Product References
Mast cells link immune sensing to antigen-avoidance behaviour.
Nature
Plum T,Binzberger R,Thiele R,Shang F,Postrach D,Fung C,Fortea M,Stakenborg N,Wang Z,Tappe-Theodor A,Poth T,MacLaren DAA,Boeckxstaens G,Kuner R,Pitzer C,Monyer H,Xin C,Bonventre JV,Tanaka S,Voehringer D,Vanden Berghe P,Strid J,Feyerabend TB,Rodewald HR
45-0112-82 was used in Flow cytometry/Cell sorting to identify the immunological sensor cell linking antigen recognition to avoidance behaviour.
Tue Aug 01 00:00:00 EDT 2023
Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis.
iScience
Zhou J,Wang H,Shu T,Wang J,Yang W,Li J,Ding L,Liu M,Sun H,Wong J,Lai PB,Tsang SW,Ward SE,Chow KL,Sung JJ,Sze-Lok Cheng A
45-0112-82 was used in Flow cytometry/Cell sorting to demonstrated that cell cycle-related kinase (CCRK) is upregulated in myeloid cells in tumor-bearing mice and in patients with hepatocellular carcinoma.
Fri Oct 20 00:00:00 EDT 2023
Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy.
Materials today. Bio
Huang J,Leng X,Jiang T,Xu L,Zheng J,Fang M,Wang J,Wang Z,Zhang L
45-0112-82 was used in Flow cytometry/Cell sorting to develop an oxygen-carrying nanoplatform loaded with perfluorooctyl bromide (PFOB, a second-generation of perfluorocarbon-based blood substitute), IR780 (a photosensitizer) and imiquimod (R837, an immune adjuvant) to reprogram immunosuppressive TME and reinforce photothermal-immunotherapy.
Sat Apr 01 00:00:00 EDT 2023
CAR-T Cell-Mediated B-Cell Depletion in Central Nervous System Autoimmunity.
Neurology(R) neuroimmunology & neuroinflammation
Gupta S,Simic M,Sagan SA,Shepherd C,Duecker J,Sobel RA,Dandekar R,Wu GF,Wu W,Pak JE,Hauser SL,Lim W,Wilson MR,Zamvil SS
45-0112-82 was used in Flow cytometry/Cell sorting to observe that anti-CD19 CAR-T cells ameliorated experimental autoimmune encephalomyelitis and thoroughly deplete B cells in peripheral tissues and in the CNS.
Wed Mar 01 00:00:00 EST 2023
Hypoxia-inducible factor 1A inhibition overcomes castration resistance of prostate tumors.
EMBO molecular medicine
Terzic J,Abu El Maaty MA,Lutzing R,Vincent A,El Bizri R,Jung M,Keime C,Metzger D
45-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that HIF1A in prostatic tumor cells is a critical factor that enables their survival after ADT, and identify it as a target for CRPC management.
Wed Jun 07 00:00:00 EDT 2023
CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases.
The Journal of experimental medicine
Zhang B,Zhang Y,Xiong L,Li Y,Zhang Y,Zhao J,Jiang H,Li C,Liu Y,Liu X,Liu H,Ping YF,Zhang QC,Zhang Z,Bian XW,Zhao Y,Hu X
45-0112-82 was used in Flow cytometry/Cell sorting to henotypically and molecularly characterize CD127-imprinted functional heterogeneity of human inflammatory monocytes with direct relevance for inflammatory diseases.
Mon Feb 07 00:00:00 EST 2022
Interleukin-10 genetically modified clinical-grade mesenchymal stromal cells markedly reinforced functional recovery after spinal cord injury via directing alternative activation of macrophages.
Cellular & molecular biology letters
Gao T,Huang F,Wang W,Xie Y,Wang B
45-0112-82 was used in Flow Cytometry to examine interleukin-10 (IL10) genetically modified clinical-grade MSCs (IL10-MSCs) and evaluate their clinical safety, effectiveness, and therapeutic mechanism in a completely transected SCI mouse model.
Thu Mar 17 00:00:00 EDT 2022
Microglial STAT1-sufficiency is required for resistance to toxoplasmic encephalitis.
PLoS pathogens
Cowan MN,Kovacs MA,Sethi I,Babcock IW,Still K,Batista SJ,O'Brien CA,Thompson JA,Sibley LA,Labuzan SA,Harris TH
45-0112-82 was used in Flow cytometry/Cell sorting to report that abrogation of STAT1 signaling in microglia, the resident immune cells of the CNS, is sufficient to induce a loss of parasite control in the CNS and susceptibility to toxoplasmic encephalitis during the early stages of chronic infection.
Thu Sep 01 00:00:00 EDT 2022
Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae.
PLoS pathogens
David S,Wong JLC,Sanchez-Garrido J,Kwong HS,Low WW,Morecchiato F,Giani T,Rossolini GM,Brett SJ,Clements A,Beis K,Aanensen DM,Frankel G
45-0112-82 was used in Flow cytometry/Cell sorting to provide a contemporary global view of OmpK36-mediated resistance mechanisms in KP, integrating surveillance and experimental data to guide treatment and drug development strategies.
Fri Jul 01 00:00:00 EDT 2022
Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation.
Cell reports
Gros M,Segura E,Rookhuizen DC,Baudon B,Heurtebise-Chrétien S,Burgdorf N,Maurin M,Kapp EA,Simpson RJ,Kozik P,Villadangos JA,Bertrand MJM,Burbage M,Amigorena S
45-0112-82 was used in Flow cytometry/Cell sorting to demonstrate that membrane repair proves crucial in containing antigen export to the cytosol and cross-presentation in cDCs.
Tue Aug 16 00:00:00 EDT 2022
Local and systemic inflammation triggers different outcomes of tumor growth related to infiltration of anti-tumor or pro-tumor macrophages.
Chinese medical journal
Liu X,Jiang Q,Shen S,Hou Y
45-0112-82 was used in Flow cytometry/Cell sorting to suggest that the different outcomes of tumor growth might be attributed to the infiltration of anti-tumor or pro-tumor immune cells, especially M1 or M2 type macrophages into tumor microenvironment.
Fri Aug 05 00:00:00 EDT 2022
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
45-0112-82 was used in flow cytometry to assess this concept by combining vascular endothelial growth factor (VEGF) pathway inhibitors that remodel the tumor vasculature with the tricyclic antidepressant imipramine, which enhances autophagy in GBM cancer cells and unexpectedly reprograms immunosuppressive tumor-associated macrophages via inhibition of histamine receptor signaling to become immunostimulatory.
Mon Oct 10 00:00:00 EDT 2022
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
45-0112-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
Human skin dermis-derived fibroblasts are a kind of functional mesenchymal stromal cells: judgements from surface markers, biological characteristics, to therapeutic efficacy.
Cell & bioscience
Tai C,Xie Z,Li Y,Feng Y,Xie Y,Yang H,Wang L,Wang B
45-0112-82 was used in Flow cytometry/Cell sorting to show that human skin dermis-derived fibroblasts were a kind of functional MSCs with functionally equivalent therapeutic efficacy in treating specific complications, indicating fibroblasts potentially had the same lineage hierarchy of origin as MSCs and had a remarkable potential as an alternative to MSCs in the treatment of a variety of diseases.
Tue Jul 12 00:00:00 EDT 2022
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.
iScience
Riding AM,Loudon KW,Guo A,Ferdinand JR,Lok LSC,Richoz N,Stewart A,Castro-Dopico T,Tuong ZK,Fiancette R,Bowyer GS,Fleming A,Gillman ES,Suchanek O,Mahbubani KT,Saeb-Parsy K,Withers D,Dougan G,Clare S,Clatworthy MR
45-0112-82 was used in Flow cytometry/Cell sorting to provide important insights into the orchestration and execution of type 17 immunity in bladder defense.
Fri Jul 15 00:00:00 EDT 2022
Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells.
eLife
Eisele AS,Cosgrove J,Magniez A,Tubeuf E,Tenreira Bento S,Conrad C,Cayrac F,Tak T,Lyne AM,Urbanus J,Perié L
45-0112-82 was used in flow cytometry to show that EPO does act directly on MPP independent of the niche and modulates fate by remodeling the clonal composition of the MPP pool.
Tue Feb 15 00:00:00 EST 2022
Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.
Science advances
Abu El Maaty MA,Terzic J,Keime C,Rovito D,Lutzing R,Yanushko D,Parisotto M,Grelet E,Namer IJ,Lindner V,Laverny G,Metzger D
45-0112-82 was used in Flow cytometry/Cell sorting to characterize prostatic intraepithelial neoplasia (PIN) progression and demonstrate that HIF1A is a target for PCa prevention and that TGM2 is a promising prognostic biomarker of early relapse after prostatectomy.
Fri Jul 22 00:00:00 EDT 2022
Vespakinin-M, a natural peptide from Vespa magnifica, promotes functional recovery in stroke mice.
