,Chen GQ,Zhou L,Wu YL
25-5981-82 was used in Flow cytometry/Cell sorting to conclude that targeting USP47 is a promising strategy to overcome TKI resistance and eradicate leukemia stem/progenitor cells in CML.
Mon Jan 04 00:00:00 EST 2021
The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function.
eLife
Clemens Z,Sivakumar S,Pius A,Sahu A,Shinde S,Mamiya H,Luketich N,Cui J,Dixit P,Hoeck JD,Kreuz S,Franti M,Barchowsky A,Ambrosio F
25-5981-82 was used in Flow cytometry/Cell sorting to derive a global metric of growing ''disorderliness'' of aging muscle.
Tue Apr 20 00:00:00 EDT 2021
Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells.
iScience
Gabriely G,Ma D,Siddiqui S,Sun L,Skillin NP,Abou-El-Hassan H,Moreira TG,Donnelly D,da Cunha AP,Fujiwara M,Walton LR,Patel A,Krishnan R,Levine SS,Healy BC,Rezende RM,Murugaiyan G,Weiner HL
25-5981-82 was used in Flow cytometry/Cell sorting to identify a previously unknown function by which LAPHi MCs promote tumor growth and offer therapeutic intervention to target these cells in cancer.
Fri Nov 19 00:00:00 EST 2021
Distinct skeletal stem cell types orchestrate long bone skeletogenesis.
eLife
Ambrosi TH,Sinha R,Steininger HM,Hoover MY,Murphy MP,Koepke LS,Wang Y,Lu WJ,Morri M,Neff NF,Weissman IL,Longaker MT,Chan CK
25-5981-82 was used in Flow Cytometry to address previously unappreciated shortcomings of SSC research.
Mon Jul 19 00:00:00 EDT 2021
Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells.
Nature communications
Freter R,Falletta P,Omrani O,Rasa M,Herbert K,Annunziata F,Minetti A,Krepelova A,Adam L,Käppel S,Rüdiger T,Wang ZQ,Goding CR,Neri F
25-5981-82 was used in Flow Cytometry to identify a dormant OSCARhigh cell population in the small intestine.
Thu Jun 03 00:00:00 EDT 2021
The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.
Cell reports
Azzoni E,Frontera V,Anselmi G,Rode C,James C,Deltcheva EM,Demian AS,Brown J,Barone C,Patelli A,Harman JR,Nicholls M,Conway SJ,Morrissey E,Jacobsen SEW,Sparrow DB,Harris AL,Enver T,de Bruijn MFTR
25-5981-82 was used in Immunocytochemistry-immunoflourescence to investigate how and when the onset of circulation affects Hematopoietic stem cells emergence.
Tue Dec 14 00:00:00 EST 2021
Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA.
Immunity
Soni C,Perez OA,Voss WN,Pucella JN,Serpas L,Mehl J,Ching KL,Goike J,Georgiou G,Ippolito GC,Sisirak V,Reizis B
25-5981-82 was used in Flow Cytometry to establish extrafollicular B cell differentiation into short-lived AFCs as a key mechanism of anti-DNA autoreactivity and reveal a major contribution of pDCs, endosomal Toll-like receptors (TLRs), and IFN-I to this pathway.
Tue Jun 16 00:00:00 EDT 2020
Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia.
The Journal of clinical investigation
Oppezzo A,Bourseguin J,Renaud E,Pawlikowska P,Rosselli F
25-5981 was used in Flow cytometry/Cell sorting to the impact of the constitutive activation of stress signaling pathways on hematopoietic stem cell maintenance and function in Fanconi anemia.
Mon Mar 02 00:00:00 EST 2020
Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia.
The Journal of clinical investigation
Crispin A,Guo C,Chen C,Campagna DR,Schmidt PJ,Lichtenstein D,Cao C,Sendamarai AK,Hildick-Smith GJ,Huston NC,Boudreaux J,Bottomley SS,Heeney MM,Paw BH,Fleming MD,Ducamp S
25-5981 was used in Flow cytometry/Cell sorting to find that HSCB expression was decreased in patient-derived fibroblasts and K562 erythroleukemia cells engineered to have the patient-specific promoter variant.
Thu Oct 01 00:00:00 EDT 2020
BRCA1 Mutational Complementation Induces Synthetic Viability.
Molecular cell
Nacson J,Di Marcantonio D,Wang Y,Bernhardy AJ,Clausen E,Hua X,Cai KQ,Martinez E,Feng W,Callén E,Wu W,Gupta GP,Testa JR,Nussenzweig A,Sykes SM,Johnson N
25-5981-82 was used in Flow Cytometry to investigate the dual roles of BRCA1 in homologous recombination.
Thu Jun 04 00:00:00 EDT 2020
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Developmental cell
Wei Q,Nakahara F,Asada N,Zhang D,Gao X,Xu C,Alfieri A,Brodin NP,Zimmerman SE,Mar JC,Guha C,Guo W,Frenette PS
25-5981-82 was used in Flow Cytometry to conclude that SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppression of osteopontin expression.
Mon Jun 08 00:00:00 EDT 2020
The lifespan quantitative trait locus gene Securin controls hematopoietic progenitor cell function.
Haematologica
Brown A,Schuetz D,Han Y,Daria D,Nattamai KJ,Eiwen K,Sakk V,Pospiech J,Saller T,van Zant G,Wagner W,Geiger H
25-5981 was used in Flow cytometry/Cell sorting to investigate the pituitary tumour-transforming gene-1 (pttg1)/securin and it's role in regulating differential responses of hematopoietic stem and progenitor cells.
Tue Apr 27 00:00:00 EDT 2021
TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts.
