Product References
Bacterial meningitis in the early postnatal mouse studied at single-cell resolution.
eLife
Wang J,Rattner A,Nathans J
352588 was used in Immunohistochemistry to imply that EC responses to infection are largely driven by the intrinsic EC response to LPS.
Thu Jun 15 00:00:00 EDT 2023
Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier.
Neuron
Ayloo S,Lazo CG,Sun S,Zhang W,Cui B,Gu C
352588 was used in Immunohistochemistry to show that vitronectin, an extracellular matrix protein secreted by central nervous system pericytes, as a regulator of blood-central nervous system barrier function via interactions with its integrin receptor, α5, in endothelial cells.
Wed May 18 00:00:00 EDT 2022
Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Translational stroke research
Yu R,Kim NS,Li Y,Jeong JY,Park SJ,Zhou B,Oh WJ
352588 was used in Immunohistochemistry to investigate whether Sema3E-Plexin-D1 signaling was involved in cerebrovascular remodeling after ischemic injury.
Tue Feb 01 00:00:00 EST 2022
Retinoid signaling regulates angiogenesis and blood-retinal barrier integrity in neonatal mouse retina.
Microcirculation (New York, N.Y. : 1994)
Engelbrecht E,Metzler MA,Sandell LL
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunohistochemistry
Fri Apr 01 00:00:00 EDT 2022
Endothelial Unc5B controls blood-brain barrier integrity.
Nature communications
Boyé K,Geraldo LH,Furtado J,Pibouin-Fragner L,Poulet M,Kim D,Nelson B,Xu Y,Jacob L,Maissa N,Agalliu D,Claesson-Welsh L,Ackerman SL,Eichmann A
352588 was used in Immunohistochemistry to identify Netrin-1-Unc5B signaling as a ligand-receptor pathway that regulates BBB integrity.
Fri Mar 04 00:00:00 EST 2022
Endothelial Unc5B controls blood-brain barrier integrity.
Nature communications
Boyé K,Geraldo LH,Furtado J,Pibouin-Fragner L,Poulet M,Kim D,Nelson B,Xu Y,Jacob L,Maissa N,Agalliu D,Claesson-Welsh L,Ackerman SL,Eichmann A
352588 was used in Immunohistochemistry to identify Netrin-1-Unc5B signaling as a ligand-receptor pathway that regulates BBB integrity.
Fri Mar 04 00:00:00 EST 2022
Immunohistochemical Analysis of Tight Junction Proteins.
Methods in molecular biology (Clifton, N.J.)
Greene C,Campbell M
352588 was used in Immunohistochemistry to discuss immunohistochemical methods to assess tight junction expression and localization and an ImageJ-based method for quantifying tight junction staining in healthy and diseased states.
Fri Jun 24 00:00:00 EDT 2022
Immunohistochemical Analysis of Tight Junction Proteins.
Methods in molecular biology (Clifton, N.J.)
Greene C,Campbell M
352588 was used in Immunohistochemistry to discuss immunohistochemical methods to assess tight junction expression and localization and an ImageJ-based method for quantifying tight junction staining in healthy and diseased states.
Fri Jun 24 00:00:00 EDT 2022
AAV-BR1 targets endothelial cells in the retina to reveal their morphological diversity and to deliver Cx43.
The Journal of comparative neurology
Ivanova E,Corona C,Eleftheriou CG,Stout RF,Körbelin J,Sagdullaev BT
352588 was used in Immunocytochemistry-immunofluorescence to utilize a recently developed AAV-BR1 system to identify distinct classes of ECs along the vascular tree using a GFP reporter and develop an inducible EC-specific ectopic Connexin 43 (Cx43) expression system using AAV-BR1-CAG-DIO-Cx43-P2A-DsRed2 in combination with a mouse line carrying inducible CreERT2 in ECs.
Wed Jun 01 00:00:00 EDT 2022
Genome Editing with AAV-BR1-CRISPR in Postnatal Mouse Brain Endothelial Cells.
