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Invitrogen
53BP1 Polyclonal Antibody
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Product Details
PA5-85851
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the carboxy-terminus of h53BP1, conjugated to a carrier protein.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2792970
Product Specific Information
Keep as concentrated solution.
Positive Control: HeLa, Neuro 2A, C8D30, NIH-3T3, HaCaT.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
53BP1 (P53-binding protein 1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, 53BP1 is phosphorylated and localizes to the presumptive sites of damage, specifically, double-strand breaks. 53BP1 may have a role in checkpoint signaling during mitosis, enhances TP53-mediated transcriptional activation, and participates in DNA repair by maintaining genomic stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 53BP1; FLJ41424; MGC138366; murine p53-binding protein; p53-binding protein 1; TP53-binding protein 1; transformation related protein 53 binding-protein 1; tumor protein 53-binding protein, 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1
Gene Aliases: 53BP1; m53BP1; p202; p53BP1; TDRD30; TP53; TP53BP1; Trp53bp1
UniProt ID: (Human) Q12888, (Mouse) P70399
Entrez Gene ID: (Human) 7158, (Mouse) 27223
DNA damage checkpoint
double-strand break repair via nonhomologous end joining
transcription, DNA-templated
cellular response to DNA damage stimulus
protein sumoylation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
cellular response to X-ray
DNA repair
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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