Product References
Investigation of Cyclo-Z Therapeutic Effect on Insulin Pathway in Alzheimer's Rat Model: Biochemical and Electrophysiological Parameters.
Molecular neurobiology
Acun AD,Kantar D,Er H,Erkan O,Derin N,Yargıcoglu P
44-752G was used in Western Blotting to characterize the effects of Cyclo-Z on the insulin pathway, memory functions, and brain oscillations in the Alzheimer's disease (AD) rat model.
Sat Jul 01 00:00:00 EDT 2023
Cognitive decline in diabetic mice predisposed to Alzheimer's disease is greater than in wild type.
Life science alliance
Carús-Cadavieco M,Berenguer López I,Montoro Canelo A,Serrano-Lope MA,González-de la Fuente S,Aguado B,Fernández-Rodrigo A,Saido TC,Frank García A,Venero C,Esteban JA,Guix F,Dotti CG
44-752G was used in Western Blotting to show that T2DM produces more severe behavioral, electrophysiological, and structural alterations in these mice compared with wild-type mice.
Thu Jun 01 00:00:00 EDT 2023
A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer's disease exacerbated with high fat diet.
Cell & bioscience
Espinosa-Jiménez T,Cano A,Sánchez-López E,Olloquequi J,Folch J,Bulló M,Verdaguer E,Auladell C,Pont C,Muñoz-Torrero D,Parcerisas A,Camins A,Ettcheto M
44-752G was used in Western Blotting to suggest that RHE-HUP could be a new candidate for the treatment of AD, even for individuals with high risk due to peripheral metabolic disturbances, given its multi-target profile which allows for the improvement of some of the most important hallmarks of the disease.
Thu Mar 09 00:00:00 EST 2023
PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes.
Cell communication and signaling : CCS
Yadav Y,Sharma M,Dey CS
44-752G was used in Western Blotting to show that, in one hand PP1γ, and not PP1α, regulates neuronal insulin signaling and insulin resistance by regulating phosphorylation of AKT2 via AKT2-AS160-GLUT4 axis.
Fri Apr 21 00:00:00 EDT 2023
MicroRNA-140-5p inhibitor attenuates memory impairment induced by amyloid-ß oligomer in vivo possibly through Pin1 regulation.
CNS neuroscience & therapeutics
Khodabakhsh P,Bazrgar M,Mohagheghi F,Parvardeh S,Ahmadiani A
44-752G was used in Western Blotting to investigate the role of miRNA-140-5p inhibition in promoting Pin1 expression and the therapeutic potential of the AntimiR-140-5p in the Aß oligomer (AßO)-induced AD rat model.
Sun Jan 01 00:00:00 EST 2023
Vitamin D and rosuvastatin alleviate type-II diabetes-induced cognitive dysfunction by modulating neuroinflammation and canonical/noncanonical Wnt/β-catenin signaling.
PloS one
Muneeb M,Mansou SM,Saleh S,Mohammed RA
44-752G was used in Western Blotting to accentuated the neuroprotective potential of VitD and RSV and provide new incentives to expand their use in T2DM-induced cognitive and memory decline.
Wed Nov 16 00:00:00 EST 2022
cPKCγ Deficiency Exacerbates Autophagy Impairment and Hyperphosphorylated Tau Buildup through the AMPK/mTOR Pathway in Mice with Type 1 Diabetes Mellitus.
Neuroscience bulletin
Zheng J,Wang Y,Liu Y,Han S,Zhang Y,Luo Y,Yan Y,Li J,Zhao L
44-752G was used in Western Blot to indicate that cPKCγ promotes autophagy through the AMPK/mTOR signaling pathway, thus reducing the level of phosphorylated Tau at Ser214 and neurofibrillary tangles.
Sat Oct 01 00:00:00 EDT 2022
Tau protein is differentially phosphorylated in young- and old-aged rats with experimentally induced hyperthyroidism.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Tan B,Babur E,Toy N,Günaydın B,Dursun N,Süer C
44-752G was used in Western Blotting to study long-term potentiation (LTP) and accompanying phosphorylation of Tau protein in different residues in the hippocampus of young and old rats with experimentally induced hyperthyroidism.
Tue Nov 01 00:00:00 EDT 2022
Alzheimer's disease like neuropathology in Down syndrome cortical organoids.
Frontiers in cellular neuroscience
Zhao HH,Haddad GG
44-752G was used in Western Blotting to use induced pluripotent stem cell (iPSC) and iPSC-derived 3D cortical organoids to model Alzheimer's disease in Down syndrome and explore the earliest cellular and molecular changes during DS fetal brain development.