International journal of biological sciences
Song X,Cui Y,Wang Y,Zhang Y,He Q,Yu Z,Xu C,Ning H,Han Y,Cai Y,Cheng X,Wang J,Teng Y,Yang X,Wang J
352588 was used in Immunohistochemistry to demonstrate that the adeno-associated virus targeting brain endothelium combined with the CRISPR/Cas9 system (AAV-BR1-CRISPR) is a useful tool for rapid identification of endothelial genes that regulate BBB integrity in vivo.
Mon Mar 21 00:00:00 EDT 2022
Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock.
Cell reports
Le TNU,Nguyen TQ,Kalailingam P,Nguyen YTK,Sukumar VK,Tan CKH,Tukijan F,Couty L,Hasan Z,Del Gaudio I,Wenk MR,Cazenave-Gassiot A,Camerer E,Nguyen LN
352588 was used in Immunohistochemistry to show that S1P export from Mfsd2b and Spns2 is essential for developing and mature vasculature.
Tue Aug 16 00:00:00 EDT 2022
A cellular and spatial map of the choroid plexus across brain ventricles and ages.
Cell
Dani N,Herbst RH,McCabe C,Green GS,Kaiser K,Head JP,Cui J,Shipley FB,Jang A,Dionne D,Nguyen L,Rodman C,Riesenfeld SJ,Prochazka J,Prochazkova M,Sedlacek R,Zhang F,Bryja V,Rozenblatt-Rosen O,Habib N,Regev A,Lehtinen MK
352588 was used in Immunohistochemistry to reveal cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.
Thu May 27 00:00:00 EDT 2021
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy.
EMBO molecular medicine
Chidiac R,Abedin M,Macleod G,Yang A,Thibeault PE,Blazer LL,Adams JJ,Zhang L,Roehrich H,Jo HN,Seshagiri S,Sidhu SS,Junge HJ,Angers S
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunocytochemistry
Wed Jul 07 00:00:00 EDT 2021
A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy.
EMBO molecular medicine
Chidiac R,Abedin M,Macleod G,Yang A,Thibeault PE,Blazer LL,Adams JJ,Zhang L,Roehrich H,Jo HN,Seshagiri S,Sidhu SS,Junge HJ,Angers S
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunocytochemistry
Wed Jul 07 00:00:00 EDT 2021
Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability.
Cardiovascular research
Yu Z,Zeng J,Wang J,Cui Y,Song X,Zhang Y,Cheng X,Hou N,Teng Y,Lan Y,Chen Y,Yang X
352588 was used in Western Blotting to generate brain endothelial cell (EC) specific Hgs knockout mice to uncover the function of Hgs in EC polarity and cerebrovascular stability.
Thu Jan 21 00:00:00 EST 2021
Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells.
Journal of cell science
Holzner S,Bromberger S,Wenzina J,Neumüller K,Holper TM,Petzelbauer P,Bauer W,Weber B,Schossleitner K
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunohistochemistry (Frozen)
Wed Sep 01 00:00:00 EDT 2021
Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells.
Journal of cell science
Holzner S,Bromberger S,Wenzina J,Neumüller K,Holper TM,Petzelbauer P,Bauer W,Weber B,Schossleitner K
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunohistochemistry (Frozen)
Wed Sep 01 00:00:00 EDT 2021
Erythrocytes, a New Contributor to Age-Associated Loss of Blood-Brain Barrier Integrity.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Amiri P,DeCastro J,Littig J,Lu HW,Liu C,Conboy I,Aran K
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunocytochemistry
Fri Oct 01 00:00:00 EDT 2021
Cryopreservation of human cerebral microvascular endothelial cells and astrocytes in suspension and monolayers.
PloS one
Marquez-Curtis LA,Bokenfohr R,McGann LE,Elliott JAW
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunocytochemistry
Thu Sep 23 00:00:00 EDT 2021
Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells.
Tissue barriers
Eustaquio Do Imperio G,Lye P,Bloise E,Matthews SG
352588 was used in Immunohistochemistry to test a hypothesis that Toll-like receptor ligands mimicking bacterial and viral infection would modify the expression and function of P-gp and BCRP in human brain endothelial cells (BECs).