Communications biology
Zhao H,Wang M,Gao Y,Wu X,Xiao H,Yang D,He F,Lv J,Xie D,Wang Q,Liu W,Luo J,Yang Z,Zhang C,Cheng J,Zhao Y
45-0112-82 was used in Flow cytometry/Cell sorting to show that targeting the VK-B2R interaction can be considered as a practical strategy for stroke therapy.
Thu Jan 20 00:00:00 EST 2022
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity.
Cell metabolism
Wang L,Wang B,Gasek NS,Zhou Y,Cohn RL,Martin DE,Zuo W,Flynn WF,Guo C,Jellison ER,Kim T,Prata LGPL,Palmer AK,Li M,Inman CL,Barber LS,Al-Naggar IMA,Zhou Y,Du W,Kuchel GA,Meves A,Tchkonia T,Kirkland JL,Robson P,Xu M
45-0112-82 was used in Flow cytometry/Cell sorting to establish that p21high cells within fat are sufficient to cause insulin resistance in vivo.
Tue Jan 04 00:00:00 EST 2022
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Immunity
Medina CB,Chiu YH,Stremska ME,Lucas CD,Poon I,Tung KS,Elliott MR,Desai B,Lorenz UM,Bayliss DA,Ravichandran KS
45-0112-82 was used in Flow cytometry/Cell sorting to uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease.
Tue Aug 10 00:00:00 EDT 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
45-0112-82 was used in Flow Cytometry to show a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke.
Mon Aug 02 00:00:00 EDT 2021
Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment.
NPJ precision oncology
Yang N,Ji F,Cheng L,Lu J,Sun X,Lin X,Lan X
45-0112 was used in Flow cytometry/Cell sorting to show that knockout of MALT1 can eliminate the antitumor effect of anti-PD-1 treatment completely by impairing the activation of CD8+ T cells.
Fri May 07 00:00:00 EDT 2021
Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation.
Nature communications
Heil J,Olsavszky V,Busch K,Klapproth K,de la Torre C,Sticht C,Sandorski K,Hoffmann J,Schönhaber H,Zierow J,Winkler M,Schmid CD,Staniczek T,Daniels DE,Frayne J,Metzgeroth G,Nowak D,Schneider S,Neumaier M,Weyer V,Groden C,Gröne HJ,Richter K,Mogler C,Taketo MM,Schledzewski K,Géraud C,Goerdt S,Koch PS
45-0112-82 was used in Flow Cytometry to show that bone marrow sinusoidal endothelial cells actively control erythropoiesis.
Mon Nov 29 00:00:00 EST 2021
Myeloid DJ-1 deficiency protects acetaminophen-induced acute liver injury through decreasing inflammatory response.
Aging
Wang B,Li J,Jiao J,Xu M,Luo Y,Wang F,Xia Q,Gao Y,Feng Y,Kong X,Sun X
45-0112-82 was used in Flow Cytometry to suggest DJ-1 as a potential therapeutic and/or prophylactic target of APAP-induced acute liver injury.
Wed Jul 21 00:00:00 EDT 2021
Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration.
Cell death discovery
Tao Y,Wang F,Xu Z,Lu X,Yang Y,Wu J,Yao C,Yi F,Li J,Huang Z,Liu Y
45-0112-82 was used in Flow Cytometry to study the involvement of foamy cells in peripheral nerve regeneration in a GSDMD-/- mouse model.
Mon Jun 14 00:00:00 EDT 2021
Platelet-Like Fusogenic Liposome-Mediated Targeting Delivery of miR-21 Improves Myocardial Remodeling by Reprogramming Macrophages Post Myocardial Ischemia-Reperfusion Injury.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Tan H,Song Y,Chen J,Zhang N,Wang Q,Li Q,Gao J,Yang H,Dong Z,Weng X,Wang Z,Sun D,Yakufu W,Pang Z,Huang Z,Ge J
45-0112-82 was used in Flow Cytometry to construct a platelet-like fusogenic liposome (PLPs) to deliver contents to the cytoplasm of target cells.
Sun Aug 01 00:00:00 EDT 2021
Mechanical Stress Induce PG-E2 in Murine Synovial Fibroblasts Originating from the Temporomandibular Joint.
Cells
Nazet U,Feulner L,Muschter D,Neubert P,Schatz V,Grässel S,Jantsch J,Proff P,Schröder A,Kirschneck C
45-0112-82 was used in Flow Cytometry to indicate that the application of prolonged advanced mechanical stress on SFs promote PG-E2 protein secretion, while the deposition of extracellular matrix components is decreased.
Mon Feb 01 00:00:00 EST 2021
Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids.
Journal for immunotherapy of cancer
Hamdan F,Ylösmäki E,Chiaro J,Giannoula Y,Long M,Fusciello M,Feola S,Martins B,Feodoroff M,Antignani G,Russo S,Kari O,Lee M,Järvinen P,Nisen H,Kreutzman A,Leusen J,Mustjoki S,McWilliams TG,Grönholm M,Cerullo V
45-0112-82 was used in Flow cytometry/Cell sorting to designed an oncolytic adenovirus to increase efficacy while minimizing toxicity of PD-L1 immunecheckpoint therapy that secretes a cross-hybrid Fc-fusion peptide against PD-L1 able to elicit effector mechanisms of an IgG1 and also IgA1 consequently activating neutrophils, a population neglected by IgG1, in order to combine multiple effector mechanisms.
Sun Aug 01 00:00:00 EDT 2021
Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions.
Science advances
Abu El Maaty MA,Grelet E,Keime C,Rerra AI,Gantzer J,Emprou C,Terzic J,Lutzing R,Bornert JM,Laverny G,Metzger D
45-0112-82 was used in Flow Cytometry to determine the impact of vitamin D signaling on prostatic precancerous lesions.
Thu Jul 01 00:00:00 EDT 2021
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Frontiers in immunology
Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L
45-0112-82 was used in Flow Cytometry to show that the phosphatase PP2Cδ played a pivotal role in regulating dendritic cells (DC) activation and function, as PP2Cδ ablation caused aberrant maturation, activation, and Th1/Th17-priming of DCs, and hence induced onset of exacerbated experimental autoimmune encephalomyelitis.
Mon Feb 28 00:00:00 EST 2022
Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways.
Cell death discovery
Li YH,Shen S,Shao T,Jin MT,Fan DD,Lin AF,Xiang LX,Shao JZ
45-0112-82 was used in Flow Cytometry to provide insights into the functional role of bone marrow-derived sesenchymal stem cell in alleviating liver fibrosis.
Mon Sep 13 00:00:00 EDT 2021
A macrophage-T cell coculture model for severe tissue injury-induced T cell death.
STAR protocols
Zhu J,Cao J,Liesz A,Roth S
45-0112-82 was used in Flow Cytometry to present an in vitro model for cell-cell interactions between innate (macrophages) and adaptive (T cells) immune cells.
Fri Dec 17 00:00:00 EST 2021
Requirement of direct contact between chondrocytes and macrophages for the maturation of regenerative cartilage.
Scientific reports
Kanda K,Asawa Y,Inaki R,Fujihara Y,Hoshi K,Hikita A
45-0112-82 was used in Flow Cytometry to provide insights for establishing a method of in vitro cartilage regeneration.
Thu Nov 18 00:00:00 EST 2021
Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype.
International journal of medical sciences
Liu X,Xu Y,Li Y,Pan Y,Zhao S,Hou Y
45-0112-82 was used in Flow cytometry/Cell sorting to create a nanocomposite of Ferumoxytol (FMT) surface-coated with β-glucan (FMT-β-glucan), which effectively suppressed melanoma growth by promoting the polarization of M1 macrophages in the tumor microenvironment, enhancing the antitumor effect both in vivo and in vitro, likely through the upregulation of Dectin-1 and activation of MAPK and NF-κB signaling pathways in macrophages.
Mon Jan 10 00:00:00 EST 2022
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
45-0112 was used in Flow cytometry/Cell sorting to investigate the function of brain-resident CD4 T cells.
Thu Aug 06 00:00:00 EDT 2020
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
45-0112 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 EST 2020
IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Cell
Sadik A,Somarribas Patterson LF,Öztürk S,Mohapatra SR,Panitz V,Secker PF,Pfänder P,Loth S,Salem H,Prentzell MT,Berdel B,Iskar M,Faessler E,Reuter F,Kirst I,Kalter V,Foerster KI,Jäger E,Guevara CR,Sobeh M,Hielscher T,Poschet G,Reinhardt A,Hassel JC,Zapatka M,Hahn U,von Deimling A,Hopf C,Schlichting R,Escher BI,Burhenne J,Haefeli WE,Ishaque N,Böhme A,Schäuble S,Thedieck K,Trump S,Seiffert M,Opitz CA
45-0112 was used in Flow cytometry/Cell sorting to show that IL4I1 blockade opens new avenues for cancer therapy.