Journal of cell science
Contreras O,Soliman H,Theret M,Rossi FMV,Brandan E
25-5981 was used in Flow cytometry/Cell sorting to show that TGF-β requires histone deacetylase activity to repress the expression of TCF7L2.
Fri Jun 19 00:00:00 EDT 2020
Connecting secretome to hematopoietic stem cell phenotype shifts in an engineered bone marrow niche.
Integrative biology : quantitative biosciences from nano to macro
Gilchrist AE,Harley BAC
25-5981-82 was used in Flow Cytometry to investigate the mechanism of how marrow-derived mesenchymal stromal and progenitor cells impacts hematopoietic stem cells fate decisions.
Fri Jul 10 00:00:00 EDT 2020
Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements.
JCI insight
Wang H,Georgakopoulou A,Li C,Liu Z,Gil S,Bashyam A,Yannaki E,Anagnostopoulos A,Pande A,Izsvák Z,Papayannopoulou T,Lieber A
25-5981 was used in Flow cytometry/Cell sorting to demonstrate that hematopoietic stem/progenitor cell (HSPC) mobilization followed by intravenous injection of integrating, helper-dependent adenovirus HDAd5/35++ vectors resulted in efficient transduction of long-term repopulating cells and disease amelioration in mouse models after in vivo selection of transduced HSPCs.
Thu Aug 20 00:00:00 EDT 2020
Androgen Receptor Signaling Positively Regulates Monocytic Development.
Frontiers in immunology
Consiglio CR,Gollnick SO
25-5981 was used in Flow cytometry/Cell sorting to investigate the role of androgen signaling in monocytic differentiation with a genetic mouse model of myeloid androgen receptor (AR) knockout (MARKO) and pharmacological inhibition of AR.
Thu Apr 29 00:00:00 EDT 2021
Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors.
Cell stem cell
Soliman H,Paylor B,Scott RW,Lemos DR,Chang C,Arostegui M,Low M,Lee C,Fiore D,Braghetta P,Pospichalova V,Barkauskas CE,Korinek V,Rampazzo A,MacLeod K,Underhill TM,Rossi FMV
25-5981 was used in Flow cytometry/Cell sorting to identifyheart-resident PDGFRa+ SCA-1+ cells as cardiac fibro/adipogenic progenitors (cFAPs) and show that they respond to ischemic damage by generating fibrogenic cells.
Thu Feb 06 00:00:00 EST 2020
β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.
Nature communications
Giannini S,Lee-Sundlov MM,Rivadeneyra L,Di Buduo CA,Burns R,Lau JT,Falet H,Balduini A,Hoffmeister KM
25-5981 was used in Flow cytometry/Cell sorting to identify the conserved B4galt1 gene as a critical regulator of thrombopoiesis in megakaryocytes.
Fri Jan 17 00:00:00 EST 2020
Dynamics of Asymmetric and Symmetric Divisions of Muscle Stem Cells In Vivo and on Artificial Niches.
Cell reports
Evano B,Khalilian S,Le Carrou G,Almouzni G,Tajbakhsh S
25-5981 was used in Flow cytometry/Cell sorting to generate SNAP-tagged histone H3-reporter mice and find that, unlike fly germline stem cells, differential fate outcomes are associated with a symmetric distribution of the H3.1 and H3.3 histone variants in mouse muscle stem cells.
Tue Mar 10 00:00:00 EDT 2020
Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Cell reports
Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR
25-5981 was used in Flow cytometry/Cell sorting to investigate the effects of loss of ld genes on adult endothelial cell.
Tue Apr 28 00:00:00 EDT 2020
Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.
Cell metabolism
Hao X,Gu H,Chen C,Huang D,Zhao Y,Xie L,Zou Y,Shu HS,Zhang Y,He X,Lai X,Zhang X,Zhou BO,Zhang CC,Chen GQ,Yu Z,Yang Y,Zheng J
25-5981 was used in Flow cytometry/Cell sorting to provide a unique angle for the study of metabolisms in stem cells, and may lead to development of novel strategies for cancer treatment.
Tue Apr 02 00:00:00 EDT 2019
Cross-talk between TGF-β and PDGFRα signaling pathways regulates the fate of stromal fibro-adipogenic progenitors.
Journal of cell science
Contreras O,Cruz-Soca M,Theret M,Soliman H,Tung LW,Groppa E,Rossi FM,Brandan E
25-5981 was used in Flow cytometry/Cell sorting to investigate the role of functional cross-talk between TGF-β and PDGFRα signaling pathways in the fate of fibro-adipogenic progenitors (FAPs).
Wed Oct 09 00:00:00 EDT 2019
Pharmacological exposures may precipitate craniosynostosis through targeted stem cell depletion.
Stem cell research
Durham E,Howie RN,Larson N,LaRue A,Cray J
25-5981-82 was used in Flow Cytometry to hypothesize that pharmacological exposures including excess thyroid hormone, nicotine, and SSRIs lead to an alteration of stem cells within the sutures resulting in premature fusion.
Tue Oct 01 00:00:00 EDT 2019
Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq.
iScience
Kwon OJ,Zhang Y,Li Y,Wei X,Zhang L,Chen R,Creighton CJ,Xin L
25-5981 was used in Flow cytometry/Cell sorting to characterise mouse Prostate stromal cells heterogeneity by single-cell RNA-seq.
Fri Mar 29 00:00:00 EDT 2019
Analysis of Hematopoietic Stem Progenitor Cell Metabolism.