Sat Apr 03 00:00:00 EDT 2021
Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid.
The Journal of experimental medicine
Lehmann GL,Hanke-Gogokhia C,Hu Y,Bareja R,Salfati Z,Ginsberg M,Nolan DJ,Mendez-Huergo SP,Dalotto-Moreno T,Wojcinski A,Ochoa F,Zeng S,Cerliani JP,Panagis L,Zager PJ,Mullins RF,Ogura S,Lutty GA,Bang J,Zippin JH,Romano C,Rabinovich GA,Elemento O,Joyner AL,Rafii S,Rodriguez-Boulan E,Benedicto I
352588 was used in Immunocytochemistry to open new avenues for the study and treatment of retinal vascular diseases and choroid-related inflammatory blinding disorders.
Mon Jun 01 00:00:00 EDT 2020
Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid.
The Journal of experimental medicine
Lehmann GL,Hanke-Gogokhia C,Hu Y,Bareja R,Salfati Z,Ginsberg M,Nolan DJ,Mendez-Huergo SP,Dalotto-Moreno T,Wojcinski A,Ochoa F,Zeng S,Cerliani JP,Panagis L,Zager PJ,Mullins RF,Ogura S,Lutty GA,Bang J,Zippin JH,Romano C,Rabinovich GA,Elemento O,Joyner AL,Rafii S,Rodriguez-Boulan E,Benedicto I
352588 was used in Immunocytochemistry to open new avenues for the study and treatment of retinal vascular diseases and choroid-related inflammatory blinding disorders.
Mon Jun 01 00:00:00 EDT 2020
Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization.
Developmental cell
Yanagida K,Engelbrecht E,Niaudet C,Jung B,Gaengel K,Holton K,Swendeman S,Liu CH,Levesque MV,Kuo A,Fu Z,Smith LEH,Betsholtz C,Hla T
352588 was used in Immunohistochemistry to show that retinal endothelial sphingosine 1-phosphate receptors (S1PRs), which restrain vascular endothelial growth factor (VEGF)-induced angiogenesis, spatially restrict expression of JunB, a member of the activator protein 1 (AP-1) family of transcription factors (TFs).
Mon Mar 23 00:00:00 EDT 2020
MEK/MELK inhibition and blood-brain barrier deficiencies in atypical teratoid/rhabdoid tumors.
Neuro-oncology
Meel MH,Guillén Navarro M,de Gooijer MC,Metselaar DS,Waranecki P,Breur M,Lagerweij T,Wedekind LE,Koster J,van de Wetering MD,Schouten-van Meeteren N,Aronica E,van Tellingen O,Bugiani M,Phoenix TN,Kaspers GJL,Hulleman E
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunofluorescence
Sat Jan 11 00:00:00 EST 2020
Fgfbp1 promotes blood-brain barrier development by regulating collagen IV deposition and maintaining Wnt/β-catenin signaling.
Development (Cambridge, England)
Cottarelli A,Corada M,Beznoussenko GV,Mironov AA,Globisch MA,Biswas S,Huang H,Dimberg A,Magnusson PU,Agalliu D,Lampugnani MG,Dejana E
352588 was used in Immunocytochemistry to conclude that Fgfbp1 is a crucial extracellular matrix protein during BBB maturation that regulates cell-cell interactions and Wnt/β-catenin activity.
Mon Aug 24 00:00:00 EDT 2020
Increased Catecholamine Levels and Inflammatory Mediators Alter Barrier Properties of Brain Microvascular Endothelial Cells in vitro.
Frontiers in cardiovascular medicine
Ittner C,Burek M,Störk S,Nagai M,Förster CY
352588 was used in Immunocytochemistry-immunoflourescence to demonstrate that the proteins forming the blood brain barrier (BBB) and the cell count are clearly influenced by catecholamine (CAT) and INF applied under oxygen glucose deprivation (OGD) conditions.