Tue Jan 03 00:00:00 EST 2023
O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies.
ACS chemical neuroscience
Permanne B,Sand A,Ousson S,Nény M,Hantson J,Schubert R,Wiessner C,Quattropani A,Beher D
44-752G was used in Inhibition Assays to provide a strong rationale for the development of OGA inhibitors as disease-modifying agents in both tauopathies and α-synucleinopathies.
Wed Apr 20 00:00:00 EDT 2022
Homozygous knockout of eEF2K alleviates cognitive deficits in APP/PS1 Alzheimer's disease model mice independent of brain amyloid β pathology.
Frontiers in aging neuroscience
Kasica NP,Zhou X,Jester HM,Holland CE,Ryazanov AG,Forshaw TE,Furdui CM,Ma T
44-752G was used in Western Blotting to report that global homozygous knockout of the eEF2K gene alleviates deficits of long-term recognition and spatial learning in a mouse model of AD (APP/PS1).
Fri Apr 21 00:00:00 EDT 2023
The Potential Neuroprotective Effects of Extracts from Oat Seedlings against Alzheimer's Disease.
Nutrients
Lee WS,Lee HJ,Yang JY,Shin HL,Choi SW,Kim JK,Seo WD,Kim EH
44-752G was used in Western Blotting to indicate that OSE treatment affects JNK/ERK/p38 MAPK signaling, with considerable inhibition in p-JNK, p-p38, and p-ERK levels seen in the brain of OSE-treated Tg-5Xfad AD mice.
Sun Oct 02 00:00:00 EDT 2022
Antagonists targeting eEF2 kinase rescue multiple aspects of pathophysiology in Alzheimer's disease model mice.
Journal of neurochemistry
Kasica NP,Zhou X,Yang Q,Wang X,Yang W,Zimmermann HR,Holland CE,Koscielniak E,Wu H,Cox AO,Lee J,Ryazanov AG,Furdui CM,Ma T
44-752G was used in Western Blotting to reveal that treatment with eEF2K inhibitors improved AD-associated synaptic plasticity impairments and cognitive dysfunction, without altering brain amyloid.
Tue Mar 01 00:00:00 EST 2022
A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer's disease.
Acta neuropathologica
García-Escudero V,Ruiz-Gabarre D,Gargini R,Pérez M,García E,Cuadros R,Hernández IH,Cabrera JR,García-Escudero R,Lucas JJ,Hernández F,Ávila J
44-752G was used in Western Blot to present evidence suggesting this new Tau isoform could be linked to the inhibition of GSK3β, which would mediate intron 12 retention by modulating the serine/arginine rich splicing factor 2 (SRSF2).
Thu Jul 01 00:00:00 EDT 2021
RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.
Cell death and differentiation
Zhao D,Zhou Y,Huo Y,Meng J,Xiao X,Han L,Zhang X,Luo H,Can D,Sun H,Huang TY,Wang X,Zhang J,Liu FR,Xu H,Zhang YW
44-752G was used in Western Blot to observe retarded axon outgrowth, elevated p35 and p25 protein levels, and increased tau phosphorylation at major Cdk5 phosphorylation sites in Rps23rg1 knockout (KO) mice.
Fri Jan 01 00:00:00 EST 2021
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.
Brain pathology (Zurich, Switzerland)
Reimer L,Betzer C,Kofoed RH,Volbracht C,Fog K,Kurhade C,Nilsson E,Överby AK,Jensen PH
44-752G was used in Western Blot to indicate that PKR, independent of other kinases and upon acute brain inflammation, is capable of triggering pathological modulation of tau, which, in turn, might form the initial pathologic seed in several tauopathies such as Alzheimer's disease and Chronic traumatic encephalopathy where inflammation is severe.
Fri Jan 01 00:00:00 EST 2021
Simple, Single-Shot Phosphoproteomic Analysis of Heat-Stable Tau Identifies Age-Related Changes in pS235- and pS396-Tau Levels in Non-human Primates.
Frontiers in aging neuroscience
Leslie SN,Kanyo J,Datta D,Wilson RS,Zeiss C,Duque A,Lam TT,Arnsten AFT,Nairn AC
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Immunohistochemistry
Wed Jan 05 00:00:00 EST 2022
Cornel Iridoid Glycoside Protects Against STAT1-Dependent Synapse and Memory Deficits by Increasing N-Methyl-D-aspartate Receptor Expression in a Tau Transgenic Mice.
