Product References
Chloride intracellular channel 1 promotes esophageal squamous cell carcinoma proliferation via mTOR signalling.
Translational oncology
Geng H,Feng C,Sun Z,Fan X,Xie Y,Gu J,Fan L,Liu G,Li C,Thorne RF,Zhang XD,Li X,Liu X
Sun Jan 01 00:00:00 EST 2023
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
Endocrinology
He W,Cheng Z,Huo Z,Lin B,Wang X,Sun Y,Yu S,Cao S,Xue J,Liu R,Lv W,Li Y,Hong S,Xiao H
Mon Jan 09 00:00:00 EST 2023
The Key Role of Initiation Timing on Stroke Rehabilitation by Remote Ischemic Conditioning with Exercise (RICE).
Neurological research
Wang Q,Wehbe A,Wills M,Li F,Geng X,Ding Y
Sat Apr 01 00:00:00 EDT 2023
Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.
Toxicology
Zhou YJ,Qiao QF,Wang LQ,Sheng TY,Cui MX,Chen QD,Wang CY,Zhang YX
Mon May 01 00:00:00 EDT 2023
Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.
Toxicology
Zhou YJ,Qiao QF,Wang LQ,Sheng TY,Cui MX,Chen QD,Wang CY,Zhang YX
Mon May 01 00:00:00 EDT 2023
JQ-1/bortezomib combination strongly impairs MM and PEL survival by inhibiting c-Myc and mTOR despite the activation of prosurvival mechanisms.
Experimental hematology
Arena A,Romeo MA,Benedetti R,Gilardini Montani MS,Cirone M
Tue Mar 21 00:00:00 EDT 2023
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Autophagy
Yan G,Li X,Zheng Z,Gao W,Chen C,Wang X,Cheng Z,Yu J,Zou G,Farooq MZ,Zhu X,Zhu W,Zhong Q,Yan X
Thu Dec 01 00:00:00 EST 2022
3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells.
Pharmaceutics
Santarelli R,Pompili C,Gilardini Montani MS,Evangelista L,Gonnella R,Cirone M
Thu Mar 17 00:00:00 EDT 2022
Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling.
Military Medical Research
Li MZ,Liu EJ,Zhou QZ,Li SH,Liu SJ,Yu HT,Pan QH,Sun F,He T,Wang WJ,Ke D,Feng YQ,Li J,Wang JZ
Thu Jul 07 00:00:00 EDT 2022
Macrophages-Related Genes Biomarkers in the Deterioration of Atherosclerosis.
Frontiers in cardiovascular medicine
Zheng Y,Qi B,Gao W,Qi Z,Liu Y,Wang Y,Feng J,Cheng X,Luo Z,Li T
Tue Jul 19 00:00:00 EDT 2022
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Metabolites
Liu M,Yue Z,Zhang B,Li F,Liu L,Li F
Thu Aug 25 00:00:00 EDT 2022
Asymptomatic Hyperuricemia Is Associated with Achilles Tendon Rupture through Disrupting the Normal Functions of Tendon Stem/Progenitor Cells.
Stem cells international
Liang J,Chen B,Li Y,Nie D,Lei C,Yang Q,Zhou Y,Li S,Chen S,Li B,Shu L,Chen L,Wang W
Thu Dec 22 00:00:00 EST 2022
Comparison of the Effects of Inorganic or Amino Acid-Chelated Zinc on Mouse Myoblast Growth in vitro and Growth Performance and Carcass Traits in Growing-Finishing Pigs.
Frontiers in nutrition
Zhang L,Guo Q,Duan Y,Lin X,Ni H,Zhou C,Li F
Fri Apr 29 00:00:00 EDT 2022
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress.
Cell death discovery
Benedetti R,Romeo MA,Arena A,Gilardini Montani MS,Di Renzo L,D'Orazi G,Cirone M
Sat Jun 25 00:00:00 EDT 2022
RIOK3-Mediated Akt phosphorylation facilitates synergistic replication of Marek's disease and reticuloendotheliosis viruses.
Virulence
Du X,Zhou D,Zhou J,Xue J,Cheng Z
Thu Dec 01 00:00:00 EST 2022
Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Frontiers in pharmacology
Liao W,Yang W,Xu J,Yan Z,Pan M,Xu X,Zhou S,Zhu Y,Lan J,Zeng M,Han X,Li S,Li Y,Liang K,Gao Y,Peng Q
Wed Nov 17 00:00:00 EST 2021
p53-R273H Sustains ROS, Pro-Inflammatory Cytokine Release and mTOR Activation While Reducing Autophagy, Mitophagy and UCP2 Expression, Effects Prevented by wtp53.