Mon Sep 28 00:00:00 EDT 2020
Increased Catecholamine Levels and Inflammatory Mediators Alter Barrier Properties of Brain Microvascular Endothelial Cells in vitro.
Frontiers in cardiovascular medicine
Ittner C,Burek M,Störk S,Nagai M,Förster CY
352588 was used in Immunocytochemistry-immunoflourescence to demonstrate that the proteins forming the blood brain barrier (BBB) and the cell count are clearly influenced by catecholamine (CAT) and INF applied under oxygen glucose deprivation (OGD) conditions.
Mon Sep 28 00:00:00 EDT 2020
A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Human molecular genetics
Wang Y,Smallwood PM,Williams J,Nathans J
352588 was used in Immunohistochemistry to explore the pathogenic basis of KIF11-associated retinal vascular disease.
Fri May 08 00:00:00 EDT 2020
3D brain angiogenesis model to reconstitute functional human blood-brain barrier in vitro.
Biotechnology and bioengineering
Lee S,Chung M,Lee SR,Jeon NL
352588 was used in Immunocytochemistry to design a 3D brain angiogenesis model with human blood-brain barrier.
Sun Mar 01 00:00:00 EST 2020
Burns Impair Blood-Brain Barrier and Mesenchymal Stem Cells Can Reverse the Process in Mice.
Frontiers in immunology
Yang J,Ma K,Zhang C,Liu Y,Liang F,Hu W,Bian X,Yang S,Fu X
352588 was used in Western Blotting to suggest that burns increase blood brain barrier permeability through both paracellular pathway and transcytosis, which can be mediated with umbilical cord-derived mesenchymal stem cell treatment.
Mon Jun 14 00:00:00 EDT 2021
Burns Impair Blood-Brain Barrier and Mesenchymal Stem Cells Can Reverse the Process in Mice.
Frontiers in immunology
Yang J,Ma K,Zhang C,Liu Y,Liang F,Hu W,Bian X,Yang S,Fu X
352588 was used in Western Blotting to suggest that burns increase blood brain barrier permeability through both paracellular pathway and transcytosis, which can be mediated with umbilical cord-derived mesenchymal stem cell treatment.
Mon Jun 14 00:00:00 EDT 2021
Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta.
eLife
Engelbrecht E,Levesque MV,He L,Vanlandewijck M,Nitzsche A,Niazi H,Kuo A,Singh SA,Aikawa M,Holton K,Proia RL,Kono M,Pu WT,Camerer E,Betsholtz C,Hla T
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunohistochemistry
Mon Feb 24 00:00:00 EST 2020
Mapping endothelial-cell diversity in cerebral cavernous malformations at single-cell resolution.
eLife
Orsenigo F,Conze LL,Jauhiainen S,Corada M,Lazzaroni F,Malinverno M,Sundell V,Cunha SI,Brännström J,Globisch MA,Maderna C,Lampugnani MG,Magnusson PU,Dejana E
352588 was used in Immunocytochemistry to comprehensively characterize subclasses of brain endothelial cells (ECs) under both normal conditions and after deletion of Pdcd10 (Ccm3) in a mouse model of CCM.
Tue Nov 03 00:00:00 EST 2020
ApoE (Apolipoprotein E) in Brain Pericytes Regulates Endothelial Function in an Isoform-Dependent Manner by Modulating Basement Membrane Components.
Arteriosclerosis, thrombosis, and vascular biology
Yamazaki Y,Shinohara M,Yamazaki A,Ren Y,Asmann YW,Kanekiyo T,Bu G
352588 was used in Immunocytochemistry-immunofluorescence to show that brain pericytes, the mural cells of the capillary walls, differentially modulate endothelial cell phenotype in an apoE isoform-dependent manner.
Wed Jan 01 00:00:00 EST 2020
Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation.
Nature neuroscience
Niu J,Tsai HH,Hoi KK,Huang N,Yu G,Kim K,Baranzini SE,Xiao L,Chan JR,Fancy SPJ
352588 was used in Immunohistochemistry to report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal rodent demyelinating injury.
Wed May 01 00:00:00 EDT 2019
Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation.