Frontiers in aging neuroscience
Ma D,Huang R,Guo K,Zhao Z,Wei W,Gu L,Li L,Zhang L
44-752G was used in Western Blot to investigate the effects and mechanisms of cornel iridoid glycoside on tau pathology and synaptic dysfunction using P301S transgenic mice.
Sat Jun 12 00:00:00 EDT 2021
Cornel Iridoid Glycoside Protects Against STAT1-Dependent Synapse and Memory Deficits by Increasing N-Methyl-D-aspartate Receptor Expression in a Tau Transgenic Mice.
Frontiers in aging neuroscience
Ma D,Huang R,Guo K,Zhao Z,Wei W,Gu L,Li L,Zhang L
44-752G was used in Western Blot to investigate the effects and mechanisms of cornel iridoid glycoside on tau pathology and synaptic dysfunction using P301S transgenic mice.
Sat Jun 12 00:00:00 EDT 2021
Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation.
Molecular psychiatry
Park J,Choi H,Kim YD,Kim SH,Kim Y,Gwon Y,Lee DY,Park SH,Heo WD,Jung YK
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Fri Oct 01 00:00:00 EDT 2021
IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease.
Cell reports
Brigas HC,Ribeiro M,Coelho JE,Gomes R,Gomez-Murcia V,Carvalho K,Faivre E,Costa-Pereira S,Darrigues J,de Almeida AA,Buée L,Dunot J,Marie H,Pousinha PA,Blum D,Silva-Santos B,Lopes LV,Ribot JC
44-752G was used in Western Blot to support the idea that cognition relies on a finely regulated balance of "inflammatory" cytokines derived from the meningeal immune system.
Tue Aug 31 00:00:00 EDT 2021
5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease.
Cell reports
Kuehner JN,Chen J,Bruggeman EC,Wang F,Li Y,Xu C,McEachin ZT,Li Z,Chen L,Hales CM,Wen Z,Yang J,Yao B
44-752G was used in Immunohistochemistry to generate 5hmC and transcriptome profiles encompassing several developmental time points of healthy forebrain organoids and organoids derived from several familial Alzheimer's disease (AD) patients.
Tue Apr 27 00:00:00 EDT 2021
Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer's model mice.
The Journal of clinical investigation
Zimmermann HR,Yang W,Kasica NP,Zhou X,Wang X,Beckelman BC,Lee J,Furdui CM,Keene CD,Ma T
44-752G was used in Western Blotting to show that distinct disruption of hippocampal AMPKα isoform expression patterns in postmortem human Alzheimer's disease(AD) patients and AD model mice.
Wed Jul 01 00:00:00 EDT 2020
Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.
Human molecular genetics
Guarascio R,Salih D,Yasvoina M,Edwards FA,Cheetham ME,van der Spuy J
44-752G was used in Immunocytochemistry to investigate if negative regulator of ubiquitin-like protein 1 plays a role in regulating the autophagy-lysosomal pathway when the ubiquitin proteasome system is compromised, thus contributing to the mechanisms targeting the removal of aggregation-prone proteins upon proteasomal impairment.
Wed Jan 01 00:00:00 EST 2020
Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment.
Human molecular genetics
Guarascio R,Salih D,Yasvoina M,Edwards FA,Cheetham ME,van der Spuy J
44-752G was used in Immunocytochemistry to investigate if negative regulator of ubiquitin-like protein 1 plays a role in regulating the autophagy-lysosomal pathway when the ubiquitin proteasome system is compromised, thus contributing to the mechanisms targeting the removal of aggregation-prone proteins upon proteasomal impairment.
Wed Jan 01 00:00:00 EST 2020
Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3×Tg-AD Model Mice.
Journal of Alzheimer's disease : JAD
Goto T,Kuramoto E,Dhar A,Wang RP,Seki H,Iwai H,Yamanaka A,Matsumoto SE,Hara H,Michikawa M,Ohyagi Y,Leung WK,Chang RC
44-752G was used in Immunohistochemistry to investigate whether neuronal death in the mesencephalic trigeminal nucleus can be spread to adjacent locus coeruleus in female triple transgenic (3Tg)-AD mice.
Thu Jun 03 00:00:00 EDT 2021
Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3×Tg-AD Model Mice.
Journal of Alzheimer's disease : JAD
Goto T,Kuramoto E,Dhar A,Wang RP,Seki H,Iwai H,Yamanaka A,Matsumoto SE,Hara H,Michikawa M,Ohyagi Y,Leung WK,Chang RC
44-752G was used in Immunohistochemistry to investigate whether neuronal death in the mesencephalic trigeminal nucleus can be spread to adjacent locus coeruleus in female triple transgenic (3Tg)-AD mice.