Biomolecules
Romeo MA,Gilardini Montani MS,Benedetti R,Arena A,D'Orazi G,Cirone M
Wed Feb 24 00:00:00 EST 2021
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
Autophagy
Zhou C,Liang Y,Zhou L,Yan Y,Liu N,Zhang R,Huang Y,Wang M,Tang Y,Ali DW,Wang Y,Michalak M,Chen XZ,Tang J
Fri Oct 01 00:00:00 EDT 2021
UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma.
Aging
Zhang M,Chen H,Qin P,Cai T,Li L,Chen R,Liu S,Chen H,Lin W,Chen H,Strickland AL,Xiong H,Jiang Q
Tue Sep 14 00:00:00 EDT 2021
New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects.
Pharmaceuticals (Basel, Switzerland)
Arena A,Romeo MA,Benedetti R,Masuelli L,Bei R,Gilardini Montani MS,Cirone M
Fri Oct 22 00:00:00 EDT 2021
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Frontiers in cell and developmental biology
Luo Q,Li X,Gan G,Yang M,Chen X,Chen F
Sat Jul 16 00:00:00 EDT 2022
Tetrandrine Modulates Rheb-mTOR Signaling-Mediated Selective Autophagy and Protects Pulmonary Fibrosis.
Frontiers in pharmacology
Liu Y,Zhong W,Zhang J,Chen W,Lu Y,Qiao Y,Zeng Z,Huang H,Cai S,Dong H
Sat Dec 11 00:00:00 EST 2021
Mammalian target of rapamycin signaling pathway is involved in synaptic plasticity of the spinal dorsal horn and neuropathic pain in rats by regulating autophagy.
Neuroreport
Hu J,Chen X,Cheng J,Kong F,Xia H,Wu J
Wed Aug 04 00:00:00 EDT 2021
The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation.
Molecular cancer
Chen LY,Wang L,Ren YX,Pang Z,Liu Y,Sun XD,Tu J,Zhi Z,Qin Y,Sun LN,Li JM
Mon Nov 23 00:00:00 EST 2020
OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism.
Journal of hepatology
Dai W,Xu L,Yu X,Zhang G,Guo H,Liu H,Song G,Weng S,Dong L,Zhu J,Liu T,Guo C,Shen X
Fri May 01 00:00:00 EDT 2020
A CRISPR knockout negative screen reveals synergy between CDKs inhibitor and metformin in the treatment of human cancer in vitro and in vivo.
Signal transduction and targeted therapy
Ma Y,Zhu Q,Liang J,Li Y,Li M,Zhang Y,Wang X,Zeng Y,Jiao Y
Wed Aug 19 00:00:00 EDT 2020
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Nature
Lu XY,Shi XJ,Hu A,Wang JQ,Ding Y,Jiang W,Sun M,Zhao X,Luo J,Qi W,Song BL
Tue Dec 01 00:00:00 EST 2020
Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors.
Aging
Chen Y,Gao H,Liu Q,Xie W,Li B,Cheng S,Guo J,Fang Q,Zhu H,Wang Z,Wang J,Li C,Zhang Y
Tue Dec 29 00:00:00 EST 2020
miR-196b-5p controls adipocyte differentiation and lipogenesis through regulating mTORC1 and TGF-β signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Shi Y,Li F,Wang S,Wang C,Xie Y,Zhou J,Li X,Wang B
Wed Jul 01 00:00:00 EDT 2020
STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I.
Autophagy
Zhou C,Qian X,Hu M,Zhang R,Liu N,Huang Y,Yang J,Zhang J,Bai H,Yang Y,Wang Y,Ali D,Michalak M,Chen XZ,Tang J
Thu Oct 01 00:00:00 EDT 2020
Leucine attenuates muscle atrophy and autophagosome formation by activating PI3K/AKT/mTOR signaling pathway in rotator cuff tears.
Cell and tissue research
Zheng R,Huang S,Zhu J,Lin W,Xu H,Zheng X
Tue Oct 01 00:00:00 EDT 2019
Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.