Thu Sep 03 00:00:00 EDT 2020
Bcl6 and Blimp1 reciprocally regulate ST2+ Treg-cell development in the context of allergic airway inflammation.
The Journal of allergy and clinical immunology
Koh B,Ulrich BJ,Nelson AS,Panangipalli G,Kharwadkar R,Wu W,Xie MM,Fu Y,Turner MJ,Paczesny S,Janga SC,Dent AL,Kaplan MH
45-0112 was used in Flow cytometry/Cell sorting to define the functions of Bcl6 in Treg cells, including Tfr cells, in the context of allergic airway inflammation.
Sun Nov 01 00:00:00 EDT 2020
Probody Therapeutic Design of 89Zr-CX-072 Promotes Accumulation in PD-L1-Expressing Tumors Compared to Normal Murine Lymphoid Tissue.
Clinical cancer research : an official journal of the American Association for Cancer Research
Giesen D,Broer LN,Lub-de Hooge MN,Popova I,Howng B,Nguyen M,Vasiljeva O,de Vries EGE,Pool M
45-0112-82 was used in Flow Cytometry to enable clinical evaluation of 89Zr-CX-072 whole-body distribution as a tool to support CX-072 drug development (NCT03013491).
Sat Aug 01 00:00:00 EDT 2020
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Proceedings of the National Academy of Sciences of the United States of America
Kitchen GB,Cunningham PS,Poolman TM,Iqbal M,Maidstone R,Baxter M,Bagnall J,Begley N,Saer B,Hussell T,Matthews LC,Dockrell DH,Durrington HJ,Gibbs JE,Blaikley JF,Loudon AS,Ray DW
45-0112-82 was used in Flow Cytometry to show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia.
Tue Jan 21 00:00:00 EST 2020
SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells.
Cancer immunology research
Hu M,Lu Y,Qi Y,Zhang Z,Wang S,Xu Y,Chen F,Tang Y,Chen S,Chen M,Du C,Shen M,Wang F,Su Y,Deng Y,Wang J
45-0112-82 was used in Flow Cytometry to study the role of SRC-3 as a coactivator of T-bet in natural killer-cell biology and indicate that targeting SRC-3 may be a promising strategy to increase the tumor surveillance function of natural killer cells.
Tue Sep 01 00:00:00 EDT 2020
Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME
45-0112-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.
Sat Feb 01 00:00:00 EST 2020
The effect of type 2 diabetes on CD36 expression and the uptake of oxLDL: Diabetes affects CD36 and oxLDL uptake.
Experimental neurology
Kanoke A,Nishijima Y,Ljungberg M,Omodaka S,Yang SY,Wong S,Rabiller G,Tominaga T,Hsieh CL,Liu J
45-0112-82 was used in Flow Cytometry to investigate whether type 2 diabetes mellitus (T2DM) affects the level of scavenger receptor CD36 and the uptake of its ligand, oxidized LDL (oxLDL); and whether pioglitazone, a drug that enhances CD36, promotes oxLDL uptake.
Tue Dec 01 00:00:00 EST 2020
Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.
Nature communications
Kimura S,Nakamura Y,Kobayashi N,Shiroguchi K,Kawakami E,Mutoh M,Takahashi-Iwanaga H,Yamada T,Hisamoto M,Nakamura M,Udagawa N,Sato S,Kaisho T,Iwanaga T,Hase K
45-0112 was used in Flow cytometry/Cell sorting to identify that the balance between infectious risk and the ability to perform immunosurveillance at the mucosal surface is dependent on osteprotegerin-dependent self-regulation of M cell differentiation.
Mon Jan 13 00:00:00 EST 2020
The micropeptide LEMP plays an evolutionarily conserved role in myogenesis.
Cell death & disease
Wang L,Fan J,Han L,Qi H,Wang Y,Wang H,Chen S,Du L,Li S,Zhang Y,Tang W,Ge G,Pan W,Hu P,Cheng H
45-0112 was used in Flow cytometry/Cell sorting to uncover a micropeptide that plays an evolutionarily conserved role in skeletal muscle differentiation, pinpointing the functional importance of this growing family of small peptides.
Mon May 11 00:00:00 EDT 2020
Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.
Frontiers in pharmacology
Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y
45-0112-82 was used in Flow Cytometry to find that FGFR3 had a novel regulatory mechanism for the stemness of LSCs in AML, and provided a promising anti-leukemia approach by interrupting FGFR3.
Tue Feb 16 00:00:00 EST 2021
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
eLife
Frye M,Stritt S,Ortsäter H,Hernandez Vasquez M,Kaakinen M,Vicente A,Wiseman J,Eklund L,Martínez-Torrecuadrada JL,Vestweber D,Mäkinen T
45-0112 was used in Flow cytometry/Cell sorting to identify the transmembrane ligand EphrinB2 and its receptor EphB4 as critical homeostatic regulators of collecting lymphatic vessel integrity.
Tue Sep 08 00:00:00 EDT 2020
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Nature communications
Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG
45-0112 was used in Flow cytometry/Cell sorting to show that cell-free mitochondrial DNA (cf-mt-DNA) released by senescent cells accumulates with aging and augments immunogenicity.
Thu Aug 27 00:00:00 EDT 2020
MicroRNAs of the miR-17~9 family maintain adipose tissue macrophage homeostasis by sustaining IL-10 expression.
eLife
Zhang X,Liu J,Wu L,Hu X
45-0112 was used in Flow cytometry/Cell sorting to identifiy miR-17~92 family miRNAs as crucial regulators of the balance between pro- and anti-inflammatory cytokines and exemplify how macrophage-intrinsic regulatory circuit exerted impactful influence on general physiology.
Thu Nov 05 00:00:00 EST 2020
Apoptotic cells induce CD103 expression and immunoregulatory function in myeloid dendritic cell precursors through integrin αv and TGF-β activation.
PloS one
Zhang A,Paidassi H,Lacy-Hulbert A,Savill J
45-0112-82 was used in Flow Cytometry to study the role of apoptotic cells arising spontaneously in the healthy mouse gut in inducing the CD103+ immunoregulatory phenotype in dendritic cells migrating to mesenteric lymph nodes.
Tue Sep 08 00:00:00 EDT 2020
Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms.
Cells
Nuti E,Rossello A,Cuffaro D,Camodeca C,Van Bael J,van der Maat D,Martens E,Fiten P,Pereira RVS,Ugarte-Berzal E,Gouwy M,Opdenakker G,Vandooren J
45-0112 was used in Flow cytometry/Cell sorting to evaluate the potential of a bivalent carboxylate inhibitor to selectively inhibit the trimeric proteoform of MMP-9 and compare this with a corresponding monovalent inhibitor.
Tue Jul 07 00:00:00 EDT 2020
Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells.
Immunity
Pokrovskii M,Hall JA,Ochayon DE,Yi R,Chaimowitz NS,Seelamneni H,Carriero N,Watters A,Waggoner SN,Littman DR,Bonneau R,Miraldi ER
45-0112 was used in Flow cytometry/Cell sorting to study regulatory interactions between transcription factors and genes within intestinal type 1, 2, and 3 innate lymphoid cells subsets.
Tue Jul 16 00:00:00 EDT 2019
A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils.
Immunity
Janela B,Patel AA,Lau MC,Goh CC,Msallam R,Kong WT,Fehlings M,Hubert S,Lum J,Simoni Y,Malleret B,Zolezzi F,Chen J,Poidinger M,Satpathy AT,Briseno C,Wohn C,Malissen B,Murphy KM,Maini AA,Vanhoutte L,Guilliams M,Vial E,Hennequin L,Newell E,Ng LG,Musette P,Yona S,Hacini-Rachinel F,Ginhoux F
45-0112 was used in Flow cytometry/Cell sorting to show that skin cDC1s are essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.
Tue Apr 16 00:00:00 EDT 2019
The methyltransferase PRMT6 attenuates antiviral innate immunity by blocking TBK1-IRF3 signaling.
Cellular & molecular immunology
Zhang H,Han C,Li T,Li N,Cao X
45-0112-82 was used in Flow Cytometry to demonstrates a methyltransferase-independent role for PRMTs.
Tue Oct 01 00:00:00 EDT 2019
TRPV1 promotes opioid analgesia during inflammation.
Science signaling
Basso L,Aboushousha R,Fan CY,Iftinca M,Melo H,Flynn R,Agosti F,Hollenberg MD,Thompson R,Bourinet E,Trang T,Altier C
45-0112-82 was used in Flow Cytometry to investigate the regulation of downstream TRPV1 signalling pathways in the transition from acute to chronic pain.
Tue Apr 02 00:00:00 EDT 2019
Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome.