Journal of visualized experiments : JoVE
Scapin G,Goulard MC,Dharampuriya PR,Cillis JL,Shah DI
25-5981 was used in Flow cytometry/Cell sorting to provide a set of clear, step-by-step instructions to measure metabolic respiration (oxygen consumption rate; OCR) and glycolysis (extracellular acidification rate; ECAR) of murine bone marrow-LineagenegSca1+c-Kit+ (LSK) HSPCs.
Sat Nov 09 00:00:00 EST 2019
Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis.
Science advances
van de Vlekkert D,Demmers J,Nguyen XX,Campos Y,Machado E,Annunziata I,Hu H,Gomero E,Qiu X,Bongiovanni A,Feghali-Bostwick CA,d'Azzo A
25-5981-82 was used in Flow Cytometry to reveal an unexpected exosome-mediated signaling pathway downstream of NEU1 deficiency that propagates a fibrotic disease and could be implicated in idiopathic forms of fibrosis in humans.
Mon Jul 01 00:00:00 EDT 2019
N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells.
Cell reports
Zhao M,Tao F,Venkatraman A,Li Z,Smith SE,Unruh J,Chen S,Ward C,Qian P,Perry JM,Marshall H,Wang J,He XC,Li L
25-5981 was used in Flow cytometry/Cell sorting to report that N-cad+ cells were functional bone and marrow stromal progenitor cells, giving rise to osteoblasts, adipocytes, and chondrocytes both in vitro and in vivo.
Tue Jan 15 00:00:00 EST 2019
c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells.
Cell reports
Shikatani EA,Besla R,Ensan S,Upadhye A,Khyzha N,Li A,Emoto T,Chiu F,Degousee N,Moreau JM,Perry HM,Thayaparan D,Cheng HS,Pacheco S,Smyth D,Noyan H,Zavitz CCJ,Bauer CMT,Hilgendorf I,Libby P,Swirski FK,Gommerman JL,Fish JE,Stampfli MR,Cybulsky MI,Rubin BB,Paige CJ,Bender TP,McNamara CA,Husain M,Robbins CS
25-5981-82 was used in Flow Cytometry to identify the nuclear transcription factor c-Myb as an important mediator of atherosclerotic disease in mice.
Tue May 21 00:00:00 EDT 2019
Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.
Frontiers in immunology
Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ
25-5981-82 was used in Flow Cytometry to indicate that CFH, through its function as a complement repressor, acts as a negative regulator of BCR signaling and limits autoimmunity.
Tue Oct 13 00:00:00 EDT 2020
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.
Nature medicine
Zhang B,Nguyen LXT,Li L,Zhao D,Kumar B,Wu H,Lin A,Pellicano F,Hopcroft L,Su YL,Copland M,Holyoake TL,Kuo CJ,Bhatia R,Snyder DS,Ali H,Stein AS,Brewer C,Wang H,McDonald T,Swiderski P,Troadec E,Chen CC,Dorrance A,Pullarkat V,Yuan YC,Perrotti D,Carlesso N,Forman SJ,Kortylewski M,Kuo YH,Marcucci G
25-5981 was used in Flow cytometry/Cell sorting to demonstrate how bone marrow endothelial cells supply miR-126 to leukemia stem cells in chronic myelogenous leukemia which modulates their quiescence and self-renewal.
Tue May 01 00:00:00 EDT 2018
Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.
Nature
Garaycoechea JI,Crossan GP,Langevin F,Mulderrig L,Louzada S,Yang F,Guilbaud G,Park N,Roerink S,Nik-Zainal S,Stratton MR,Patel KJ
25-5981 was used in Flow cytometry/Cell sorting to identify how the choice of DNA-repair pathway and a stringent p53 response limit the transmission of aldehyde-induced mutations in stem cells.
Thu Jan 11 00:00:00 EST 2018
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling.
Immunity
Spidale NA,Sylvia K,Narayan K,Miu B,Frascoli M,Melichar HJ,Zhihao W,Kisielow J,Palin A,Serwold T,Love P,Kobayashi M,Yoshimoto M,Jain N,Kang J
25-5981-82 was used in Flow Cytometry to generate reporter mice for the Tγδ17 lineage-defining transcription factor SOX13 and identify fetal-origin, intrathymic Sox13+ progenitors.
Tue Nov 20 00:00:00 EST 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
25-5981 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.
Cancer cell
Lee SC,North K,Kim E,Jang E,Obeng E,Lu SX,Liu B,Inoue D,Yoshimi A,Ki M,Yeo M,Zhang XJ,Kim MK,Cho H,Chung YR,Taylor J,Durham BH,Kim YJ,Pastore A,Monette S,Palacino J,Seiler M,Buonamici S,Smith PG,Ebert BL,Bradley RK,Abdel-Wahab O
25-5981 was used in Flow cytometry/Cell sorting to identify shared consequences of splicing-factor mutations and the basis for their mutual exclusivity.
Mon Aug 13 00:00:00 EDT 2018
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Cell stem cell
Hsu JI,Dayaram T,Tovy A,De Braekeleer E,Jeong M,Wang F,Zhang J,Heffernan TP,Gera S,Kovacs JJ,Marszalek JR,Bristow C,Yan Y,Garcia-Manero G,Kantarjian H,Vassiliou G,Futreal PA,Donehower LA,Takahashi K,Goodell MA
25-5981 was used in Flow cytometry/Cell sorting to establish the clinical relevance of PPM1D mutations in clonal haematopoiesis and the importance of studying mutation-treatment interactions.
Thu Nov 01 00:00:00 EDT 2018
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell stem cell
Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H
25-5981 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.
Thu Apr 05 00:00:00 EDT 2018
Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential.