Cell communication and signaling : CCS
Zhou C,Wang M,Yang J,Xiong H,Wang Y,Tang J
Thu Aug 22 00:00:00 EDT 2019
Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yang Y,Qi Q,Wang Y,Shi Y,Yang W,Cen Y,Zhu E,Li X,Chen D,Wang B
Fri Jun 01 00:00:00 EDT 2018
Cysteine-rich protein 61 regulates adipocyte differentiation from mesenchymal stem cells through mammalian target of rapamycin complex 1 and canonical Wnt signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yang Y,Qi Q,Wang Y,Shi Y,Yang W,Cen Y,Zhu E,Li X,Chen D,Wang B
Fri Jun 01 00:00:00 EDT 2018
EPS8 regulates proliferation, apoptosis and chemosensitivity in BCR-ABL positive cells via the BCR-ABL/PI3K/AKT/mTOR pathway.
Oncology reports
Huang R,Liu H,Chen Y,He Y,Kang Q,Tu S,He Y,Zhou X,Wang L,Yang J,Wu A,Li Y
Mon Jan 01 00:00:00 EST 2018
EPS8 regulates proliferation, apoptosis and chemosensitivity in BCR-ABL positive cells via the BCR-ABL/PI3K/AKT/mTOR pathway.
Oncology reports
Huang R,Liu H,Chen Y,He Y,Kang Q,Tu S,He Y,Zhou X,Wang L,Yang J,Wu A,Li Y
Mon Jan 01 00:00:00 EST 2018
MAN1B1 is associated with poor prognosis and modulates proliferation and apoptosis in bladder cancer.
Gene
Wang HF,Wu JH,Gai JW,Yang SQ,Ma QT,Ma HS,Feng Q
Sun Dec 30 00:00:00 EST 2018
MAN1B1 is associated with poor prognosis and modulates proliferation and apoptosis in bladder cancer.
Gene
Wang HF,Wu JH,Gai JW,Yang SQ,Ma QT,Ma HS,Feng Q
Sun Dec 30 00:00:00 EST 2018
Macrophages confer resistance to PI3K inhibitor GDC-0941 in breast cancer through the activation of NF-κB signaling.
Cell death & disease
Usman MW,Gao J,Zheng T,Rui C,Li T,Bian X,Cheng H,Liu P,Luo F
Tue Jul 24 00:00:00 EDT 2018
Macrophages confer resistance to PI3K inhibitor GDC-0941 in breast cancer through the activation of NF-κB signaling.
Cell death & disease
Usman MW,Gao J,Zheng T,Rui C,Li T,Bian X,Cheng H,Liu P,Luo F
Tue Jul 24 00:00:00 EDT 2018
FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Huang T,Liu D,Wang Y,Li P,Sun L,Xiong H,Dai Y,Zou M,Yuan X,Qiu H
Fri Nov 09 00:00:00 EST 2018
FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Huang T,Liu D,Wang Y,Li P,Sun L,Xiong H,Dai Y,Zou M,Yuan X,Qiu H
Fri Nov 09 00:00:00 EST 2018
Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Jin J,Hu K,Ye M,Wu D,He Q
Tue Sep 18 00:00:00 EDT 2018
Rapamycin Reduces Podocyte Apoptosis and is Involved in Autophagy and mTOR/ P70S6K/4EBP1 Signaling.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Jin J,Hu K,Ye M,Wu D,He Q
Tue Sep 18 00:00:00 EDT 2018
Highly Selective, Potent, and Oral mTOR Inhibitor for Treatment of Cancer as Autophagy Inducer.
Journal of medicinal chemistry
Guo Q,Yu C,Zhang C,Li Y,Wang T,Huang Z,Wang X,Zhou W,Li Y,Qin Z,Wang C,Gao R,Nie Y,Ma Y,Shi Y,Zheng J,Yang S,Fan Y,Xiang R
Thu Feb 08 00:00:00 EST 2018
Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells.
Oncology reports
Liu X,Duan C,Ji J,Zhang T,Yuan X,Zhang Y,Ma W,Yang J,Yang L,Jiang Z,Yu H,Liu Y
Sat Jul 01 00:00:00 EDT 2017
Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells.
Oncology reports
Liu X,Duan C,Ji J,Zhang T,Yuan X,Zhang Y,Ma W,Yang J,Yang L,Jiang Z,Yu H,Liu Y
Sat Jul 01 00:00:00 EDT 2017
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Oncotarget
Wang D,Wang M,Jiang N,Zhang Y,Bian X,Wang X,Roberts TM,Zhao JJ,Liu P,Cheng H
Tue Mar 15 00:00:00 EDT 2016
Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer.
Oncotarget
Wang D,Wang M,Jiang N,Zhang Y,Bian X,Wang X,Roberts TM,Zhao JJ,Liu P,Cheng H
Tue Mar 15 00:00:00 EDT 2016