Thu Jun 03 00:00:00 EDT 2021
Estrogens Inhibit Amyloid-β-Mediated Paired Helical Filament-Like Conformation of Tau Through Antioxidant Activity and miRNA 218 Regulation in hTau Mice.
Journal of Alzheimer's disease : JAD
Guglielmotto M,Manassero G,Vasciaveo V,Venezia M,Tabaton M,Tamagno E
44-752G was used in Western Blot to find that biological sex influences the effect of amyloid-β42 (Aβ42) monomers on pathological tau conformational change.
Thu Sep 09 00:00:00 EDT 2021
ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice.
Aging
Duan R,Xue X,Zhang QQ,Wang SY,Gong PY,E Y,Jiang T,Zhang YD
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Thu Jul 23 00:00:00 EDT 2020
ACE2 activator diminazene aceturate ameliorates Alzheimer's disease-like neuropathology and rescues cognitive impairment in SAMP8 mice.
Aging
Duan R,Xue X,Zhang QQ,Wang SY,Gong PY,E Y,Jiang T,Zhang YD
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Thu Jul 23 00:00:00 EDT 2020
Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.
Neurobiology of disease
Chiasseu M,Fesharaki-Zadeh A,Saito T,Saido TC,Strittmatter SM
44-752G was used in Immunocytochemistry, Western Blot, Immunohistochemistry to reveal that rmCHI enhances accumulation of amyloid-β and hyperphosphorylated tau inclusions, as well as neuroinflammation in AppNL-F/NL-F mice.
Sun Nov 01 00:00:00 EDT 2020
Truncation of Tau selectively facilitates its pathological activities.
The Journal of biological chemistry
Gu J,Xu W,Jin N,Li L,Zhou Y,Chu D,Gong CX,Iqbal K,Liu F
44-752G was used in Western Blotting to suggest that the first 150 aa and the last 50 aa protect Tau from pathological characteristics and that their deletions facilitate pathological activities.
Fri Oct 02 00:00:00 EDT 2020
Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo.
Frontiers in aging neuroscience
Miao J,Shi R,Li L,Chen F,Zhou Y,Tung YC,Hu W,Gong CX,Iqbal K,Liu F
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Thu Oct 01 00:00:00 EDT 2020
Mitophagy Failure in APP and Tau Overexpression Model of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD
Martín-Maestro P,Gargini R,García E,Simón D,Avila J,García-Escudero V
44-752G was used in Western Blot to understand the contribution of the main proteins involved in Alzheimer's disease such as amyloid-β protein precursor and tau.
Thu Oct 01 00:00:00 EDT 2020
Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer's Disease.
Frontiers in neuroanatomy
Furcila D,Domínguez-Álvaro M,DeFelipe J,Alonso-Nanclares L
44-752G was used in Immunohistochemistry to examine the possible relationship of both Aβ plaques and NFTs with neuronal loss in several hippocampal fields (DG, CA3, CA1, and subiculum) of 11 demented AD patients.
Thu Oct 01 00:00:00 EDT 2020
Memantine Differentially Regulates Tau Phosphorylation Induced by Chronic Restraint Stress of Varying Duration in Mice.
Neural plasticity
Liu Y,Cao L,Zhang X,Liang Y,Xu Y,Zhu C
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Mon May 13 00:00:00 EDT 2019
A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain.
Acta neuropathologica communications
Ercan-Herbst E,Ehrig J,Schöndorf DC,Behrendt A,Klaus B,Gomez Ramos B,Prat Oriol N,Weber C,Ehrnhoefer DE
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in ELISA
Tue Dec 03 00:00:00 EST 2019
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models.
eLife
Silva MC,Ferguson FM,Cai Q,Donovan KA,Nandi G,Patnaik D,Zhang T,Huang HT,Lucente DE,Dickerson BC,Mitchison TJ,Fischer ES,Gray NS,Haggarty SJ
44-752G was used in Western Blotting to demonstrate that aberrant tau in FTD patient-derived neurons is amenable to targeted degradation, representing an important advance for therapeutics.
Mon Mar 25 00:00:00 EDT 2019
A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation.
The Journal of biological chemistry
Ajit D,Trzeciakiewicz H,Tseng JH,Wander CM,Chen Y,Ajit A,King DP,Cohen TJ
44-752G was used in Western Blotting to indicate that a complex tau PTM code likely regulates tau pathogenesis, highlighting the potential utility of manipulating and detoxifying tau strains through site-specific tau-targeting approaches.