International journal of molecular medicine
Li L,Dong L,Zhao D,Gao F,Yan J
45-0112-82 was used in Flow Cytometry to explore the regulatory effects of pulmonary cDCs on acute lung inflammation and injury in lipopolysaccharide (LPS)‚induced ARDS.
Thu Aug 01 00:00:00 EDT 2019
The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.
Cell reports
Gentili M,Lahaye X,Nadalin F,Nader GPF,Puig Lombardi E,Herve S,De Silva NS,Rookhuizen DC,Zueva E,Goudot C,Maurin M,Bochnakian A,Amigorena S,Piel M,Fachinetti D,Londoño-Vallejo A,Manel N
45-0112 was used in Flow cytometry/Cell sorting to reveal a preferential functional association of nuclear cGAS with centromeres.
Tue Feb 26 00:00:00 EST 2019
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.
Cell reports
Gawish R,Bulat T,Biaggio M,Lassnig C,Bago-Horvath Z,Macho-Maschler S,Poelzl A,Simonović N,Prchal-Murphy M,Rom R,Amenitsch L,Ferrarese L,Kornhoff J,Lederer T,Svinka J,Eferl R,Bosmann M,Kalinke U,Stoiber D,Sexl V,Krmpotić A,Jonjić S,Müller M,Strobl B
45-0112 was used in Flow cytometry/Cell sorting to provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.
Tue Feb 26 00:00:00 EST 2019
Chronic alcohol consumption exacerbates murine cytomegalovirus infection via impairing nonspecific and specific NK activation in mice.
FASEB bioAdvances
Little A,Li Y,Zhang F,Zhang H
45-0112-82 was used in Flow Cytometry to demonstrate that chronic alcohol consumption exacerbates cytomegalovirus infection via impairing nonspecific and specific NK cell activation, specifically IFN-γ and perforin production.
Tue Jan 01 00:00:00 EST 2019
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis.
Nature communications
Ershaid N,Sharon Y,Doron H,Raz Y,Shani O,Cohen N,Monteran L,Leider-Trejo L,Ben-Shmuel A,Yassin M,Gerlic M,Ben-Baruch A,Pasmanik-Chor M,Apte R,Erez N
45-0112-82 was used in Flow Cytometry to find that fibroblasts sense damage-associated molecular patterns (DAMPs), and in response activate the NLRP3 inflammasome pathway, resulting in instigation of pro-inflammatory signalling and secretion of IL-1β.
Thu Sep 26 00:00:00 EDT 2019
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Nature communications
Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N
45-0112 was used in Flow cytometry/Cell sorting to demonstrate the promotion of plasma cell development and function by the unfolded protein response pathway is regulated by Ufbp1.
Wed Mar 06 00:00:00 EST 2019
Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue.
Cell reports
Li B,Li L,Li M,Lam SM,Wang G,Wu Y,Zhang H,Niu C,Zhang X,Liu X,Hambly C,Jin W,Shui G,Speakman JR
45-0112-82 was used in Flow Cytometry to indicate that gut microbiota contributes to upregulated thermogenesis in the cold environment and that this may be partially mediated via butyrate.
Tue Mar 05 00:00:00 EST 2019
LL37 Inhibits Aspergillus fumigatus Infection via Directly Binding to the Fungus and Preventing Excessive Inflammation.
Frontiers in immunology
Luo XL,Li JX,Huang HR,Duan JL,Dai RX,Tao RJ,Yang L,Hou JY,Jia XM,Xu JF
45-0112-82 was used in Flow cytometry to examine the interaction between LL37 and Aspergillus fumigatus and found that synthetic LL37 could directly bind to the surface of Aspergillus fumigatus, disrupting the integrity of the cell wall in vitro.
Tue Jul 21 00:00:00 EDT 2020
Non-classical monocytes as mediators of tissue destruction in arthritis.
Annals of the rheumatic diseases
Puchner A,Saferding V,Bonelli M,Mikami Y,Hofmann M,Brunner JS,Caldera M,Goncalves-Alves E,Binder NB,Fischer A,Simader E,Steiner CW,Leiss H,Hayer S,Niederreiter B,Karonitsch T,Koenders MI,Podesser BK,O'Shea JJ,Menche J,Smolen JS,Redlich K,Blüml S
45-0112 was used in Flow cytometry/Cell sorting to deduce that non-classical monocytes are pivotal cells in arthritis tissue damage.
Mon Oct 01 00:00:00 EDT 2018
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.
The Journal of experimental medicine
Nair S,Huynh JP,Lampropoulou V,Loginicheva E,Esaulova E,Gounder AP,Boon ACM,Schwarzkopf EA,Bradstreet TR,Edelson BT,Artyomov MN,Stallings CL,Diamond MS
45-0112 was used in Flow cytometry/Cell sorting to study the role of Immune responsive gene 1 in the modulation of inflammation during Mycobacterium tuberculosis infection.
Mon Apr 02 00:00:00 EDT 2018
Murine CMV induces type 1 IFN that impairs differentiation of MDSCs critical for transplantation tolerance.
Blood advances
Dangi A,Zhang L,Zhang X,Luo X
45-0112 was used in Flow cytometry/Cell sorting to provide a solid foundation for seeking effective therapies for promoting transplantation tolerance in settings of CMV infection.
Tue Mar 27 00:00:00 EDT 2018
Macrophages orchestrate breast cancer early dissemination and metastasis.
Nature communications
Linde N,Casanova-Acebes M,Sosa MS,Mortha A,Rahman A,Farias E,Harper K,Tardio E,Reyes Torres I,Jones J,Condeelis J,Merad M,Aguirre-Ghiso JA
45-0112 was used in Flow cytometry/Cell sorting to show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+early cancer cells.
Tue Jan 02 00:00:00 EST 2018
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.
Nature communications
Cambré I,Gaublomme D,Burssens A,Jacques P,Schryvers N,De Muynck A,Meuris L,Lambrecht S,Carter S,de Bleser P,Saeys Y,Van Hoorebeke L,Kollias G,Mack M,Simoens P,Lories R,Callewaert N,Schett G,Elewaut D
45-0112 was used in Flow cytometry/Cell sorting to study the role of mechanical strain in controlling site-specific localisation of inflammation and tissue damage in arthritis.
Mon Nov 05 00:00:00 EST 2018
Adrenal hormones mediate disease tolerance in malaria.
Nature communications
Vandermosten L,Pham TT,Knoops S,De Geest C,Lays N,Van der Molen K,Kenyon CJ,Verma M,Chapman KE,Schuit F,De Bosscher K,Opdenakker G,Van den Steen PE
Tue Oct 30 00:00:00 EDT 2018
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
45-0112 was used in Flow cytometry/Cell sorting to demonstrate for the first time that type 2 diabetes mellitus induces an haematopoietic stem cell-autonomous mechanism that causes impaired wound healing.
Tue Jan 02 00:00:00 EST 2018
Collagenase-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry.
Bio-protocol
Czupalla CJ,Yousef H,Wyss-Coray T,Butcher EC
45-0112-82 was used in Flow Cytometry to report that the integrity of the brain endothelium is compromised in a plethora of neuropathologies.
Tue Nov 20 00:00:00 EST 2018
Characterization of Multiple Cytokine Combinations and TGF-β on Differentiation and Functions of Myeloid-Derived Suppressor Cells.
International journal of molecular sciences
Lee CR,Lee W,Cho SK,Park SG
45-0112 was used in Flow cytometry/Cell sorting to examine the effect of various cytokine combinations with transforming growth factor-β on myeloid-derived suppressor cells derived from bone marrow cells.
Thu Mar 15 00:00:00 EDT 2018
Non-redundant Functions of IL-6 Produced by Macrophages and Dendritic Cells in Allergic Airway Inflammation.
Frontiers in immunology
Gubernatorova EO,Gorshkova EA,Namakanova OA,Zvartsev RV,Hidalgo J,Drutskaya MS,Tumanov AV,Nedospasov SA
45-0112 was used in Flow cytometry/Cell sorting to indicate that IL-6 plays a pathogenic role in the HDM-induced asthma model and that lung macrophages and dendritic cells are the predominant sources of pathogenic IL-6 but contribute differently to the disease.
Wed Oct 02 00:00:00 EDT 2019
Estriol Reduces Pulmonary Immune Cell Recruitment and Inflammation to Protect Female Mice From Severe Influenza.
Endocrinology
Vermillion MS,Ursin RL,Attreed SE,Klein SL
45-0112-82 was used in Flow cytometry/Cell sorting to suggest that exogenous E3 confers protection during IAV infection through immunomodulatory mechanisms and that E3 may have broad therapeutic potential in the context of both infectious and noninfectious inflammatory diseases.
Sat Sep 01 00:00:00 EDT 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
45-0112 was used in Flow cytometry/Cell sorting to demonstrate a method for the rapid/robust production of mast cells from pluripotent stem cells.
Tue Oct 09 00:00:00 EDT 2018
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.