Nature neuroscience
Niu J,Tsai HH,Hoi KK,Huang N,Yu G,Kim K,Baranzini SE,Xiao L,Chan JR,Fancy SPJ
352588 was used in Immunohistochemistry to report an interaction between oligodendroglia and vasculature in MS that distinguishes human white matter injury from normal rodent demyelinating injury.
Wed May 01 00:00:00 EDT 2019
Mixed Vehicle Emissions Induces Angiotensin II and Cerebral Microvascular Angiotensin Receptor Expression in C57Bl/6 Mice and Promotes Alterations in Integrity in a Blood-Brain Barrier Coculture Model.
Toxicological sciences : an official journal of the Society of Toxicology
Suwannasual U,Lucero J,Davis G,McDonald JD,Lund AK
352588 was used in Immunohistochemistry to indicate that inhalation exposure to traffic-generated pollutants results in altered BBB integrity, mediated through Ang II-AT1 signaling and inflammation, which is exacerbated by an HF diet.
Thu Aug 01 00:00:00 EDT 2019
Regional Differences in Tight Junction Protein Expression in the Blood-DRG Barrier and Their Alterations after Nerve Traumatic Injury in Rats.
International journal of molecular sciences
Lux TJ,Hu X,Ben-Kraiem A,Blum R,Chen JT,Rittner HL
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunofluorescence
Tue Dec 31 00:00:00 EST 2019
Dlg1 activates beta-catenin signaling to regulate retinal angiogenesis and the blood-retina and blood-brain barriers.
eLife
Cho C,Wang Y,Smallwood PM,Williams J,Nathans J
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunohistochemistry
Wed May 08 00:00:00 EDT 2019
Blood-retina barrier failure and vision loss in neuron-specific degeneration.
JCI insight
Ivanova E,Alam NM,Prusky GT,Sagdullaev BT
352588 was used in Immunohistochemistry-immunofluorescence to study how changing neuronal activity prevalent at the onset of neurodegenerative disease affects neurovascular elements.
Tue Mar 19 00:00:00 EDT 2019
Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis.
Cell stem cell
Wang J,Cui Y,Yu Z,Wang W,Cheng X,Ji W,Guo S,Zhou Q,Wu N,Chen Y,Chen Y,Song X,Jiang H,Wang Y,Lan Y,Zhou B,Mao L,Li J,Yang H,Guo W,Yang X
352588 was used in Immunohistochemistry to delineate how the brain endothelium maintains lactate homeostasis and contributes to adult hippocampal neurogenesis and cognitive functions.
Thu Dec 05 00:00:00 EST 2019
Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures.
eLife
Wang Y,Sabbagh MF,Gu X,Rattner A,Williams J,Nathans J
352588 was used in Immunohistochemistry to study beta-catenin signalling in endothelial cells in high permeability vascular systems compared to barrier-competent endothelial cells.
Mon Apr 01 00:00:00 EDT 2019
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Nature neuroscience
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J
352588 was used in Immunohistochemistry to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.
Mon Oct 01 00:00:00 EDT 2018
Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood-brain barrier and blood-retina barrier development and maintenance.
Proceedings of the National Academy of Sciences of the United States of America
Wang Y,Cho C,Williams J,Smallwood PM,Zhang C,Junge HJ,Nathans J
352588 was used in Immunohistochemistry-immunofluorescence to define the extent of CNS region-specific cooperation for several components of the Norrin and Wnt7a/Wnt7b systems.
Tue Dec 11 00:00:00 EST 2018
Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.
Neurobiology of disease
Zbesko JC,Nguyen TV,Yang T,Frye JB,Hussain O,Hayes M,Chung A,Day WA,Stepanovic K,Krumberger M,Mona J,Longo FM,Doyle KP
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunofluorescence
Sun Apr 01 00:00:00 EDT 2018
Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function.
Journal of the American Heart Association
Patel MM,Behar AR,Silasi R,Regmi G,Sansam CL,Keshari RS,Lupu F,Lupu C
352588 was used in Immunohistochemistry-wholemount to study the role of androgen-dependent tissue factor pathway inhibitor regulating protein in vivo, specifically related to vascular development, stability, and function.