Fri Nov 08 00:00:00 EST 2019
Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice.
Scientific reports
Zhang Y,Wu F,Iqbal K,Gong CX,Hu W,Liu F
44-752G was used in Western Blotting to characterise Alzheimer-like alterations behaviourally, biochemically and immunohistochemically 6 weeks and 7 months after unilateral mild-to-moderate controlled cortical impact in human tau transgenic mice.
Thu Mar 07 00:00:00 EST 2019
Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease.
Frontiers in aging neuroscience
Zhou Y,Shi J,Chu D,Hu W,Guan Z,Gong CX,Iqbal K,Liu F
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Sat Apr 09 00:00:00 EDT 2022
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
Journal of Alzheimer's disease : JAD
Hu W,Tung YC,Zhang Y,Liu F,Iqbal K
44-752G was used in Immunohistochemistry-immunofluorescence to test the effect of repetitive mild traumatic brain injury on tau hyperphosphorylation, in triple-transgenic mouse model of Alzheimer's disease.
Mon Jul 15 00:00:00 EDT 2019
Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury.
Journal of Alzheimer's disease : JAD
Hu W,Tung YC,Zhang Y,Liu F,Iqbal K
44-752G was used in Immunohistochemistry-immunofluorescence to test the effect of repetitive mild traumatic brain injury on tau hyperphosphorylation, in triple-transgenic mouse model of Alzheimer's disease.
Mon Jul 15 00:00:00 EDT 2019
A Study of Amyloid-β and Phosphotau in Plaques and Neurons in the Hippocampus of Alzheimer's Disease Patients.
Journal of Alzheimer's disease : JAD
Furcila D,DeFelipe J,Alonso-Nanclares L
44-752G was used in Immunohistochemistry-immunofluorescence to study the possible relationship between the presence and distribution of different neurochemical types of amyloid-Β plaques and hyperphosphorylated-Tau immunoreactive neurons.
Mon Jul 15 00:00:00 EDT 2019
Tau deletion promotes brain insulin resistance.
The Journal of experimental medicine
Marciniak E,Leboucher A,Caron E,Ahmed T,Tailleux A,Dumont J,Issad T,Gerhardt E,Pagesy P,Vileno M,Bournonville C,Hamdane M,Bantubungi K,Lancel S,Demeyer D,Eddarkaoui S,Vallez E,Vieau D,Humez S,Faivre E,Grenier-Boley B,Outeiro TF,Staels B,Amouyel P,Balschun D,Buee L,Blum D
44-752G was used in Western Blotting to find that tau deletion leads to an impaired hippocampal response to insulin, caused by altered IRS-1 and PTEN activity.
Mon Aug 07 00:00:00 EDT 2017
Liraglutide Improves Water Maze Learning and Memory Performance While Reduces Hyperphosphorylation of Tau and Neurofilaments in APP/PS1/Tau Triple Transgenic Mice.
Neurochemical research
Chen S,Sun J,Zhao G,Guo A,Chen Y,Fu R,Deng Y
44752G was used in western blot to elucidate how liraglutide affects disease and cognitive function in a mouse model of Alzheimer disease
Tue Aug 01 00:00:00 EDT 2017
A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.
Scientific reports
Trzeciakiewicz H,Tseng JH,Wander CM,Madden V,Tripathy A,Yuan CX,Cohen TJ
44752G was used in western blot to study the mechanisms of pathogenesis via tau acetylation in Alzheimer's disease
Mon Mar 13 00:00:00 EDT 2017
Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A.
Molecular neurodegeneration
Willén K,Edgar JR,Hasegawa T,Tanaka N,Futter CE,Gouras GK
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Wed Aug 23 00:00:00 EDT 2017
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
The Journal of biological chemistry
Boselli M,Lee BH,Robert J,Prado MA,Min SW,Cheng C,Silva MC,Seong C,Elsasser S,Hatle KM,Gahman TC,Gygi SP,Haggarty SJ,Gan L,King RW,Finley D
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Fri Nov 24 00:00:00 EST 2017
An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons.
The Journal of biological chemistry
Boselli M,Lee BH,Robert J,Prado MA,Min SW,Cheng C,Silva MC,Seong C,Elsasser S,Hatle KM,Gahman TC,Gygi SP,Haggarty SJ,Gan L,King RW,Finley D
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Fri Nov 24 00:00:00 EST 2017
A validated antibody panel for the characterization of tau post-translational modifications.