Cell stem cell
Judson RN,Quarta M,Oudhoff MJ,Soliman H,Yi L,Chang CK,Loi G,Vander Werff R,Cait A,Hamer M,Blonigan J,Paine P,Doan LTN,Groppa E,He W,Su L,Zhang RH,Xu P,Eisner C,Low M,Barta I,Lewis CB,Zaph C,Karimi MM,Rando TA,Rossi FM
25-5981-82 was used in Flow Cytometry to reveal that in vitro expansion of MuSCS and subsequent yields are obstructed by methyltransferase Setd7, which can be bypassed through its inhibition, improving respective therapeutic prospects.
Thu Feb 01 00:00:00 EST 2018
Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.
Blood advances
Su H,Sun CW,Liu SM,He X,Hu H,Pawlik KM,Townes TM,Han X,Klug CA,Henary M,Chen Y,Li L,Zheng YG,Zhao X
25-5981 was used in Flow cytometry/Cell sorting to characterise the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.
Tue Nov 13 00:00:00 EST 2018
Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis.
Journal of cell science
Pala F,Di Girolamo D,Mella S,Yennek S,Chatre L,Ricchetti M,Tajbakhsh S
25-5981 was used in Flow cytometry/Cell sorting to characterise the metabolic pathways that mediate the commitment and differentiation of mouse skeletal muscle stem cells, and how their modulation can influence the cell state.
Fri Jul 27 00:00:00 EDT 2018
Small-RNA sequencing identifies dynamic microRNA deregulation during skeletal muscle lineage progression.
Scientific reports
Castel D,Baghdadi MB,Mella S,Gayraud-Morel B,Marty V,Cavaillé J,Antoniewski C,Tajbakhsh S
25-5981 was used in Flow cytometry/Cell sorting to uncover a key resource for functional analyses of miRNAs in skeletal myogenesis and in the regulation of stem cell self-renewal and tissue homeostasis.
Fri Mar 09 00:00:00 EST 2018
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Cell stem cell
Qian P,De Kumar B,He XC,Nolte C,Gogol M,Ahn Y,Chen S,Li Z,Xu H,Perry JM,Hu D,Tao F,Zhao M,Han Y,Hall K,Peak A,Paulson A,Zhao C,Venkatraman A,Box A,Perera A,Haug JS,Parmely T,Li H,Krumlauf R,Li L
25-5981 was used in Flow cytometry/Cell sorting to demonstrate roles for retinoid signaling and the DERARE in maintaining HSCs and preventing leukemogenesis by coordinate regulation of Hoxb genes.
Thu May 03 00:00:00 EDT 2018
MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.
Frontiers in immunology
Knolle MD,Chin SB,Rana BMJ,Englezakis A,Nakagawa R,Fallon PG,Git A,McKenzie ANJ
25-5981 was used in Flow cytometry/Cell sorting to identify a subset of micro-RNAs that are regulated upon group-2 innate lymphoid cells (ILC2) activation, and establish a specific role for miR-155 in regulating ILC2 survival following activation.
Mon Sep 30 00:00:00 EDT 2019
Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.
Cell reports
Barros-Silva JD,Linn DE,Steiner I,Guo G,Ali A,Pakula H,Ashton G,Peset I,Brown M,Clarke NW,Bronson RT,Yuan GC,Orkin SH,Li Z,Baena E
25-5981 was used in Flow cytometry/Cell sorting to analyse the molecular heterogeneity in basal and luminal prostate compartments.
Tue Dec 18 00:00:00 EST 2018
Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply.
Nature communications
Liu C,Han T,Stachura DL,Wang H,Vaisman BL,Kim J,Klemke RL,Remaley AT,Rana TM,Traver D,Miller YI
25-5981 was used in Flow cytometry/Cell sorting to demonstrate the requirement for lipoprotein lipase activity in haematopoietic stem progenitor cell maintenance.
Tue Apr 03 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
25-5981 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 EST 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
25-5981 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.
Tue Jul 10 00:00:00 EDT 2018
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Nature medicine
Schneider C,Oellerich T,Baldauf HM,Schwarz SM,Thomas D,Flick R,Bohnenberger H,Kaderali L,Stegmann L,Cremer A,Martin M,Lohmeyer J,Michaelis M,Hornung V,Schliemann C,Berdel WE,Hartmann W,Wardelmann E,Comoglio F,Hansmann ML,Yakunin AF,Geisslinger G,Ströbel P,Ferreirós N,Serve H,Keppler OT,Cinatl J
25598182 was used in flow cytometry to demonstrate that SAMHD1 reduces nucleoside analog cytarabine cytotoxicity in acute myeloid leukemia cells
Wed Feb 01 00:00:00 EST 2017
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.
Nature medicine
Fenouille N,Bassil CF,Ben-Sahra I,Benajiba L,Alexe G,Ramos A,Pikman Y,Conway AS,Burgess MR,Li Q,Luciano F,Auberger P,Galinsky I,DeAngelo DJ,Stone RM,Zhang Y,Perkins AS,Shannon K,Hemann MT,Puissant A,Stegmaier K
25-5981 was used in Flow cytometry/Cell sorting to investigate the effect of MECOM on cellular metabolism.
Wed Mar 01 00:00:00 EST 2017
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Nature immunology
Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT
25-5981 was used in Flow cytometry/Cell sorting to examine the significance of ubiquitin signalling in coordinating RNA processing by Toll-like receptor pathways during an immune response and in premalignant haematologic diseases.
Wed Feb 01 00:00:00 EST 2017
Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy.
Cancer research
Huang WY,Lai SF,Chiu HY,Chang M,Plikus MV,Chan CC,Chen YT,Tsao PN,Yang TL,Lee HS,Chi P,Lin SJ
25-5981 was used in Flow cytometry/Cell sorting to identify that hair follicles mobilise ectopic progenitors from distinct transit-amplifying cell compartments for regeneration in adaptation to the severity of dystrophy induced by ionising radiation.