Tue Nov 20 00:00:00 EST 2018
Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation.
Neuron
Cho C,Smallwood PM,Nathans J
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunohistochemistry
Wed Aug 30 00:00:00 EDT 2017
Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation.
Neuron
Chow BW,Gu C
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunohistochemistry
Wed Mar 22 00:00:00 EDT 2017
Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis.
Neuron
Andreone BJ,Chow BW,Tata A,Lacoste B,Ben-Zvi A,Bullock K,Deik AA,Ginty DD,Clish CB,Gu C
352588 was used in Immunohistochemistry-immunofluorescence to study the role of central nervous system endothelial cell lipid composition in the regulation of blood-brain barrier permeability.
Wed May 03 00:00:00 EDT 2017
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.
Proceedings of the National Academy of Sciences of the United States of America
Yanagida K,Liu CH,Faraco G,Galvani S,Smith HK,Burg N,Anrather J,Sanchez T,Iadecola C,Hla T
352588 was used in immunohistochemistry - free floating to describe a role for sphingosine 1-phosphate receptor-1 in regulating blood brain barrier permeability
Tue Apr 25 00:00:00 EDT 2017
Vascular Pericyte Impairment and Connexin43 Gap Junction Deficit Contribute to Vasomotor Decline in Diabetic Retinopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ivanova E,Kovacs-Oller T,Sagdullaev BT
352588 was used in Immunohistochemistry to study the mechanisms contributing to the early impairment of blood flow in diseases such as stroke and diabetes.
Wed Aug 09 00:00:00 EDT 2017
Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration.
Scientific reports
Hong X,Margariti A,Le Bras A,Jacquet L,Kong W,Hu Y,Xu Q
Mon Jul 17 00:00:00 EDT 2017
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.
JCI insight
Ogura S,Kurata K,Hattori Y,Takase H,Ishiguro-Oonuma T,Hwang Y,Ahn S,Park I,Ikeda W,Kusuhara S,Fukushima Y,Nara H,Sakai H,Fujiwara T,Matsushita J,Ema M,Hirashima M,Minami T,Shibuya M,Takakura N,Kim P,Miyata T,Ogura Y,Uemura A
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunohistochemistry
Thu Feb 09 00:00:00 EST 2017
Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.
Acta neuropathologica
Lewandowski SA,Nilsson I,Fredriksson L,Lönnerberg P,Muhl L,Zeitelhofer M,Adzemovic MZ,Nichterwitz S,Lawrence DA,Hedlund E,Eriksson U
352588 was used in immunohistochemistry to study how acceleration of ALS neurodegeneration is caused by presymptomatic activation of the PDGF-CC pathway
Tue Mar 01 00:00:00 EST 2016
CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature.
PLoS pathogens
Swanson PA,Hart GT,Russo MV,Nayak D,Yazew T,Peña M,Khan SM,Janse CJ,Pierce SK,McGavern DB
352588 was used in immunohistochemistry - frozen section to show that parasite-specific CD8 positive T cell-induced fatal vascular breakdown and subsequent neuronal death in an animal model of cerebral malaria
Thu Dec 01 00:00:00 EST 2016
Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles.
Journal of neuroinflammation
Paul D,Baena V,Ge S,Jiang X,Jellison ER,Kiprono T,Agalliu D,Pachter JS
352588 was used in Immunocytochemistry-immunoflourescence to investigate whether extracellular vesicles derived from brain microvascular endothelial cells of the blood-brain barrier play a role in transferring claudin-5 to leukocytes during neuroinflammation.
Wed Nov 16 00:00:00 EST 2016
Structural and functional features of central nervous system lymphatic vessels.