Molecular neurodegeneration
Ercan E,Eid S,Weber C,Kowalski A,Bichmann M,Behrendt A,Matthes F,Krauss S,Reinhardt P,Fulle S,Ehrnhoefer DE
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Tue Nov 21 00:00:00 EST 2017
Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma.
BMC neuroscience
O'Hare Doig RL,Chiha W,Giacci MK,Yates NJ,Bartlett CA,Smith NM,Hodgetts SI,Harvey AR,Fitzgerald M
44-752G was used in Immunohistochemistry to determine how flux through specific ion channels contributes to the various pathologies, using partial optic nerve transection in adult female rats to model secondary degeneration following neurotrauma.
Mon Aug 14 00:00:00 EDT 2017
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Annals of neurology
Takeda S,Commins C,DeVos SL,Nobuhara CK,Wegmann S,Roe AD,Costantino I,Fan Z,Nicholls SB,Sherman AE,Trisini Lipsanopoulos AT,Scherzer CR,Carlson GA,Pitstick R,Peskind ER,Raskind MA,Li G,Montine TJ,Frosch MP,Hyman BT
44-752G was used in blocking or activating experiment to assess the accumulation in the cerebrospinal fluid of seed-competent HMW tau specis in an Alzheimer's disease mouse model and in human patients
Thu Sep 01 00:00:00 EDT 2016
Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.
Aging cell
Manassero G,Guglielmotto M,Zamfir R,Borghi R,Colombo L,Salmona M,Perry G,Odetti P,Arancio O,Tamagno E,Tabaton M
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Sat Oct 01 00:00:00 EDT 2016
Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy.
Journal of Alzheimer's disease : JAD
Zimova I,Brezovakova V,Hromadka T,Weisova P,Cubinkova V,Valachova B,Filipcik P,Jadhav S,Smolek T,Novak M,Zilka N
44752G was used in western blot to describe the molecular and behavioral features of R3m/4 transgenic mice expressing human non-mutated truncated tau protein and assess these mice as a model for Alzheimer's disease
Tue Sep 06 00:00:00 EDT 2016
Short-term treadmill exercise increased tau insolubility and neuroinflammation in tauopathy model mice.
Neuroscience letters
Elahi M,Motoi Y,Matsumoto SE,Hasan Z,Ishiguro K,Hattori N
44-752G was used in western blot to test if short-term treadmill exercise changes tau modifications
Fri Jan 01 00:00:00 EST 2016
Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells.
Frontiers in neuroscience
He X,Li Z,Rizak JD,Wu S,Wang Z,He R,Su M,Qin D,Wang J,Hu X
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Wed Sep 30 00:00:00 EDT 2020
Epigenetic mechanisms underlying cognitive impairment and Alzheimer disease hallmarks in 5XFAD mice.
Aging
Griñán-Ferré C,Sarroca S,Ivanova A,Puigoriol-Illamola D,Aguado F,Camins A,Sanfeliu C,Pallàs M
44-752G was used in western blot to characterize epigenetic changes in 5XFAD mice
Fri Apr 01 00:00:00 EDT 2016
The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model.
Nature communications
Li T,Braunstein KE,Zhang J,Lau A,Sibener L,Deeble C,Wong PC
44-752G was used in immunohistochemistry - paraffin section to elucidate the pathological conversion of tau facilitated by the neuritic plaque in an Alzheimer's disease mouse model
Mon Jul 04 00:00:00 EDT 2016
Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence.
Experimental gerontology
Griñan-Ferré C,Palomera-Ávalos V,Puigoriol-Illamola D,Camins A,Porquet D,Plá V,Aguado F,Pallàs M
44-752G was used in Western Blotting to find impairment in emotional behaviour with regard to fear and anxiety in young SAMP8 vs. age-mated SAMR1.
Fri Jul 01 00:00:00 EDT 2016
Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly.