Nature
Camell CD,Sander J,Spadaro O,Lee A,Nguyen KY,Wing A,Goldberg EL,Youm YH,Brown CW,Elsworth J,Rodeheffer MS,Schultze JL,Dixit VD
45-0112 was used in Flow cytometry/Cell sorting to show that adipose tissue macrophages regulate the age-related reduction in adipocyte lipolysis in mice by lowering the bioavailability of noradrenaline.
Thu Oct 05 00:00:00 EDT 2017
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Cell
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
45-0112-82 was used in Flow Cytometry to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.
Thu Aug 24 00:00:00 EDT 2017
Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.
Circulation research
Yan X,Zhang H,Fan Q,Hu J,Tao R,Chen Q,Iwakura Y,Shen W,Lu L,Zhang Q,Zhang R
45-0112 was used in Flow cytometry/Cell sorting to determine whether Dectin-2 signalling is involved in the healing process and cardiac remodelling after myocardial infarction and to elucidate the underlying molecular mechanisms.
Fri Mar 31 00:00:00 EDT 2017
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
The Journal of experimental medicine
Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG
45-0112 was used in Flow cytometry/Cell sorting to describe the key role of the previously uncharacterised protein Eros in host defence.
Mon Apr 03 00:00:00 EDT 2017
Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity.
The Journal of experimental medicine
Alloatti A,Rookhuizen DC,Joannas L,Carpier JM,Iborra S,Magalhaes JG,Yatim N,Kozik P,Sancho D,Albert ML,Amigorena S
45-0112 was used in Flow cytometry/Cell sorting to determine that Sec22b-dependent cross-presentation in dendritic cells is required to initiate CD8 T cell responses to dead cells, and induce effective anti-tumour immune responses during anti-PD-1 treatment.
Mon Aug 07 00:00:00 EDT 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
45-0112 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy.
Brain : a journal of neurology
Laurent C,Dorothée G,Hunot S,Martin E,Monnet Y,Duchamp M,Dong Y,Légeron FP,Leboucher A,Burnouf S,Faivre E,Carvalho K,Caillierez R,Zommer N,Demeyer D,Jouy N,Sazdovitch V,Schraen-Maschke S,Delarasse C,Buée L,Blum D
45-0112 was used in Flow cytometry/Cell sorting to elucidate the contribution of brain immune cells in tau-driven pathophysiology in Alzheimer's.
Sun Jan 01 00:00:00 EST 2017
Staphylococcal serine protease-like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus.
The Journal of allergy and clinical immunology
Stentzel S,Teufelberger A,Nordengrün M,Kolata J,Schmidt F,van Crombruggen K,Michalik S,Kumpfmüller J,Tischer S,Schweder T,Hecker M,Engelmann S,Völker U,Krysko O,Bachert C,Bröker BM
45-0112 was used in Flow cytometry/Cell sorting to identify Spls as triggering allergens released by S aureus, opening prospects for diagnosis and causal therapy of asthma.
Wed Feb 01 00:00:00 EST 2017
FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection.
Frontiers in immunology
Baranek T,Morello E,Valayer A,Aimar RF,Bréa D,Henry C,Besnard AG,Dalloneau E,Guillon A,Dequin PF,Narni-Mancinelli E,Vivier E,Laurent F,Wei Y,Paget C,Si-Tahar M
45-0112 was used in Flow cytometry/Cell sorting to determine the expression and role of FHL2 in natural killer cell biology.
Wed Nov 20 00:00:00 EST 2019
Rediscovering peritoneal macrophages in a murine endometriosis model.
Human reproduction (Oxford, England)
Yuan M,Li D,An M,Li Q,Zhang L,Wang G
45-0112 was used in Flow Cytometry to study the role of large and small peritoneal macrophages in endometriosis.
Sun Jan 01 00:00:00 EST 2017
Retinoic Acid Regulates Immune Responses by Promoting IL-22 and Modulating S100 Proteins in Viral Hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Jie Z,Liang Y,Yi P,Tang H,Soong L,Cong Y,Zhang K,Sun J
45-0112 was used in Flow cytometry/Cell sorting to determine the role of retinoic acid in IL-22 production during hepatitis infection.
Mon May 01 00:00:00 EDT 2017
Neurodegeneration Enhances the Development of Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Lang SC,Harre U,Purohit P,Dietel K,Kienhöfer D,Hahn J,Baum W,Herrmann M,Schett G,Mielenz D
45-0112 was used in Flow cytometry/Cell sorting to show that tau-transgenic mice that develop neurodegenerative disease characterized by deposition of tau tangles in the brain are highly susceptible to developing arthritis.
Wed Mar 15 00:00:00 EDT 2017
Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration.
BioMed research international
Müller J,von Bernstorff W,Heidecke CD,Schulze T
Fri Apr 28 00:00:00 EDT 2017
Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells.
Journal of neuroimmunology
Benedek G,Zhang J,Nguyen H,Kent G,Seifert HA,Davin S,Stauffer P,Vandenbark AA,Karstens L,Asquith M,Offner H
Fri Sep 15 00:00:00 EDT 2017
Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.
PLoS neglected tropical diseases
Floudas A,Cluxton CD,Fahel J,Khan AR,Saunders SP,Amu S,Alcami A,Fallon PG
45-0112 was used in Flow cytometry/Cell sorting to demonstrate the unique protein composition of the S. mansoni male worm secretome and immunomodulatory activity of S. mansoni Cyclophilin A.
Sun Oct 01 00:00:00 EDT 2017
Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.
Frontiers in cellular neuroscience
Cruz SA,Hari A,Qin Z,Couture P,Huang H,Lagace DC,Stewart AFR,Chen HH
45-0112 was used in Flow cytometry/Cell sorting to identify that IRF2 binding protein 2 expression in macrophages/microglia is important in limiting inflammation and stroke injury, by mediating the beneficial effect of interferon beta.
Thu Mar 17 00:00:00 EDT 2022
CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality.
The Journal of biological chemistry
Thylur RP,Wu X,Gowda NM,Punnath K,Neelgund SE,Febbraio M,Gowda DC
45-0112 was used in Flow cytometry/Cell sorting to study the function of CD36 in malaria immunity.
Fri Jun 02 00:00:00 EDT 2017
Ebola Virus Glycoprotein Induces an Innate Immune Response In vivo via TLR4.
Frontiers in microbiology
Lai CY,Strange DP,Wong TAS,Lehrer AT,Verma S
45-0112 was used in Flow cytometry/Cell sorting to investigate the early immune response to purified Ebola virus glycoprotein alone in vitro and in vivo.
Tue Sep 29 00:00:00 EDT 2020
Preferential TNFα signaling via TNFR2 regulates epithelial injury and duct obstruction in experimental biliary atresia.
JCI insight
Shivakumar P,Mizuochi T,Mourya R,Gutta S,Yang L,Luo Z,Bezerra JA
45-0112 was used in Flow cytometry/Cell sorting to determine factors regulating the pathogenic mechanisms of biliary atresia.
Thu Mar 09 00:00:00 EST 2017
IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing.
The Journal of investigative dermatology
Rak GD,Osborne LC,Siracusa MC,Kim BS,Wang K,Bayat A,Artis D,Volk SW
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that cutaneous injury promotes an IL-33-dependent group 2 ILC response and that abrogation of this response can impair efficient wound closure.
Mon Feb 01 00:00:00 EST 2016
Identification of a Hematopoietic Cell Dedifferentiation-Inducing Factor.
Journal of cellular physiology
Li Y,Adomat H,Guns ET,Hojabrpour P,Duronio V,Curran TA,Jalili RB,Jia W,Delwar Z,Zhang Y,Elizei SS,Ghahary A
45011282 was used in immunocytochemistry to investigate if conditioned medium from proliferating fibroblasts induce a subset of hematopoietic cells to become adherent fibroblast-like cells
Wed Jun 01 00:00:00 EDT 2016
Investigations of immunotoxicity and allergic potential induced by topical application of triclosan in mice.
Journal of immunotoxicology
Anderson SE,Meade BJ,Long CM,Lukomska E,Marshall NB
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that dermal exposure to the antimicrobial agent triclosan induces stimulation of the immune system in a murine model.
Fri Sep 30 00:00:00 EDT 2016
Evaluation of the irritancy and hypersensitivity potential following topical application of didecyldimethylammonium chloride.
Journal of immunotoxicology
Anderson SE,Shane H,Long C,Lukomska E,Meade BJ,Marshall NB
45-0112 was used in Flow cytometry/Cell sorting to investigate the irritancy and hypersensivity potential of didecyldimethylammonium chloride (DDAC).
Fri Jul 01 00:00:00 EDT 2016
p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα.