Wed Nov 15 00:00:00 EST 2017
Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle.
Cell stem cell
Chiche A,Le Roux I,von Joest M,Sakai H,Aguín SB,Cazin C,Salam R,Fiette L,Alegria O,Flamant P,Tajbakhsh S,Li H
25-5981 was used in Flow cytometry/Cell sorting to study the effects of acute and chronic injury on transcription-factor-mediated reprogramming in skeletal muscle.
Thu Mar 02 00:00:00 EST 2017
Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis.
Stem cell research & therapy
Xue XL,Han XD,Li Y,Chu XF,Miao WM,Zhang JL,Fan SJ
25-5981 was used in Flow cytometry/Cell sorting to suggest that ATX could be used as a potent therapeutic agent to protect the hematopoietic system against TBI-induced bone marrow suppression.
Mon Jan 23 00:00:00 EST 2017
Understanding Hematopoietic Stem Cell Development through Functional Correlation of Their Proliferative Status with the Intra-aortic Cluster Architecture.
Stem cell reports
Batsivari A,Rybtsov S,Souilhol C,Binagui-Casas A,Hills D,Zhao S,Travers P,Medvinsky A
25-5981 was used in Flow cytometry/Cell sorting to observe time-specific changes in intra-aortic hematopoietic clusters corresponding to HSC maturation stages.
Tue Jun 06 00:00:00 EDT 2017
Selective Expression of Flt3 within the Mouse Hematopoietic Stem Cell Compartment.
International journal of molecular sciences
Mooney CJ,Cunningham A,Tsapogas P,Toellner KM,Brown G
25-5981 was used in Flow cytometry/Cell sorting to investigate the functional heterogeneity of hematopoietic stem and progenitor cell populations.
Fri May 12 00:00:00 EDT 2017
Inhibition of Stat3 signaling ameliorates atrophy of the soleus muscles in mice lacking the vitamin D receptor.
Skeletal muscle
Gopinath SD
25-5981 was used in Flow cytometry/Cell sorting to analyse the role of signal transducer and activator of transcription 3 (Stat3) signaling in the skeletal muscles of mice.
Wed Jan 25 00:00:00 EST 2017
Identification of blood vascular endothelial stem cells by the expression of protein C receptor.
Cell research
Yu QC,Song W,Wang D,Zeng YA
25-5981 was used in Flow cytometry/Cell sorting to investigate the existence and identity of vascular endothelial stem cells, showing that these cells express the protein C receptor.
Sat Oct 01 00:00:00 EDT 2016
MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C.
The Journal of clinical investigation
Zhu N,Chen M,Eng R,DeJong J,Sinha AU,Rahnamay NF,Koche R,Al-Shahrour F,Minehart JC,Chen CW,Deshpande AJ,Xu H,Chu SH,Ebert BL,Roeder RG,Armstrong SA
25-5981 was used in Flow cytometry/Cell sorting to show that loss of JMJD1C substantially decreased LSC frequency and caused differentiation of MLL-AF9- and homeobox A9-driven leukemias.
Tue Mar 01 00:00:00 EST 2016
Fibrillin-1 microfibrils influence adult bone marrow hematopoiesis.
Matrix biology : journal of the International Society for Matrix Biology
Smaldone S,Bigarella CL,Del Solar M,Ghaffari S,Ramirez F
25-5981 was used in Flow cytometry/Cell sorting to investigate adult haematopoiesis in mice with Cre-mediated inactivation of the fibrillin-1 gene in the mesenchyme of the forming limbs.
Wed Dec 20 00:00:00 EST 2017
In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.
PloS one
Guo H,Cooper S,Friedman AD
25-5981 was used in Flow cytometry/Cell sorting to study how the in vivo deletion of the Cebpa +37kb enhancer reduces Cebpa mRNA in myeloid progenitors but not in non-hematopoietic tissues impairing granulopoiesis.
Mon Aug 01 00:00:00 EDT 2016
Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2-/- Hematopoietic Stem and Progenitor Cells.
Stem cell reports
Yoon YM,Storm KJ,Kamimae-Lanning AN,Goloviznina NA,Kurre P
25-5981 was used in Flow cytometry/Cell sorting to elucidate the role of Fanconi anemia proteins in HSPC development.
Tue Nov 08 00:00:00 EST 2016
The non-canonical Wnt receptor Ryk regulates hematopoietic stem cell repopulation in part by controlling proliferation and apoptosis.
Cell death & disease
Famili F,Perez LG,Naber BA,Noordermeer JN,Fradkin LG,Staal FJ
25-5981 was used in Flow cytometry/Cell sorting to investigate the role of the non-canonical Wnt receptor Ryk in haematopoiesis and lymphoid development.
Thu Nov 24 00:00:00 EST 2016
Targeting megakaryocytic-induced fibrosis in myeloproliferative neoplasms by AURKA inhibition.
Nature medicine
Wen QJ,Yang Q,Goldenson B,Malinge S,Lasho T,Schneider RK,Breyfogle LJ,Schultz R,Gilles L,Koppikar P,Abdel-Wahab O,Pardanani A,Stein B,Gurbuxani S,Mullally A,Levine RL,Tefferi A,Crispino JD
25-5981 was used in Flow cytometry/Cell sorting to demonstrate that megakaryocytes drive fibrosis in PMF and that targeting them with AURKA inhibitors has the potential for therapeutic benefit.
Tue Dec 01 00:00:00 EST 2015
Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.