Proceedings of the National Academy of Sciences of the United States of America
Ohnishi T,Yanazawa M,Sasahara T,Kitamura Y,Hiroaki H,Fukazawa Y,Kii I,Nishiyama T,Kakita A,Takeda H,Takeuchi A,Arai Y,Ito A,Komura H,Hirao H,Satomura K,Inoue M,Muramatsu S,Matsui K,Tada M,Sato M,Saijo E,Shigemitsu Y,Sakai S,Umetsu Y,Goda N,Takino N,Takahashi H,Hagiwara M,Sawasaki T,Iwasaki G,Nakamura Y,Nabeshima Y,Teplow DB,Hoshi M
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Tue Aug 11 00:00:00 EDT 2015
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
Annals of neurology
Kaufman AC,Salazar SV,Haas LT,Yang J,Kostylev MA,Jeng AT,Robinson SA,Gunther EC,van Dyck CH,Nygaard HB,Strittmatter SM
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Mon Jun 01 00:00:00 EDT 2015
The choice of general anesthetics may not affect neuroinflammation and impairment of learning and memory after surgery in elderly rats.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Zhang J,Tan H,Jiang W,Zuo Z
44-752G was used in western blot to test if anesthetic choice affects cognitive impairment and neuroinflammation in elderly rat
Sun Mar 01 00:00:00 EST 2015
Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation.
Neurobiology of aging
Wang Y,Yang R,Gu J,Yin X,Jin N,Xie S,Wang Y,Chang H,Qian W,Shi J,Iqbal K,Gong CX,Cheng C,Liu F
44-752G was used in western blot to study the role of glycogen synthase kinase-3beta and protein phosphatase 2A in regulation of tau hyperphosphorylation
Thu Jan 01 00:00:00 EST 2015
GSK-3β-dependent downregulation of γ-taxilin and αNAC merge to regulate ER stress responses.
Cell death & disease
Hotokezaka Y,Katayama I,van Leyen K,Nakamura T
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Thu Apr 16 00:00:00 EDT 2015
Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation.
Scientific reports
Wang Y,Zhang Y,Hu W,Xie S,Gong CX,Iqbal K,Liu F
44-752G was used in western blot to characterize postmortem behavior and the rapid alteration of protein phosphorylation
Thu Oct 29 00:00:00 EDT 2015
Amyloid and tau pathology of familial Alzheimer's disease APP/PS1 mouse model in a senescence phenotype background (SAMP8).
Age (Dordrecht, Netherlands)
Porquet D,Andrés-Benito P,Griñán-Ferré C,Camins A,Ferrer I,Canudas AM,Del Valle J,Pallàs M
44-752G was used in western blot to characterize cognitive and neuropathological Alzheimer's disease markers in a novel mouse model
Sun Feb 01 00:00:00 EST 2015
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Nature communications
Takeda S,Wegmann S,Cho H,DeVos SL,Commins C,Roe AD,Nicholls SB,Carlson GA,Pitstick R,Nobuhara CK,Costantino I,Frosch MP,Müller DJ,Irimia D,Hyman BT
44-752G was used in western blot to research Alzheimer's disease brain and neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau
Tue Oct 13 00:00:00 EDT 2015
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Iliff JJ,Chen MJ,Plog BA,Zeppenfeld DM,Soltero M,Yang L,Singh I,Deane R,Nedergaard M
44-752G was used in western blot to study how extracellular proteins are cleared from the brain
Wed Dec 03 00:00:00 EST 2014
MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease.
Neuroscience
Zhao ZB,Wu L,Xiong R,Wang LL,Zhang B,Wang C,Li H,Liang L,Chen SD
44-752G was used in western blot to elucidate the mechanisms that regulate UCHL1 levels in Alzheimer's disease AD.
Fri Sep 05 00:00:00 EDT 2014
Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
The European journal of neuroscience
Maurin H,Lechat B,Borghgraef P,Devijver H,Jaworski T,Van Leuven F
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Tue Jul 01 00:00:00 EDT 2014
Specificity of anti-tau antibodies when analyzing mice models of Alzheimer's disease: problems and solutions.
PloS one
Petry FR,Pelletier J,Bretteville A,Morin F,Calon F,Hébert SS,Whittington RA,Planel E
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Mon Dec 22 00:00:00 EST 2014
Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease.
Biochimica et biophysica acta
Pedrós I,Petrov D,Allgaier M,Sureda F,Barroso E,Beas-Zarate C,Auladell C,Pallàs M,Vázquez-Carrera M,Casadesús G,Folch J,Camins A
44-752G was used in western blot to investigate the abnormalites in hippocampal energy metabolism in the pathogenesis of Alzheimer disease.
Mon Sep 01 00:00:00 EDT 2014
MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Absalon S,Kochanek DM,Raghavan V,Krichevsky AM
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Wed Sep 11 00:00:00 EDT 2013
Dietary resveratrol prevents Alzheimer's markers and increases life span in SAMP8.
Age (Dordrecht, Netherlands)
Porquet D,Casadesús G,Bayod S,Vicente A,Canudas AM,Vilaplana J,Pelegrí C,Sanfeliu C,Camins A,Pallàs M,del Valle J
44-752G was used in western blot to elucidate the role of dietary resveratrol in SAMP8 mice.