Scientific reports
Lopez-Guadamillas E,Fernandez-Marcos PJ,Pantoja C,Muñoz-Martin M,Martínez D,Gómez-López G,Campos-Olivas R,Valverde AM,Serrano M
45-0112 was used in Flow cytometry/Cell sorting to examine the expression of several tumour suppressors upon fasting in mice.
Mon Oct 10 00:00:00 EDT 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
45-0112 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.
Wed Jun 01 00:00:00 EDT 2016
Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation.
Nature communications
Jackson-Jones LH,Duncan SM,Magalhaes MS,Campbell SM,Maizels RM,McSorley HJ,Allen JE,Bénézech C
45-0112 was used in Flow cytometry/Cell sorting to reveal a link between inflammation, IL-33 release by FALC stromal cells, ILC2 activation and pleural B-cell activation in FALCs, resulting in local and antigen-specific IgM production.
Thu Sep 01 00:00:00 EDT 2016
CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts.
Journal of translational medicine
De Cesare M,Sfondrini L,Pennati M,De Marco C,Motta V,Tagliabue E,Deraco M,Balsari A,Zaffaroni N
45-0112 was used in Flow cytometry/Cell sorting to indicate that locally administered CpG-ODN1826 is able to markedly affect the growth of both early- and late-stage DMPM orthotopic xenografts in the absence of severe side effects.
Mon Jan 25 00:00:00 EST 2016
ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.
eLife
Pearson C,Thornton EE,McKenzie B,Schaupp AL,Huskens N,Griseri T,West N,Tung S,Seddon BP,Uhlig HH,Powrie F
45-0112 was used in Flow cytometry/Cell sorting to investigate how a small population of innate lymphoid cells (ILCs) has large effects on immune homeostasis, showing that ILC3s produce GM-CSF to orchestrate acute intestinal inflammation.
Mon Jan 18 00:00:00 EST 2016
Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma.
Respiratory research
Baker K,Raemdonck K,Dekkak B,Snelgrove RJ,Ford J,Shala F,Belvisi MG,Birrell MA
45-0112 was used in Flow cytometry/Cell sorting to study the role of TRPV1 in rodent models of asthma, showing that TRPV1 KO or pharmacological inhibition of TRPV1 leads to decreased symptoms, suggesting it may be a target for further investigation.
Thu Jun 02 00:00:00 EDT 2016
Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections.
Nature medicine
Dalli J,Chiang N,Serhan CN
45-0112 was used in Flow cytometry/Cell sorting to elucidate the structures of four new host-protective molecules produced in neutrophil-endothelial cocultures that increase with atorvastatin and clear infections.
Tue Sep 01 00:00:00 EDT 2015
Bacillary replication and macrophage necrosis are determinants of neutrophil recruitment in tuberculosis.
Microbes and infection
Repasy T,Martinez N,Lee J,West K,Li W,Kornfeld H
45-0112 was used in Flow cytometry/Cell sorting to study the link between infection-induced necrosis of mononuclear phagocytes and neutrophil accumulation in the lungs of mice challenged with Mycobacterium tuberculosis, showing that bacillary replication and macrophage necrosis are determinants of neutrophil recruitment.
Sat Aug 01 00:00:00 EDT 2015
Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage.
British journal of pharmacology
Hwaiz R,Rahman M,Zhang E,Thorlacius H
45-0112 was used in Flow cytometry/Cell sorting to investigate whether platelet-derived CXCL4 might support pulmonary neutrophilia in abdominal sepsis, showing that secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage.
Sun Nov 01 00:00:00 EDT 2015
Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen.
Frontiers in immunology
Schneider Z,Jani PK,Szikora B,Végh A,Kövesdi D,Iliás A,Cervenak J,Balogh P,Kurucz I,Kacskovics I
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that Tg mice that overexpress bFcRn developed efficient immune response against very low dose of antigen.
Mon Aug 10 00:00:00 EDT 2015
Circumventing Y. pestis Virulence by Early Recruitment of Neutrophils to the Lungs during Pneumonic Plague.
PLoS pathogens
Vagima Y,Zauberman A,Levy Y,Gur D,Tidhar A,Aftalion M,Shafferman A,Mamroud E
45-0112 was used in Flow cytometry/Cell sorting to investigate the mechanisms responsible for delayed neutrophil homing to the lungs during Pneumonic plague.
Fri May 01 00:00:00 EDT 2015
Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice.
Journal of virology
Morales DJ,Monte K,Sun L,Struckhoff JJ,Agapov E,Holtzman MJ,Stappenbeck TS,Lenschow DJ
45-0112 was used in Flow cytometry/Cell sorting to characterise the pathogenesis of influenza A virus and Sendai virus in ISG15(-/-) mice, showing that these mice are more susceptible to infection, and that ISG15 does not seem to directly inhibit virus replication or modulation of the acute immune response.
Thu Jan 01 00:00:00 EST 2015
Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.
Molecular therapy oncolytics
Kober C,Weibel S,Rohn S,Kirscher L,Szalay AA
45-0112 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy.
Wed Apr 27 00:00:00 EDT 2016
Newly recruited CD11b+, GR-1+, Ly6C(high) myeloid cells augment tumor-associated immunosuppression immediately following the therapeutic administration of oncolytic reovirus.
Journal of immunology (Baltimore, Md. : 1950)
Clements DR,Sterea AM,Kim Y,Helson E,Dean CA,Nunokawa A,Coyle KM,Sharif T,Marcato P,Gujar SA,Lee PW
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that reovirus augments tumour-associated immunosuppression immediately following its therapeutic administration.
Fri May 01 00:00:00 EDT 2015
Alterations in antigen-specific naive CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge.
Journal of immunology (Baltimore, Md. : 1950)
Cabrera-Perez J,Condotta SA,James BR,Kashem SW,Brincks EL,Rai D,Kucaba TA,Badovinac VP,Griffith TS
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that the recovery of CD4 T cells from sepsis-induced lymphopenia is accompanied by alterations to the composition and function of the Ag-specific CD4 T cell repertoire.
Sun Feb 15 00:00:00 EST 2015
Inhibition of the CXCL12/CXCR4 chemokine axis with AMD3100, a CXCR4 small molecule inhibitor, worsens murine hepatic injury.
Hepatology research : the official journal of the Japan Society of Hepatology
Saiman Y,Jiao J,Fiel MI,Friedman SL,Aloman C,Bansal MB
45-0112 was used in Flow cytometry/Cell sorting to suggest that inhibition of the CXCR4/CXCL12 chemokine axis is injurious through modulation of the hepatic inflammatory response.
Wed Jul 01 00:00:00 EDT 2015
Investigations into the Immunotoxicity and Allergic Potential Induced by Topical Application of N-Butylbenzenesulfonamide (NBBS) in a Murine Model.
Journal of toxicology and environmental health. Part A
Marrocco A,Meade BJ,Long CM,Lukomska E,Marshall NB,Anderson SE
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that dermal exposure to NBBS, other than liver and kidney toxicity, did not apparently induce immunotoxicity in a murine model.
Wed Jan 13 00:00:00 EST 2016
Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury.
Journal of neuroinflammation
Febinger HY,Thomasy HE,Pavlova MN,Ringgold KM,Barf PR,George AM,Grillo JN,Bachstetter AD,Garcia JA,Cardona AE,Opp MR,Gemma C
45-0112 was used in Flow cytometry/Cell sorting to evaluate the range of effects resulting from the genetic deletion of CX3CR1.
Wed Sep 02 00:00:00 EDT 2015
Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells.
PloS one
Zhang J,Li L,Baldwin AS,Friedman AD,Paz-Priel I
45-0112 was used in Flow cytometry/Cell sorting to study the effects of IKKβ and NF-κB p65 on hematopoietic lineage commitment and progenitor self-renewal and functional long-term hematopoietic stem cells.
Wed Apr 13 00:00:00 EDT 2016
CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production.
Nature communications
Arnold L,Perrin H,de Chanville CB,Saclier M,Hermand P,Poupel L,Guyon E,Licata F,Carpentier W,Vilar J,Mounier R,Chazaud B,Benhabiles N,Boissonnas A,Combadiere B,Combadiere C
45-0112 was used in Flow cytometry/Cell sorting to show that CX3CR1 deficiency promotes muscle repair and rescues Ccl2-/- mice from impaired muscle regeneration through altering macrophage function.
Thu Dec 03 00:00:00 EST 2015
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.
Nature medicine
Gibbs J,Ince L,Matthews L,Mei J,Bell T,Yang N,Saer B,Begley N,Poolman T,Pariollaud M,Farrow S,DeMayo F,Hussell T,Worthen GS,Ray D,Loudon A
45-0112 was used in Flow cytometry/Cell sorting to study the regulatory mechanism linking the circadian clock and glucocorticoid hormones, to control time-of-day variation and the magnitude of pulmonary inflammation.
Fri Aug 01 00:00:00 EDT 2014
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid.