Nature
Louveau A,Smirnov I,Keyes TJ,Eccles JD,Rouhani SJ,Peske JD,Derecki NC,Castle D,Mandell JW,Lee KS,Harris TH,Kipnis J
352588 was used in immunohistochemistry - frozen section to investigate the mechanisms that regulate the entrance and exit of immune cells from the central nervous system
Thu Jul 16 00:00:00 EDT 2015
Sox7, Sox17, and Sox18 Cooperatively Regulate Vascular Development in the Mouse Retina.
PloS one
Zhou Y,Williams J,Smallwood PM,Nathans J
352588 was used in immunohistochemistry to determine the roles of Sox7, Sox17, and Sox18 in the developing and mature mouse vasculature
Wed Jul 06 00:00:00 EDT 2016
Real-time estimation of paracellular permeability of cerebral endothelial cells by capacitance sensor array.
Scientific reports
Hyun Jo D,Lee R,Hyoung Kim J,Oh Jun H,Geol Lee T,Hun Kim J
352588 was used in immunocytochemistry to evaluate capacitance sensor array for the estimation of paracellular permeability of cerebral endothelial cells
Fri Jun 05 00:00:00 EDT 2015
Canonical WNT signaling components in vascular development and barrier formation.
The Journal of clinical investigation
Zhou Y,Wang Y,Tischfield M,Williams J,Smallwood PM,Rattner A,Taketo MM,Nathans J
352588 was used in immunohistochemistry to elucidate the contribution of canonical Wnt pathway members to the vascular development of the central nervous system and in the specification of the blood-brain barrier and blood-retina barrier
Mon Sep 01 00:00:00 EDT 2014
Cellular resolution maps of X chromosome inactivation: implications for neural development, function, and disease.
Neuron
Wu H,Luo J,Yu H,Rattner A,Mo A,Wang Y,Smallwood PM,Erlanger B,Wheelan SJ,Nathans J
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunofluorescence
Wed Jan 08 00:00:00 EST 2014
Gpr124 controls CNS angiogenesis and blood-brain barrier integrity by promoting ligand-specific canonical wnt signaling.
Developmental cell
Zhou Y,Nathans J
352588 was used in Immunohistochemistry to examine the role of Gpr124 in central nervous system angiogenesis as a coactivator of Wnt7a and Wnt7b-stimulated canonical Wnt signalling.
Mon Oct 27 00:00:00 EDT 2014
The role of the hypoxia response in shaping retinal vascular development in the absence of Norrin/Frizzled4 signaling.
Investigative ophthalmology & visual science
Rattner A,Wang Y,Zhou Y,Williams J,Nathans J
352588 was used in immunohistochemistry to investigate the relationship between hypoxia response and Norrin/Frizzled4 signaling during retinal vascular development
Thu Nov 20 00:00:00 EST 2014
EndMT contributes to the onset and progression of cerebral cavernous malformations.
Nature
Maddaluno L,Rudini N,Cuttano R,Bravi L,Giampietro C,Corada M,Ferrarini L,Orsenigo F,Papa E,Boulday G,Tournier-Lasserve E,Chapon F,Richichi C,Retta SF,Lampugnani MG,Dejana E
352588 was used in western blot to study the role of endothelial-to-mesenchymal transition in the onset and progression of cerebral cavernous malformations
Thu Jun 27 00:00:00 EDT 2013
Norrin/Frizzled4 signaling in retinal vascular development and blood brain barrier plasticity.
Cell
Wang Y,Rattner A,Zhou Y,Williams J,Smallwood PM,Nathans J
Published figure using Claudin 5 monoclonal antibody (Product # 352588) in Immunofluorescence
Fri Dec 07 00:00:00 EST 2012
Wnt signaling mediates pathological vascular growth in proliferative retinopathy.
Circulation
Chen J,Stahl A,Krah NM,Seaward MR,Dennison RJ,Sapieha P,Hua J,Hatton CJ,Juan AM,Aderman CM,Willett KL,Guerin KI,Mammoto A,Campbell M,Smith LE
352588 was used in Western Blotting to demonstrate an important role of Wnt signalling in pathological vascular development in retinopathy and show a novel function of Cln5 in promoting angiogenesis.
Tue Oct 25 00:00:00 EDT 2011