Tue Oct 01 00:00:00 EDT 2013
Microtubule-associated protein tau in bovine retinal photoreceptor rod outer segments: comparison with brain tau.
Biochimica et biophysica acta
Yamazaki A,Nishizawa Y,Matsuura I,Hayashi F,Usukura J,Bondarenko VA
44-752G was used in western blot to characterize tau in the rod outer segment of bovine retinal photoreceptors.
Tue Oct 01 00:00:00 EDT 2013
Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy.
PloS one
Theunis C,Crespo-Biel N,Gafner V,Pihlgren M,López-Deber MP,Reis P,Hickman DT,Adolfsson O,Chuard N,Ndao DM,Borghgraef P,Devijver H,Van Leuven F,Pfeifer A,Muhs A
44-752G was used in Western Blotting to demonstrate that a liposome-based vaccine elicited, rapidly and robustly, specific antisera in wild-type mice and in Tau.P301L mice.
Thu Jan 22 00:00:00 EST 2015
An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide.
Acta neuropathologica
Bolognin S,Blanchard J,Wang X,Basurto-Islas G,Tung YC,Kohlbrenner E,Grundke-Iqbal I,Iqbal K
44-752G was used in immunohistochemistry - free floating and western blot to report that expression of the N-terminal I2NTF and C-terminal I2CTF halves of I2PP2A in rat brain reproduced key features of Alzheimer's disease
Sun Jan 01 00:00:00 EST 2012
A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease.
Toxicological sciences : an official journal of the Society of Toxicology
Li G,Cai F,Yan W,Li C,Wang J
Fri Jun 01 00:00:00 EDT 2012
Epigenetic changes in Alzheimer's disease: decrements in DNA methylation.
Neurobiology of aging
Mastroeni D,Grover A,Delvaux E,Whiteside C,Coleman PD,Rogers J
44-752G was used in Immunohistochemistry-immunofluorescence to evaluate immunoreactivity for two markers of DNA methylation and eight methylation maintenance factors in entorhinal cortex layer II.
Wed Dec 01 00:00:00 EST 2010
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry
Yu Y,Run X,Liang Z,Li Y,Liu F,Liu Y,Iqbal K,Grundke-Iqbal I,Gong CX
Sun Mar 01 00:00:00 EST 2009
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry
Yu Y,Run X,Liang Z,Li Y,Liu F,Liu Y,Iqbal K,Grundke-Iqbal I,Gong CX
Sun Mar 01 00:00:00 EST 2009
Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes.
Endocrinology
Kim B,Backus C,Oh S,Hayes JM,Feldman EL
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Tue Dec 01 00:00:00 EST 2009
Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes.
Endocrinology
Kim B,Backus C,Oh S,Hayes JM,Feldman EL
Published figure using Phospho-Tau (Ser396) polyclonal antibody (Product # 44-752G) in Western Blot
Tue Dec 01 00:00:00 EST 2009
Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease.
PloS one
Mastroeni D,McKee A,Grover A,Rogers J,Coleman PD
44-752G was used in immunohistochemistry - free floating to examine DNA methylation in a set of monozygotic twins discordant for Alzheimer's disease
Wed Aug 12 00:00:00 EDT 2009
Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.
Molecular and cellular biology
Jossin Y,Goffinet AM
44-752G was used in western blot identify and investigate Reelin-regulated signaling pathways in the brain
Mon Oct 01 00:00:00 EDT 2007
Identification of small molecules that interfere with radial neuronal migration and early cortical plate development.
Cerebral cortex (New York, N.Y. : 1991)
Zhou L,Jossin Y,Goffinet AM
44-752G was used in Western Blotting to identify molecules which may provide new tools to study a neuronal migration and cortical plate development.
Mon Jan 01 00:00:00 EST 2007
Pseudophosphorylation of tau protein alters its ability for self-aggregation.
Journal of neurochemistry
Haase C,Stieler JT,Arendt T,Holzer M
Mon Mar 01 00:00:00 EST 2004
Pseudophosphorylation of tau protein alters its ability for self-aggregation.
Journal of neurochemistry
Haase C,Stieler JT,Arendt T,Holzer M
Mon Mar 01 00:00:00 EST 2004
Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein.
The Journal of biological chemistry
Alonso AD,Zaidi T,Novak M,Barra HS,Grundke-Iqbal I,Iqbal K
Fri Oct 12 00:00:00 EDT 2001