Nature
Colegio OR,Chu NQ,Szabo AL,Chu T,Rhebergen AM,Jairam V,Cyrus N,Brokowski CE,Eisenbarth SC,Phillips GM,Cline GW,Phillips AJ,Medzhitov R
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that tumour-cell-derived lactic acid has an important signalling role in the induction of tumour-associated macrophage polarization.
Thu Sep 25 00:00:00 EDT 2014
Collective nitric oxide production provides tissue-wide immunity during Leishmania infection.
The Journal of clinical investigation
Olekhnovitch R,Ryffel B,Müller AJ,Bousso P
45-0112 was used in Flow cytometry/Cell sorting to investigate the contribution of cell-intrinsic and cell-extrinsic nitric oxide activity on the control of Leishmania major infection.
Tue Apr 01 00:00:00 EDT 2014
Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation.
The Journal of clinical investigation
Li J,Razumilava N,Gores GJ,Walters S,Mizuochi T,Mourya R,Bessho K,Wang YH,Glaser SS,Shivakumar P,Bezerra JA
45-0112 was used in Flow cytometry/Cell sorting to demonstrate the role of the Th2-promoting cytokine, IL-33, in cholangiocyte proliferation.
Tue Jul 01 00:00:00 EDT 2014
Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection.
Proceedings of the National Academy of Sciences of the United States of America
Dalli J,Chiang N,Serhan CN
45-0112 was used in Flow cytometry/Cell sorting to identify conserved chemical signals and pathways in mouse, and human tissues that enhance host immune responses to contain infections.
Tue Nov 04 00:00:00 EST 2014
Gemcitabine enhances the efficacy of reovirus-based oncotherapy through anti-tumour immunological mechanisms.
British journal of cancer
Gujar SA,Clements D,Dielschneider R,Helson E,Marcato P,Lee PW
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that reovirus and gemcitabine combination treatment postpones peritoneal carcinomatosis development and prolongs the survival of cancer-bearing hosts.
Tue Jan 07 00:00:00 EST 2014
T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.
Mucosal immunology
Chu DK,Mohammed-Ali Z,Jiménez-Saiz R,Walker TD,Goncharova S,Llop-Guevara A,Kong J,Gordon ME,Barra NG,Gillgrass AE,Van Seggelen H,Khan WI,Ashkar AA,Bramson JL,Humbles AA,Kolbeck R,Waserman S,Jordana M
45-0112 was used in Flow cytometry/Cell sorting to reveal intestinal Th2 priming is initiated by an autocrine/paracrine acting CD4(+) Th cell-intrinsic IL-4 program that is controlled by DC OX40L.
Sat Nov 01 00:00:00 EDT 2014
Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection.
PLoS pathogens
Neal LM,Knoll LJ
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that stimulation of TLR11 by TgPRF promotes recruitment of Ly6Chi CCR2+ monocytes, which can provide resistance to pathogens.
Sun Jun 01 00:00:00 EDT 2014
Apoptotic cell administration is detrimental in murine renal ischaemia reperfusion injury.
Journal of inflammation (London, England)
Hesketh EE,Kluth DC,Hughes J
45-0112 was used in Flow cytometry/Cell sorting to study tissue damage and immune responses following renal ischaemia reperfusion injury and assess whether administration of apoptotic cells represents a novel line of therapy.
Wed Oct 15 00:00:00 EDT 2014
GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis.
Journal of immunology (Baltimore, Md. : 1950)
Zhou Q,Ho AW,Schlitzer A,Tang Y,Wong KH,Wong FH,Chua YL,Angeli V,Mortellaro A,Ginhoux F,Kemeny DM
45-0112 was used in Flow cytometry/Cell sorting to identify GM-CSF-licensed CD11b(+) lung DCs as a key component for induction of Th2 responses.
Tue Jul 15 00:00:00 EDT 2014
GM-CSF but not IL-17 is critical for the development of severe interstitial lung disease in SKG mice.
Journal of immunology (Baltimore, Md. : 1950)
Shiomi A,Usui T,Ishikawa Y,Shimizu M,Murakami K,Mimori T
45-0112 was used in Flow cytometry/Cell sorting to investigate the importance of GM-CSF in the development of severe interstitial lung disease.
Tue Jul 15 00:00:00 EDT 2014
Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Jiao J,Dragomir AC,Kocabayoglu P,Rahman AH,Chow A,Hashimoto D,Leboeuf M,Kraus T,Moran T,Carrasco-Avino G,Friedman SL,Merad M,Aloman C
45-0112 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells in neutrophil homeostasis, showing a central role in regulation of bone marrow release and survival of neutrophils.
Tue Apr 01 00:00:00 EDT 2014
CCR5 knockout prevents neuronal injury and behavioral impairment induced in a transgenic mouse model by a CXCR4-using HIV-1 glycoprotein 120.
Journal of immunology (Baltimore, Md. : 1950)
Maung R,Hoefer MM,Sanchez AB,Sejbuk NE,Medders KE,Desai MK,Catalan IC,Dowling CC,de Rozieres CM,Garden GA,Russo R,Roberts AJ,Williams R,Kaul M
45-0112 was used in Flow cytometry/Cell sorting to investigate the role of CCR5 in HIV-1-associated dementia, showing that CCR5 knockout prevents neuronal injury and behavioral impairment in a mouse model.
Fri Aug 15 00:00:00 EDT 2014
Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.
Carcinogenesis
Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB
45-0112 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.
Tue Apr 01 00:00:00 EDT 2014
Pneumolysin expression by streptococcus pneumoniae protects colonized mice from influenza virus-induced disease.
Virology
Wolf AI,Strauman MC,Mozdzanowska K,Williams KL,Osborne LC,Shen H,Liu Q,Garlick D,Artis D,Hensley SE,Caton AJ,Weiser JN,Erikson J
45-0112-82 was used in Flow Cytometry to investigate severity of influenza virus response with respiratory microbe presence.
Fri Aug 01 00:00:00 EDT 2014
C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation.
The Journal of biological chemistry
Zhao XQ,Zhu LL,Chang Q,Jiang C,You Y,Luo T,Jia XM,Lin X
45-0112 was used in Flow cytometry/Cell sorting to investigate the mechanism by which Dectin-3 induces Mincle expression.
Fri Oct 24 00:00:00 EDT 2014
Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.
PloS one
Deng B,Wang CW,Arnardottir HH,Li Y,Cheng CY,Dalli J,Serhan CN
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that human macrophages can produce a bioactive product with anti-inflammatory properties, identified in the maresin metabolome as maresin 2.
Mon Mar 30 00:00:00 EDT 2015
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
45-0112 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow.
The Journal of experimental medicine
Devi S,Wang Y,Chew WK,Lima R,A-González N,Mattar CN,Chong SZ,Schlitzer A,Bakocevic N,Chew S,Keeble JL,Goh CC,Li JL,Evrard M,Malleret B,Larbi A,Renia L,Haniffa M,Tan SM,Chan JK,Balabanian K,Nagasawa T,Bachelerie F,Hidalgo A,Ginhoux F,Kubes P,Ng LG
45-0112 was used in Flow cytometry/Cell sorting to examine bone marrow neutrophil activity in response to G-CSF or CXCR4 inhibition by plerixafor treatments in vivo.
Mon Oct 21 00:00:00 EDT 2013
Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.
Molecular therapy : the journal of the American Society of Gene Therapy
Gujar S,Dielschneider R,Clements D,Helson E,Shmulevitz M,Marcato P,Pan D,Pan LZ,Ahn DG,Alawadhi A,Lee PW
45-0112 was used in Flow cytometry/Cell sorting to develop a virus-based therapy that suppresses immunomodulation and targets ovarian peritoneal carcinomatosis.
Fri Feb 01 00:00:00 EST 2013
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
McKee AS,Burchill MA,Munks MW,Jin L,Kappler JW,Friedman RS,Jacobelli J,Marrack P
45-0112 was used in Flow cytometry/Cell sorting to study how aluminium acts as an adjuvant by introducing host DNA into the cytoplasm of dendritic cells, where it engages receptors promoting MHC II presentation.
Tue Mar 19 00:00:00 EDT 2013
Role of NK cells in host defense against pulmonary type A Francisella tularensis infection.
Microbes and infection
Schmitt DM,O'Dee DM,Brown MJ,Horzempa J,Russo BC,Morel PA,Nau GJ
45-0112 was used in Flow cytometry/Cell sorting to investigate role of NK cells against F.tularensis infection in vivo, with LVS-vaccinated murine hosts.
Fri Mar 01 00:00:00 EST 2013
TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity.
The Journal of investigative dermatology
Mohammed J,Gunderson AJ,Khong HH,Koubek RD,Udey MC,Glick AB
45-0112 was used in Flow cytometry/Cell sorting to highlight a role for keratinocyte-derived TGFβ1 in dendritic cell trafficking and in the initiation of skin inflammation.