Blood
Kosoff RE,Aslan JE,Kostyak JC,Dulaimi E,Chow HY,Prudnikova TY,Radu M,Kunapuli SP,McCarty OJ,Chernoff J
25-5981 was used in Flow cytometry/Cell sorting to identify a novel role for Pak2 as an important regulator of megakaryopoiesis, polyploidization and cytoskeletal mechanics in developing megakaryocytes.
Thu May 07 00:00:00 EDT 2015
Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis.
The Journal of clinical investigation
Liu F,Cheng G,Hamard PJ,Greenblatt S,Wang L,Man N,Perna F,Xu H,Tadi M,Luciani L,Nimer SD
25-5981 was used in Flow cytometry/Cell sorting to demonstrate that PRMT5 plays distinct roles in hematopoietic stem and progenitor cell behaviour and is essential for adult hematopoietic cell maintenance.
Tue Sep 01 00:00:00 EDT 2015
Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Free radical biology & medicine
Xu G,Wu H,Zhang J,Li D,Wang Y,Wang Y,Zhang H,Lu L,Li C,Huang S,Xing Y,Zhou D,Meng A
25-5981 was used in Flow cytometry/Cell sorting to study how metformin has the potential to be used as a novel radioprotectant to ameliorate TBI-induced long-term BM injury.
Thu Oct 01 00:00:00 EDT 2015
Transcriptional Pathways in cPGI2-Induced Adipocyte Progenitor Activation for Browning.
Frontiers in endocrinology
Bayindir I,Babaeikelishomi R,Kocanova S,Sousa IS,Lerch S,Hardt O,Wild S,Bosio A,Bystricky K,Herzig S,Vegiopoulos A
25-5981 was used in Magnetic cell separation to develop models for the mechanistic investigation of progenitor-mediated beige/brite adipocyte differentiation.
Tue Sep 08 00:00:00 EDT 2015
EphA2 Is a Therapy Target in EphA2-Positive Leukemias but Is Not Essential for Normal Hematopoiesis or Leukemia.
PloS one
Charmsaz S,Beckett K,Smith FM,Bruedigam C,Moore AS,Al-Ejeh F,Lane SW,Boyd AW
25-5981 was used in Flow cytometry/Cell sorting to explore the role of EphA2 in haematopoiesis and leukaemogenesis.
Tue May 03 00:00:00 EDT 2016
Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.
PloS one
Povinelli BJ,Kokolus KM,Eng JW,Dougher CW,Curtin L,Capitano ML,Sailsbury-Ruf CT,Repasky EA,Nemeth MJ
25-5981 was used in Flow cytometry/Cell sorting to demonstrate that chronic stress of laboratory mice increases the resistance of hematopoietic stem and progenitor cells to irradiation-induced apoptosis.
Tue Feb 09 00:00:00 EST 2016
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Nature medicine
Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA
25-5981 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.
Wed Oct 01 00:00:00 EDT 2014
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Nature medicine
Bruns I,Lucas D,Pinho S,Ahmed J,Lambert MP,Kunisaki Y,Scheiermann C,Schiff L,Poncz M,Bergman A,Frenette PS
25-5981 was used in Flow cytometry/Cell sorting to indicate that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior.
Sat Nov 01 00:00:00 EDT 2014
Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2-inducing allergen exposures.
The Journal of allergy and clinical immunology
Gold MJ,Antignano F,Halim TY,Hirota JA,Blanchet MR,Zaph C,Takei F,McNagny KM
25-5981 was used in Flow cytometry/Cell sorting to reveal a critical role for ILC2s in the development of adaptive type 2 responses to local antigen exposure.
Tue Apr 01 00:00:00 EDT 2014
Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells.
Molecular metabolism
Singer K,DelProposto J,Morris DL,Zamarron B,Mergian T,Maley N,Cho KW,Geletka L,Subbaiah P,Muir L,Martinez-Santibanez G,Lumeng CN
25-5981 was used in Flow cytometry/Cell sorting to demonstrate how metabolic signals potentiate leukocyte production and dietary priming of haematopoietic progenitors contributes to adipose tissue inflammation.
Mon Sep 01 00:00:00 EDT 2014
The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells.
Journal of leukocyte biology
Guo H,Ma O,Friedman AD
25-5981 was used in Flow cytometry/Cell sorting to assess the selectiveness of the C/EBPα enhancer to regulate gene expression in particular cell types.
Mon Sep 01 00:00:00 EDT 2014
Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.
Stem cells (Dayton, Ohio)
Povinelli BJ,Nemeth MJ
25-5981 was used in Flow cytometry/Cell sorting to study whether Ryk protein regulates the response of haematopoietic stem cells to Wnt5a.
Wed Jan 01 00:00:00 EST 2014
Dasatinib targets B-lineage cells but does not provide an effective therapy for myeloproliferative disease in c-Cbl RING finger mutant mice.
PloS one
Duyvestyn JM,Taylor SJ,Dagger SA,Orandle M,Morse HC,Thien CB,Langdon WY
25-5981 was used in Flow cytometry/Cell sorting to determine whether the multi-kinase inhibitor dasatinib would provide an effective therapy for myeloproliferative diseases involving c-Cbl mutations.
Mon Jun 29 00:00:00 EDT 2015
LT-HSC Methylcellulose Assay.
Bio-protocol
Kerenyi MA
25-5981-82 was used in Flow cytometry/Cell sorting to describe an LT-HSCs methylcellulose colony-forming assay, as a fast complementary in vitro method to directly assess LT-HSC differentiation capacity.
