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Invitrogen
4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (ARC1963)
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 5
4-1BB Ligand Antibody (MA5-38063) in WB
Western blot was performed using Anti-4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (ARC1963) (Product # MA5-38063) and 27 and 30 kDa bands corresponding to 4-1BBL/CD137 Ligand/TNFSF9 were observed across cell lines tested except Hep G2. Whole cell extracts (30 µg lysate) of Raji (Lane 1), Raji treated with PMA (Lane 2), THP-1 (Lane 3), HeLa (Lane 4), MOLT-4 (Lane 5), IMR-32 (Lane 6), HEL 92.1.7 (Lane 7) and Hep G2 (Lane 8) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX), 10 well. Resolved proteins... View More
Product Details
MA5-38063
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC1963
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 155-254 of human 4-1BBL/CD137L (P41273)
Conjugate
Form
Liquid
Concentration
0.98 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897981
Product Specific Information
Positive Samples: HeLa, Raji, SH-SY5Y, Mouse lung, Mouse brain, Rat lung
Immunogen sequence: GEGSGSVSLA LHLQPLRSAA GAAALALTVD LPPASSEARN SAFGFQGRLL HLSAGQRLGV HLHTEARARH AWQLTQGATV LGLFRVTPEI PAGLPSPRSE
Target Information
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4 1 BB Ligand; 4 1 BBL; 4-1BB ligand; 4-1BBL; 41BB Ligand; 41BBL; CD 137 Ligand; CD 137L; CD137 Ligand; CDw137L; costimulatory molecule; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; TNFRSF9; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; Tumor necrosis factor ligand superfamily member 9
Gene Aliases: 4-1BB-L; 4-1BBL; AI848817; CD137L; Cd157l; Ly63l; TNFSF9; TNLG5A
UniProt ID: (Human) P41273, (Mouse) P41274
Entrez Gene ID: (Human) 8744, (Mouse) 21950, (Rat) 353218
immune response
cell-cell signaling
positive regulation of interferon-gamma production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of activated T cell proliferation
regulation of cell proliferation
myeloid dendritic cell differentiation
positive regulation of cytotoxic T cell differentiation
apoptotic process
signal transduction
cell proliferation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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