Tue Jan 01 00:00:00 EST 2013
Characterization and evaluation of a new oncolytic vaccinia virus strain LIVP6.1.1 for canine cancer therapy.
Bioengineered
Gentschev I,Patil SS,Adelfinger M,Weibel S,Geissinger U,Frentzen A,Chen NG,Yu YA,Zhang Q,Ogilvie G,Szalay AA
45-0112 was used in Flow cytometry/Cell sorting to demonstrate the efficacy of new VACV strain LIVP6.1.1 for canine cancer therapy.
Wed Sep 04 00:00:00 EDT 2013
A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Teo TH,Lum FM,Claser C,Lulla V,Lulla A,Merits A,Rénia L,Ng LF
45-0112 was used in Flow cytometry/Cell sorting to assess the roles of T cells in Chikungunya virus infection using immunodeficient mice.
Tue Jan 01 00:00:00 EST 2013
Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.
Journal of immunology (Baltimore, Md. : 1950)
Hams E,Locksley RM,McKenzie AN,Fallon PG
45-0112 was used in Flow cytometry/Cell sorting to investigate the role of IL-25-responsive innate cells in regulating weight and glucose homeostasis.
Sun Dec 01 00:00:00 EST 2013
Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents.
Chemistry & biology
Dalli J,Winkler JW,Colas RA,Arnardottir H,Cheng CY,Chiang N,Petasis NA,Serhan CN
45-0112 was used in Flow cytometry/Cell sorting to investigate the effect of synthetic Resolvins on inflammatory responses.
Thu Feb 21 00:00:00 EST 2013
Chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis.
PloS one
Jupelli M,Shimada K,Chiba N,Slepenkin A,Alsabeh R,Jones HD,Peterson E,Chen S,Arditi M,Crother TR
45-0112 was used in Flow cytometry/Cell sorting to investigate how chlamydia pneumoniae infection in mice induces chronic lung inflammation, iBALT formation, and fibrosis..
Sat Aug 02 00:00:00 EDT 2014
CD36 contributes to malaria parasite-induced pro-inflammatory cytokine production and NK and T cell activation by dendritic cells.
PloS one
Gowda NM,Wu X,Kumar S,Febbraio M,Gowda DC
45-0112 was used in Flow cytometry/Cell sorting to imply that the effect of CD36 on malaria immunity is imprinted early during infection when parasite load is low.
Tue Aug 05 00:00:00 EDT 2014
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity
Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA
45-0112 was used in an ELISA assay to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.
Fri Sep 21 00:00:00 EDT 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
45-0112 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 EDT 2012
A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade.
Molecular therapy : the journal of the American Society of Gene Therapy
Agudo J,Ruzo A,Kitur K,Sachidanandam R,Blander JM,Brown BD
45-0112 was used in Flow cytometry/Cell sorting to characterise the transient innate immune reaction to lentiviral vector, and evaluate a means for its prevention during LV-mediated gene transfer.
Sat Dec 01 00:00:00 EST 2012
Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response.
PLoS pathogens
Ribeiro-Gomes FL,Peters NC,Debrabant A,Sacks DL
45-0112 was used in Flow cytometry/Cell sorting to study how exploitation of immunosuppressive effects by L.major following rapid uptake by skin neutrophils allows inhibition of acquired resistance.
Wed Feb 01 00:00:00 EST 2012
Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation.
European journal of immunology
Dahlem T,Cho S,Spangrude GJ,Weis JJ,Weis JH
45-0112 was used in Flow cytometry/Cell sorting to investigate the role of the transcriptional repressor Snai3 protein in the derivation of cells of the haematopoietic system.
Sun Apr 01 00:00:00 EDT 2012
The ubiquitin-like protein, ISG15, is a novel tumor-associated antigen for cancer immunotherapy.
Cancer immunology, immunotherapy : CII
Wood LM,Pan ZK,Seavey MM,Muthukumaran G,Paterson Y
45-0112 was used in Flow cytometry/Cell sorting to investigate ISG15, a novel tumor-associated antigen for cancer immunotherapy.
Tue May 01 00:00:00 EDT 2012
Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions.
Journal of immunology (Baltimore, Md. : 1950)
Deguine J,Breart B,Lemaître F,Bousso P
45-0112 was used in Flow cytometry/Cell sorting to investigate how natural killer cells integrate signals from antibody-coated targets and stress ligands on tumour cells.
Sat Dec 15 00:00:00 EST 2012
Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcoma.
PloS one
Gentschev I,Adelfinger M,Josupeit R,Rudolph S,Ehrig K,Donat U,Weibel S,Chen NG,Yu YA,Zhang Q,Heisig M,Thamm D,Stritzker J,Macneill A,Szalay AA
45-0112 was used in Flow cytometry/Cell sorting to describe the establishment of an in vivo model of canine soft tissue sarcoma, allowing preclinical evaluation of oncolytic vaccinia virus for therapy.
Thu Sep 20 00:00:00 EDT 2012
Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody.
PloS one
Patil SS,Gentschev I,Adelfinger M,Donat U,Hess M,Weibel S,Nolte I,Frentzen A,Szalay AA
45-0112 was used in Flow cytometry/Cell sorting to analyse oncolytic vaccinia virus-mediated delivery and production of scAb GLAF-1 and the oncolytic and immunological effects on canine cancer.
Thu Mar 28 00:00:00 EDT 2013
Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.
Journal of the American Heart Association
Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M
45-0112 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.
Mon Oct 01 00:00:00 EDT 2012
Early sensing of Yersinia pestis airway infection by bone marrow cells.
Frontiers in cellular and infection microbiology
Vagima Y,Levy Y,Gur D,Tidhar A,Aftalion M,Abramovich H,Zahavy E,Zauberman A,Flashner Y,Shafferman A,Mamroud E
45-0112 was used in Flow cytometry/Cell sorting to indicate that lung infection by Y. pestis is sensed by BM cells early after infection, although bacterial colonization of the BM occurs at late disease stages.
Wed Dec 11 00:00:00 EST 2013
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
45-0112 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 EDT 2011
Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract.
mBio
Parker D,Martin FJ,Soong G,Harfenist BS,Aguilar JL,Ratner AJ,Fitzgerald KA,Schindler C,Prince A
45-0112 was used in Flow cytometry/Cell sorting to show how the extracellular pathogen Streptococcus pneumoniae activates type I interferon signalling in the murine lung, and the role of this response in bacterial clearance.
Thu Oct 27 00:00:00 EDT 2011
Novel proresolving aspirin-triggered DHA pathway.
Chemistry & biology
Serhan CN,Fredman G,Yang R,Karamnov S,Belayev LS,Bazan NG,Zhu M,Winkler JW,Petasis NA
45-0112 was used in Flow cytometry/Cell sorting to investigate endogenous mechanisms of the resolution of acute inflammation, showing a novel proresolving aspirin-triggered DHA pathway.
Fri Aug 26 00:00:00 EDT 2011
High-fructose, medium chain trans fat diet induces liver fibrosis and elevates plasma coenzyme Q9 in a novel murine model of obesity and nonalcoholic steatohepatitis.
Hepatology (Baltimore, Md.)
Kohli R,Kirby M,Xanthakos SA,Softic S,Feldstein AE,Saxena V,Tang PH,Miles L,Miles MV,Balistreri WF,Woods SC,Seeley RJ
45-0112 was used in Flow cytometry/Cell sorting to demonstrate that nongenetically modified mice maintained on an HFHC diet in addition to developing obesity have increased hepatic ROS and a NASH-like phenotype with significant fibrosis.
Wed Sep 01 00:00:00 EDT 2010
CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection.
Infection and immunity
Eppert BL,Motz GT,Wortham BW,Flury JL,Borchers MT
45-0112 was used in Flow cytometry/Cell sorting to investigate the roles of CCR7 in the host defense against pulmonary infection, showing that CCR7 deficiency leads to leukocyte activation and increased infection clearance.
Sat May 01 00:00:00 EDT 2010
CBFbeta is critical for AML1-ETO and TEL-AML1 activity.
Blood
Roudaia L,Cheney MD,Manuylova E,Chen W,Morrow M,Park S,Lee CT,Kaur P,Williams O,Bushweller JH,Speck NA
45-0112 was used in Flow cytometry/Cell sorting to validate the AML1-ETO and TEL-AML1 chimeric protein Runt domain/CBFbeta interaction as a therapeutic target in core binding factor leukemias.
Thu Mar 26 00:00:00 EDT 2009
Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism.
Molecular therapy : the journal of the American Society of Gene Therapy
Devey L,Ferenbach D,Mohr E,Sangster K,Bellamy CO,Hughes J,Wigmore SJ
45-0112 was used in Flow cytometry/Cell sorting to study ischemia reperfusion injury protection in the liver by tissue-resident macrophages via a heme oxygenase-1-dependent mechanism.
Thu Jan 01 00:00:00 EST 2009