Sat May 03 00:00:00 EDT 2014
Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
The Journal of biological chemistry
Ito K,Yamazaki S,Yamamoto R,Tajima Y,Yanagida A,Kobayashi T,Kato-Itoh M,Kakuta S,Iwakura Y,Nakauchi H,Kamiya A
25-5981 was used in Flow cytometry/Cell sorting to investigate the precise role and expression pattern of brain-expressed X-linked genes in endocrine and tissue stem/progenitor cells in mice.
Fri Oct 24 00:00:00 EDT 2014
Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells.
PloS one
Ma O,Hong S,Guo H,Ghiaur G,Friedman AD
25-5981 was used in Flow cytometry/Cell sorting to demonstrate that C/EBPα silencing or knockdown alters myeloid lineage specification and differing levels favour granulocyte/monocyte specification.
Thu Jun 25 00:00:00 EDT 2015
Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells.
Nature communications
Kwon OJ,Valdez JM,Zhang L,Zhang B,Wei X,Su Q,Ittmann MM,Creighton CJ,Xin L
25-5981 was used in Flow cytometry/Cell sorting to study a pro-metastatic function of Notch signalling during prostate cancer progression.
Tue Jul 22 00:00:00 EDT 2014
Correlated miR-mRNA expression signatures of mouse hematopoietic stem and progenitor cell subsets predict "Stemness" and "Myeloid" interaction networks.
PloS one
Heiser D,Tan YS,Kaplan I,Godsey B,Morisot S,Cheng WC,Small D,Civin CI
25-5981 was used in Flow cytometry/Cell sorting to demonstrate the regulation of intricate haematopoietic networks by miRNAs.
Thu Jan 15 00:00:00 EST 2015
Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9.
Molecular therapy. Methods & clinical development
Stitelman DH,Brazelton T,Bora A,Traas J,Merianos D,Limberis M,Davey M,Flake AW
25-5981 was used in Flow cytometry/Cell sorting to study the efficiency of gene transfer via adeno-associated virus vector serotype 2/9 to muscle satellite cells at different developmental stages, to show that higher efficiency of transfer occurs at E16 when satellite cells (muscle stem cells) migrate.
Wed May 27 00:00:00 EDT 2015
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
Cell
Yamamoto R,Morita Y,Ooehara J,Hamanaka S,Onodera M,Rudolph KL,Ema H,Nakauchi H
25-5981 was used in Flow cytometry/Cell sorting to identify multipotent progenitors of myeloid cells and study differentiation pathways giving rise to common myeloid cells.
Thu Aug 29 00:00:00 EDT 2013
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress.
Blood
Singh RP,Franke K,Kalucka J,Mamlouk S,Muschter A,Gembarska A,Grinenko T,Willam C,Naumann R,Anastassiadis K,Stewart AF,Bornstein S,Chavakis T,Breier G,Waskow C,Wielockx B
25-5981 was used in Flow cytometry/Cell sorting to study the role of PHD2 in HSC compartment maintenance.
Thu Jun 27 00:00:00 EDT 2013
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice.
Blood
Doyle AD,Jacobsen EA,Ochkur SI,McGarry MP,Shim KG,Nguyen DT,Protheroe C,Colbert D,Kloeber J,Neely J,Shim KP,Dyer KD,Rosenberg HF,Lee JJ,Lee NA
25-5981 was used in Flow cytometry/Cell sorting to investigate the contributions of the granule proteins MBP-1 and EPX to eosinophil activity using double knockout mice.
Thu Aug 01 00:00:00 EDT 2013
p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.
Leukemia
Raman R,Kumar RS,Hinge A,Kumar S,Nayak R,Xu J,Szczur K,Cancelas JA,Filippi MD
25-5981 was used in Flow cytometry/Cell sorting to show that p190-B regulates the conditions for normal haematopoiesis during development.
Fri Nov 01 00:00:00 EDT 2013
Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils.
Journal of leukocyte biology
Doyle AD,Jacobsen EA,Ochkur SI,Willetts L,Shim K,Neely J,Kloeber J,Lesuer WE,Pero RS,Lacy P,Moqbel R,Lee NA,Lee JJ
25-5981 was used in Flow cytometry/Cell sorting to develop a novel murine strain to allow a better definition of the role of eosinophils in health and disease.
Mon Jul 01 00:00:00 EDT 2013
Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.
The American journal of pathology
Guijarro MV,Dahiya S,Danielson LS,Segura MF,Vales-Lara FM,Menendez S,Popiolek D,Mittal K,Wei JJ,Zavadil J,Cordon-Cardo C,Pandolfi PP,Hernando E
25-5981 was used in Flow cytometry/Cell sorting to elucidate the mechanisms driving cytogenetically complex sarcoma development.
Sat Jun 01 00:00:00 EDT 2013
Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.
Molecular and cellular biology
Yasunaga S,Ohtsubo M,Ohno Y,Saeki K,Kurogi T,Tanaka-Okamoto M,Ishizaki H,Shirai M,Mihara K,Brock HW,Miyoshi J,Takihara Y
25-5981 was used in Flow cytometry/Cell sorting to investigate the effects of Scmh1 on Geminin and Histone H2A, and the mechanisms therein.
Fri Feb 01 00:00:00 EST 2013
Flow cytometry analysis of murine hematopoietic stem cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Mayle A,Luo M,Jeong M,Goodell MA
25-5981 was used in Flow cytometry/Cell sorting to discuss methods for rapid flow cytometric analysis of peripheral blood cell types and novel strategies for working with rare cell populations such as hematopoietic stem cells in the analysis of cell cycle status by BrdU, Ki-67, and Pyronin Y staining.
Tue Jan 01 00:00:00 EST 2013
NF-Y is necessary for hematopoietic stem cell proliferation and survival.
Blood
Bungartz G,Land H,Scadden DT,Emerson SG
25-5981 was used in Flow cytometry/Cell sorting to show that the trimeric transcription factor NF-Y is critical for the survival of cycling, but not quiescent hematopoietic stem cells.
Thu Feb 09 00:00:00 EST 2012
Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner.
Blood
Capitano ML,Nemeth MJ,Mace TA,Salisbury-Ruf C,Segal BH,McCarthy PL,Repasky EA
25-5981 was used in Flow cytometry/Cell sorting to study the factors limiting the immune system recovery process after chemo- and radiotherapy.
Thu Sep 27 00:00:00 EDT 2012
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Blood
de Bruin AM,Libregts SF,Valkhof M,Boon L,Touw IP,Nolte MA
25-5981 was used in Flow cytometry/Cell sorting to demonstrate that the pro-inflammatory cytokine IFNγ is involved in orchestrating inflammation-induced myelopoiesis.
Thu Feb 09 00:00:00 EST 2012
Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.
The Journal of clinical investigation
Malinge S,Bliss-Moreau M,Kirsammer G,Diebold L,Chlon T,Gurbuxani S,Crispino JD
25-5981 was used in Flow cytometry/Cell sorting to show that the calcineurin/NFAT pathway can be both proleukaemic in children and antitumorigenic in adults.
Thu Mar 01 00:00:00 EST 2012
Contribution of an aged microenvironment to aging-associated myeloproliferative disease.
PloS one
Vas V,Wandhoff C,Dörr K,Niebel A,Geiger H
25-5981 was used in Flow cytometry/Cell sorting to investigate the contribution of an aged bone marrow niche to the age-associated increase in leukemia incidence.
Fri Jun 29 00:00:00 EDT 2012
Defective hematopoietic stem cell and lymphoid progenitor development in the Ts65Dn mouse model of Down syndrome: potential role of oxidative stress.
Antioxidants & redox signaling
Lorenzo LP,Chen H,Shatynski KE,Clark S,Yuan R,Harrison DE,Yarowsky PJ,Williams MS
25-5981 was used in Flow cytometry/Cell sorting to identify a link between oxidative stress and diminished IL-7Rα expression and function associated with defective haematologic development in a DS mouse model.
Sat Oct 15 00:00:00 EDT 2011
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration.
Development (Cambridge, England)
Sambasivan R,Yao R,Kissenpfennig A,Van Wittenberghe L,Paldi A,Gayraud-Morel B,Guenou H,Malissen B,Tajbakhsh S,Galy A
25-5981 was used in Flow cytometry/Cell sorting to show that muscle regeneration in mice is dependent on Pax7(+) satellite cells, with important implications for myopathic conditions and stem cell-based therapeutics.
Thu Sep 01 00:00:00 EDT 2011
Deletion of tristetraprolin caused spontaneous reactive granulopoiesis by a non-cell-autonomous mechanism without disturbing long-term hematopoietic stem cell quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Kaplan IM,Morisot S,Heiser D,Cheng WC,Kim MJ,Civin CI
25-5981 was used in Flow cytometry/Cell sorting to characterise hematopoiesis in TTP KO mice to show that TTP is a master regulator of inflammatory cytokine expression during homeostasis that controls granulocyte production.
Tue Mar 01 00:00:00 EST 2011
Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling.
Journal of immunology (Baltimore, Md. : 1950)
MacNamara KC,Oduro K,Martin O,Jones DD,McLaughlin M,Choi K,Borjesson DL,Winslow GM
25-5981 was used in Flow cytometry/Cell sorting to provide evidence that IFN-γ acts to control infection by directly promoting myeloid cell differentiation.
Sat Jan 15 00:00:00 EST 2011
Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome.
Blood
Ng AP,Hyland CD,Metcalf D,Carmichael CL,Loughran SJ,Di Rago L,Kile BT,Alexander WS
25-5981 was used in Flow cytometry/Cell sorting to suggest that increased ERG gene dosage may be a key consequence of trisomy 21 that predisposes to malignant hematologic disorders in Down syndrome.
Thu May 13 00:00:00 EDT 2010
Characterization of endothelial progenitor cells mobilization following cutaneous wounding.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Morris LM,Klanke CA,Lang SA,Pokall S,Maldonado AR,Vuletin JF,Alaee D,Keswani SG,Lim FY,Crombleholme TM
25-5981 was used in Flow cytometry/Cell sorting to characterize bone marrow (BM)-derived endothelial progenitor cell (EPC) mobilization following cutaneous wounding in mice.
Mon Nov 15 00:00:00 EST 2010
The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.
Blood
Yokota T,Oritani K,Butz S,Kokame K,Kincade PW,Miyata T,Vestweber D,Kanakura Y
25-5981 was used in Flow cytometry/Cell sorting to study hematopoietic stem cell (HSC) characteristics for improved understanding of their development and stage-related functions, showing that the endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.
Thu Mar 26 00:00:00 EDT 2009
Loss of the Rho GTPase activating protein p190-B enhances hematopoietic stem cell engraftment potential.
Blood
Xu H,Eleswarapu S,Geiger H,Szczur K,Daria D,Zheng Y,Settleman J,Srour EF,Williams DA,Filippi MD
25-5981 was used in Flow cytometry/Cell sorting to suggest that p190-B is a target for HSC-based therapies requiring maintenance of engraftment phenotype.
Thu Oct 22 00:00:00 EDT 2009
Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Jankovic V,Ciarrocchi A,Boccuni P,DeBlasio T,Benezra R,Nimer SD
25-5981 was used in Flow cytometry/Cell sorting to demonstrate the role of Id1 in hematopoietic stem cell (HSC) self-renewal.
Tue Jan 23 00:00:00 EST 2007
